Changes in hyaluronan deposition during early respiratory distress syndrome in premature monkeys.

abstract：:The IQ's of Jamaican boys aged 6-10 were associated significantly with the presence or absence of severe malnutrition in infancy, with height at time of IQ testing, and with a measure of the boys' social background. A multiple correlation coefficient of 0.674 was obtained between IQ and the three factors. Social backg...

journal_title：Pediatric research

authors： Richardson SA

更新日期：1976-01-01 00:00:00

abstract：:Biotin responsive multiple carboxylase deficiency was suspected in a third trimester conceptus on the basis of enzymatic confirmation in fibroblasts cultured from an earlier sibling who suffered a demise in the immediate neonatal period. Maternal urinary organic acid profile was normal throughout the final 4 wk of pre...

journal_title：Pediatric research

authors： Roth KS,Yang W,Allan L,Saunders M,Gravel RA,Dakshinamurti K

更新日期：1982-02-01 00:00:00

abstract：:Cerebral blood flow (CBF) was measured by means of Celabeled microspheres in infant (20-day-old) and adult (3-month-old) rats, anesthetised with Na-5-ethyl-5-(1-methylpropyl)2-thiobarbituric acid. Cerebral arteriovenous differences of acetoacetate, D-beta-hydroxybutyrate, glucose, lactate, and oxygen and brain DNA con...

journal_title：Pediatric research

authors： Dahlquist G,Persson B

更新日期：1976-11-01 00:00:00

abstract：:The specific activities of four folate enzymes have been measured in livers from preterm infants (Group 1), full-term infants (Group 2), and from control subjects (Group 3). The four enzymes studied were methylene tetrahydrofolate reductase (EC 1.1.1.68), methionine synthetase (EC 2.1.1.13), methylenetetrahydrofolate ...

journal_title：Pediatric research

authors： Kalnitsky A,Rosenblatt D,Zlotkin S

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Maternal thyroid deficiency can increase Rho-kinase procontractile influence in arteries of 2-week-old progeny. Here we hypothesized that augmented role of Rho-kinase persists in arteries from adult progeny of hypothyroid rats. METHODS:Dams were treated with 6-propyl-2-thiouracil (PTU) in drinking water (0....

journal_title：Pediatric research

authors： Gaynullina DK,Sofronova SI,Shvetsova AA,Selivanova EK,Sharova AP,Martyanov AA,Tarasova OS

更新日期：2018-07-01 00:00:00

abstract：:Early childhood overweight and obesity have alarmingly increased over the years. Adulthood obesity is a well demonstrated significant independent predictor of cardiovascular risk (CVR) and/or mortality, which predisposes to the major components of metabolic syndrome (MS). Evidence of MS in obese children has been also...

journal_title：Pediatric research

authors： Aggoun Y

更新日期：2007-06-01 00:00:00

abstract：:We tested whether reoxygenation with 100% O(2) for 5 min after experimental asphyxia in newborn piglets was as efficient as 100% O(2) for 20 min compared with room air. Forty-one anesthetized piglets, 1-3 d old, were randomized to cerebral hypoxemia-ischemia-hypercapnia (HIH) or control (n = 5). HIH was achieved by ve...

journal_title：Pediatric research

authors： Solas AB,Munkeby BH,Saugstad OD

更新日期：2004-07-01 00:00:00

abstract：:DNA segments that are separated from the promoter region of a gene by many thousands of bases may nonetheless regulate the transcriptional activity of that gene. This finding has led to the investigation of mechanisms underlying long-range chromatin interactions. In intermitotic cells, chromosomes decondense, filling ...

journal_title：Pediatric research

authors： Ling JQ,Hoffman AR

更新日期：2007-05-01 00:00:00

abstract：:Purified human liver arylsulfatase A on polyacrylamide gel electrophoresis at pH 4.0 is separated into two protein forms with enzymatic activity and two distinct inactive subunits. All of these components were immunologically distinguishable using different antisera preparations. In late infantile metachromatic leukod...

