Peripheral blood immune response elicited by beta-lactoglobulin in childhood cow's milk allergy.

abstract：BACKGROUND:Toll-like receptor (TLR)-mediated inflammation may contribute to neonatal sepsis, for which pentoxifylline (PTX), a phosphodiesterase inhibitor that raises intracellular cAMP, is a candidate adjunctive therapy. We characterized the anti-inflammatory effects of PTX toward TLR-mediated production of inflammato...

journal_title：Pediatric research

authors： Speer EM,Dowling DJ,Ozog LS,Xu J,Yang J,Kennady G,Levy O

更新日期：2017-05-01 00:00:00

abstract：:The purpose of this project was to study the role of lipid peroxidation in oxygen-induced lung injury in the newborn lamb. It was our hypothesis that injury to the microvascular bed of the lung by oxygen would coincide with a burst of peroxidative activity and would be accompanied by an increased rate of excretion of ...

journal_title：Pediatric research

authors： Hansen TN,Smith CV,Gest AL,Smith HW,Giesler M

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Although it is commonly accepted that upper airway obstruction (UAO) increases gastroesophageal reflux (GER), the link is poorly understood and insufficiently documented. In addition, while hypoxia is often encountered in infants with UAO, its consequences on GER are virtually unknown. The two aims of the pr...

journal_title：Pediatric research

authors： Michaud A,Jia WL,Djeddi D,Samson N,Nadeau C,Geha S,Praud JP

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Aminoglycoside exposure is a common cause of acute kidney injury (AKI). Delay in the diagnosis of AKI using conventional biomarkers has been one of the important obstacles in applying early effective interventions. We tested the hypothesis that urinary metabolomics could identify novel early biomarkers for t...

journal_title：Pediatric research

authors： Hanna MH,Segar JL,Teesch LM,Kasper DC,Schaefer FS,Brophy PD

更新日期：2013-05-01 00:00:00

abstract：:The global burden of kidney disease is increasing, and several etiologies first begin in childhood. Risk factors for pediatric kidney disease are common in Africa, but data regarding its prevalence are lacking. We completed a systematic review of community-based studies describing the prevalence of proteinuria, hematu...

journal_title：Pediatric research

authors： Kayange NM,Smart LR,Tallman JE,Chu EY,Fitzgerald DW,Pain KJ,Peck RN

更新日期：2015-02-01 00:00:00

abstract：:We have shown previously that polynucleotides enhance in vitro antibody and Ig production in response to T-dependent antigens in mice and augment Ig production by adult human peripheral blood mononuclear cells. Herein, we report their effects on umbilical cord blood mononuclear cells (CBMNC) obtained from full-term ba...

journal_title：Pediatric research

authors： Jyonouchi H,Zhang-Shanbhag L,Georgieff M,Tomita Y

更新日期：1993-11-01 00:00:00

abstract：:We studied the pre- and postnatal developmental regulation of the hepatic type I IGF receptor in the rat. Fetal rat liver membranes bound IGF-I throughout the latter part of gestation (d 17 to 21). After birth, binding diminished rapidly, reaching barely detectable levels by the 13th postnatal d. However, the presence...

journal_title：Pediatric research

authors： Gruppuso PA,Walker TD,Carter PA

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:After birth, breastfeeding is the exclusive source of hormonal signaling between mother and infant. Hospitalized infants often receive donor milk when their own mother's milk is unavailable. METHODS:The presence of insulin, leptin, cortisol, progesterone, and testosterone was examined in samples from milk b...

journal_title：Pediatric research

authors： Vass RA,Bell EF,Colaizy TT,Schmelzel ML,Johnson KJ,Walker JR,Ertl T,Roghair RD

更新日期：2020-10-01 00:00:00

abstract：:To determine whether epidermal growth factor (EGF) or EGF-like transforming growth factors (TGFs) are present in ovine fetal tissues, we have tested acid-ethanol extracts of ovine fetal kidney for the ability to induce anchorage-independent growth of normal rat kidney fibroblasts in soft agar and to compete with 125I-...

journal_title：Pediatric research

authors： Freemark M,Comer M

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Social determinants of health (SDH) can substantially impact health outcomes. A systematic review, however, has never been conducted on associations of SDH with congenital heart disease (CHD) outcomes. The aim, therefore, was to conduct such a systematic review. METHODS:Seven databases were searched through...

journal_title：Pediatric research

authors： Davey B,Sinha R,Lee JH,Gauthier M,Flores G

更新日期：2020-10-17 00:00:00

abstract：:Primary immunodeficiencies (PIDs) have traditionally been defined according to their immunologic phenotype. Far from being concluded, the search for human genes that, when mutated, cause PID is actively being pursued. During the last year, four novel genetic defects that cause severe combined immunodeficiency and seve...

