Caries resistance in children with chronic renal failure: plaque pH, salivary pH, and salivary composition.

Abstract:

:We studied properties of saliva and of dental plaque which affect the caries process in an effort to understand the low prevalence of caries in patients with chronic renal failure. Plaque pH, before and following carbohydrate exposure, saliva pH, and saliva composition were evaluated in children and adolescents with chronic renal failure (n = 10) and successful renal transplantation (n = 11), and in two comparison groups of healthy children with few caries (n = 15) and numerous caries (n = 15). Salivary urea nitrogen concentration was elevated in all subjects with elevated serum urea nitrogen concentration. Chronic renal failure subjects had significantly higher salivary urea nitrogen concentration than transplanted subjects. Plaque pH correlated directly with salivary urea nitrogen concentration and was significantly more alkaline in chronic renal failure than transplant or comparison groups. Salivary urea nitrogen concentration accounted for the majority of variability in plaque pH; salivary pH and salivary phosphorous contributed negligibly. Absolute pH drop following carbohydrate exposure did not differ among groups, but because baseline plaque pH was elevated for chronic renal failure subjects, minimum pH did not attain cariogenic levels. Our data support the hypothesis that the relative paucity of caries in patients with chronic renal failure results from alteration of plaque by metabolic end products of urea metabolism. Our data further suggest that transplanted patients whose renal function is normal may be at increased risk of caries, especially if enamel hypoplasia is present and oral hygiene is poor.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Peterson S,Woodhead J,Crall J

doi

10.1203/00006450-198508000-00003

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

796-9

issue

8

eissn

0031-3998

issn

1530-0447

journal_volume

19

pub_type

杂志文章
  • Maternally administered dexamethasone at 0.7 of gestation suppresses maternal and fetal pituitary and adrenal responses to hypoxemia in sheep.

    abstract::Women who are at risk of preterm delivery are treated with antenatal steroids to facilitate fetal lung maturation. During this period, there is a potential for fetal or maternal hypoxemia to occur. Fetal responses to hypoxemia in sheep are well documented. However, less is known regarding maternal responses to hypoxem...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000117847.59343.B2

    authors: Kutzler MA,Coksaygan T,Ferguson AD,Vincent SE,Nathanielsz PW

    更新日期:2004-05-01 00:00:00

  • The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months.

    abstract:BACKGROUND:Insulin-like growth factor (IGF)-I and -II play an important role in prenatal growth. During the first 2 months from birth, body fat doubles, and rapid weight gain during this time increases future risk of cardiometabolic disease. The aim of this study was to determine whether IGF measurements at birth assoc...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0331-x

    authors: Hawkes CP,Grimberg A,Kenny LC,Kiely M,Hourihane JOB,Irvine AD,McPhaul MJ,Caulfield MP,Zemel BS,Murray DM

    更新日期:2019-04-01 00:00:00

  • Effects of oxygen-induced lung damage on megakaryocytopoiesis and platelet homeostasis in a rat model.

    abstract::The association between lung injury and thrombocytopenia was investigated by comparing the megakaryocyte and platelet counts, and platelet activation using P-selectin as a marker, between the prepulmonary (right atrial) and postpulmonary (left atrial) blood in adult and neonatal (preterm and term) rats with and withou...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000079186.86219.29

    authors: Yang J,Yang M,Xu F,Li K,Lee SK,Ng PC,Tam JS,Yuen PM,Fok TF

    更新日期:2003-09-01 00:00:00

  • Quantitative evaluation of the extent of hepatic enzyme changes in Reye syndrome compared with normal liver or with non-Reye liver disorders: objective criteria for animal models.

    abstract::Five enzymes were measured in 50 liver specimens (18 normal liver, 20 Reye liver, 12 diverse liver disorders other than Reye syndrome). The enzymes were: glutamic dehydrogenase (E.C. 1.4.1.3), monoamine oxidase (E.C. 1.4.3.4), lactate dehydrogenase (E.C. 1.1.1.27), D-glucose-6-phosphate dehydrogenase (E.C. 1.1.1.49), ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198501000-00006

    authors: Mitchell RA,Arcinue EL,Partin JC,Partin JS,Ram ML,Chang CH,Smialek J,Sarnaik A

