Abstract：
:We studied the effects of a diet that was low in fat, high in carbohydrate (CHO) on milk lipid composition and de novo endogenous fatty acid synthesis by the mammary gland in five lactating women. The women consumed either a low fat (LF) (5% fat, 80% CHO) diet or a high fat (HF) (40% fat, 45% CHO) diet. Fat synthesis was determined after an oral dose of 500 mg/kg D2O by measuring the incorporation of deuterium into C10:0 to C18:0 saturated fatty acids of milk fat and plasma triglycerides by gas chromatography-mass spectrometry. Synthesis of plasma C16:0 and C18:0 triglycerides was barely detectable while women consumed the HF diet, but was increased 6-fold during the LF diet. Medium chain fatty acids secreted by the mammary gland increased from 12.8% (HF diet) to 16.3% (LF diet) in milk fat from four of five subjects (p = 0.027). Medium chain fatty acid secretion, however, increased from 13.9% (HF diet) to 29.9% (LF diet) in one subject. The primary fatty acids synthesized during lactation were C10:0, C12:0, and C14:0 in the majority of women studied. The LF diet significantly increased the apparent synthesis of C14:0 (p = 0.05), whereas no changes were observed in C12:0, C16:0, or C18:0. One subject had highly enriched C16:0 and C18:0 fatty acids in her milk on the LF diet, which could have been the result of mammary synthesis or of transport and secretion of hepatically synthesized lipids.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Hachey DL,Silber GH,Wong WW,Garza Cdoi
10.1203/00006450-198901000-00015subject
Has Abstractpub_date
1989-01-01 00:00:00pages
63-8issue
1eissn
0031-3998issn
1530-0447journal_volume
25pub_type
杂志文章abstract：:The effects of early protein-deficiency on lung development were studied in the rat. Newborn male rats were nursed in groups of eight. Control dams and pups received a 15% protein diet during the whole experiment. Test mothers only received 12 and 8% proteins from the 7th and the 14th day of lactation. Test rats fed a...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198707000-00012
更新日期：1987-07-01 00:00:00
abstract：:N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) and N-formyl-L-methionyl-L-phenylalanine (FMP) were used to investigate neutrophil (PMN) aggregation. Neutrophils were isolated from healthy adult volunteers and term newborn cord blood. Neutrophil aggregation was measured after the addition of FMLP and FMP. Adult P...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198312000-00013
更新日期：1983-12-01 00:00:00
abstract：:Leukotrienes C4 and D4 and thromboxane A2 are potent vasoconstrictors that may mediate pulmonary vasoconstriction in many clinical situations. There is a complex interaction among leukotrienes and thromboxane A2, because inhibition of thromboxane synthesis prevents some of the hemodynamic effects of exogenous leukotri...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198908000-00001
更新日期：1989-08-01 00:00:00
abstract：:Sleep organization of infants may be influenced by differences in nutrient intakes from human milk and formula. Because sleep/awake and sleep stage patterns affect energy expenditure, we hypothesized that differences in sleep organization between breast-fed and formula-fed infants might account in part for differences...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199211000-00003
更新日期：1992-11-01 00:00:00
abstract：:Surfactant-associated proteins (SP-A, SP-B, and SP-C) are critical for the endogenous function of surfactant. Keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF) are key regulators of lung development. The objective of this study was to evaluate the effects of early mechanical ventilation on...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181256aeb
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:This study aimed to determine the prevalence of respiratory pathogens among newborns admitted to a neonatal medium care unit (NMCU) and to identify clinical predictors. METHODS:A 1-y observational study was performed of neonates admitted to an NMCU in Amsterdam, The Netherlands. Nasopharyngeal samples were ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2012.176
更新日期：2013-03-01 00:00:00
abstract：:Neonatal hypoxic-ischemic encephalopathy (HIE) is a clinically defined neurological condition after lack of oxygen and often associated with cardiac dysfunction in term infants. Therapeutic hypothermia (HT) after birth is neuroprotective in infants with HIE. However, it is not known whether HT is also cardioprotective...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e31822941ee
更新日期：2011-10-01 00:00:00
abstract：:We studied the effect of maternal concentration and mode of administration on transfer rate of TSH-releasing hormone (TRH) in an in vitro model of dually perfused isolated lobule of human term placenta. Varying concentrations (4-40 microg dL(-1)) of TRH were added either to the open maternal circulation to mimic an in...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199705000-00012
