Abstract:
:The purpose of this study was to assess differences in sound spectra of crying of term newborns in relation to different pain levels. Fifty-seven consecutively born neonates were evaluated during heel-prick performed with different analgesic techniques. Crying was recorded and frequency spectrograms analyzed. A pain score on the DAN (Douleur Aiguë du Nouveau-né) scale was assigned to each baby after the sampling. Three features were considered and correlated with the corresponding DAN scores: 1) whole spectral form; 2) the fundamental frequency of the first cry emitted (F0); and 3) root mean square sound pressure normalized to its maximum. After emission of the first cry, babies with DAN scores >8, but not with DAN scores < or =8 (p < 0.001), showed a pattern ("siren cry") characterized by a sequence of almost identical cries with a period on the order of 1 s. A statistically significant correlation was found between root mean square (r2 = 89%, p < 0.01), F0 (r2 = 32%, p < 0.05), siren cry (r2 = 68.2%, p = 0.02), and DAN score. F0 did not show significant correlation with DAN score in the subset of neonates with DAN scores < or =8 (r2 = 1.4%, p = 0.94), and babies with a DAN score >8 had a significantly higher F0 than those with lower DAN scores (p = 0.016). An alarm threshold exists between high (>8) and low (< or =8) DAN scores: crying has different features in these two groups. When pain exceeds a DAN score of 8, usually a first cry at a high pitch is emitted, followed by the siren cry, with a sound level maintained near its maximum.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Bellieni CV,Sisto R,Cordelli DM,Buonocore Gdoi
10.1203/01.PDR.0000099793.99608.CBsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
142-6issue
1eissn
0031-3998issn
1530-0447pii
01.PDR.0000099793.99608.CBjournal_volume
55pub_type
杂志文章abstract::To determine whether epidermal growth factor (EGF) or EGF-like transforming growth factors (TGFs) are present in ovine fetal tissues, we have tested acid-ethanol extracts of ovine fetal kidney for the ability to induce anchorage-independent growth of normal rat kidney fibroblasts in soft agar and to compete with 125I-...
journal_title:Pediatric research
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journal_title:Pediatric research
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doi:
更新日期:1991-04-01 00:00:00
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更新日期:2011-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1203/00006450-197504000-00002
更新日期:1975-04-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-04-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1203/00006450-200105000-00010
更新日期:2001-05-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199812000-00018
更新日期:1998-12-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197602000-00014
更新日期:1976-02-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.pdr.0000191816.57544.b4
更新日期:2006-01-01 00:00:00
abstract::A method is developed for the detection of homozygotes and heterozygote carriers of Niemann-Pick disease type A by employing a high performance liquid chromatography (HPLC) technique for the measurement of sphingomyelin (SP) as well as for the assay of the enzyme sphingomyelinase (SPase) in skin fibroblasts and amniot...
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pub_type: 杂志文章
doi:10.1203/00006450-197805000-00008
更新日期:1978-05-01 00:00:00