Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.

abstract：BACKGROUND:Necrotizing enterocolitis is characterized by intestinal inflammation and epithelial barrier dysfunction. Mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 plays a pivotal role in the feedback control of MAPK signaling, which regulates inflammation and apoptosis. We hypothesized that MKP-1 prevents...

journal_title：Pediatric research

authors： Talavera MM,Kralik N,Jin Y,Chen B,Liu Y,Nelin LD

更新日期：2015-08-01 00:00:00

abstract：:We injected 3-day-old (neonatal), 8-day-old (infant), and 8-wk-old (adult) Sprague-Dawley rats with monocrotaline to examine the effect of a toxic agent at various stages of lung development. Two and four weeks after injection the rats were killed and the heart and lungs removed: the right and left ventricles were sep...

journal_title：Pediatric research

authors： Todd L,Mullen M,Olley PM,Rabinovitch M

更新日期：1985-07-01 00:00:00

abstract：:Aspiration is a major cause of lung disease in infants and young children. As the symptoms and signs of aspiration are not specific, the diagnosis is delayed due to a low index of suspicion and low sensitivity and specificity of the available diagnostic tests. In the present study, we evaluated the utility of microsph...

journal_title：Pediatric research

authors： Springer C,Benita S,Sherman Y,Gursoy N,Gilhar D,Avital A

更新日期：2005-09-01 00:00:00

abstract：:Pregnane steroids have sedative and neuroprotective effects on the brain, due to interactions with the steroid-binding site of the GABAA receptor. In the adult brain, synthesis of the pregnane steroids is increased in response to stress. Therefore, we have used umbilicoplacental embolization to mimic chronic placental...

journal_title：Pediatric research

authors： Nguyen PN,Billiards SS,Walker DW,Hirst JJ

更新日期：2003-12-01 00:00:00

abstract：:Naloxone has been shown to reverse the hemodynamic sequelae of experimental septic shock in adult animal models. Its effectiveness in the newborn has not been studied. To further investigate the efficacy of naloxone, we instrumented 18 piglets for continuous measurement of mean arterial pressure, mean pulmonary arteri...

journal_title：Pediatric research

authors： Miller RR,Menke JA,Hansen NB,Zwick DL,Bickers RG,Nowicki PT

更新日期：1986-08-01 00:00:00

abstract：:Mutations in multidrug resistance 3 gene (MDR3 or ABCB4) underlie progressive familial intrahepatic cholestasis type 3 (PFIC3), a severe pediatric liver disease progressing to cirrhosis. Abcb4-/- mice exhibit slowly developing hepatic lesions that can be accelerated by feeding a cholic acid (CA)-supplemented diet. We ...

journal_title：Pediatric research

authors： Lamireau T,Bouchard G,Yousef IM,Clouzeau-Girard H,Rosenbaum J,Desmoulière A,Tuchweber B

更新日期：2007-02-01 00:00:00

abstract：:Previous studies have reported differences in muscle function and metabolism between patients with cystic fibrosis (CF) and healthy controls (HC), but it is currently unknown whether these abnormalities are specific to CF or also seen in other airway diseases. In this study, we used magnetic resonance spectroscopy (MR...

journal_title：Pediatric research

authors： Wells GD,Wilkes DL,Schneiderman JE,Rayner T,Elmi M,Selvadurai H,Dell SD,Noseworthy MD,Ratjen F,Tein I,Coates AL

更新日期：2011-01-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) is a devastating intestinal disease of premature infants. Maternal milk has been suggested to be partially protective against NEC; however, the mechanisms of this protection are not defined. The aim of this study was to examine the effect(s) of artificial feeding of rat milk (RM)-versus...

journal_title：Pediatric research

authors： Dvorak B,Halpern MD,Holubec H,Dvorakova K,Dominguez JA,Williams CS,Meza YG,Kozakova H,McCuskey RS

更新日期：2003-03-01 00:00:00

abstract：:The renal effects of endothelin-1 were investigated in 16 anesthetized and mechanically ventilated newborn rabbits. Renal blood flow and glomerular filtration rate were determined by the clearance of para-aminohippuric acid and inulin, respectively. Each animal acted as its own control. In eight newborn rabbits, a bol...

journal_title：Pediatric research

authors： Semama DS,Thonney M,Guignard JP,Gouyon JB

更新日期：1993-08-01 00:00:00

abstract：:Irreversible congenital heart block (CHB) and the transient rash of neonatal lupus are strongly associated with maternal antibodies to SSA/Ro and SSB/La proteins; however, the precise mechanism by which these antibodies mediate organ-specific injury is not yet defined. Culturing of keratinocytes has provided critical ...

