Abstract：
:The effects of early protein-deficiency on lung development were studied in the rat. Newborn male rats were nursed in groups of eight. Control dams and pups received a 15% protein diet during the whole experiment. Test mothers only received 12 and 8% proteins from the 7th and the 14th day of lactation. Test rats fed a diet of 8% protein were weaned at 21 days and maintained on the low protein diet for 1 month. This caused a marked decrease in body weight gain, but lung/body weight ratio was not affected. Lung DNA and protein content, lung protein concentration, but not lung DNA concentration were decreased, suggesting the presence of fewer and smaller cells than in control lungs. Volume-pressure curves were performed on excised lungs. With air-filling, the curve obtained in rats fed a diet with 8% proteins was shifted downward and to the right, even when expressed as percent of maximal volume. Its exponential analysis assessed a decrease in lung compliance. In contrast, with saline-filling, the recoil pressure was decreased in rats fed a diet with 8% proteins. Both with air and saline-filling, the pressure at lung rupture was increased in malnourished rats. It is concluded that protein-deficiency from the neonatal period increases surface forces, decreases tissue elastic forces, and augments resistance of the lung to rupture.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Kalenga M,Henquin JCdoi
10.1203/00006450-198707000-00012subject
Has Abstractpub_date
1987-07-01 00:00:00pages
45-9issue
1eissn
0031-3998issn
1530-0447journal_volume
22pub_type
杂志文章abstract：:Although obstructive nephropathy is a frequent cause of renal insufficiency in infancy, factors influencing adaptation to chronic partial ureteral obstruction (CPUO) are poorly understood. Guinea pigs were subjected to unilateral CPUO within the first 2 days of life (Group I) and microsphere studies were performed at ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198412000-00008
更新日期：1984-12-01 00:00:00
abstract：:Diabetes mellitus is characterized by microangiopathy and increased angiogenic response in various organs. Basic fibroblast growth factor (bFGF) as well as vascular endothelial growth factor (VEGF) are both angiogenic and are involved in vascular endothelial cell growth. The purpose of this study was to determine seru...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199812000-00008
更新日期：1998-12-01 00:00:00
abstract：:All enzymes of the urea cycle are demonstrable in circulating leukocytes. They show the same relative activities as those in liver except for argininosuccinate synthetase + lyase (combined) which seems to be disproportionately active. To see whether leukocytes reflect liver activity, blood from patients with three hep...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197506000-00004
更新日期：1975-06-01 00:00:00
abstract：BACKGROUND:Although it is commonly accepted that upper airway obstruction (UAO) increases gastroesophageal reflux (GER), the link is poorly understood and insufficiently documented. In addition, while hypoxia is often encountered in infants with UAO, its consequences on GER are virtually unknown. The two aims of the pr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0920-8
更新日期：2020-05-01 00:00:00
abstract：:Genetic variants of surfactant protein B (SP-B) have been associated with respiratory distress syndrome (RDS) in the prematurely born infant. We wished to determine linkage between RDS and SP-B single nucleotide polymorphisms (SNPs) [-18 (A/C), 1013 (A/C), 1580 (C/T), and 9306 (A/G)] or SP-B-linked microsatellite [(D2...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000203145.48585.2c
更新日期：2006-04-01 00:00:00
abstract：:To evaluate the maturation of glucose homeostasis in the small for gestational age (SGA) neonate, glucose kinetics were measured with 78% enriched D-[U-13C]glucose by the prime plus constant infusion technique in nine SGA infants and compared with the rate obtained in seven term appropriate for gestational age infants...
