Age-related differences in the direct cardiac effects of cisapride: narrower safety range in the hearts of young rabbits.

abstract：:Heart rate turbulence (HRT) is a chronotropic response of the sinus heart rhythm to ventricular premature beat (VPB). Children show decreasing heart rate together with the maturation of the autonomic nervous system. The aim of the research was to assess the relationship between HRT parameters, age, and heart rate and ...

journal_title：Pediatric research

authors： Kowalewski M,Alifier M,Bochen D,Urban M

更新日期：2007-12-01 00:00:00

abstract：:Three patients with Menkes' disease, an inherited disorder of copper transport, were studied to determine whether the copper deficiency was associated with a lipoprotein disorder. Hypocuprinemia was documented in all three cases. Two patients had severe copper and ceruloplasmin deficiencies, whereas the third patient ...

journal_title：Pediatric research

authors： Blackett PR,Lee DM,Donaldson DL,Fesmire JD,Chan WY,Holcombe JH,Rennert OM

更新日期：1984-09-01 00:00:00

abstract：:The microchemical study of growth cartilage biopsies may improve the classification and the genetic advice of some types of growth disturbances and contribute to the understanding of biochemical defects. Small tibial growth cartilage biopsies were performed during orthopedic surgery in cases with achondroplasia, pseud...

journal_title：Pediatric research

authors： Stanescu V,Maroteaux P

更新日期：1975-10-01 00:00:00

abstract：:There is in vitro evidence that the ductus venosus of the fetal and newborn lamb relaxes to administration of E-series prostaglandins. We performed this study to determine whether the ductus venosus of the newborn lamb could be reopened by an infusion of prostaglandin E1. Fifteen lambs between 4 and 28 h of life and s...

journal_title：Pediatric research

authors： Morin FC 3rd

更新日期：1987-03-01 00:00:00

abstract：:LBW infants are at risk of iron deficiency (ID), which is associated with impaired nervous system development and may lead to prolonged auditory brainstem response (ABR) latencies. We hypothesized that iron supplementation shortens ABR latencies in marginally LBW (MLBW, 2000-2500 g) infants. In a randomized, controlle...

journal_title：Pediatric research

authors： Berglund SK,Westrup B,Haraldsson E,Engström B,Domellöf M

更新日期：2011-12-01 00:00:00

abstract：:To study the effects of podocyte injury on glomerular maturation and underlying mechanisms of such effects, puromycin aminonucleoside (PAN) was given to neonatal mice at 1 d post partum (1 dpp). Mice with PAN injection had smaller kidney weight (KW) and body weight (BW) at all times and smaller KW/BW at 4, 8, and 12 d...

journal_title：Pediatric research

authors： Ma J,Rossini M,Yang HC,Zuo Y,Fogo AB,Ichikawa I

更新日期：2007-10-01 00:00:00

abstract：:Deficiency of the lipoprotein complex, surfactant, can lead to respiratory distress syndrome (RDS) in the prematurely born infant. The surfactant proteins (SP) play important roles in the function of surfactant. Previously, we have characterized four allelic variants of the SP-A1 gene (6A, 6A2, 6A3, and 6A4) and five ...

journal_title：Pediatric research

authors： Kala P,Ten Have T,Nielsen H,Dunn M,Floros J

更新日期：1998-02-01 00:00:00

abstract：:Altered pulmonary vascular resistance might be a factor for delayed closure of the ductus arteriosus (DA) in preterm infants. Angiotensin II plays a central role in the elevation of pulmonary vascular resistance. Angiotensin II exerts its vasoconstrictor effect on the angiotensin II type 1 receptor (AT1R). Homozygous ...

journal_title：Pediatric research

authors： Treszl A,Szabo M,Dunai G,Nobilis A,Kocsis I,Machay T,Tulassay T,Vasarhelyi B

更新日期：2003-11-01 00:00:00

abstract：:We report reference values for osteocalcin and bone and liver alkaline phosphatase (ALP) isoforms in serum from 114 healthy children and adolescents, age 7-16 y. The bone and liver ALP isoforms were measured by high performance liquid chromatography (HPLC). Six ALP isoforms were separated and quantified in all samples...

journal_title：Pediatric research

authors： Magnusson P,Häger A,Larsson L

更新日期：1995-12-01 00:00:00

abstract：:The rat undergoes profound maturational changes in the intestinal structure and function during the third week of its life. To investigate the role of peripheral glucocorticoid metabolism in this process, we studied the postnatal maturation of intestinal structure and function. The peripheral metabolism of glucocortic...

