Abstract:
:We describe a method based on a Fabry-Perot interferometer at the tip of an optic fiber with a diameter of 0.25 mm for direct measurement of tracheal pressure in pediatric respiratory monitoring. The response time of the pressure transducer and its influence on the resistance of pediatric endotracheal tubes (internal diameter, 2.5 to 5 mm) during constant and dynamic flow at different ventilator settings in a lung model were measured. The transducer was positioned at -1.5 (inside), 0, and +1.5 cm (outside) relative to the tip of the endotracheal tube and compared with a reference pressure inside the trachea. The clinical application of the transducer was tested in five pediatric patients. The response time of the transducer was 1.3 ms. The influence of the fiberoptic transducer on tube resistance was negligible during constant flow in inspiratory and expiratory directions for all endotracheal tubes tested. There was no difference in pressure measurements with the transducer positioned at or 1.5 cm below or above the tip of the endotracheal tube during dynamic measurements. During clinical circumstances insertion of the fiberoptic transducer was easy, recordings were stable, and the safety of the patient was not jeopardized. The fiberoptic transducer provided a reliable and promising way of monitoring tracheal pressure in intubated pediatric patients. The presence of the probe did not interfere with either pressure-flow relationship or patient care and safety. The technique is proposed for monitoring of respiratory mechanics and calculation of changes in tube resistance caused by kinking and secretions.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Sondergaard S,Karason S,Hanson A,Nilsson K,Hojer S,Lundin S,Stenqvist Odoi
10.1203/00006450-200203000-00013subject
Has Abstractpub_date
2002-03-01 00:00:00pages
339-45issue
3eissn
0031-3998issn
1530-0447journal_volume
51pub_type
杂志文章abstract::A series of in vivo experiments is described in which [1-13C]phytanic acid was given as an oral substrate to a healthy subject and two patients showing an impairment in phytanic acid degradation, one with Refsum's disease and one with chondrodysplasia punctata. After intake of the substrate by the control in a dose of...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199211000-00016
更新日期:1992-11-01 00:00:00
abstract::This report describes a third mucopolysaccharidosis in animals: canine mucopolysaccharidosis VII. The affected dog was the offspring of a father-daughter mating. Weakness in the rear legs was evident at 8 weeks of age and became progressively worse. He had a large head, a shortened maxilla, and corneal granularities. ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198410000-00014
更新日期:1984-10-01 00:00:00
abstract::Previous studies suggest that the endotoxin lipopolysaccharide (LPS) may have dual effects on brain damage induced by hypoxia-ischemia (HI) in 7-d-old rats, depending on the exposure paradigm. Although a 4-h interval between LPS administration and HI results in sensitization to HI brain injury, tolerance is observed w...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.pdr.0000191140.87314.ce
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The aim of our study was to understand the relationship between consanguineous marriages and reproductive outcomes. METHODS:A total of 999 families were recruited from five Muslim populations of Jammu region. Family pedigrees were drawn to access the family history and inbreeding status in terms of coeffici...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2016.177
更新日期:2017-01-01 00:00:00
abstract::We investigated the early postnatal changes of the mesenteric circulation and its relation to the systemic circulation in 15 preterm infants. The infants were studied before the first feeding on d 1 and pre- and postprandially on d 3, 4, 5, and 7. Blood flow velocity was measured by ultrasound Doppler in the superior ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199602000-00015
更新日期:1996-02-01 00:00:00
abstract::Yesterday's immunodeficiencies emphasized the clinical and familial associations of the syndromes and date from the 1920s (ataxia-telangiectasia, chronic mucocutaneous candidiasis), the 1930s (Wiskott-Aldrich syndrome), skipping the 1940s, but blossoming in the 15-y period from 1950 to 1965. In this period, primary im...