    更新日期:1985-01-01 00:00:00

  • aEEG and neurologic exam findings correlate with hypoxic-ischemic brain damage severity in a piglet survival model.

    abstract:BACKGROUND:Newborn pigs offer theoretical advantages for studying newborn hypoxic-ischemic (HI) brain damage because of a development and structure similar to the human brain. However, the correlation between functional features and actual HI brain damage has not been reported. METHODS:Newborn pigs were examined daily...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0282-2

    authors: Barata L,Cabañas A,Lafuente H,Vargas C,Ceprián M,Campa L,Jiménez-Sánchez L,Pazos MR,Alvarez FJ,Martínez-Orgado J

    更新日期:2019-03-01 00:00:00

  • Intravenous immune globulin for the prevention of infections in children with symptomatic human immunodeficiency virus infection.

    abstract::Infection with human immunodeficiency virus (HIV) causes a progressive immunodeficiency, often manifested in adults by the development of infections with relatively rare, opportunistic organisms. However, in HIV-infected children, recurrent serious infections with common encapsulated bacteria, as well as recurrent min...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审

    doi:10.1203/00006450-199305001-00464

    authors: Mofenson LM,Moye J Jr

    更新日期:1993-01-01 00:00:00

  • Low incidence of childhood celiac disease in The Netherlands.

    abstract::The incidence and prevalence of celiac disease vary internationally. We studied the incidence of identified cases of childhood celiac disease in six Dutch provinces that cover 47.9% of the surface area and 67.6% of the total population of The Netherlands. Children with celiac disease aged 0-14 y, diagnosed from Januar...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199502000-00015

    authors: George EK,Mearin ML,van der Velde EA,Houwen RH,Bouquet J,Gijsbers CF,Vandenbroucke JP

    更新日期:1995-02-01 00:00:00

  • Prostaglandin E1 opens the ductus venosus in the newborn lamb.

    abstract::There is in vitro evidence that the ductus venosus of the fetal and newborn lamb relaxes to administration of E-series prostaglandins. We performed this study to determine whether the ductus venosus of the newborn lamb could be reopened by an infusion of prostaglandin E1. Fifteen lambs between 4 and 28 h of life and s...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198703000-00002

    authors: Morin FC 3rd

    更新日期:1987-03-01 00:00:00

  • Effect of methylxanthines on diaphragmatic fatigue in the piglet.

    abstract::Studies in adult animal and human subjects have suggested that the methylxanthine drugs can delay the onset or attenuate the severity of diaphragmatic fatigue. We have investigated the effect of aminophylline and caffeine on the pressure-generating capacity of the fatigued diaphragm in 1-mo-old piglets. Measurements o...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199211000-00019

    authors: Mayock DE,Standaert TA,Woodrum DE

    更新日期:1992-11-01 00:00:00

  • Respiratory metabolism in preterm infants: the measurement of oxygen consumption during prolonged periods.

    abstract::We have developed a method for measuring oxygen consumption (Vo2) in preterm infants in their normal incubator environment over prolonged periods. The results of measurements made over 24 h in 18 infants are presented. In normally grown infants, the mean Vo2 was 9.66 +/- 1.25 liters/kg X 24 h (SD) (6.71 +/- 0.87 ml/kg...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198410000-00003

    authors: Abdulrazzaq YM,Brooke OG

    更新日期:1984-10-01 00:00:00

  • Nitric oxide increases the survival of rats with a high oxygen exposure.