journal_title：Pediatric research

authors： Pácha J,Vagnerová R,Bryndová J

更新日期：2003-05-01 00:00:00

abstract：:We banded the trachea of 4-wk-old male rats and studied lung growth, lung morphometry, and static pulmonary mechanics 4 wk later. We compared the experimental animals to sham-operated male littermates of the same age, 8-wk-old normal male littermates, and weight-matched rats of a younger age. Tracheal banded animals w...

journal_title：Pediatric research

authors： Kida K,Thurlbeck WM

更新日期：1981-03-01 00:00:00

abstract：:Twelve-h overnight urine and serum samples obtained simultaneously at 20-min intervals were assayed for growth hormone (GH). Ninety-one children, 5 to 16 y (Tanner stage 1 to 3) participated; group 1 were healthy children, group 2 were children with organic GH deficiency, and group 3 had idiopathic growth failure and ...

journal_title：Pediatric research

authors： Albini CH,Sotos J,Sherman B,Johanson A,Celniker A,Hopwood N,Quattrin T,Mills BJ,MacGillivray MH

更新日期：1991-06-01 00:00:00

abstract：:We investigated early postnatal changes of the mesenteric circulation and its relationship to the systemic circulation in two groups of newborn infants. Group I (n = 10) was studied before the first feeding at 1 h and preprandially at 6 and 24 h. Group II (n = 10) was studied before the first feeding at 2 h of age and...

journal_title：Pediatric research

authors： Martinussen M,Brubakk AM,Linker DT,Vik T,Yao AC

更新日期：1994-09-01 00:00:00

abstract：:To determine the developmental changes in the myocardial current during fetal life, and to evaluate the clinical usefulness of magnetocardiography for prenatal diagnosis of cardiac hypertrophy or enlargement, we approximated the magnitude of the one-current dipole of the fetal heart using fetal magnetocardiography (fM...

journal_title：Pediatric research

authors： Horigome H,Shiono J,Shigemitsu S,Asaka M,Matsui A,Kandori A,Miyashita T,Tsukada K

更新日期：2001-08-01 00:00:00

abstract：:Birth is characterized by swift and complex transitions in hemodynamic and respiratory variables. Unrecognized pathologies or incidents may quickly become fatal or cause permanent damage. This article introduces an essential component of an acute perinatal care simulator, namely a model for educational simulation of n...

journal_title：Pediatric research

authors： Sá-Couto CD,Andriessen P,Van Meurs WL,Ayres-de-Campos D,Sá-Couto PM

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Despite substantial heritability in pubertal development, children differ in maturational tempo. HYPOTHESES:(i) puberty and its duration are influenced by early changes in height and adiposity. (ii) Adiposity rebound (AR) is a marker for pubertal tempo. METHODS:We utilized published prospective data from 6...

journal_title：Pediatric research

authors： German A,Shmoish M,Hochberg Z

更新日期：2015-10-01 00:00:00

abstract：:Several studies analyzing the immune responses in patients with cow's milk allergy (CMA) have used T-cell lines or T-cell clones that require prolonged in vitro cell culturing and may result in a switched cell phenotype and function. We investigated immune responses to beta-lactoglobulin (b-LG) in peripheral blood mon...

journal_title：Pediatric research

authors： Vocca I,Canani RB,Camarca A,Ruotolo S,Nocerino R,Radano G,Del Mastro A,Troncone R,Gianfrani C

更新日期：2011-12-01 00:00:00

abstract：:This investigation was undertaken to determine the nature of acute alterations in renal function following the production of hypoxemia, hypercarbia, and acidosis in newborn piglets 6-96 hr of age. After completion of the surgical procedure piglets were allowed to recover from the effects of anesthesia. When respirator...

journal_title：Pediatric research

authors： Alward CT,Hook JB,Helmbrath TA,Bailie MD

更新日期：1978-03-01 00:00:00

abstract：:Alterations of the architecture of cerebral white matter in the developing human brain can affect cortical development and result in functional disabilities. A line scan diffusion-weighted magnetic resonance imaging (MRI) sequence with diffusion tensor analysis was applied to measure the apparent diffusion coefficient...

journal_title：Pediatric research

authors： Hüppi PS,Maier SE,Peled S,Zientara GP,Barnes PD,Jolesz FA,Volpe JJ

更新日期：1998-10-01 00:00:00

abstract：:We hypothesized that nitric oxide (NO) production by the fetal ductus arteriosus is limited because of low fetal PO2, but that at neonatal PO2, NO might be an important regulator of ductus arteriosus tone. We exposed isolated rings of fetal lamb ductus arteriosus to elevated PO2. L-NG-nitro-L-arginine methyl ester (L-...

