Abnormal retinal optic nerve morphology in young adults after intrauterine growth restriction.

abstract：:Factors affecting bone turnover in premature infants are not entirely clear but certainly are different from those influencing bones of adults and children. To identify fetal and maternal factors that might influence bone turnover, we prospectively studied 50 infants (30 preterm and 20 full-term) born at Ain Shams Uni...

journal_title：Pediatric research

authors： Aly H,Moustafa MF,Amer HA,Hassanein S,Keeves C,Patel K

更新日期：2005-05-01 00:00:00

abstract：:Cancer stem cells (CSC) are recently proposed to be the cancer initiating cells responsible for tumorigenesis and contribute to cancer resistance. Advances have been made in identifying and enriching CSC in leukemia and several solid tumors, including breast, brain and lung cancers. These studies suggest that, like no...

journal_title：Pediatric research

authors： Guo W,Lasky JL 3rd,Wu H

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Gender is increasingly recognized as an important influence on brain development, disease susceptibility, and response to pharmacologic/rehabilitative treatments. In regenerative medicine, it remains entirely unknown whether there is an interaction between transplanted stem cells and host gender that might b...

journal_title：Pediatric research

authors： Ashwal S,Ghosh N,Turenius CI,Dulcich M,Denham CM,Tone B,Hartman R,Snyder EY,Obenaus A

更新日期：2014-05-01 00:00:00

abstract：:Rats were fed a 50% galactose diet during pregnancy and nursing, and the testes were later examined and hormone levels determined in male offspring. Exposure to galactose for various periods during pregnancy, throughout the entire gestation, or postnatally to nursing mother until pups were 5 wk of age produced no sign...

journal_title：Pediatric research

authors： Chen YT,Mattison DR,Bercu BB,Schulman JD

更新日期：1984-04-01 00:00:00

abstract：:Beta cells are partially replaced in neonatal rodents after deletion with streptozotocin (STZ). Exposure of pregnant rats to a low protein (LP) diet impairs endocrine pancreas development in the offspring, leading to glucose intolerance in adulthood. Our objective was to determine whether protein restriction has a sim...

journal_title：Pediatric research

authors： Cox AR,Gottheil SK,Arany EJ,Hill DJ

更新日期：2010-07-01 00:00:00

abstract：:Bilirubin-IX alpha photooxidation products were detected by high performance liquid chromatography in the urine of neonates undergoing phototherapy for hyperbilirubinemia. The in vivo photoproducts were identified by chromatographic comparison with authentic synthetic standards using two complementary methods. Bilirub...

journal_title：Pediatric research

authors： Lightner DA,Linnane WP 3rd,Ahlfors CE

更新日期：1984-08-01 00:00:00

abstract：:Galactose metabolism was studied in human ovarian tissue obtained from 14 women controls between 21 and 72 y of age, and one 21-y-old galactosemic patient with hypergonadotrophic hypogonadism. Tissue slices were incubated with 1-14C-galactose, and labeled intermediates were analyzed by anion-exchange column chromatogr...

journal_title：Pediatric research

authors： Xu YK,Ng WG,Kaufman FR,Lobo RA,Donnell GN

更新日期：1989-02-01 00:00:00

abstract：:To elucidate the impact of nutrition in cystic fibrosis (CF), we compared the phenotypic traits of Cftr -/- mice fed either a lipid-enriched liquid diet (Peptamen) or a standard chow combined with polyethylenglycol osmotic laxative (PEG), two strategies commonly used to prevent intestinal obstruction in CF mice. Survi...

journal_title：Pediatric research

authors： Cottart CH,Bonvin E,Rey C,Wendum D,Bernaudin JF,Dumont S,Lasnier E,Debray D,Clément A,Housset C,Bonora M

更新日期：2007-11-01 00:00:00

abstract：:A new animal experimental model of human neuroblastoma is described. The model involves xenotransplantation of a poorly differentiated human neuroblastoma cell line (SH-SY5Y) to the subcutaneous tissue in the hind leg of nude rats (WAG mu/rnu). Injection of 20 million cells suspended in 0.2 mL of medium in each hind l...

journal_title：Pediatric research

authors： Wassberg E,Påhlman S,Westlin JE,Christofferson R

更新日期：1997-03-01 00:00:00

abstract：:Shigellosis in children can cause growth retardation, worsening of malnutrition, and hypoproteinemia. To assess the effects of ingestion of a protein-rich diet during convalescence, 22 children aged 2 to 4 y with culture-proven shigellosis were randomly assigned after 5 d of antibiotic treatment to 21-d feeding regime...

