Abstract:
OBJECTIVE:To determine associations of low superior vena cava (SVC) flow (≤55 ml/kg/min) and low right ventricular output (RVO) (≤150 ml/kg/min) in preterm infants. DESIGN/METHODS:An observational study in infants <30 weeks gestation randomized to receive immediate (<10 s) or delayed cord clamping (DCC) (≥60 s). RESULTS:The study enrolled 265 infants with a mean (SD) gestation 28 (2) weeks. Eighty-six (33%) infants had low SVC flow and 81 (31%) infants had low RVO. In multivariate analysis, low SVC flow was associated with gestation; low RVO was associated with DCC, gender and 5-minute Apgar; whereas mean RVO was negatively associated with both FiO2 and mean airway pressure (MAP) at 9 h and 24 h. Low SVC flow was associated with ductus arteriosus (DA) treatment. Infants with low RVO had higher mortality on univariate analysis, but this was not significant after adjusting for gestation. CONCLUSIONS:SVC flow was associated with gestation, whilst RVO was associated with placental transfusion, gender, condition at birth, and early respiratory adaptation. Compared to infants with normal values, more infants with low SVC flow were treated for DA, but infants with low RVO had no significant difference in mortality or morbidity.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Popat H,Robledo KP,Kirby A,Sebastian L,Evans N,Gill A,Kluckow M,Sinhal S,de Waal K,Tarnow-Mordi W,Osborn Ddoi
10.1038/s41390-019-0348-1subject
Has Abstractpub_date
2019-07-01 00:00:00pages
71-76issue
1eissn
0031-3998issn
1530-0447pii
10.1038/s41390-019-0348-1journal_volume
86pub_type
杂志文章,多中心研究,随机对照试验abstract::Pathomechanisms involved in obstructive apneas remain obscure. Apnea arousal failure has been proposed as a cause for sudden death during sleep. The present study hypothesizes an interdependency between upper airway dilating submental muscle electromyogram (EMG) activity (EMGsub), diaphragmatic muscle activity (EMGdia...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199509000-00005
更新日期:1995-09-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章,评审
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journal_title:Pediatric research
pub_type: 杂志文章,评审
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
abstract::Uteroplacental insufficiency and subsequent intrauterine growth retardation (IUGR) increase the risk of insulin resistance in humans and rats. Aberrant skeletal muscle lipid metabolism contributes to the pathogenesis of insulin resistance. Peroxisome proliferator-activated receptor-gamma co-activator-1 (PGC-1) is a tr...
journal_title:Pediatric research
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abstract::Although cisapride is widely used to treat gastrointestinal motility disorders, it has been associated with QT prolongation, torsades de pointes, and cardiac arrest. Only in children, however, has atrioventricular (AV) block after cisapride been reported. This study used Langendorff perfusion to determine the direct e...
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更新日期:2003-03-01 00:00:00
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journal_title:Pediatric research
pub_type: 临床试验,杂志文章
doi:10.1038/pr.2015.162
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abstract::Cancer stem cells (CSC) are recently proposed to be the cancer initiating cells responsible for tumorigenesis and contribute to cancer resistance. Advances have been made in identifying and enriching CSC in leukemia and several solid tumors, including breast, brain and lung cancers. These studies suggest that, like no...
journal_title:Pediatric research
pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
abstract::DNA segments that are separated from the promoter region of a gene by many thousands of bases may nonetheless regulate the transcriptional activity of that gene. This finding has led to the investigation of mechanisms underlying long-range chromatin interactions. In intermitotic cells, chromosomes decondense, filling ...
journal_title:Pediatric research
pub_type: 杂志文章,评审
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198802000-00004
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:1991-03-01 00:00:00
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1203/00006450-199505000-00021
更新日期:1995-05-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-02-01 00:00:00
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更新日期:1975-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1203/00006450-198507000-00019
更新日期:1985-07-01 00:00:00
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更新日期:1998-02-01 00:00:00
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abstract::Naloxone has been shown to reverse the hemodynamic sequelae of experimental septic shock in adult animal models. Its effectiveness in the newborn has not been studied. To further investigate the efficacy of naloxone, we instrumented 18 piglets for continuous measurement of mean arterial pressure, mean pulmonary arteri...
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pub_type: 杂志文章
doi:10.1203/00006450-198608000-00001
更新日期:1986-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1203/00006450-199601000-00022
更新日期:1996-01-01 00:00:00