Adverse neuropsychiatric development following perinatal brain injury: from a preclinical perspective.

abstract：BACKGROUND:After birth, breastfeeding is the exclusive source of hormonal signaling between mother and infant. Hospitalized infants often receive donor milk when their own mother's milk is unavailable. METHODS:The presence of insulin, leptin, cortisol, progesterone, and testosterone was examined in samples from milk b...

journal_title：Pediatric research

authors： Vass RA,Bell EF,Colaizy TT,Schmelzel ML,Johnson KJ,Walker JR,Ertl T,Roghair RD

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Subgaleal hemorrhage (SGH) is reported to be associated with severe hemodynamic instability, coagulopathy, and even mortality. The importance of the presence or absence of neonatal encephalopathy in predicting SGH outcomes has not been explored. The aim of this study was to determine the relationship of clin...

journal_title：Pediatric research

authors： El-Dib M,Parziale MP,Johnson L,Benson CB,Grant PE,Robinson J,Volpe JJ,Inder T

更新日期：2019-08-01 00:00:00

abstract：:The microchemical study of growth cartilage biopsies may improve the classification and the genetic advice of some types of growth disturbances and contribute to the understanding of biochemical defects. Small tibial growth cartilage biopsies were performed during orthopedic surgery in cases with achondroplasia, pseud...

journal_title：Pediatric research

authors： Stanescu V,Maroteaux P

更新日期：1975-10-01 00:00:00

abstract：:This study was made to determine the life span of adult red cells transfused to early preterm infants. Nineteen very preterm infants (birth weight, 878.7 +/- 221 g; gestational age, 26.8 +/- 1.5 wk at birth) were sampled weekly after their last blood transfusion to determine the level (%) of fetal Hb in their circulat...

journal_title：Pediatric research

authors： Bard H,Widness JA

更新日期：1997-07-01 00:00:00

abstract：:Responses of pial arterioles to topically applied arachidonic acid, conversion of exogenous arachidonic acid to prostanoids, and pial arteriolar dilation to hypercapnia were examined before and at progressive times after treatment with indomethacin (5 mg/kg i.v.) in chloralose-anesthetized newborn pigs with closed cra...

journal_title：Pediatric research

authors： Leffler CW,Mirro R,Shibata M,Parfenova H,Armstead WM,Zuckerman S

更新日期：1993-06-01 00:00:00

abstract：:In eight newborn lambs, the adaption of blood to acidosis was studied by sequential measurements of P50 in vitro (pH 7.4; 37 degrees C) and P50 in vivo (animal's pH and temperature, 39 degrees C) during the course of HCl-induced metabolic acidosis. The benefit of the change in both P50 on tissue oxygen tension was stu...

journal_title：Pediatric research

authors： Berthiaume Y,Bureau MA,Bégin R

更新日期：1981-05-01 00:00:00

abstract：:Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cereb...

journal_title：Pediatric research

authors： Idro R,Marsh K,John CC,Newton CR

更新日期：2010-10-01 00:00:00

abstract：:Lung development progresses through a process reliant on mechanical cell stretch. However, this process is not well defined at the molecular level. Our goal was to globally analyze the transcriptome of fetal mouse lungs following short periods of tracheal occlusion (TO) to identify cellular processes that are rapidly ...

journal_title：Pediatric research

authors： Seaborn T,St-Amand J,Cloutier M,Tremblay MG,Maltais F,Dinel S,Moulin V,Khan PA,Piedboeuf B

更新日期：2008-02-01 00:00:00

abstract：:We used in vivo microdialysis to determine the impact of a focal hypoxic-ischemic insult on hippocampal amino acid efflux in the immature brain. Microdialysis probes were inserted into the right hippocampus of postnatal d 7 rats. To induce hypoxic-ischemic injury, the right carotid artery was ligated and animals were ...

journal_title：Pediatric research

authors： Silverstein FS,Naik B,Simpson J

更新日期：1991-12-01 00:00:00

abstract：:This study was conducted to investigate myocardial excitation-contraction coupling in the fetus of the diabetic rabbit (FDM). On day 14 of gestation, diabetes was induced in pregnant rabbits by alloxan injection. On day 28 of gestation, mechanical function of the fetal myocardium was determined in the isolated arteria...

journal_title：Pediatric research

authors： Nakanishi T,Matsuoka S,Uemura S,Shimizu T,Nishioka K,Neufeld ND,Jarmakani JM

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Early recognition of patients at risk for sepsis is paramount to improve clinical outcomes. We hypothesized that subtle signatures of illness are present in physiological and biochemical time series of pediatric-intensive care unit (PICU) patients in the early stages of sepsis. METHODS:We developed multivar...