journal_title：Pediatric research
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：INTRODUCTION:Very early preterm infants (VPIs) are exposed to unpredictable noise in neonatal intensive care units. Their ability to perceive moderate acoustic environmental changes has not been fully investigated. RESULTS:Physiological values of the 598 isolated sound peaks (SPs) that were 5-10 and 10-15 dB slow-resp...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2011.76
更新日期：2012-04-01 00:00:00
abstract：:Oxidant stress has been implicated as playing a role in the pathogenesis of cholestatic liver injury. The objective of this study was to determine whether the xanthine oxidase/xanthine dehydrogenase enzyme system was involved in this oxidant stress. Adult Sprague-Dawley rats were treated with the xanthine oxidase inhi...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199809000-00022
更新日期：1998-09-01 00:00:00
abstract：INTRODUCTION:The Coulter LH780 hematology analyzer can evaluate mean neutrophil volume (MNV), conductivity (MNC), scatter (MNS), and distribution width (DW). We sought to investigate the value of volume, conductivity, and scatter (VCS) parameters in diagnosis and treatment efficacy of neonatal sepsis. RESULTS:We obser...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2011.16
更新日期：2012-01-01 00:00:00
abstract：:Early-life stress has been shown to destabilize the homeostatic synaptic plasticity and compromise the developing brain to the later encountered insults. This study would determine the long-term epileptogenic effect of neonatal isolation (NI) on early-life seizure. There were five groups: normal rearing (NR) rats; NI ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181b337d2
更新日期：2009-10-01 00:00:00
abstract：:Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency encountered in the neonatal intensive care unit. Despite advances in neonatal care, NEC remains a leading cause of morbidity and mortality among premature infants. Epidemiologic studies have identified multiple factors that ...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1203/PDR.0b013e31815ed64c
更新日期：2008-02-01 00:00:00
abstract：:The effect of somatomedin and cortisol on embryonic chick cartilage in vitro indicates that somatomedin stimulates 35SO4 uptake while cortisol decreases it with no effect on glycosaminoglycan turnover. Xylosyltransferase activity is increased in crude fractions of somatomedin-treated cartilage but decreased in cortiso...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197902000-00002
更新日期：1979-02-01 00:00:00
abstract：:Chloroform:methanol extracts of bovine pulmonary surfactant contain small hydrophobic proteins, designated surfactant-associated apoproteins 6,000 (SAP-6), but do not contain the major surfactant-associated 35,000-dalton glycoprotein, designated SAP-35. Examination of lipid extract surfactant on sodium dodecylsulfate-...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198801000-00006
更新日期：1988-01-01 00:00:00
abstract：:In an effort to characterize the hepatic abnormality in patients with alpha1-antitrypsin deficiency, three unrelated children with the disorder (Pi types ZZ and SZ), two heterozygous parents (Pi type MZ), and three normal subjects (Pi type MM) were studied. As expected, the livers of the ZZ- and SZ-deficient subjects ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197601000-00007
更新日期：1976-01-01 00:00:00
abstract：BACKGROUND:Near-infrared spectroscopy is used in the assessment of regional splanchnic oxygen saturation (rsSO2), but solid reference values are scarce. We aimed to establish reference values of rsSO2 for preterm infants during the first week after birth, both crude and modeled based on predictors. METHODS:We included...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-01323-3
更新日期：2021-01-27 00:00:00
abstract：:Factors affecting bone turnover in premature infants are not entirely clear but certainly are different from those influencing bones of adults and children. To identify fetal and maternal factors that might influence bone turnover, we prospectively studied 50 infants (30 preterm and 20 full-term) born at Ain Shams Uni...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000160591.70409.C8
更新日期：2005-05-01 00:00:00
abstract：:Jejunal biopsies obtained from 45 children referred for a variety of clinical conditions were examined histologically and by standard immunofluorescence methods. The number of plasma cells was recorded per "mucosal tissue unit". The results showed that most of the immunoglobulin A (IgA) counts in infants under 3 yr wi...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197906000-00002
更新日期：1979-06-01 00:00:00
abstract：BACKGROUND:Prematurity may influence the levels of amino acids, enzymes, and endocrine markers obtained through newborn screening. Identifying which analytes are the most affected by degree of prematurity could provide insight into how prematurity impacts metabolism. METHODS:Analytes from blood spots assayed by Newbor...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2013.212
更新日期：2014-02-01 00:00:00
