Sex differences in the ovine fetal cortisol response to stress.

Abstract:

:This study tested the hypothesis that the sexually dimorphic adrenocortical response to stress is already established before birth. Chronically instrumented late gestation pregnant sheep carrying 16 male and 15 female age-matched singleton fetuses were subjected to an acute episode of hypoxic stress. Maternal and fetal blood gases, adrenocorticotrophic hormone (ACTH), and cortisol were measured. In addition, six male and six female fetuses received the ACTH analog, Synacthen, and plasma cortisol was measured. During hypoxic stress, the increment in plasma cortisol was 2-fold greater in male versus females fetuses (30.6 ± 3.2 versus 14.3 ± 2.0 ng/mL; p < 0.001) mediated, in part, by greater adrenocortical sensitivity to ACTH. The data support the hypothesis tested and show that sex-specific differences in the cortisol stress response are present before birth with the output of cortisol being much greater in male than in female fetuses.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Giussani DA,Fletcher AJ,Gardner DS

doi

10.1203/PDR.0b013e3182042a20

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

118-22

issue

2

eissn

0031-3998

issn

1530-0447

journal_volume

69

pub_type

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