journal_title：Pediatric research

authors： Shapira E,DeGregorio RR,Nadler HL

更新日期：1978-03-01 00:00:00

abstract：:The mitochondria play a major role in the regulation of intracellular calcium. Despite the fact that the enterocytes receive the majority of absorbed calcium, the role of the intestinal mitochondria in calcium transport during maturation is not known. Therefore, the current studies were designed to characterize calciu...

journal_title：Pediatric research

authors： Kikuchi T,Kikuchi K,Arab N,Ghishan FK

更新日期：1989-01-01 00:00:00

abstract：:Stimulation of cutaneous thermoreceptors may be an important factor in the initiation of continuous breathing at birth. Maintenance of a patent airway is also important in the continuation of effective ventilation after birth, but whereas in the adult the principal pharyngeal dilator is the genioglossus muscle, in the...

journal_title：Pediatric research

authors： Johnston BM,Gunn TR,Gluckman PD

更新日期：1988-03-01 00:00:00

abstract：:Sleep organization of infants may be influenced by differences in nutrient intakes from human milk and formula. Because sleep/awake and sleep stage patterns affect energy expenditure, we hypothesized that differences in sleep organization between breast-fed and formula-fed infants might account in part for differences...

journal_title：Pediatric research

authors： Butte NF,Jensen CL,Moon JK,Glaze DG,Frost JD Jr

更新日期：1992-11-01 00:00:00

abstract：:To determine the role of pili in mediating adherence of type b and nontypeable Haemophilus influenzae to several respiratory cell types, piliated bacteria, nonpiliated phase variants, and nonpiliated mutants possessing insertionally inactivated pilin genes were tested. Both piliated and nonpiliated strains adhered to ...

journal_title：Pediatric research

authors： Gilsdorf JR,Tucci M,Marrs CF

更新日期：1996-02-01 00:00:00

abstract：:Gastrointestinal (GI) blood flow, O2 transport, and O2 uptake were measured during recovery from severe hypoxemia in newborn piglets. Hypoxemia was induced by lowering the inspired O2 concentration to 0.05 for 15 min. This resulted in an 82% decrease in GI O2 uptake. Recovery measurements were obtained 5 and 65 min af...

journal_title：Pediatric research

authors： Nowicki PT,Miller RR,Hansen NB,Hayes JR

更新日期：1985-11-01 00:00:00

abstract：:Carlo Agostoni, MD, and Kwang Sik Kim, MD, are the Guest Editors for this annual review issue on Nutrition and the Microbiome. Dr Agostoni is a Professor of Pediatrics at the Department of Clinical Sciences and Community Health, University of Milan, within the Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, ...

journal_title：Pediatric research

authors： Agostoni C,Kim KS

更新日期：2015-01-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is highly concentrated in CNS tissues. Although breast milk contains the fatty acids DHA and arachidonic acid, infant formulas marketed in North America do not contain these nutrients. The potential deleterious effects of rearing infants with formulas devoid of ...

journal_title：Pediatric research

authors： Champoux M,Hibbeln JR,Shannon C,Majchrzak S,Suomi SJ,Salem N Jr,Higley JD

更新日期：2002-03-01 00:00:00

abstract：:The effects of fetal hypoxemia on blood coagulation (platelet count, prothrombin time, partial thromboplastin time, fibrinogen, factors II, V, VI, VIII, IX, X, XI, XII, XIII and von Willebrands activities, fibrin degradation products, and fibrin monomer) were evaluated in nine chronically catheterized fetal lambs earl...

journal_title：Pediatric research

authors： Kisker CT,Robillard JE,Clarke WR

更新日期：1982-01-01 00:00:00

abstract：:Animal models with complex cortical development are useful for improving our understanding of the wide spectrum of neurodevelopmental challenges facing human preterm infants. MRI techniques can define both cerebral injury and alterations in cerebral development with translation between animal models and the human infa...

journal_title：Pediatric research

authors： Barnette AR,Neil JJ,Kroenke CD,Griffith JL,Epstein AA,Bayly PV,Knutsen AK,Inder TE