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:Recent studies suggest that infantile hypertrophic pyloric stenosis (IHPS) and congenital heart defects (CHDs) may share some genetic risk factors, but little is known about the co-occurrence of the two conditions in patients. METHODS:Our study cohort included 2,212,756 persons born in Denmark 1977-2013. We...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-019-0369-9
更新日期：2019-06-01 00:00:00
abstract：:Epidermal growth factor (EGF), a potent mitogen present in milk, is postulated to play an important physiologic role in the ontogeny of the intestine. An artificial rat milk, free of EGF, was developed and fed to newborn rats in an effort to evaluate the physiologic role of EGF on intestinal glucose transport. Compari...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198704000-00017
更新日期：1987-04-01 00:00:00
abstract：:The auditory brainstem response (ABR) was monitored during infusion of bilirubin in six ventilated newborn rhesus monkeys (138-145 d gestation) while acute changes in pH were produced by varying inspired CO2. Prolonged respiratory acidosis without bilirubin infusion produced minimal changes in the ABR (one animal). CO...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199307000-00002
更新日期：1993-07-01 00:00:00
abstract：:This study reports the Hb, erythropoietin (Epo), and reticulocyte course at different postnatal ages (range, 8-83 d) of 56 blood samples from 30 newborns (range, one or two blood samples from each newborn) with erythroblastosis fetalis (18 intrauterine transfused (IUTd) and 12 non-IUTd). Hb, Epo, and reticulocyte valu...
journal_title：Pediatric research
pub_type： 临床试验,杂志文章
doi：10.1203/00006450-199608000-00027
更新日期：1996-08-01 00:00:00
abstract：:Serum copper (Cu) and zinc (Zn) concentrations were measured in neonates with an appropriate birth weight for gestational age (AGA) and in small-for-gestational age infants. At 7 days of age, there was a positive correlation between serum Cu concentration and gestational age (GA) (r = 0.63; P < 0.001) and a negative c...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198009000-00005
更新日期：1980-09-01 00:00:00
abstract：:To determine the importance of peroxisomes and mitochondria in hydroxyeicosatetraenoic acid (HETE) oxidation in vivo, urinary excretion of 12- and 15-HETE was measured in eight patients with a peroxisome deficiency disorder (Zellweger syndrome) showing normal mitochondrial beta-oxidation capacity, in three patients wi...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199601000-00022
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Pediatric myocarditis is a rare disease with substantial mortality. Little is known regarding its prognostic factors. We hypothesize that certain comorbidities and procedural needs may increase risks of poor outcomes. This study aims to identify prognostic factors for pediatric myocarditis. METHODS:The nati...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-01268-7
更新日期：2020-11-18 00:00:00
abstract：:Children with inflammatory bowel disease are known to be at risk of osteopenia. The cause of this osteopenia is likely to be multifactorial, but the inflammatory process with its characteristic overproduction of cytokines has been implicated. To investigate this possible contribution of the disease activity to the dev...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200008000-00008
更新日期：2000-08-01 00:00:00
abstract：:Carbohydrate and lipid intakes have both been found to modulate the metabolism of long-chain fatty acids. To define the respective influence of these two energy substrates on plasma fatty acid concentrations, 32 studies were performed in 16 parenterally fed newborn infants (mean +/- SEM, birth wt: 2.15 +/- 0.1 kg, age...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198910000-00002
更新日期：1989-10-01 00:00:00
abstract：:Compliant immature airways sustain significant deformation following positive pressure ventilation. To evaluate the structural changes induced by in vivo positive pressure ventilation, tracheae of preterm lambs (107-116 d gestational age) were studied histologically. Nonventilated (group I: n = 7) and ventilated (grou...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198911000-00014
更新日期：1989-11-01 00:00:00
abstract：:It is increasingly recognized that the abnormal physiologic consequences of pulmonary hypertension (PH) may contribute to poor cardiopulmonary health in premature babies. Conflicting literature has led to clinical uncertainty, pathological misinterpretation, and variability in treatment approaches among practitioners....
