Neutrophil chemotaxis to leukotriene B4 in vitro is decreased for the human neonate.

abstract：BACKGROUND:Irisin is a myokine secreted by skeletal muscle during physical activity. Irisin treatment increased cortical bone mineral density (BMD) in young healthy mice and restored bone and muscle mass loss in a mouse model of disuse-induced osteoporosis and muscular atrophy. In humans, Irisin was positively correlat...

journal_title：Pediatric research

authors： Colaianni G,Faienza MF,Sanesi L,Brunetti G,Pignataro P,Lippo L,Bortolotti S,Storlino G,Piacente L,D'Amato G,Colucci S,Grano M

更新日期：2019-03-01 00:00:00

abstract：:Alpha-mannosidosis is a lysosomal storage disorder resulting from deficient activity of lysosomal alpha-mannosidase. It has been described previously in humans, cattle, and cats, and is characterized in all of these species principally by neuronal storage leading to progressive mental deterioration. Two guinea pigs wi...

journal_title：Pediatric research

authors： Crawley AC,Jones MZ,Bonning LE,Finnie JW,Hopwood JJ

更新日期：1999-11-01 00:00:00

abstract：:The incidence and prevalence of celiac disease vary internationally. We studied the incidence of identified cases of childhood celiac disease in six Dutch provinces that cover 47.9% of the surface area and 67.6% of the total population of The Netherlands. Children with celiac disease aged 0-14 y, diagnosed from Januar...

journal_title：Pediatric research

authors： George EK,Mearin ML,van der Velde EA,Houwen RH,Bouquet J,Gijsbers CF,Vandenbroucke JP

更新日期：1995-02-01 00:00:00

abstract：:Treatment with phototherapy or with the lipase inhibitor orlistat decreases plasma unconjugated bilirubin (UCB) concentrations in hyperbilirubinemic Gunn rats. We investigated the mechanism(s) underlying the effects of orlistat, phototherapy, and combined treatment, using steady-state 3H-UCB kinetics. After three week...

journal_title：Pediatric research

authors： Hafkamp AM,Havinga R,Ostrow JD,Tiribelli C,Pascolo L,Sinaasappel M,Verkade HJ

更新日期：2006-04-01 00:00:00

abstract：:We examined the effect of inspiratory resistive loaded breathing (IRL) on the electromyographic (EMG) activity of the costal and crural diaphragm in nine anesthetized spontaneously breathing piglets (age 10-23 days, weight 2.8-4.4 kg). Bipolar wire electrodes were inserted into the anterior paratendinous costal diaphr...

journal_title：Pediatric research

authors： Watchko JF,Mayock DE,Standaert TA,Woodrum DE

更新日期：1987-01-01 00:00:00

abstract：:Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine distention. Heredity is 25-40% and mostly involves the maternal genome, with contribution of the fetal genome. Si...

journal_title：Pediatric research

authors： Hallman M,Haapalainen A,Huusko JM,Karjalainen MK,Zhang G,Muglia LJ,Rämet M

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The earliest onset of puberty had shifted downward, which may be due to the role of early growth and development factors in childhood. METHODS:All of 1575 Kindergarten Two (K2) children from Anhui province, China were followed up to elementary school. Girls (n = 342) with available data on AR and breast dev...

journal_title：Pediatric research

authors： Fang J,Gong C,Su P,Wan Y,Zhang Z,Tao F,Sun Y

更新日期：2020-06-08 00:00:00

abstract：:Studies in adult animal and human subjects have suggested that the methylxanthine drugs can delay the onset or attenuate the severity of diaphragmatic fatigue. We have investigated the effect of aminophylline and caffeine on the pressure-generating capacity of the fatigued diaphragm in 1-mo-old piglets. Measurements o...

journal_title：Pediatric research

authors： Mayock DE,Standaert TA,Woodrum DE

更新日期：1992-11-01 00:00:00

abstract：:We hypothesized that fetal pancreatic digestive enzymes play a role in the lung damage after meconium aspiration. We studied the effect of meconium on the A549 alveolar epithelial cell line. The exposure of the cells to 0.5 to 5% meconium resulted in significant disruption of connections between A549 cells and caused ...

journal_title：Pediatric research

authors： Ivanov VA,Gewolb IH,Uhal BD

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Infantile hemangioma (IH) is the most frequent vascular tumor of early childhood. Recently, propranolol, a nonselective β1- and β2-adrenoceptor inhibitor, was introduced into the therapy of severe proliferating IH with excellent results. However, the underlying mechanism of action of propranolol is still unc...