journal_title：Pediatric research

authors： Clyman RI,Waleh N,Black SM,Riemer RK,Mauray F,Chen YQ

更新日期：1998-05-01 00:00:00

abstract：:Kawasaki disease (KD) is an acute vasculitis of young childhood predominantly affecting the coronary arteries. IgA plasma cells have been found to infiltrate vascular and nonvascular tissues in fatal acute KD. To determine whether IgA B-lymphocytes were increased in the peripheral blood of patients with KD, we perform...

journal_title：Pediatric research

authors： Shingadia D,O'Gorman M,Rowley AH,Shulman ST

更新日期：2001-10-01 00:00:00

abstract：:Childhood obesity is a predisposing factor for adult cardiovascular diseases. Human serum paraoxonase (PON1) may protect against atherosclerosis by hydrolyzing lipid peroxides in oxidized LDL. Alterations and potential correlations of PON1 activities, leptin and adiponectin levels in childhood obesity were studied. We...

journal_title：Pediatric research

authors： Koncsos P,Seres I,Harangi M,Illyés I,Józsa L,Gönczi F,Bajnok L,Paragh G

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) has been implicated as a key mechanism in the pathogenesis of liver fibrosis. The miR-200 family has been shown to inhibit EMT. METHODS:Liver fibrosis levels were assessed with Masson's trichrome staining of liver samples obtained from biliary atresia (BA) patient...

journal_title：Pediatric research

authors： Xiao Y,Zhou Y,Chen Y,Zhou K,Wen J,Wang Y,Wang J,Cai W

更新日期：2015-02-01 00:00:00

abstract：:Hyperprostaglandin E syndrome (HPS), the prenatal variant of Bartter's syndrome, is characterized by a marked and selective stimulation of prostaglandin E (PGE2) synthesis. In the study group HPS patients showed increased urinary levels of PGE2, an index of renal, and of 11 alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor...

journal_title：Pediatric research

authors： Nüsing RM,Schaub TP,Klein T,Schweer H,Seyberth HW

更新日期：1997-08-01 00:00:00

abstract：:Tyrosine (Tyr) phosphorylation is implicated in the modification of several erythrocyte functions, such as metabolic pathways and membrane transport, as well as in signal transduction systems. Here we describe the map of Tyr-phosphorylated soluble proteins of newborn red blood cells (RBC) using an in vitro model simul...

journal_title：Pediatric research

authors： Marzocchi B,Ciccoli L,Tani C,Leoncini S,Rossi V,Bini L,Perrone S,Buonocore G

更新日期：2005-10-01 00:00:00

abstract：:In seven patients with mucopolysaccharidoses (1 Hurler, 1 Hurler-Scheie, 4 Hunter, 1 Sly), cranial (1)H-magnetic resonance spectroscopy was performed to evaluate the accumulation of mucopolysaccharides and biochemical changes in the CNS in vivo before and after bone marrow transplantation (BMT). In two of seven patien...

journal_title：Pediatric research

authors： Takahashi Y,Sukegawa K,Aoki M,Ito A,Suzuki K,Sakaguchi H,Watanabe M,Isogai K,Mizuno S,Hoshi H,Kuwata K,Tomatsu S,Kato S,Ito T,Kondo N,Orii T

更新日期：2001-03-01 00:00:00

abstract：:Cancer stem cells (CSC) are recently proposed to be the cancer initiating cells responsible for tumorigenesis and contribute to cancer resistance. Advances have been made in identifying and enriching CSC in leukemia and several solid tumors, including breast, brain and lung cancers. These studies suggest that, like no...

journal_title：Pediatric research

authors： Guo W,Lasky JL 3rd,Wu H

更新日期：2006-04-01 00:00:00

abstract：:Increased deposition of hyaluronan (HA) is part of the early response to fibrogenic stimulus in the lung exposed to bleomycin injury and has been associated with increased lung water in adult animals. Early respiratory distress syndrome (RDS) in premature infants is characterized by increased lung water, and late sequ...

journal_title：Pediatric research

authors： Juul SE,Kinsella MG,Jackson JC,Truog WE,Standaert TA,Hodson WA

更新日期：1994-02-01 00:00:00

abstract：:This study aimed to characterize early neonatal microvascular function after preeclamptic pregnancy with respect to infant sex and in utero growth. Peripheral microvascular blood flow was examined prospectively from 6 to 72 h of age using laser Doppler flowmetry in a cohort of term infants of normotensive women and wo...

journal_title：Pediatric research

authors： Stark MJ,Clifton VL,Wright IM

更新日期：2009-03-01 00:00:00

abstract：:The use of auditory brainstem response (ABR) for assessment of hearing in the neonate has not been without challenge. Although numerous articles have appeared, agreement regarding the utility of neonatal ABR testing does not exist. In review of the current studies and commentaries, a clear majority are favorable to ne...

journal_title：Pediatric research

authors： Cox LC

更新日期：1984-08-01 00:00:00