journal_title:Pediatric research
pub_type: 历史文章,杂志文章,评审
doi:10.1203/00006450-199305001-00007
更新日期:1993-01-01 00:00:00
abstract::The secreted protein sonic hedgehog (Shh) is essential for normal development of many organs. Targeted disruption of Shh in mouse leads to near complete absence of craniofacial skeletal elements at birth, and mutation of SHH in human causes holoprosencephaly (HPE), frequently associated with defects of derivatives of ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.pdr.0000199911.17287.3e
更新日期:2006-03-01 00:00:00
abstract::Whether severe hypoglycemia alone or in combination with hyperketonemia might cause deterioration of cardiac function has been controversial. Therefore, the influence of acute hypoglycemia (mean 33 mg/dL) with and without hyperketonemia (mean 1.3 and 3.3 mM) on cardiac function, substrate utilization, and myocardial h...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198912000-00002
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:The earliest onset of puberty had shifted downward, which may be due to the role of early growth and development factors in childhood. METHODS:All of 1575 Kindergarten Two (K2) children from Anhui province, China were followed up to elementary school. Girls (n = 342) with available data on AR and breast dev...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/s41390-020-1001-8
更新日期:2020-06-08 00:00:00
abstract::We studied the effects of a diet that was low in fat, high in carbohydrate (CHO) on milk lipid composition and de novo endogenous fatty acid synthesis by the mammary gland in five lactating women. The women consumed either a low fat (LF) (5% fat, 80% CHO) diet or a high fat (HF) (40% fat, 45% CHO) diet. Fat synthesis ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198901000-00015
更新日期:1989-01-01 00:00:00
abstract::Cardiovascular responses to feeding have been observed in several species during various periods of development and have been implicated in the development of cardiovascular regulation. In the rat, these responses are characterized by short-lasting, large increases in blood pressure (BP) and moderate increases in hear...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199207000-00007
更新日期:1992-07-01 00:00:00
abstract::We examined adult sheep lymphocytes for the following surface markers: Surface membrane immunoglobulin, antigen identified by anti-sheep thymocyte globulin and complement receptors. We quantitated sheep peripheral blood mononuclear leukocyte proliferative responses to mitogens and alloantigens, and demonstrated a neut...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198405000-00012
更新日期:1984-05-01 00:00:00
abstract::We evaluated the hypothesis that increased endogenous opioid activity mediates part or all of the left ventricular contractile and pump dysfunction previously demonstrated in HCl-induced metabolic acidemia. Eighteen Western newborn lambs were catheterized and instrumented; pacing wires were sutured to the right atrial...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198806000-00023
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Kawasaki disease (KD) is an acute febrile illness associated with the development of vasculitis. Administration of intravenous immunoglobulin (IVIG) is the standard treatment for KD. However, IVIG treatment is not effective in approximately 15% of children with KD. Some reports have presented evidence of imm...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2015.12
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Extremely preterm birth is associated with subsequent behavioral problems. We hypothesized that perinatal systemic inflammation, a risk factor for cerebral white matter injury and cognitive impairment, is associated with behavior problems observed at 2 y. METHODS:In a cohort of 600 children born before 28 w...
journal_title:Pediatric research
pub_type: 杂志文章,多中心研究
doi:10.1038/pr.2014.41
更新日期:2014-06-01 00:00:00
abstract::Neurological injury is the primary lethal mechanism of injury in children, and the primary etiology of long-term disability after trauma. Laboratories and clinical/translational teams have sought to develop stem/progenitor cell therapies to improve recovery in a clinical setting in which there is no significant repara...
journal_title:Pediatric research
pub_type: 杂志文章,评审
doi:10.1038/pr.2017.253
更新日期:2018-01-01 00:00:00
abstract::Vascular dopamine (DA1) receptors may modulate circulatory hemodynamics in lambs. We evaluated resting dopaminergic tone in lambs by pharmacologically manipulating peripheral DA1 receptors with i.v. SCH 23390, (a highly selective, competitive DA1 receptor antagonist) and i.v. fenoldopam, (a highly selective DA1 recept...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199302000-00018
更新日期:1993-02-01 00:00:00
abstract::Superoxide anion generation during severe asphyxia and reventilation was assessed in newborn pigs. Using closed cranial windows over the parietal cortices, superoxide dismutase (SOD)-inhibitable nitroblue tetrazolium (NBT) reduction was determined during asphyxia/reventilation. Asphyxia was induced by turning off the ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199012000-00015
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Some of the health advantages of breast-fed as compared to formula-fed infants have been suggested to be due to metabolic programming effects resulting from early nutrition. METHODS:In a prospective double-blinded randomized trial, 160 infants <2 mo of age were randomized to experimental formula (EF) with a...
