β1-Adrenoceptor mRNA level reveals distinctions between infantile hemangioma and vascular malformations.

abstract：:The mucopolysaccharidoses (MPS) are inherited metabolic disorders resulting from the defective catabolism of glycosaminoglycans. In this report, we find that the stimulation of MPS connective tissue cells by the inflammatory cytokines causes enhanced secretion of several matrix-degrading metalloproteinases (MMPs). In ...

journal_title：Pediatric research

authors： Simonaro CM,D'Angelo M,Haskins ME,Schuchman EH

更新日期：2005-05-01 00:00:00

abstract：:Unconjugated bilirubin promotes intestinal secretion without affecting nutrient digestion or absorption. In the current study, the effects of unconjugated bilirubin (UCB) on the barrier function of the intestinal epithelium were investigated. The apical side of human intestinal cell line Caco-2 monolayers was challeng...

journal_title：Pediatric research

authors： Raimondi F,Crivaro V,Capasso L,Maiuri L,Santoro P,Tucci M,Barone MV,Pappacoda S,Paludetto R

更新日期：2006-07-01 00:00:00

abstract：:The etiology of biliary atresia (BA) is not yet understood, but recent studies have shown inflammation with an up-regulated interferon (IFN) activity in the intra- and extrahepatic bile ducts of patients with BA. These findings support an inflammatory/infectious cause of BA as mimicked in our infective murine model. T...

journal_title：Pediatric research

authors： Kuebler JF,Czech-Schmidt G,Leonhardt J,Ure BM,Petersen C

更新日期：2006-06-01 00:00:00

abstract：:We have previously demonstrated that vagal phase-response curves (PRC), which characterize the effects of critically timed, brief vagal stimuli on sinus node automaticity, exhibit a fundamentally different shape in the canine newborn than in the adult. In this study we analyzed the changes in sinus cycle length in res...

journal_title：Pediatric research

authors： Pickoff AS,Rios R,Stolfi A,Wang SN

更新日期：1994-01-01 00:00:00

abstract：:Thyrotropin releasing hormone (TRH) and its precursor peptide pGlu-His-Pro-Gly (TRH-Gly) were measured in serum and in a variety of tissues of developing rats using specific RIA. TRH and TRH-Gly immunoreactivities were detected in most tissues. TRH concentrations were highest in pancreas, in which mean (+/- SEM) TRH c...

journal_title：Pediatric research

authors： Fuse Y,Polk DH,Lam RW,Fisher DA

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:This study aimed to assess cortical gray matter growth and maturation in neonates with congenital heart disease (CHD). METHODS:Thirty-one (near) term neonates with severe CHD (8 univentricular heart malformation (UVH), 21 d-transposition of great arteries (d-TGA) and 2 aortic coarctation) underwent cerebral...

journal_title：Pediatric research

authors： Claessens NH,Moeskops P,Buchmann A,Latal B,Knirsch W,Scheer I,Išgum I,de Vries LS,Benders MJ,von Rhein M

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Serum caffeine concentrations >20 μg/ml (100 μmol/l) in infants treated for apnea of prematurity increases TNF-α and decreases IL-10, changes that perhaps are linked to comorbidities. We hypothesize that this proinflammatory cytokine profile may be linked to differential binding of caffeine to adenosine rece...

journal_title：Pediatric research

authors： Chavez-Valdez R,Ahlawat R,Wills-Karp M,Gauda EB

更新日期：2016-07-01 00:00:00

abstract：:Nutrition in early life, growth, and subsequent health over a lifetime are significantly interrelated. The aim of this study was to assess body composition changes in exclusively breast-fed infants from birth up to 6 mo of age. An observational, prospective, cohort study was conducted. Fifty-nine full-term, healthy, e...

journal_title：Pediatric research

authors： Roggero P,Giannì ML,Orsi A,Piemontese P,Amato O,Liotto N,Morlacchi L,Taroni F,Fields DA,Catalano PM,Mosca F

更新日期：2010-12-01 00:00:00

abstract：:Uteroplacental insufficiency and subsequent intrauterine growth retardation (IUGR) increase the risk of insulin resistance in humans and rats. Aberrant skeletal muscle lipid metabolism contributes to the pathogenesis of insulin resistance. Peroxisome proliferator-activated receptor-gamma co-activator-1 (PGC-1) is a tr...

journal_title：Pediatric research

authors： Lane RH,Maclennan NK,Daood MJ,Hsu JL,Janke SM,Pham TD,Puri AR,Watchko JF