journal_title：Pediatric research

authors： Tseng CE,Miranda E,Di Donato F,Boutjdir M,Rashbaum W,Chan EK,Buyon JP

更新日期：1999-02-01 00:00:00

abstract：:To study the effects of cytomegalovirus infection on T-lymphocyte subpopulations, we determined helper (Lyt 1.2) and suppressor (Lyt 2.2) T-lymphocyte subset numbers using monoclonal antibodies and measured lymphocyte responsiveness to mitogen during sublethal murine cytomegalovirus (MCMV) infection of 3-wk-old Balb/c...

journal_title：Pediatric research

authors： Sell MS,Bale JF Jr,Giller RH

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Social determinants of health (SDH) can substantially impact health outcomes. A systematic review, however, has never been conducted on associations of SDH with congenital heart disease (CHD) outcomes. The aim, therefore, was to conduct such a systematic review. METHODS:Seven databases were searched through...

journal_title：Pediatric research

authors： Davey B,Sinha R,Lee JH,Gauthier M,Flores G

更新日期：2020-10-17 00:00:00

abstract：:Acute postasphyxial encephalopathy around the time of birth remains a major cause of death and disability. The possibility that hypothermia may be able to prevent or lessen asphyxial brain injury is a "dream revisited". In this review, a historical perspective is provided from the first reported use of therapeutic hyp...

journal_title：Pediatric research

authors： Gunn AJ,Laptook AR,Robertson NJ,Barks JD,Thoresen M,Wassink G,Bennet L

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Early recognition of patients at risk for sepsis is paramount to improve clinical outcomes. We hypothesized that subtle signatures of illness are present in physiological and biochemical time series of pediatric-intensive care unit (PICU) patients in the early stages of sepsis. METHODS:We developed multivar...

journal_title：Pediatric research

authors： Spaeder MC,Moorman JR,Tran CA,Keim-Malpass J,Zschaebitz JV,Lake DE,Clark MT

更新日期：2019-11-01 00:00:00

abstract：:During the transition at birth to air breathing, regulation of surfactant release from alveolar type II (ATII) cells is critical. Atrial natriuretic peptide (ANP) stimulates natriuretic peptide receptor-A (NPR-A) and increases intracellular cGMP. We examined the changes in ANP and NPR-A in respiratory epithelium durin...

journal_title：Pediatric research

authors： D'Angelis CA,Holm BA,Lakshminrusimha S,Nickerson PA,Swartz DD,Sokolowski J,Nielsen LC,Ryan RM

更新日期：2008-03-01 00:00:00

abstract：:Little is known about factors determining height outcome during GH treatment in Turner syndrome (TS). We investigated 987 TS children within the Kabi International Growth Study (KIGS) who had reached near adult height (NAH) after >4 y GH treatment (including >1 y before puberty). Through multiple regression analysis w...

journal_title：Pediatric research

authors： Ranke MB,Lindberg A,Ferrández Longás A,Darendeliler F,Albertsson-Wikland K,Dunger D,Cutfield WS,Tauber M,Wilton P,Wollmann HA,Reiter EO,KIGS International Board.

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of BPD includes inflammation and oxidative stress in the immature lung. Corticosteroids improve respiratory status and outcome, but the optimal treatment regimen for benefit with low systemic effects is uncertain. METHODS:In a pilot dose escalation trial, we administered ≤5 daily doses of b...

journal_title：Pediatric research

authors： Ballard PL,Torgerson D,Wadhawan R,Hudak ML,Weitkamp JH,Harris J,Asselin J,Chapin C,Ballard RA,McEvoy CT

更新日期：2021-01-19 00:00:00

abstract：:BACKGROUNDLow birth weight is associated with childhood stunting, but equivalent associations for birth body composition (BC) remain unknown. The aim of this study was to assess associations between birth BC and height-for-age z-score (HAZ) at 2 years of age.METHODSIn a prospective cohort study, fat mass (FM) and fat-...

journal_title：Pediatric research

authors： Admassu B,Wells JCK,Girma T,Andersen GS,Owino V,Belachew T,Michaelsen KF,Abera M,Wibaek R,Friis H,Kæstel P

更新日期：2017-08-01 00:00:00

abstract：:The present study examined the extent to which abundance of the prolactin receptor (PRLR) and a range of primary mitochondrial proteins are influenced by either maternal nutrition and/or fetal number in adipose tissue. Pregnant sheep were control fed [consuming 100% of total metabolizable energy (ME) requirements (tak...

journal_title：Pediatric research

authors： Budge H,Dandrea J,Mostyn A,Evens Y,Watkins R,Sullivan C,Ingleton P,Stephenson T,Symonds ME