journal_title:Pediatric research
pub_type: 杂志文章,随机对照试验
doi:10.1038/pr.2014.110
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Infantile hemangioma (IH) is the most frequent vascular tumor of early childhood. Recently, propranolol, a nonselective β1- and β2-adrenoceptor inhibitor, was introduced into the therapy of severe proliferating IH with excellent results. However, the underlying mechanism of action of propranolol is still unc...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2013.16
更新日期:2013-04-01 00:00:00
abstract::There has been recent interest in the use of the phosphodiesterase-5 inhibitor sildenafil for treating pulmonary hypertension. We examined the interaction between inhaled nitric oxide (iNO) and i.v. sildenafil in 12 piglets with acute pulmonary hypertension and lung injury secondary to meconium aspiration. Six animals...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.PDR.0000112033.81970.C2
更新日期:2004-03-01 00:00:00
abstract::The aim of this study was to produce a neonatal piglet model which, avoiding vessel ligation, exposed the whole animal to hypoxia and produced dose-dependent clinical encephalopathy and neuropathologic damage similar to that seen after birth asphyxia. Twenty-three piglets were halothane-anesthetized. Hypoxia was induc...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199611000-00014
更新日期:1996-11-01 00:00:00
abstract::BackgroundAcute kidney injury (AKI) is common in pediatric inpatients and is associated with increased morbidity, mortality, and length of stay. Its early identification can reduce severity.MethodsTo create and validate an electronic health record (EHR)-based AKI screening tool, we generated temporally distinct develo...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2017.116
更新日期:2017-09-01 00:00:00
abstract::Accurate interpretation of the results of GH stimulation tests is of pivotal importance not only in the evaluation of the etiology of growth retardation in children but also in the selection of the best candidates for GH therapy. We performed this study to test a novel immunofunctional GH ( IFGH) assay that makes use ...
journal_title:Pediatric research
pub_type: 评论,杂志文章
doi:10.1203/00006450-200011000-00010
更新日期:2000-11-01 00:00:00
abstract::We studied the effect of maternal concentration and mode of administration on transfer rate of TSH-releasing hormone (TRH) in an in vitro model of dually perfused isolated lobule of human term placenta. Varying concentrations (4-40 microg dL(-1)) of TRH were added either to the open maternal circulation to mimic an in...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199705000-00012
更新日期:1997-05-01 00:00:00
abstract::Heme oxygenase (HO), the rate-limiting enzyme in the formation of bilirubin, is expressed in the lung and may serve as an antioxidant. This enzyme results in the formation of antioxidant bile pigments and the degradation of pro-oxidant heme. We wanted to evaluate the differences in expression of HO-1, the inducible fo...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-200301000-00010
更新日期:2003-01-01 00:00:00
abstract::Evidence is increasing for a role of polymorphisms in maternal or fetal innate immune response genes in preterm birth. Toll-like receptors (TLRs) are important receptors in the innate immunity. The genotype distribution of two TLR2 single nucleotide polymorphisms (SNPs) and one TLR4 SNP were determined among 524 neona...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e31813c9401
更新日期:2007-10-01 00:00:00
abstract::The first days of postnatal life are energetically demanding as metabolic functions change dramatically to accommodate drastic environmental and physiologic transitions after birth. It is increasingly appreciated that metabolic pathways are not only crucial for nutrition but also play important roles in regulating inf...
journal_title:Pediatric research
pub_type: 杂志文章,评审
doi:10.1038/s41390-019-0647-6
更新日期:2020-01-01 00:00:00
abstract::Hypothalamic growth hormone releasing hormone (GHRH) stimulates pituitary growth hormone secretion, which is essential for normal postnatal growth. Reports of an immunoreactive and biologically active GHRH-like peptide in placenta led us to investigate placental expression of GHRH mRNA. Placentas from d 19 gestation f...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199105010-00019
更新日期:1991-05-01 00:00:00
abstract::To investigate the detailed pattern of change in circulating gonadotropin and testosterone concentrations around the onset of puberty and to determine the temporal relationship between the gonadotropin and testosterone secretion, plasma gonadotropin and testosterone were measured at 20-min intervals for 24 h in 21 nor...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199308000-00026
更新日期:1993-08-01 00:00:00