    abstract::The purpose of this study was to begin to examine the influence of inhaled NO on O2 toxicity. The survival of Sprague-Dawley rats exposed to >95% O2, >95% O2 + 10 ppm NO, >95% O2 + 100 ppm NO, and >95% O2 + 3 ppm NO2 was determined. Survival at 120 h was 2/24 in >95% O2, 2/12 in >95% O2 + 10 ppm NO, and 1/12 in >95% O...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199806000-00003

    authors: Nelin LD,Welty SE,Morrisey JF,Gotuaco C,Dawson CA

    更新日期:1998-06-01 00:00:00

  • Heat shock protein 72 (HSPA1B) gene polymorphism and Toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children.

    abstract::Innate immunity and urinary tract response play a central role in the development of urinary tract infection (UTI). Heat shock protein (HSP) 72 and Toll-like receptor (TLR) 4 are among the key elements of innate defence mechanisms. This study assesses the role of HSPA1B A(1267)G and TLR4 A(896)G polymorphisms using al...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/pdr.0b013e318030d1f4

    authors: Karoly E,Fekete A,Banki NF,Szebeni B,Vannay A,Szabo AJ,Tulassay T,Reusz GS

    更新日期:2007-03-01 00:00:00

  • Ligating the ductus arteriosus before birth causes persistent pulmonary hypertension in the newborn lamb.

    abstract::We determined whether closing the ductus arteriosus of the fetal lamb several d before birth would cause persistent pulmonary hypertension after birth. Six experimental fetuses who had their ductus arteriosus ligated 3-17 d before delivery, three control fetuses who had sham ligation of the ductus arteriosus 14 d befo...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198903000-00005

    authors: Morin FC 3rd

    更新日期:1989-03-01 00:00:00

  • Higher incidence of small Y chromosome in humans with trisomy 21 (Down syndrome).

    abstract::The length of the Y chromosome was measured in 42 black patients with trisomy 21 (47,XY,+21) and a similar number of normal individuals of American black ancestry. The length of the Y was expressed as a function of Y/F ratio and arbitrarily classified into five groups using subjectively defined criteria as follows: ve...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198209000-00012

    authors: Verma RS,Huq A,Madahar C,Qazi Q,Dosik H

    更新日期:1982-09-01 00:00:00

  • Hydrolysis of dipeptides by human and ovine placentas.

    abstract::Human and ovine placental tissue homogenates were assayed for dipeptidase activity in vitro. Glycyl-L-leucine, L-leucyl glycine, glycyl-L-lysine, and L-lysyl glycine were hydrolyzed by placental homogenates. The pH optimum for the reaction was 8.0. The relationship between enzyme activity and concentration was linear ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198104000-00013

    authors: Crandell SS,Adcock EW 3rd,Morriss FH Jr

    更新日期:1981-04-01 00:00:00

  • Lung and systemic inflammation in preterm lambs on continuous positive airway pressure or conventional ventilation.

    abstract::Intratracheal lipopolysaccharide (LPS) causes acute inflammation and injurious mechanical ventilation results in pulmonary and systemic inflammation. We aimed to determine in preterm lungs if continuous positive airway pressure (CPAP) protects against pulmonary and systemic inflammation, compared with conventional mec...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e318189487e

    authors: Polglase GR,Hillman NH,Ball MK,Kramer BW,Kallapur SG,Jobe AH,Pillow JJ

    更新日期:2009-01-01 00:00:00

  • Total parenteral nutrition in the newborn: energy substrates and plasma total fatty acids.

    abstract::Carbohydrate and lipid intakes have both been found to modulate the metabolism of long-chain fatty acids. To define the respective influence of these two energy substrates on plasma fatty acid concentrations, 32 studies were performed in 16 parenterally fed newborn infants (mean +/- SEM, birth wt: 2.15 +/- 0.1 kg, age...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198910000-00002

    authors: Pineault M,Lepage G,Bisaillon S,Roy CC,Chessex P

    更新日期:1989-10-01 00:00:00

  • Uridine diphosphate hexoses in leukocytes and fibroblasts of classic galactosemics and patients with other metabolic diseases.