journal_title：Pediatric research

authors： Kabir I,Butler T,Underwood LE,Rahman MM

更新日期：1992-12-01 00:00:00

abstract：:IL-8/CXC ligand (CXCL) 8 is ingested in high concentrations by the human fetus/neonate with amniotic fluid and human milk, and is also produced constitutively by intestinal epithelial cells (IEC). We have shown that recombinant human IL-8/CXCL8 (rhIL-8/CXCL8) protects cultured IEC against tumor necrosis factor (TNF)-a...

journal_title：Pediatric research

authors： Maheshwari A,Lacson A,Lu W,Fox SE,Barleycorn AA,Christensen RD,Calhoun DA

更新日期：2004-08-01 00:00:00

abstract：:The specific activities of four folate enzymes have been measured in livers from preterm infants (Group 1), full-term infants (Group 2), and from control subjects (Group 3). The four enzymes studied were methylene tetrahydrofolate reductase (EC 1.1.1.68), methionine synthetase (EC 2.1.1.13), methylenetetrahydrofolate ...

journal_title：Pediatric research

authors： Kalnitsky A,Rosenblatt D,Zlotkin S

更新日期：1982-08-01 00:00:00

abstract：:Compliant immature airways sustain significant deformation following positive pressure ventilation. To evaluate the structural changes induced by in vivo positive pressure ventilation, tracheae of preterm lambs (107-116 d gestational age) were studied histologically. Nonventilated (group I: n = 7) and ventilated (grou...

journal_title：Pediatric research

authors： Deoras KS,Wolfson MR,Bhutani VK,Shaffer TH

更新日期：1989-11-01 00:00:00

abstract：:We describe a method based on a Fabry-Perot interferometer at the tip of an optic fiber with a diameter of 0.25 mm for direct measurement of tracheal pressure in pediatric respiratory monitoring. The response time of the pressure transducer and its influence on the resistance of pediatric endotracheal tubes (internal ...

journal_title：Pediatric research

authors： Sondergaard S,Karason S,Hanson A,Nilsson K,Hojer S,Lundin S,Stenqvist O

更新日期：2002-03-01 00:00:00

abstract：:We examined the effect of inspiratory resistive loaded breathing (IRL) on the electromyographic (EMG) activity of the costal and crural diaphragm in nine anesthetized spontaneously breathing piglets (age 10-23 days, weight 2.8-4.4 kg). Bipolar wire electrodes were inserted into the anterior paratendinous costal diaphr...

journal_title：Pediatric research

authors： Watchko JF,Mayock DE,Standaert TA,Woodrum DE

更新日期：1987-01-01 00:00:00

abstract：:In eight newborn lambs, the adaption of blood to acidosis was studied by sequential measurements of P50 in vitro (pH 7.4; 37 degrees C) and P50 in vivo (animal's pH and temperature, 39 degrees C) during the course of HCl-induced metabolic acidosis. The benefit of the change in both P50 on tissue oxygen tension was stu...

journal_title：Pediatric research

authors： Berthiaume Y,Bureau MA,Bégin R

更新日期：1981-05-01 00:00:00

abstract：:Sugar alcohols have been found to play an important osmoregulatory role both in unicellular organisms and, more recently, in multicellular organisms, including mammals. This study shows that myo-inositol accumulates in the brains of chronically hypernatremic mice, as had been earlier found in rats, and demonstrates fo...

journal_title：Pediatric research

authors： Thurston JH,Sherman WR,Hauhart RE,Kloepper RF

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Hirschsprung disease (HSCR) is the third most common congenital disorder of the gastrointestinal tract. This study aims to elucidate changes in protein expression between the normal and aganglionic hindgut in human HSCR. METHODS:The biopsies were obtained from the normal and aganglionic hindgut in human HSC...

journal_title：Pediatric research

authors： Zhang SC,Chen F,Jiang KL,Yuan ZW,Wang WL

更新日期：2014-06-01 00:00:00

abstract：:Studies have shown that human neonates who develop group B streptococcal sepsis usually lack opsonic antibody (Ab) to their infecting strain and that these neonates may also have impaired polymorphonuclear leukocyte (PMN) function. The present study was designed to determine the efficacy of administration of PMNs or o...

journal_title：Pediatric research

authors： Santos JI,Shigeoka AO,Hill HR

更新日期：1980-12-01 00:00:00

abstract：:The purpose of this study was to develop a strictly controlled chemical system in vitro to evaluate the efficacy of lead (Pb) chelators. Moreover, these experiments were carried out to understand further the complex interactions between Pb chelating agents, calcium-regulating hormones, and bone cell metabolism. The ef...

journal_title：Pediatric research

authors： Rosen JF,Markowitz ME

更新日期：1980-04-01 00:00:00

abstract：:The activity of lysozyme in saliva and serum was determined in 51 patients with cystic fibrosis. Measurements were made on two occasions at least 1 month apart and compared to those of 25 normal healthy individuals of the same ages, sex, and race. The mean serum lysozyme activity of normal individuals was 5.8 microgra...