更新日期：2003-06-01 00:00:00

abstract：:This study investigated the effects of intraventricular/periventricular blood on cerebral cAMP production and cortical cerebrovascular reactivity. Under halothane and N2O anesthesia, 3 mL of either autologous blood or artificial cerebrospinal fluid (CSF) were injected into the left caudate nucleus; volume was adequate...

journal_title：Pediatric research

authors： Pourcyrous M,Parfenova H,Shibata M,Bada HS,Korones SB,Leffler CW

更新日期：1997-09-01 00:00:00

abstract：:The purpose of this project was to study the role of lipid peroxidation in oxygen-induced lung injury in the newborn lamb. It was our hypothesis that injury to the microvascular bed of the lung by oxygen would coincide with a burst of peroxidative activity and would be accompanied by an increased rate of excretion of ...

journal_title：Pediatric research

authors： Hansen TN,Smith CV,Gest AL,Smith HW,Giesler M

更新日期：1990-12-01 00:00:00

abstract：:BackgroundBeing aware of the impact of low birth weight on late-onset hypertension, our aim was to describe systolic blood pressure (sBP) and renal function in 3-5-year-old preterm-born children and to determine which perinatal factors or childhood factors were associated with an altered renal function at 5 years in t...

journal_title：Pediatric research

authors： Vieux R,Gerard M,Roussel A,Sow A,Gatin A,Guillemin F,Hascoet JM

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Pediatric myocarditis is a rare disease with substantial mortality. Little is known regarding its prognostic factors. We hypothesize that certain comorbidities and procedural needs may increase risks of poor outcomes. This study aims to identify prognostic factors for pediatric myocarditis. METHODS:The nati...

journal_title：Pediatric research

authors： Chou FS,Ghimire LV

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:Despite substantial heritability in pubertal development, children differ in maturational tempo. HYPOTHESES:(i) puberty and its duration are influenced by early changes in height and adiposity. (ii) Adiposity rebound (AR) is a marker for pubertal tempo. METHODS:We utilized published prospective data from 6...

journal_title：Pediatric research

authors： German A,Shmoish M,Hochberg Z

更新日期：2015-10-01 00:00:00

abstract：:The major variation in effect between undiluted cystic fibrosis and heterozygote sera on rabbit tracheal epithelium was in terms of the time after exposure at which changes occurred. Exposure to both types of sera for 3 min caused release of goblet cell mucus and ciliary resorption possibly by apical swelling of colum...

journal_title：Pediatric research

authors： Kennedy JR,Allen PL

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:Appearance of sleep cycling has been associated with good outcome in term and preterm infants, but the normal time of its appearance has not been determined. The objectives of this study were, to correlate the time of sleep cycling appearance and the length of quiet sleep in neonates with different degrees o...

journal_title：Pediatric research

authors： Abramsky R,Stavsky M,Novack V,Shany E

更新日期：2020-03-01 00:00:00

abstract：:Altered transfer of nutrients from mother to conceptus may be involved in the pathogenesis of the developmental disturbances in offspring of diabetic mothers. In our study, the embryonic uptake of a saturated (palmitic acid) and a nonsaturated (arachidonic acid) fatty acid was evaluated in a normal and a diabetes-like...

journal_title：Pediatric research

authors： Engström E,Haglund A,Eriksson UJ

更新日期：1991-08-01 00:00:00

abstract：:Basal and pentagastrin-stimulated gastric acid secretion was measured in 26 healthy newborn infants on the 1st and 2nd days of life. Basal acid outputs (BAO) on day 1 (0.378 mEq/hr) and day 2 (0.388 mEq/hr) were similar and not significantly different from the maximal acid outputs (MAO) on day 1 (0.413 mEq/hr) and day...

journal_title：Pediatric research

authors： Euler AR,Byrne WJ,Meis PJ,Leake RD,Ament ME

更新日期：1979-01-01 00:00:00

abstract：:In eight newborn lambs, the adaption of blood to acidosis was studied by sequential measurements of P50 in vitro (pH 7.4; 37 degrees C) and P50 in vivo (animal's pH and temperature, 39 degrees C) during the course of HCl-induced metabolic acidosis. The benefit of the change in both P50 on tissue oxygen tension was stu...

journal_title：Pediatric research

authors： Berthiaume Y,Bureau MA,Bégin R

更新日期：1981-05-01 00:00:00

abstract：:We hypothesized that fetal pancreatic digestive enzymes play a role in the lung damage after meconium aspiration. We studied the effect of meconium on the A549 alveolar epithelial cell line. The exposure of the cells to 0.5 to 5% meconium resulted in significant disruption of connections between A549 cells and caused ...