    abstract::To examine uridine diphosphate hexose (UDPhexose) content of cells that have more complete metabolic patterns than erythrocytes, which have been commonly used in the study of galactosemia, the concentrations of uridine diphosphate galactose (UDPgalactose) and uridine diphosphate glucose (UDPglucose) were determined in...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199411000-00014

    authors: Gibson JB,Reynolds RA,Palmieri MJ,States B,Berry GT,Segal S

    更新日期:1994-11-01 00:00:00

  • Changes in hyaluronan deposition during early respiratory distress syndrome in premature monkeys.

    abstract::Increased deposition of hyaluronan (HA) is part of the early response to fibrogenic stimulus in the lung exposed to bleomycin injury and has been associated with increased lung water in adult animals. Early respiratory distress syndrome (RDS) in premature infants is characterized by increased lung water, and late sequ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199402000-00024

    authors: Juul SE,Kinsella MG,Jackson JC,Truog WE,Standaert TA,Hodson WA

    更新日期:1994-02-01 00:00:00

  • Associations of measures of systemic blood flow used in a randomized trial of delayed cord clamping in preterm infants.

    abstract:OBJECTIVE:To determine associations of low superior vena cava (SVC) flow (≤55 ml/kg/min) and low right ventricular output (RVO) (≤150 ml/kg/min) in preterm infants. DESIGN/METHODS:An observational study in infants <30 weeks gestation randomized to receive immediate (<10 s) or delayed cord clamping (DCC) (≥60 s). RESU...

    journal_title:Pediatric research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1038/s41390-019-0348-1

    authors: Popat H,Robledo KP,Kirby A,Sebastian L,Evans N,Gill A,Kluckow M,Sinhal S,de Waal K,Tarnow-Mordi W,Osborn D

    更新日期:2019-07-01 00:00:00

  • Effects of Bifidobacterium breve on inflammatory gene expression in neonatal and weaning rat intestine.

    abstract:INTRODUCTION:To examine the immune-modulatory effects of probiotics during early infancy, Bifidobacterium breve M-16V (B. breve) was administered to rat pups during the newborn or weaning period, and the expression of inflammatory genes was investigated using a cDNA microarray and real-time PCR. RESULTS:After B. breve...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2011.11

    authors: Ohtsuka Y,Ikegami T,Izumi H,Namura M,Ikeda T,Ikuse T,Baba Y,Kudo T,Suzuki R,Shimizu T

    更新日期:2012-01-01 00:00:00

  • The effects of intraventricular/periventricular blood on cerebral 3',5'-cyclic adenosine monophosphate concentration and cerebrovascular reactivity in newborn pigs.

    abstract::This study investigated the effects of intraventricular/periventricular blood on cerebral cAMP production and cortical cerebrovascular reactivity. Under halothane and N2O anesthesia, 3 mL of either autologous blood or artificial cerebrospinal fluid (CSF) were injected into the left caudate nucleus; volume was adequate...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199709000-00010

    authors: Pourcyrous M,Parfenova H,Shibata M,Bada HS,Korones SB,Leffler CW

    更新日期:1997-09-01 00:00:00

  • Rare GATA5 sequence variants identified in individuals with bicuspid aortic valve.

    abstract:BACKGROUND:Bicuspid aortic valve (BAV) is the most common type of congenital heart disease (CHD) and has a proposed genetic etiology. BAV is categorized by cusp fusion, with right-left (R-L) cusp fusion being associated with additional CHD, and right-noncoronary cusp (R-NC) fusion being associated with aortic valve dys...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2014.67

    authors: Bonachea EM,Chang SW,Zender G,LaHaye S,Fitzgerald-Butt S,McBride KL,Garg V

    更新日期:2014-08-01 00:00:00

  • 11-Beta hydroxysteroid dehydrogenase type 2 in human adult and fetal lung and its regulation by sex steroids.