journal_title：Pediatric research

authors： Spaeder MC,Moorman JR,Tran CA,Keim-Malpass J,Zschaebitz JV,Lake DE,Clark MT

更新日期：2019-11-01 00:00:00

abstract：:BackroundMicrocephaly can either be isolated or it may coexist with other neurological entities and/or multiple congenital anomalies, known as syndromic microcephaly. Although many syndromic cases can be classified based on the characteristic phenotype, some others remain uncertain and require further investigation. T...

journal_title：Pediatric research

authors： Tsoutsou E,Tzetis M,Giannikou K,Braoudaki M,Mitrakos A,Amenta S,Selenti N,Kanavakis E,Zafeiriou D,Kitsiou-Tzeli S,Fryssira H

更新日期：2017-08-01 00:00:00

abstract：:Two infants with disorders of propionate metabolism were studied at 7 months of age to determine optimum levels of intake of protein and calories to meet the requirements for essential amino acid for growth in infancy, and at the same time minimize the accumulation of toxic intermediates. An effect of alanine was foun...

journal_title：Pediatric research

authors： Kelts DG,Ney D,Bay C,Saudubray JM,Nyhan WL

更新日期：1985-01-01 00:00:00

abstract：:The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between clinically obese black and white children and if a difference existed to determine whether it was related to hematological profiles and/or physical activity/inactivity levels. Twenty-three black and 21 white...

journal_title：Pediatric research

authors： Andreacci JL,Robertson RJ,Dubé JJ,Aaron DJ,Dixon CB,Arslanian SA

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Animal models have shown that insulin-like growth factor I (IGF-I) may mediate protein-induced kidney growth. Our aim was to analyze the effect of IGF-I on protein-induced kidney growth in healthy infants. METHODS:This is a secondary analysis of a randomized trial that compared growth of infants fed with a ...

journal_title：Pediatric research

authors： Luque V,Escribano J,Grote V,Ferre N,Koletzko B,Gruszfeld D,Socha P,Langhendries JP,Goyens P,Closa-Monasterolo R,European Childhood Obesity Project.

更新日期：2013-08-01 00:00:00

abstract：:Fifty patients with haemophilia B, belonging to 29 kindreds, were investigated with a highly sensitive immunoradiometric assay based on a homologous antibody to factor IX. The assay measures factor IX antigen (f.IX:Ag) in plasma down to 0.025 U/dl. Seventeen of 18 investigated patients with severe haemophilia B had ve...

journal_title：Pediatric research

authors： Ljung R,Holmberg L

更新日期：1982-03-01 00:00:00

abstract：:Previous studies have shown that proton magnetic resonance spectroscopy (MRS) is useful in predicting neurologic prognosis in children with traumatic brain injury (TBI). Reductions in N-acetyl derived metabolites and presence of lactate have been predictive of poor outcomes. We examined another spectroscopy metabolite...

journal_title：Pediatric research

authors： Ashwal S,Holshouser B,Tong K,Serna T,Osterdock R,Gross M,Kido D

更新日期：2004-10-01 00:00:00

abstract：:The head sizes of 38 patients, growth hormone (GH) deficient following craniospinal (n = 26) or cranial irradiation (n = 12), have been assessed before (n = 38) and on completion of GH therapy (n = 15) or at the end of a similar period of observation without GH (n = 7). These results were compared to the change in hea...

journal_title：Pediatric research

authors： Clayton PE,Shalet SM,Price DA,Surtees RA,Pearson D

更新日期：1987-10-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of blue light phototherapy on the expression of circadian genes in peripheral blood mononuclear cells (PBMC) and plasma melatonin levels in neonates. Real-time reverse-transcriptase polymerase chain reaction (RT-PCR) was used to determine the expression of Bmal1 ...

journal_title：Pediatric research

authors： Chen A,Du L,Xu Y,Chen L,Wu Y

更新日期：2005-12-01 00:00:00

abstract：:During the transition at birth to air breathing, regulation of surfactant release from alveolar type II (ATII) cells is critical. Atrial natriuretic peptide (ANP) stimulates natriuretic peptide receptor-A (NPR-A) and increases intracellular cGMP. We examined the changes in ANP and NPR-A in respiratory epithelium durin...

journal_title：Pediatric research

authors： D'Angelis CA,Holm BA,Lakshminrusimha S,Nickerson PA,Swartz DD,Sokolowski J,Nielsen LC,Ryan RM

更新日期：2008-03-01 00:00:00

abstract：:We measured body composition, basal metabolic rate (BMR), and total energy expenditure in 28 nonobese and 35 obese adolescents aged 12-18 y using indirect calorimetry and the doubly labeled water method. BMR was highly correlated with fat-free mass in both the nonobese and obese groups (r = 0.77 and 0.84, respectively...

