Abstract:
:Data are scant regarding the development of cerebrovascular autoregulation in intrauterine growth-restricted (IUGR) newborns. We tested the hypothesis that IUGR improves the ability of neonates to withstand critical periods of gradual hemorrhagic hypotension by optimizing cerebrovascular autoregulation. Studies were conducted on 1-d-old anesthetized piglets divided into groups of normal weight (NW, n = 14, body weight = 1518 +/- 122 g) and IUGR (n = 14, body weight = 829 +/- 50 g) animals. Physiologic parameters, including regional cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO(2)), were similar in NW and IUGR piglets under baseline conditions. Controlled arterial blood loss [hemorrhagic hypotension (HH)] induced a stepwise reduction of the mean arterial blood pressure of 49 +/- 3 mm Hg (mild HH), 39 +/- 3 mm Hg (moderate HH), and 30 +/- 3 mm Hg (severe HH) in seven NW and seven IUGR piglets (p < 0.05). In NW piglets, cortical CBF and CMRO(2) was reduced already at moderate HH (p < 0.05). A similar CMRO(2) reduction occurred during severe HH in NW and IUGR piglets (p < 0.05). In addition, during mild and moderate HH, primarily in IUGR piglets, an increase in regional CBF of brainstem, cerebellum, and thalamus was shown compared with baseline values (p < 0.05). Furthermore, under these conditions, cerebral cortex blood flow was maintained in newborn IUGR animals. In contrast, NW piglets exhibited a significant reduction in CBF (p < 0.05) during moderate HH. Thus, IUGR resulted in an improved ability to withstand critical periods of gradual oxygen deficit as shown by improved cerebrovascular autoregulation during hemorrhagic hypotension.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Bauer R,Walter B,Vollandt R,Zwiener Udoi
10.1203/01.PDR.0000139425.94975.77subject
Has Abstractpub_date
2004-10-01 00:00:00pages
639-46issue
4eissn
0031-3998issn
1530-0447pii
01.PDR.0000139425.94975.77journal_volume
56pub_type
杂志文章abstract::We used quin2, a high affinity fluorescent calcium indicator to measure free cytosolic Ca++ in neutrophils isolated from fresh heparinized blood of 13 cystic fibrosis (CF) patients (age range 6-32 yr) and 11 healthy individuals (age range 25-41 yr) as controls. The mean value of free cytosolic Ca++ for CF patients was...
journal_title:Pediatric research
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更新日期:1985-04-01 00:00:00
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journal_title:Pediatric research
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journal_title:Pediatric research
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abstract::We have previously discovered that the adult Drosophila melanogaster is tolerant to a low O2 environment, withstanding hours of total O2 deprivation without showing any evidence of cell injury. Subsequently, our laboratory embarked on the study of hypoxia tolerance using a mutagenesis and overexpression screens to beg...
journal_title:Pediatric research
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journal_title:Pediatric research
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abstract::Fifty patients with haemophilia B, belonging to 29 kindreds, were investigated with a highly sensitive immunoradiometric assay based on a homologous antibody to factor IX. The assay measures factor IX antigen (f.IX:Ag) in plasma down to 0.025 U/dl. Seventeen of 18 investigated patients with severe haemophilia B had ve...
journal_title:Pediatric research
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doi:10.1203/00006450-198203000-00019
更新日期:1982-03-01 00:00:00
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journal_title:Pediatric research
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更新日期:2003-05-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Pediatric research
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更新日期:2017-04-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198410000-00014
更新日期:1984-10-01 00:00:00
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journal_title:Pediatric research
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doi:10.1038/pr.2015.112
更新日期:2015-10-01 00:00:00
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更新日期:1988-04-01 00:00:00
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journal_title:Pediatric research
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更新日期:2002-06-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198307000-00004
更新日期:1983-07-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3181b40a80
更新日期:2009-09-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/00006450-199309000-00025
更新日期:1993-09-01 00:00:00
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更新日期:2006-05-01 00:00:00
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更新日期:1999-05-01 00:00:00
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更新日期:2020-04-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00
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更新日期:2018-07-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1984-10-01 00:00:00
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journal_title:Pediatric research
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更新日期:1992-01-01 00:00:00
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journal_title:Pediatric research
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更新日期:1990-01-01 00:00:00
abstract::We used in vivo microdialysis to determine the impact of a focal hypoxic-ischemic insult on hippocampal amino acid efflux in the immature brain. Microdialysis probes were inserted into the right hippocampus of postnatal d 7 rats. To induce hypoxic-ischemic injury, the right carotid artery was ligated and animals were ...
journal_title:Pediatric research
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更新日期:1991-12-01 00:00:00
abstract::It is customary to estimate the uteroplacental function in singletons by defining appropriateness of birth weight by gestational age. Such a measure, however, is not available for the entire multiple pregnancy set. We evaluate a new index, total triplet birth weight, expressed as multiples of the median (MOM) birth we...
journal_title:Pediatric research
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doi:10.1203/01.pdr.0000202757.47761.76
更新日期:2006-04-01 00:00:00