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2017.200
更新日期：2017-12-01 00:00:00
abstract：:A number of neuromuscular diseases are associated with molecular defects in the mitochondrial DNA (mtDNA). These include: 1) a missense mutation at nucleotide 11778 in the mtDNA of Leber's hereditary optic neuropathy patients; 2) a heterogeneous array of deletions in the mtDNA of ocular myopathy patients; and 3) small...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199011000-00023
更新日期：1990-11-01 00:00:00
abstract：:We evaluated bone mineralization by single photon absorptiometry at 2 y in a cohort of preterm infants studied since birth. Infants were fed human milk fortified with Ca [to achieve 80 mg/dL (19.96 mmol/L)] and P [40 mg/dL (12.91 mmol/L)] from wk 2 through 8 after birth. After hospital discharge, infants were divided ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199206000-00009
更新日期：1992-06-01 00:00:00
abstract：:In dissociated whole brain cell cultures from newborn mice, we have previously shown that during glucose deprivation under normoxia, D-beta-hydroxybutyrate and oleic acid are increasingly used for energy production. We now asked whether this glucose dependency of the utilization of D-beta-hydroxybutyrate and oleic aci...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198911000-00023
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:Exposure to inflammation exacerbates injury in neonatal encephalopathy (NE). We hypothesized that brain biomarker mRNA, cytokine mRNA and microRNA differentiate inflammation (E. coli LPS), hypoxia (Hypoxia), and inflammation-sensitized hypoxia (LPS+Hypoxia) in an NE piglet model. METHODS:Sixteen piglets wer...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0986-3
更新日期：2020-06-10 00:00:00
abstract：BACKGROUND:The preterm newborn is at high risk of developing cardiovascular compromise during the first day of life and this is associated with increased risk of brain injury. Standard treatments are volume expansion and administration of inotropes, typically dopamine and/or dobutamine, but there is limited evidence th...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2016.156
更新日期：2016-12-01 00:00:00
abstract：:The antiendotoxin effect of polymyxin B was investigated in experimentally induced septicemia in rabbits. The Pasteurella multocida organisms were sensitive to the antibacterial action of penicillin but not to polymyxin B. Animals pre-treated with polymyxin showed positive blood cultures and significantly reduced plas...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197901000-00011
更新日期：1979-01-01 00:00:00
abstract：:Our aim was to compare white matter (WM) microstructure in preterm infants with and without punctate WM lesions on MRI using tract-based spatial statistics (TBSS) and probabilistic tractography. We studied 23 preterm infants with punctate lesions, median GA at birth 30 (25-35) wk, and 23 GA- and sex-matched preterm co...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3182182836
更新日期：2011-06-01 00:00:00
abstract：:Ca2+ transients were examined in embryonic chick hearts with an experimentally induced cardiac neural crest-related outflow tract defect known as persistent truncus arteriosus (PTA). In all of the animal models of neural crest-related heart defects, prenatal mortality is too high to be attributed to structural defects...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199712000-00002
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:We examined whether increased dairy intake was associated with changes in the levels of bone-related biochemical markers in overweight/obese adolescent girls undergoing a 12-week diet and exercise intervention. METHODS:Thirty-five girls were assigned to a low dairy group (LDa; 0-2 servings/day; n = 16) or a...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0834-5
更新日期：2020-12-01 00:00:00
abstract：:Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency encountered in the neonatal intensive care unit. Despite advances in neonatal care, NEC remains a leading cause of morbidity and mortality among premature infants. Epidemiologic studies have identified multiple factors that ...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1203/PDR.0b013e31815ed64c
更新日期：2008-02-01 00:00:00
abstract：:The etiology of the tall stature almost invariably seen in homocystinuric patients is not known. The effect of metabolic control and the role of the GH-IGF system on growth were investigated in 10 patients with homocystinuria. There was a direct correlation between the plasma free homocyst(e)ine and growth velocity SD...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200106000-00014
更新日期：2001-06-01 00:00:00