更新日期：2003-02-01 00:00:00

abstract：:Epithelial hyperplasia is an early feature of the renal and biliary lesions in autosomal recessive polycystic kidney disease (ARPKD). To explore the cellular basis of this hyperplasia we isolated, cultured, and characterized biliary tract epithelium from common bile duct explants of mice with ARPKD (the BPK mouse) and...

journal_title：Pediatric research

authors： Nauta J,Sweeney WE,Rutledge JC,Avner ED

更新日期：1995-06-01 00:00:00

abstract：:BackgroundExtracellular adenine nucleotides contribute to ischemia-reperfusion injury following infant cardiopulmonary bypass (CPB), whereas conversion to adenosine may be protective. Alkaline phosphatase (AP), a key enzyme responsible for this conversion, decreases after infant CPB. Indirect evidence suggests that so...

journal_title：Pediatric research

authors： Persson JN,Baird CH,Tong S,Urban TT,Klawitter J,Wischmeyer PE,Davidson JA

更新日期：2018-04-01 00:00:00

abstract：:Leptin, a hormone secreted by adipocytes, is elevated in blood of obese adults. It is unknown whether the concentration is affected by gender, ethnicity, age, or stage of sexual maturation in children. We measured serum leptin levels in 183 children and 27 young adults using a double-antibody ELISA assay. Body fat mas...

journal_title：Pediatric research

authors： Ellis KJ,Nicolson M

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Although it is commonly accepted that upper airway obstruction (UAO) increases gastroesophageal reflux (GER), the link is poorly understood and insufficiently documented. In addition, while hypoxia is often encountered in infants with UAO, its consequences on GER are virtually unknown. The two aims of the pr...

journal_title：Pediatric research

authors： Michaud A,Jia WL,Djeddi D,Samson N,Nadeau C,Geha S,Praud JP

更新日期：2020-05-01 00:00:00

abstract：:The perinatal ontogeny of preprotachykinin-A gene expression was assessed in central respiration-related structures. On the day of birth, there was an enhanced expression of preprotachykinin-A mRNA in the region of the nucleus tractus solitarii, the primary relay station for respiratory and cardiovascular reflexes. Th...

journal_title：Pediatric research

authors： Srinivasan M,Yamamoto Y,Persson H,Lagercrantz H

更新日期：1991-04-01 00:00:00

abstract：:Isolated TSH deficiency leading to hypothyroidism seems to be a rare condition, escaping the diagnosis by neonatal screening programs, which are based on the primary determination of TSH. This is the first report of a case with an autosomal recessive TSH defect caused by a homozygous mutation of the betaTSH gene that ...

journal_title：Pediatric research

authors： Biebermann H,Liesenkötter KP,Emeis M,Oblanden M,Grüters A

更新日期：1999-08-01 00:00:00

abstract：:It is customary to estimate the uteroplacental function in singletons by defining appropriateness of birth weight by gestational age. Such a measure, however, is not available for the entire multiple pregnancy set. We evaluate a new index, total triplet birth weight, expressed as multiples of the median (MOM) birth we...

journal_title：Pediatric research

authors： Blickstein I,Salihu HM,Keith LG,Alexander GR

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Aminoglycoside exposure is a common cause of acute kidney injury (AKI). Delay in the diagnosis of AKI using conventional biomarkers has been one of the important obstacles in applying early effective interventions. We tested the hypothesis that urinary metabolomics could identify novel early biomarkers for t...

journal_title：Pediatric research

authors： Hanna MH,Segar JL,Teesch LM,Kasper DC,Schaefer FS,Brophy PD

更新日期：2013-05-01 00:00:00

abstract：:Neonatal jaundice is a common condition that could potentially lead to severe neurotoxicity. In this electrophysiological study we observed the effects of a short-term bilirubin injection on evoked potentials (population spike, PS) and long-term potentiation (LTP) in the hippocampal CA3 region of Sprague Dawley rats i...

journal_title：Pediatric research

authors： Zhang L,Liu W,Tanswell AK,Luo X

更新日期：2003-06-01 00:00:00

abstract：:The use of tissue engineering to develop new urinary bladder could have direct impact on children suffering from congenital bladder dysfunction. Current bladder tissue engineering protocols rely on scaffolds to support the ingrowth of new cells and the subsequent development of new tissues. The interaction between cel...

journal_title：Pediatric research

authors： Roth CC

更新日期：2010-05-01 00:00:00

abstract：:Defective arousal mechanisms are viewed as contributory to sleep hypopnea disorders and sudden infant death syndrome. Sighs (i.e. augmented breaths) as well as startles have not traditionally been viewed as arousal-related phenomena in infants. We hypothesized that, if sighs and startles are the initial event in a seq...

journal_title：Pediatric research

authors： Wulbrand H,McNamara F,Thach BT

更新日期：1998-11-01 00:00:00