journal_title：Pediatric research

authors： Hughes WT,Koblin BA,Rosenstein BJ

更新日期：1982-10-01 00:00:00

abstract：:Wu and colleagues analyzed the placental pathology from a subset of the neonates in the NEATO trial who had reports available and correlated the placental pathology findings with outcomes. This study highlights the importance of placental pathology, and its potential to bring precision medicine to critically-ill neona...

journal_title：Pediatric research

authors： Jantzie LL,Robinson S

更新日期：2020-04-01 00:00:00

abstract：:A series of in vivo experiments is described in which [1-13C]phytanic acid was given as an oral substrate to a healthy subject and two patients showing an impairment in phytanic acid degradation, one with Refsum's disease and one with chondrodysplasia punctata. After intake of the substrate by the control in a dose of...

journal_title：Pediatric research

authors： ten Brink HJ,Schor DS,Kok RM,Stellaard F,Kneer J,Poll-The BT,Saudubray JM,Jakobs C

更新日期：1992-11-01 00:00:00

abstract：:We have performed clinical, in vitro biochemical, and genetic studies of a patient with severe insulin resistance, considerable growth restriction, and Rabson-Mendenhall syndrome (patient RM-3). The blood IGF-I level was undetectable in this patient, although the GH level was moderately decreased. During the postprand...

journal_title：Pediatric research

authors： Desbois-Mouthon C,Magré J,Duprey J,Caron M,Blivet-Van Eggelpoel MJ,Daubas C,Gourmelen M,Chevallier B,Rizkalla S,Robert JJ,Capeau J

更新日期：1997-07-01 00:00:00

abstract：:Sudden infant death syndrome (SIDS) is multifactorial and may result from the interaction of a number of environmental, genetic, and developmental factors. We studied three major genes causing long QT syndrome in 42 Japanese SIDS victims and found five mutations, KCNQ1-K598R, KCNH2-T895M, SCN5A-F532C, SCN5A-G1084S, an...

journal_title：Pediatric research

authors： Otagiri T,Kijima K,Osawa M,Ishii K,Makita N,Matoba R,Umetsu K,Hayasaka K

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Postnatal growth restriction (PNGR) in premature infants increases risk of pulmonary hypertension (PH). In a rodent model, PNGR causes PH, while combining PNGR and hyperoxia increases PH severity. We hypothesized that PNGR causes intestinal dysbiosis and that treatment with a probiotic attenuates PNGR-associ...

journal_title：Pediatric research

authors： Wedgwood S,Warford C,Agvatisiri SR,Thai PN,Chiamvimonvat N,Kalanetra KM,Lakshminrusimha S,Steinhorn RH,Mills DA,Underwood MA

更新日期：2020-02-01 00:00:00

abstract：:Sodium deficiency is associated with decreased muscle growth and protein synthesis. We investigated the influence of diet-induced sodium deficiency on the rate and extent of compensatory growth of the right lung after left pneumonectomy in young rats of 83 +/- 1 g body weight. Starting 1 wk before surgery, all rats we...

journal_title：Pediatric research

authors： Gallaher KJ,Wolpert E,Wassner S,Rannels DE

更新日期：1990-11-01 00:00:00

abstract：:Blood volume (BV), red cell mass (RCM; Cr-51) and plasma volume (125I-labeled albumin) were measured in 205 piglets from 28 litters shortly after birth. Spontaneous cord rupture in healthy piglets occurred during delivery (n = 25) or within 190 sec of birth (n = 82). Spontaneous and induced delay of cord rupture resul...

journal_title：Pediatric research

authors： Linderkamp O,Betke K,Güntner M,Jap GH,Riegel KP,Walser K

更新日期：1981-01-01 00:00:00

abstract：:Alterations of the architecture of cerebral white matter in the developing human brain can affect cortical development and result in functional disabilities. A line scan diffusion-weighted magnetic resonance imaging (MRI) sequence with diffusion tensor analysis was applied to measure the apparent diffusion coefficient...

journal_title：Pediatric research

authors： Hüppi PS,Maier SE,Peled S,Zientara GP,Barnes PD,Jolesz FA,Volpe JJ

更新日期：1998-10-01 00:00:00

abstract：:Human autoimmune lymphoproliferative syndrome (ALPS) is caused by defective CD95-mediated apoptosis of lymphocytes. In most patients, heterozygous mutations within the CD95 gene are found. Mutated proteins interfere with CD95-signaling in a dominant-negative way. However, the penetrance of clinical disease is variable...

journal_title：Pediatric research

authors： Fuchs H,Posovszky C,Lahr G,van der Werff ten Bosch J,Boehler T,Debatin KM

更新日期：2009-02-01 00:00:00