Abstract:
INTRODUCTION:The Coulter LH780 hematology analyzer can evaluate mean neutrophil volume (MNV), conductivity (MNC), scatter (MNS), and distribution width (DW). We sought to investigate the value of volume, conductivity, and scatter (VCS) parameters in diagnosis and treatment efficacy of neonatal sepsis. RESULTS:We observed significant increases in MNV, volume distribution width (VDW), conductivity distribution width (CDW), and significant decreases in MNC and MNS in septic newborns. There were significant decreases in MNV, VDW, and CDW, whereas MNC and MNS increased at the end of the treatment. Gram-negative sepsis caused higher MNV and VDW than Gram-positive sepsis. DISCUSSION:This is the largest reported study seeking to determine cutoff levels of neutrophil VCS parameters in diagnosis of sepsis, and the first study in the evaluation of treatment efficacy and the effects of sepsis onset time and birth weight. We suggest that neutrophil VCS parameters and their DWs are useful both for early diagnosis and evaluation of treatment efficacy in neonatal sepsis without requirement for any extra blood collection. METHODS:Peripheral blood samples from 304 newborns, 206 in group I (76 proven and 130 clinical sepsis) and 98 in group II (control group), were studied on diagnosis, 3rd day, and at the end of the treatment.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Celik IH,Demirel G,Aksoy HT,Erdeve O,Tuncer E,Biyikli Z,Dilmen Udoi
10.1038/pr.2011.16subject
Has Abstractpub_date
2012-01-01 00:00:00pages
121-5issue
1eissn
0031-3998issn
1530-0447pii
pr201116journal_volume
71pub_type
杂志文章abstract::We studied properties of saliva and of dental plaque which affect the caries process in an effort to understand the low prevalence of caries in patients with chronic renal failure. Plaque pH, before and following carbohydrate exposure, saliva pH, and saliva composition were evaluated in children and adolescents with c...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198508000-00003
更新日期:1985-08-01 00:00:00
abstract::Changes in high-density lipoprotein (HDL) subclass distribution were evaluated in a group of premature infants during the early postnatal period to ascertain whether enteral feeding brought about a rapid shift from neonatal to adult-like distributions. All infants were fed a combination of breast milk and formula. Cor...
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journal_title:Pediatric research
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journal_title:Pediatric research
pub_type: 杂志文章
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journal_title:Pediatric research
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doi:10.1203/00006450-198707000-00012
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doi:10.1203/00006450-199106010-00002
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journal_title:Pediatric research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199311000-00013
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journal_title:Pediatric research
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更新日期:1982-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1203/00006450-199311000-00023
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journal_title:Pediatric research
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更新日期:2015-01-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197707000-00006
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journal_title:Pediatric research
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doi:10.1203/00006450-199402000-00008
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-04-20 00:00:00