Abstract:
:A child presented with obstructive sleep apnea (OSA) and a near-fatal airway obstruction and respiratory arrest shortly after receiving chloral hydrate (CH). We, therefore, hypothesize that CH might selectively depress upper airway maintaining muscles such as the genioglossus and so predispose to airway obstruction. Genioglossus (GG) and diaphragmatic (DIA) integrated electromyograms (I EMGs) were recorded in four cats and four rabbits before and after hypnotic doses of CH ranging from 200-1000 mg/kg. Results were similar in both species. Peak GG I EMG decreased within 10-20 min after CH in seven of eight animals. Average peak GG I EMGs were decreased from 100% before CH to as low as 37.0 +/- 27.2% (SD) after CH (P less than 0.001). Minimum GG I EMGs fell from 47.2 +/- 27.2% of peak values before CH to as low as 16.0 +/- 9.7% after CH (P less than 0.01). Phasic GG I EMGs decreased from 53.8 +/- 25.1% of peak control activity to as low as 20.6 +/- 24.6% after CH (P less than 0.05). By contrast, peak and phasic DIA I EMGs after CH were not significantly different from those before CH administration. We conclude that hypnotic doses of CH may preferentially depress GG activity as compared with DIA activity. Selective depression of airway-maintaining muscular contraction by CH may place susceptible patients at risk for life-threatening airway obstruction and may preclude the use of CH to facilitate sleep for polygraphic evaluations in patients suspected of having OSA.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Hershenson M,Brouillette RT,Olsen E,Hunt CEdoi
10.1203/00006450-198406000-00006subject
Has Abstractpub_date
1984-06-01 00:00:00pages
516-9issue
6eissn
0031-3998issn
1530-0447journal_volume
18pub_type
杂志文章abstract::Small bowel resection decreases brush border membrane (BBM) glucose uptake kinetics. Oral epidermal growth factor (EGF) returns net glucose transport across intact tissue to control levels despite persistence of a defect in BBM glucose uptake. The purpose of this study was to examine the effects of resection and EGF t...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.PDR.0000098500.94041.9B
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine in detail levels and patterns of physical activity in preschool children and the effects of gender and BMI on this activity. METHODS:Two hundred and fifty-three children aged 5 y participating in the Copenhagen Prospective Studies on Asthma in Childhood wore an accelerom...
journal_title:Pediatric research
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更新日期:2004-01-01 00:00:00
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journal_title:Pediatric research
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journal_title:Pediatric research
pub_type: 杂志文章,meta分析
doi:10.1038/s41390-019-0409-5
更新日期:2019-08-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/00006450-197601000-00011
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journal_title:Pediatric research
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更新日期:1999-04-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197910000-00020
更新日期:1979-10-01 00:00:00
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doi:10.1203/00006450-198907000-00002
更新日期:1989-07-01 00:00:00
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更新日期:2000-05-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2016.169
更新日期:2016-12-01 00:00:00
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journal_title:Pediatric research
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doi:10.1038/pr.2016.52
更新日期:2016-07-01 00:00:00
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更新日期:2005-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00
abstract::Premature birth causes significant health risks of the neonate and increases the cost for neonatal care. Urogenital infection, often caused by Gram-negative bacteria, is a known risk factor. Toll-like receptor-4 (TLR4) is the major endotoxin-signaling receptor and as such is crucial for the initiation of the innate im...
journal_title:Pediatric research
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更新日期:2002-09-01 00:00:00
abstract::Taurine is an essential amino acid during fetal life and appears to be vital for the growth of the fetus and for the development of the CNS. In intrauterine growth restriction (IUGR), fetal plasma concentrations of taurine are reduced, and we tested the hypothesis that this is caused by altered placental transport of ...
journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197805000-00008
更新日期:1978-05-01 00:00:00
abstract::Acute kidney injury (AKI) is common in premature infants and is associated with poor outcomes. Novel biomarkers can detect AKI promptly. Because premature infants are born with underdeveloped kidneys, baseline biomarker values may differ. We describe baseline values of urinary neutrophil gelatinase-associated lipocali...
journal_title:Pediatric research
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更新日期:2011-09-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1983-12-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-200010000-00022
更新日期:2000-10-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2012.151
更新日期:2013-01-01 00:00:00