Abstract:
:To determine the influence of an altered carotid body function on the laryngeal chemoreflex (LCR) response, reflex apnea was induced by laryngeal water stimulation during normoxia or acute hypoxia in unanesthetized awake lambs in which the ventilatory response to acute hypoxia was attenuated by prolonged postnatal hypoxemia. Prolonged hypoxemia (H) was induced in seven lambs for 12 d after birth through exposure to 0.10 fraction of inspired oxygen. Five control lambs were kept in 0.21 fraction of inspired oxygen. Studies were performed repeatedly during the first 7 wk after birth. The ventilatory response to LCR stimulation, expressed as a percent decrease in minute ventilation, was tested in 0.21, 0.14, and 0.10 fraction of inspired oxygen. H after birth resulted in a markedly increased inhibition of ventilation in response to LCR stimulation and postponed the age-related decrease in LCR response. A potential failure to recover from apnea occurred only in the H lambs, and in these lambs there was a significantly greater requirement for mechanical ventilation after LCR stimulation. Acute hypoxemia preceding LCR stimulation significantly attenuated the ventilatory response in both control and H lambs, with a stronger effect in the H lambs. There was no difference between the two groups in heart rate response to LCR stimulation. Acute hypoxemia significantly augmented reflex bradycardia in the H lambs. These results show that there is a relationship between H immediately after birth--which is known to delay resetting of carotid chemoreceptors--and augmented ventilatory inhibition in response to LCR stimulation. They do not confirm the theory that acute hypoxia reinforces reflex apnea.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Sladek M,Grogaard JB,Parker RA,Sundell HWdoi
10.1203/00006450-199312000-00024subject
Has Abstractpub_date
1993-12-01 00:00:00pages
813-20issue
6eissn
0031-3998issn
1530-0447journal_volume
34pub_type
杂志文章abstract::Ambulatory blood pressure (ABP) monitoring offers a reliable method for determining blood pressure (BP) in children. The aim of this cohort study was to examine whether maternal preeclampsia is associated with elevated BP in an offspring. The study population consisted of 57 children born to preeclamptic mothers (PRE)...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.pdr.0000196734.54473.e3
更新日期:2006-02-01 00:00:00
abstract::Hereditary surfactant protein B (SP-B) deficiency has been lethal in the first year of life without lung transplantation. We tested the hypothesis that SP-B gene mutations may result in milder phenotypes by investigating the mechanisms for lung disease in two children with less severe symptoms than have been previousl...
journal_title:Pediatric research
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更新日期:2000-09-01 00:00:00
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更新日期:2010-04-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.PDR.0000169976.20029.64
更新日期:2005-08-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/00006450-199206000-00009
更新日期:1992-06-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/00006450-199304000-00004
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Infantile hemangioma (IH) is the most frequent vascular tumor of early childhood. Recently, propranolol, a nonselective β1- and β2-adrenoceptor inhibitor, was introduced into the therapy of severe proliferating IH with excellent results. However, the underlying mechanism of action of propranolol is still unc...
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pub_type: 杂志文章
doi:10.1038/pr.2013.16
更新日期:2013-04-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2014.11
更新日期:2014-05-01 00:00:00
abstract::Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cereb...
journal_title:Pediatric research
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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doi:10.1203/01.PDR.0000058923.08017.6F
更新日期:2003-05-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199808000-00016
更新日期:1998-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1203/00006450-198911000-00014
更新日期:1989-11-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3181bf5fab
更新日期:2010-01-01 00:00:00
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更新日期:2013-09-01 00:00:00
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doi:10.1203/PDR.0b013e31815685b9
更新日期:2007-11-01 00:00:00
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更新日期:2016-09-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199812000-00008
更新日期:1998-12-01 00:00:00
abstract::Sparse-fur mice, 28 d of age with the x-chromosomal inherited defect of ornithine carbamoyltransferase, were used to investigate if tryptophan and the serotonin pathway in the brain are affected in this animal model which closely resembles the human inborn error of metabolism. Increased concentrations of tryptophan an...
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pub_type: 杂志文章
doi:10.1203/00006450-198404000-00014
更新日期:1984-04-01 00:00:00
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doi:10.1203/01.PDR.0000099793.99608.CB
更新日期:2004-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198101000-00014
更新日期:1981-01-01 00:00:00
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更新日期:2004-10-01 00:00:00
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journal_title:Pediatric research
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更新日期:2007-09-01 00:00:00
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更新日期:1980-11-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199310000-00017
更新日期:1993-10-01 00:00:00
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更新日期:2021-01-19 00:00:00
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journal_title:Pediatric research
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1203/00006450-199603000-00017
更新日期:1996-03-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199804000-00016
更新日期:1998-04-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-200008000-00018
更新日期:2000-08-01 00:00:00