journal_title：Pediatric research

authors： Pessach I,Walter J,Notarangelo LD

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Secreted frizzled-related protein 5 (SFRP5) is an adipokine protecting against obesity-related insulin resistance and diabetes. SFRP5 binds to wingless type mouse mammary tumor virus (MMTV) integration site family member 5A (WNT5A) to improve insulin sensitivity. We performed the first study of SFRP5 and WNT...

journal_title：Pediatric research

authors： Prats-Puig A,Soriano-Rodríguez P,Carreras-Badosa G,Riera-Pérez E,Ros-Miquel M,Gomila-Borja A,de Zegher F,Ibáñez L,Bassols J,López-Bermejo A

更新日期：2014-06-01 00:00:00

abstract：:Chronic fetal anemia causes polyhydramnios and fetal hydrops and is associated with increased fetal diuresis and natriuresis. To determine the role of atrial natriuretic peptide (ANP) in the renal adaptation to chronic fetal anemia we studied the effects of HS-142-1 (HS), a specific inhibitor of the guanylate cyclase-...

journal_title：Pediatric research

authors： Silberbach M,Woods LL,Hohimer AR,Shiota T,Matsuda Y,Davis LE

更新日期：1995-11-01 00:00:00

abstract：:Purified human liver arylsulfatase A on polyacrylamide gel electrophoresis at pH 4.0 is separated into two protein forms with enzymatic activity and two distinct inactive subunits. All of these components were immunologically distinguishable using different antisera preparations. In late infantile metachromatic leukod...

journal_title：Pediatric research

authors： Shapira E,DeGregorio RR,Nadler HL

更新日期：1978-03-01 00:00:00

abstract：:Obese children have a great risk of hypertension and cardiovascular morbidity in adults. The insulin-like growth factor type II (IGF-II) regulates glucose homeostasis, cardiovascular functions, and lipid metabolism. IGF2 gene variants have shown a strong association with weight, body mass index (BMI), and metabolic pr...

journal_title：Pediatric research

authors： Faienza MF,Santoro N,Lauciello R,Calabrò R,Giordani L,Di Salvo G,Ventura A,Delvecchio M,Perrone L,Del Giudice EM,Cavallo L

更新日期：2010-04-01 00:00:00

abstract：:We have previously discovered that the adult Drosophila melanogaster is tolerant to a low O2 environment, withstanding hours of total O2 deprivation without showing any evidence of cell injury. Subsequently, our laboratory embarked on the study of hypoxia tolerance using a mutagenesis and overexpression screens to beg...

journal_title：Pediatric research

authors： Zhou D,Visk DW,Haddad GG

更新日期：2009-09-01 00:00:00

abstract：:Gaucher disease, the most common of the sphingolipidoses, results from the inherited deficiency of the enzyme glucocerebrosidase (EC 3.2.1.45). Although type 2 (acute neuronopathic) Gaucher disease is associated with rapidly progressive and fatal neurologic deterioration, the pathophysiologic mechanisms leading to the...

journal_title：Pediatric research

authors： Orvisky E,Sidransky E,McKinney CE,Lamarca ME,Samimi R,Krasnewich D,Martin BM,Ginns EI

更新日期：2000-08-01 00:00:00

abstract：:This paper has been retracted at the request of the authors. ...

journal_title：Pediatric research

authors： Choi CW,Kim BI,Mason SN,Potts-Kant EN,Brahmajothi MV,Auten RL

更新日期：2019-11-01 00:00:00

abstract：:This study tested the hypothesis that the sexually dimorphic adrenocortical response to stress is already established before birth. Chronically instrumented late gestation pregnant sheep carrying 16 male and 15 female age-matched singleton fetuses were subjected to an acute episode of hypoxic stress. Maternal and feta...

journal_title：Pediatric research

authors： Giussani DA,Fletcher AJ,Gardner DS

更新日期：2011-02-01 00:00:00

abstract：:The ciliated, mucus-secreting urn cell complex (UCC) is found swimming in the coelomic cavity of the marine invertebrate Sipunculus nudus. This cell complex, which can be maintained in suspension cultures, responds to various stimuli by hypersecreting mucus in the form of a cohesive mucus "tail." This tail can be meas...