journal_title：Pediatric research

authors： Bandini LG,Schoeller DA,Dietz WH

更新日期：1990-02-01 00:00:00

abstract：:Long-term EEG monitoring (LTM) with several electrodes could be a useful tool for surveillance of the brain during the first critical days of life. This study aimed to assess the feasibility of multichannel LTM for automated analysis of EEG activity from d 1 to 3 using eight electrodes. Premature infants (GA <31 wk; n...

journal_title：Pediatric research

authors： Schumacher EM,Westvik AS,Larsson PG,Lindemann R,Westvik J,Stiris TA

更新日期：2011-05-01 00:00:00

abstract：:The immunological competence of neonatal rabbits inoculated intradermally with Treponema pallidum was examined. Both cellular responses and the production of humoral antibody to specific T. pallidum antigens and to nonspecific antigens or mitogens were investigated. In blast transformation assays, splenic and poplitea...

journal_title：Pediatric research

authors： Gamboa D,Miller JN,Lukehart SA,Baker-Zander SA,Sell S

更新日期：1984-10-01 00:00:00

abstract：:To elucidate the impact of nutrition in cystic fibrosis (CF), we compared the phenotypic traits of Cftr -/- mice fed either a lipid-enriched liquid diet (Peptamen) or a standard chow combined with polyethylenglycol osmotic laxative (PEG), two strategies commonly used to prevent intestinal obstruction in CF mice. Survi...

journal_title：Pediatric research

authors： Cottart CH,Bonvin E,Rey C,Wendum D,Bernaudin JF,Dumont S,Lasnier E,Debray D,Clément A,Housset C,Bonora M

更新日期：2007-11-01 00:00:00

abstract：:BackgroundPoor aerobic fitness is associated with worsening of asthma symptoms, and fitness training may improve asthma control. The mechanism linking fitness with asthma is not known. We hypothesized that repeated bouts of exercise would lead to a downregulation of glucocorticoid receptor (GR) expression on circulati...

journal_title：Pediatric research

authors： Lu KD,Cooper D,Haddad F,Zaldivar F,Kraft M,Radom-Aizik S

更新日期：2017-08-01 00:00:00

abstract：:Long-term parenteral nutrition (TPN) in children is associated with sustained hyperinsulinemia due to a high nutriment infusion flow 12 h/24 h, with plausible lipotoxicity secondary to repeated lipid infusions and with changes in incretin hormone release. The aim of this study was to test whether long-term TPN can lea...

journal_title：Pediatric research

authors： Beltrand J,Colomb V,Marinier E,Daubrosse C,Alison M,Burcelin R,Cani PD,Chevenne D,Marchal CL

更新日期：2007-11-01 00:00:00

abstract：:The worldwide burden of disease due to Epstein-Barr virus (EBV) infection is enormous. Diseases include endemic Burkitt lymphoma, infectious mononucleosis, cancers after transplantation, Hodgkin lymphoma, and nasopharyngeal carcinoma. A prophylactic EBV vaccine has the potential to significantly reduce the incidence a...

journal_title：Pediatric research

authors： Balfour HH Jr,Schmeling DO,Grimm-Geris JM

更新日期：2020-01-01 00:00:00

abstract：:The presence of high concentrations of sodium in the sweat of patients with cystic fibrosis is widely accepted by all investigators as one of the most important manifestations of the genetic defect. However, the simple means of sweat collection utilized for diagnostic purposes has been extended to the biochemical and ...

journal_title：Pediatric research

authors： Sens DA,Simmons MA,Spicer SS

更新日期：1985-08-01 00:00:00

abstract：INTRODUCTION:The Coulter LH780 hematology analyzer can evaluate mean neutrophil volume (MNV), conductivity (MNC), scatter (MNS), and distribution width (DW). We sought to investigate the value of volume, conductivity, and scatter (VCS) parameters in diagnosis and treatment efficacy of neonatal sepsis. RESULTS:We obser...

journal_title：Pediatric research

authors： Celik IH,Demirel G,Aksoy HT,Erdeve O,Tuncer E,Biyikli Z,Dilmen U

更新日期：2012-01-01 00:00:00

abstract：:Several markers of growth and biochemical development in the rat were studied after administration of prostacyclin (PGI2) and 16, 16-dimethyl prostaglandin E2 (16, 16DM PGE2). Intermittent administration of PGI2 for 3 days to 10- and 19-day-old animals, with subsequent sacrifice at 14 and 23 days, resulted in signific...

journal_title：Pediatric research

authors： Neu J,Hoffmann RG,Crim WN

更新日期：1983-07-01 00:00:00