journal_title：Pediatric research

authors： Rössler J,Haubold M,Gilsbach R,Jüttner E,Schmitt D,Niemeyer CM,Hein L

更新日期：2013-04-01 00:00:00

abstract：:The length of the Y chromosome was measured in 42 black patients with trisomy 21 (47,XY,+21) and a similar number of normal individuals of American black ancestry. The length of the Y was expressed as a function of Y/F ratio and arbitrarily classified into five groups using subjectively defined criteria as follows: ve...

journal_title：Pediatric research

authors： Verma RS,Huq A,Madahar C,Qazi Q,Dosik H

更新日期：1982-09-01 00:00:00

abstract：:Twenty-two reported cases of neuroblastoma missed by the mass screening programs were reviewed (six cases in Sapporo City where a quantitative measurement for both vanillylmandelic acid (VMA) and homovanillic acid (HVA) is used and 16 cases in the districts of qualitative judgment only for VMA), and some potential fac...

journal_title：Pediatric research

authors： Nishi M,Miyake H,Takeda T,Takasugi N,Sato Y,Hanai J,Kawai T

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Clinicians could modify dietary interventions during early infancy by monitoring fat and fat-free mass accretion in very preterm infants. METHODS:Preterm infants were randomly assigned to either having reports on infant body composition available to the clinicians caring for them (intervention group) or not...

journal_title：Pediatric research

authors： Salas AA,Jerome ML,Chandler-Laney P,Ambalavanan N,Carlo WA

更新日期：2020-11-01 00:00:00

abstract：:We have recently purified autoantigen polypeptides reacting with celiac disease patient sera IgA from the extracellular noncollagenous matrix compartment of fetal lung tissue. These molecules trigger the production of different tissue antibodies, the so-called antireticulin and antiendomysium antibodies in celiac dise...

journal_title：Pediatric research

authors： Marttinen A,Mäki M

更新日期：1993-10-01 00:00:00

abstract：:BackgroundThe mechanisms underlying aberrant activation of intestinal Toll-like receptor 4 (TLR4) signaling in necrotizing enterocolitis (NEC) remain unclear. In this study, we examined the role of single-immunoglobulin interleukin-1 receptor-related molecule (SIGIRR), an inhibitor of TLR signaling, in modulating expe...

journal_title：Pediatric research

authors： Fawley J,Cuna A,Menden HL,McElroy S,Umar S,Welak SR,Gourlay DM,Li X,Sampath V

更新日期：2018-01-01 00:00:00

abstract：:Left ventricular (LV) output nearly triples at birth, in association with increases in serum catecholamines. Similar increases in catecholamines in utero, however, do not increase output. We hypothesized that catecholamines increase contractility in utero, but that output cannot increase until LV loading conditions ar...

journal_title：Pediatric research

authors： Berning RA,Klautz RJ,Teitel DF

更新日期：1997-01-01 00:00:00

abstract：:Leukotrienes C4 and D4 and thromboxane A2 are potent vasoconstrictors that may mediate pulmonary vasoconstriction in many clinical situations. There is a complex interaction among leukotrienes and thromboxane A2, because inhibition of thromboxane synthesis prevents some of the hemodynamic effects of exogenous leukotri...

journal_title：Pediatric research

authors： Soifer SJ,Schreiber MD,Heymann MA

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF), a well-characterized regulator of angiogenesis, has been mechanistically implicated in retinal neovascularization and in the pathogenesis of retinopathy of prematurity. However, the ontogeny of VEGF expression in the human fetal retina is not well known. Because ret...

journal_title：Pediatric research

authors： Ma IT,McConaghy S,Namachivayam K,Halloran BA,Kurundkar AR,MohanKumar K,Maheshwari A,Ohls RK

更新日期：2015-04-01 00:00:00

abstract：:Prolonged unconjugated hyperbilirubinemia in infants associated with breast milk feeding is a common pediatric problem known as breast milk jaundice (BMJ). A polymorphic mutation (G71R) of bilirubin UDP-glucuronosyltransferase (UGT1A1) is a known cause of BMJ on the infantile side, but the responsible components of br...

journal_title：Pediatric research

authors： Ota Y,Maruo Y,Matsui K,Mimura Y,Sato H,Takeuchi Y

更新日期：2011-11-01 00:00:00

abstract：:An assessment of pulsatile secretion of luteinizing hormone (LH), measured by both immunoassay (I-LH) and rat interstitial cell testosterone production bioassay (B-LH), as well as of follicle-stimulating hormone and glycoprotein hormone alpha-subunit was carried out in seven normal prepubertal and six normal premenarc...