abstract：:It has been shown that glucocorticoids accelerate lung development by limiting alveolar formation resulting from a premature maturation of the alveolar septa. Based on these data, the aim of the present work was to analyze the influence of dexamethasone on cell cycle control mechanisms during postnatal lung developmen...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200202000-00008
更新日期：2002-02-01 00:00:00
abstract：:There has been recent interest in the use of the phosphodiesterase-5 inhibitor sildenafil for treating pulmonary hypertension. We examined the interaction between inhaled nitric oxide (iNO) and i.v. sildenafil in 12 piglets with acute pulmonary hypertension and lung injury secondary to meconium aspiration. Six animals...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000112033.81970.C2
更新日期：2004-03-01 00:00:00
abstract：:Bacillus Calmette-Guerin (BCG) vaccination can protect animals from asthma, but the effect of BCG on childhood asthma prevention is controversial in humans. To verify the hypothesis that the BCG anti-asthma effect in childhood might be reversed by a respiratory virus infection, newborn BALB/c mice were divided into fi...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000196368.08210.5c
更新日期：2006-02-01 00:00:00
abstract：:The present study investigates the effects of polycythemia on renal hemodynamics and function in 15 anesthetized newborn dogs, 2-10 days of age. Microspheres were used to study renal blood flow. Experimental animals received an exchange transfusion with adult dog packed red blood cells resulting in an increase in hema...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198202000-00014
更新日期：1982-02-01 00:00:00
abstract：:To define respiratory effects of peripheral acidemia during early development, we injected lactic acid (LA) into the jugular vein of 32 1- to 7-d-old rabbit pups and four adult rabbits. The body weight of newborns varied between 67 +/- 17 g in 1-d-old and 119.8 +/- 33.7 g in 7-d-old animals versus 4 +/- 0.1 kg in adul...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199106010-00006
更新日期：1991-06-01 00:00:00
abstract：:In persistent hyperinsulinemic hypoglycemia of infancy, ketone body concentrations are abnormally low at times of hypoglycemia, depriving the brain of its most important alternative fuel. The neuroprotective effect of endogenous ketone bodies is evidenced by animal and human studies, but knowledge about exogenous supp...
journal_title：Pediatric research
pub_type： 临床试验,杂志文章
doi：10.1203/00006450-200208000-00025
更新日期：2002-08-01 00:00:00
abstract：:The dipeptides carnosine and anserine, found exclusively in meats, are hydrolyzed in serum by the enzyme carnosinase. Several reports of serum carnosinase deficiency describe a variable phenotype, which ranges from normal to severe psychomotor retardation, hypotonia, and myoclonic seizures in the first year of life. W...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199702000-00009
更新日期：1997-02-01 00:00:00
abstract：:Acute kidney injury (AKI) is common in premature infants and is associated with poor outcomes. Novel biomarkers can detect AKI promptly. Because premature infants are born with underdeveloped kidneys, baseline biomarker values may differ. We describe baseline values of urinary neutrophil gelatinase-associated lipocali...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3182275164
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Intrauterine growth restriction (IUGR) increases the risk of adult-onset hypercholesterolemia. High-fat diet (HFD) consumption potentiates IUGR-induced increased cholesterol. Cholesterol is converted to bile acids by Cyp7a1 in preparation for excretion. We hypothesized that IUGR rats fed a HFD will have incr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2014.117
更新日期：2014-11-01 00:00:00
abstract：:The activity of UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase (EC 2.4.2.26), the enzyme that catalyzes the initiation of the polysaccharide chain linkage to the core protein of proteoglycans, was measured in costal cartilage from 20 fetal sheep of 65-138 days gestation. Activity of the enzyme was es...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198512000-00003
更新日期：1985-12-01 00:00:00
abstract：:Girls with Turner syndrome (TS) are treated with supraphysiological doses of growth hormone (GH) to improve final height; however in some girls, the growth response can be poor. This may reflect aberrations in GH and/or IGF-I actions at the cellular level, and thus this study compared the response of skin fibroblasts ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e31821b570b
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:The aim of our study was to understand the relationship between consanguineous marriages and reproductive outcomes. METHODS:A total of 999 families were recruited from five Muslim populations of Jammu region. Family pedigrees were drawn to access the family history and inbreeding status in terms of coeffici...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2016.177
更新日期：2017-01-01 00:00:00