journal_title：Pediatric research

authors： Ivanov VA,Gewolb IH,Uhal BD

更新日期：2010-09-01 00:00:00

abstract：:Genetic factors are implicated in pathogenesis of neonatal hyperbilirubinemia. In this nested case-control study, we determined 1) frequency of thymine-adenine (TA)n promoter polymorphism and Gly71Arg mutation in uridine diphosphoglucuronate-glucuronosyltransferase 1A1 (UGT1A1) gene in neonates > or =35-wk gestation p...

journal_title：Pediatric research

authors： Agrawal SK,Kumar P,Rathi R,Sharma N,DAS R,Prasad R,Narang A

更新日期：2009-06-01 00:00:00

abstract：:Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine distention. Heredity is 25-40% and mostly involves the maternal genome, with contribution of the fetal genome. Si...

journal_title：Pediatric research

authors： Hallman M,Haapalainen A,Huusko JM,Karjalainen MK,Zhang G,Muglia LJ,Rämet M

更新日期：2019-03-01 00:00:00

abstract：:Blood mononuclear cells from newborns and from adults, immune or nonimmune to herpes simplex virus, were cultured with IL 2 and herpes simplex virus and the amount of gamma-interferon in the supernatant measured after 3 days. The newborn and nonimmune adult cells made equivalent trace amounts of gamma-interferon in cu...

journal_title：Pediatric research

authors： Hayward AR,Herberger M,Saunders D

更新日期：1986-05-01 00:00:00

abstract：:Local delivery of Escherichia coli beta-galactosidase gene (beta-gal) to surfactant protein-A (SP-A)-producing cells by a replication-defective recombinant adenovirus (AdCMV.beta-gal) was tested in human 8-12-wk-old fetal lung explants cultured in Waymouth's medium. In contrast to uninfected explants, direct addition ...

journal_title：Pediatric research

authors： Messina E,Muhlhauser J,Giuliano M,Pandolfi A,Morgese G,Procopio A

更新日期：1996-07-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR) is a recognized risk factor for neurologic deficits later in life. Abnormal fetal blood flow in the presence of fetal growth retardation helps to distinguish true fetal growth impairment from small but normally grown infants. The present study aimed to investigate the influence o...

journal_title：Pediatric research

authors： Ley D,Marsal K,Dahlgren J,Hellstrom A

更新日期：2004-07-01 00:00:00

abstract：:Heme oxygenase (HO), the rate-limiting enzyme in the formation of bilirubin, is expressed in the lung and may serve as an antioxidant. This enzyme results in the formation of antioxidant bile pigments and the degradation of pro-oxidant heme. We wanted to evaluate the differences in expression of HO-1, the inducible fo...

journal_title：Pediatric research

authors： Dennery PA,Lee CS,Ford BS,Weng YH,Yang G,Rodgers PA

更新日期：2003-01-01 00:00:00

abstract：:Despite the availability of successful prevention strategies to prevent excessive hyperbilirubinemia, the neurological sequelae of bilirubin neurotoxicity (BNTx) still occur throughout the world. Kernicterus, encephalopathy due to BNTx, is now understood to be a spectrum of severity and phenotypes known as kernicterus...

journal_title：Pediatric research

authors： Riordan SM,Shapiro SM

更新日期：2020-01-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of constant light in a neonatal care unit on the development of the sleep-and-wakefulness rhythm in preterm infants. Two groups of infants (57 preterm infants without other complications and 58 healthy term infants) were prospectively studied over infancy by a da...

journal_title：Pediatric research

authors： Shimada M,Segawa M,Higurashi M,Akamatsu H

更新日期：1993-02-01 00:00:00

abstract：:Alterations in the pancreatic secretion of fluid and of enzymes in response to either pilocarpine (15 mg/kg) or an octapeptide of cholecystokinin (0.1 microgram/kg) have been found in rats that received daily injections of reserpine (0.5 mg/kg) for 7 days. During a 3-hr secretory period, significant reductions in the ...

journal_title：Pediatric research

authors： McCurdy RE,Martinez R

更新日期：1981-09-01 00:00:00

abstract：:We have previously demonstrated that enterally administered heparin-binding EGF-like growth factor (HB-EGF) produced in Escherichia coli decreases the incidence and severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis (NEC). In preparation for upcoming human clinical trials, large-scale p...

journal_title：Pediatric research

authors： Radulescu A,Zorko NA,Yu X,Besner GE

更新日期：2009-04-01 00:00:00