journal_title：Pediatric research

authors： Reiter EO,Biggs DE,Veldhuis JD,Beitins IZ

更新日期：1987-04-01 00:00:00

abstract：:The newborn immune system differs quantitatively and functionally from that of adults. Development of the immune system has important implications for childhood diseases. The immaturity of the immune system in the first years of life may contribute to failure of tolerance induction and in the development of allergic d...

journal_title：Pediatric research

authors： Koning H,Baert MR,Oranje AP,Savelkoul HF,Neijens HJ

更新日期：1996-09-01 00:00:00

abstract：:Exposure of neonatal rats to > or = 95% O2 for 2 wk, a widely used model of oxidant/antioxidant interactions in neonatal lung injury, results in arrested lung growth without the dysplastic lesions observed in chronic human neonatal lung injury. To determine whether dysplastic lung cell growth would be seen at lesser O...

journal_title：Pediatric research

authors： Han RN,Buch S,Tseu I,Young J,Christie NA,Frndova H,Lye SJ,Post M,Tanswell AK

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Preterm infants have a greater risk of necrotizing enterocolitis following transfusion. It is hypothesized that high glucose concentrations in red blood cell (RBC) preservatives lead to increased methylglyoxal (MG) metabolism, causing glycation-driven damage to transfused RBCs. Such changes to the RBCs could...

journal_title：Pediatric research

authors： Kiefer AS,Fleming T,Eckert GJ,Poindexter BB,Nawroth PP,Yoder MC

更新日期：2014-03-01 00:00:00

abstract：:Essential fatty acid deficiency (EFAD) occurs in infants fed fat-free mixtures of glucose and amino acids. Although infusion of lipid emulsion rapidly reverses clinical symptoms, little is known about effects on tissue fatty acids. To study this question, five groups (n = 4/group) of neonatal pigs were studied. Three ...

journal_title：Pediatric research

authors： Andersen DW,Filer LJ Jr,Stegink LD

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Bicuspid aortic valve (BAV) is the most common type of congenital heart disease (CHD) and has a proposed genetic etiology. BAV is categorized by cusp fusion, with right-left (R-L) cusp fusion being associated with additional CHD, and right-noncoronary cusp (R-NC) fusion being associated with aortic valve dys...

journal_title：Pediatric research

authors： Bonachea EM,Chang SW,Zender G,LaHaye S,Fitzgerald-Butt S,McBride KL,Garg V

更新日期：2014-08-01 00:00:00

abstract：:Intracellular levels of cysteine (CSH) and reduced glutathione (GSH) in the kidney and liver of rats from the newborn to the adult period have been determined using a sensitive high performance liquid chromatography method. In the kidney, the intracellular level of free CSH increased 4-fold from 1 to 4 nmol/mg protein...

journal_title：Pediatric research

authors： States B,Foreman JW,Segal S

更新日期：1987-11-01 00:00:00

abstract：:To study the effects of cytomegalovirus infection on T-lymphocyte subpopulations, we determined helper (Lyt 1.2) and suppressor (Lyt 2.2) T-lymphocyte subset numbers using monoclonal antibodies and measured lymphocyte responsiveness to mitogen during sublethal murine cytomegalovirus (MCMV) infection of 3-wk-old Balb/c...

journal_title：Pediatric research

authors： Sell MS,Bale JF Jr,Giller RH

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Childhood body mass index (BMI) trajectory classes are rarely linked to early puberty risk, particularly among Chinese children. We estimated early puberty risk across BMI trajectory classes, investigated factors contributing to pubertal development, and examined differences in final adult height between chi...

journal_title：Pediatric research

authors： Fan HY,Lee YL,Hsieh RH,Yang C,Chen YC

更新日期：2020-07-01 00:00:00

abstract：:Adenylate cyclase activity was measured in membrane preparations of cultured fibroblasts from controls and patients with cystic fibrosis. Enzyme activity increased as the transition from exponential growth to confluence occurred; sodium fluoride-stimulated activity more markedly displayed this relationship than basal ...

journal_title：Pediatric research

authors： Wright RK,Buehler BA,Schott SN,Rennert OM

更新日期：1978-08-01 00:00:00

abstract：:Compliant immature airways sustain significant deformation following positive pressure ventilation. To evaluate the structural changes induced by in vivo positive pressure ventilation, tracheae of preterm lambs (107-116 d gestational age) were studied histologically. Nonventilated (group I: n = 7) and ventilated (grou...

journal_title：Pediatric research

authors： Deoras KS,Wolfson MR,Bhutani VK,Shaffer TH

更新日期：1989-11-01 00:00:00