journal_title：Pediatric research

authors： Kurlandsky LE,Berninger RW,Talamo RC

更新日期：1980-11-01 00:00:00

abstract：:WT1 is located on the short arm of human chromosome 11 and consists of 10 coding exons. Mutations of this gene have been reported to be the cause of Wilms' tumor, congenital male genitourinary malformations, and/or renal disorders. We describe here a novel WT1 gene mutation, i.e. a point mutation at intron 7 (+2) in b...

journal_title：Pediatric research

authors： Sakamoto J,Takata A,Fukuzawa R,Kikuchi H,Sugiyama M,Kanamori Y,Hashizume K,Hata JI

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Continuous and intermittent bolus orogastric feedings are strategies used in infants unable to tolerate normal feeds. METHODS:To determine the effects of feeding modality on protein synthesis in different tissues, neonatal pigs received a balanced formula by orogastric tube as an intermittent bolus feed eve...

journal_title：Pediatric research

authors： El-Kadi SW,Gazzaneo MC,Suryawan A,Orellana RA,Torrazza RM,Srivastava N,Kimball SR,Nguyen HV,Fiorotto ML,Davis TA

更新日期：2013-08-01 00:00:00

abstract：:Up to 20% of pregnant women smoke and there is indirect evidence that certain tobacco-specific metabolites can cross the placental barrier and are genotoxic to the fetus. The presence of micronuclei results from chromosome damage and reflects the degree of underlying genetic instability. Fetal blood was obtained from ...

journal_title：Pediatric research

authors： Zalacain M,Sierrasesumaga L,Larrañnaga C,Patiñno-García A

更新日期：2006-08-01 00:00:00

abstract：:Continuous EEG monitoring has not been used widely in neonatal intensive care, especially in the care of extremely premature infants, probably in part because of a lack of a reliable quantitative method. The purpose of this study was to quantify the EEG of the very premature infants just after birth by using spectral ...

journal_title：Pediatric research

authors： Victor S,Appleton RE,Beirne M,Marson AG,Weindling AM

更新日期：2005-03-01 00:00:00

abstract：:Vitamin K deficiency is a relatively common condition in neonates. However, the role of vitamin K in neonatal bone metabolism remains to be determined. Osteocalcin (OC) is the most abundant noncollagenous protein in bone, and is regulated to be gamma-carboxylated by vitamin K. In this study, we measured gamma-carboxyl...

journal_title：Pediatric research

authors： Shimizu N,Shima M,Hirai H,Nakajima S,Nishimura K,Yamaoka K,Okada S

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Previous studies indicate an increased risk for neuropsychological difficulties in young children prenatally exposed to opioids and polysubstances, but longitudinal information is scarce. The present longitudinal study investigated whether these waned, persisted, or increased over time. METHODS:The cognitiv...

journal_title：Pediatric research

authors： Nygaard E,Moe V,Slinning K,Walhovd KB

更新日期：2015-09-01 00:00:00

abstract：:We measured body composition, basal metabolic rate (BMR), and total energy expenditure in 28 nonobese and 35 obese adolescents aged 12-18 y using indirect calorimetry and the doubly labeled water method. BMR was highly correlated with fat-free mass in both the nonobese and obese groups (r = 0.77 and 0.84, respectively...

journal_title：Pediatric research

authors： Bandini LG,Schoeller DA,Dietz WH

更新日期：1990-02-01 00:00:00

abstract：:There are substantial alterations in fuel homeostasis immediately after birth. Leptin is a putative regulator of energy metabolism. Consequently, the aim of this study was to examine whether there are changes in circulating leptin concentrations during the early postnatal period. Umbilical cord mixed blood samples wer...

journal_title：Pediatric research

authors： Hytinantti T,Koistinen HA,Koivisto VA,Karonen SL,Andersson S

更新日期：1999-02-01 00:00:00

abstract：:We determined the inhibitory effects of concentrations of tin- and zinc protoporphyrin (1-100 microM) and mesoporphyrin (0.1-10 microM) on the in vitro heme oxygenase (HO) (E.C.1.14.99.3) activity in liver, spleen, and intestine 13,000 x g tissue supernatants from fasted adult male Wistar rats through measurement of c...

journal_title：Pediatric research

authors： Vreman HJ,Gillman MJ,Stevenson DK

更新日期：1989-10-01 00:00:00

abstract：:The purpose of this study is to determine whether the oxidative injury markers, protein carbonyls and malondialdehyde (MDA), are elevated in tracheal aspirates from very low birth weight (< 1500 g) infants; to determine whether levels correlate with myeloperoxidase as a marker of neutrophil inflammation; and to assess...

journal_title：Pediatric research

authors： Buss IH,Darlow BA,Winterbourn CC

更新日期：2000-05-01 00:00:00