    abstract::11-Beta hydroxysteroid dehydrogenase type 2 (HSD2) oxidizes the biologically active glucocorticoid (GC), cortisol, to inactive cortisone. We characterized HSD2 gene expression and activity in human adult and fetal lung tissues and in cultured fetal lung explants, and examined the potential regulation of HSD2 in the fe...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3180676cf3

    authors: Garbrecht MR,Klein JM,McCarthy TA,Schmidt TJ,Krozowski ZS,Snyder JM

    更新日期:2007-07-01 00:00:00

  • Insulin-like growth factor I, its binding proteins 1 and 3, and growth hormone-binding protein in children and adolescents with insulin-dependent diabetes mellitus: clinical implications.

    abstract::Values of IGF-I after extraction, its binding proteins, and the high affinity GH-binding protein (BP) are not well established in pediatric patients with insulin-dependent diabetes mellitus (IDDM). We report data for IGF-I, IGFBP-1, and -3, and GHBP in 92 Spanish children with IDDM, separated according to pubertal sta...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199606000-00011

    authors: Muñoz MT,Barrios V,Pozo J,Argente J

    更新日期:1996-06-01 00:00:00

  • Peripheral blood immune response elicited by beta-lactoglobulin in childhood cow's milk allergy.

    abstract::Several studies analyzing the immune responses in patients with cow's milk allergy (CMA) have used T-cell lines or T-cell clones that require prolonged in vitro cell culturing and may result in a switched cell phenotype and function. We investigated immune responses to beta-lactoglobulin (b-LG) in peripheral blood mon...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e318232739c

    authors: Vocca I,Canani RB,Camarca A,Ruotolo S,Nocerino R,Radano G,Del Mastro A,Troncone R,Gianfrani C

    更新日期:2011-12-01 00:00:00

  • General immune dampening is associated with disturbed metabolism at diagnosis of type 1 diabetes.

    abstract:BACKGROUND:Type 1 diabetes (T1D) is a serious diagnosis with the prospect of grave short- and long-term complications and even death if poorly managed. An attempt has been made to describe how clinical and immunological deviations might influence each other close to the diagnosis of T1D. METHODS:Sixty-nine newly diagn...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2013.167

    authors: Rydén A,Ludvigsson J,Fredrikson M,Faresjö M

    更新日期:2014-01-01 00:00:00

  • Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation?

    abstract::Prenatal exposure to infection and subsequent inflammatory responses have been implicated in the etiology of schizophrenia and autism. In this review, we summarize current evidence from human and animal studies supporting the hypothesis that the pathogenesis of these two disorders is linked via exposure to inflammatio...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1203/PDR.0b013e318212c196

    authors: Meyer U,Feldon J,Dammann O

    更新日期:2011-05-01 00:00:00

  • Newborn polymorphonuclear leukocyte aggregation: a study of physical properties and ultrastructure using chemotactic peptides.

    abstract::N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) and N-formyl-L-methionyl-L-phenylalanine (FMP) were used to investigate neutrophil (PMN) aggregation. Neutrophils were isolated from healthy adult volunteers and term newborn cord blood. Neutrophil aggregation was measured after the addition of FMLP and FMP. Adult P...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198312000-00013

    authors: Olson TA,Ruymann FB,Cook BA,Burgess DP,Henson SA,Thomas PJ

    更新日期:1983-12-01 00:00:00

  • Neonatal body composition: dual-energy X-ray absorptiometry, magnetic resonance imaging, and three-dimensional chemical shift imaging versus chemical analysis in piglets.

    abstract::An animal study to evaluate dual-energy x-ray absorptiometry (DXA) and magnetic resonance (MR) imaging and spectroscopy for measurement of neonatal body composition was performed. Twenty-three piglets with body weights ranging from 848 to 7550 g were used. After measuring total body water, animals were killed and body...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199910000-00018

    authors: Fusch C,Slotboom J,Fuehrer U,Schumacher R,Keisker A,Zimmermann W,Moessinger A,Boesch C,Blum J

    更新日期:1999-10-01 00:00:00