更新日期：2009-07-01 00:00:00

abstract：:Although the pathogenesis of necrotizing enterocolitis remains uncertain, ischemia appears to be an important contributing factor to the development of this disorder. Reperfusion plays a major role in ischemia-related injury, and oxygen free radicals produced during reperfusion most likely contribute to the injury. Th...

journal_title：Pediatric research

authors： Papparella A,DeLuca FG,Oyer CE,Pinar H,Stonestreet BS

更新日期：1997-08-01 00:00:00

abstract：:Endothelin-1 can cause pulmonary vasoconstriction via endothelin-A (ET(A)) receptor activation. We hypothesized that ET(A) blockers (EMD 122946 and BQ 610) would reduce hypoxia-induced (HYP) but not group B streptococcal infusion (GBS)-induced pulmonary hypertension in a juvenile whole animal model. Pulmonary hyperten...

journal_title：Pediatric research

authors： Ambalavanan N,Philips JB 3rd,Bulger A,Oparil S,Chen YF

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PH) in patients with bronchopulmonary dysplasia (BPD) results from vasoconstriction and/or vascular remodeling, which can be regulated by mitogen-activated protein kinases (MAPKs). MAPKs are deactivated by dual-specificity phosphatases (DUSPs). We hypothesized that single-nucleotide p...

journal_title：Pediatric research

authors： Chen LL,Zmuda EJ,Talavera MM,Frick J,Brock GN,Liu Y,Klebanoff MA,Trittmann JK

更新日期：2020-01-01 00:00:00

abstract：:The visual evoked potential (VEP) of five healthy, near-term exteriorized fetal lambs was compared with the VEP obtained from the same animals during the first hour after ventilation. Characteristics of the individual wave components and their relationship to blood pressure, heart rate, and arterial blood gas measurem...

journal_title：Pediatric research

authors： Woods JR Jr,Coppes V,Brooks DE,Knowles PJ,Freeman M,Parisi V,Omara P,McCarty GE

更新日期：1981-11-01 00:00:00

abstract：:In a patient with extrapyramidal movement disorder and extremely low creatinine concentrations in serum and urine, in vivo proton magnetic resonance spectroscopy disclosed a generalized depletion of creatinine in the brain. Oral substitution of arginine, a substrate for creatine synthesis, resulted in an increase of b...

journal_title：Pediatric research

authors： Stöckler S,Holzbach U,Hanefeld F,Marquardt I,Helms G,Requart M,Hänicke W,Frahm J

更新日期：1994-09-01 00:00:00

abstract：:Factors, such as insulin, found in human and pig colostrum and mature milk likely influence small intestinal growth and development. Although pharmacologic doses of insulin injected parenterally may accelerate small intestinal development in altricial animals such as the rodent, the effects of oral insulin on intestin...

journal_title：Pediatric research

authors： Shulman RJ

更新日期：1990-08-01 00:00:00

abstract：:Placental steroid sulfatase deficiency is a genetic disorder only recently reported in the medical literature. Most documented cases of placental sulfatase deficiency have been marked by delay in onset of labor, lack of cervical dilatation, and relative refractoriness of oxytocic agents and amniotomy. We have studied ...

journal_title：Pediatric research

authors： Shapiro LJ,Cousins L,Fluharty AL,Stevens RL,Kihara H

更新日期：1977-08-01 00:00:00

abstract：:The ontogenetic renal responsiveness to exogenous cortisol was examined in the chronically cannulated ovine fetus. The contribution of effects at proximal and distal tubule of the kidney were studied also. Cortisol (81.5 micrograms/h) was infused into immature ovine fetuses (mean gestational age -113.9 days) on five o...

journal_title：Pediatric research

authors： Towstoless MK,McDougall JG,Wintour EM

更新日期：1989-07-01 00:00:00

abstract：:We evaluated the effectiveness of administration of high-dose busulfan (BU), an alkylating agent with substantial myeloablative but negligible immunosuppressive properties, on the engraftment of congenic normal bone marrow and spleen cells (hematopoietic cell transplantation; HCT) in murine galactosylceramidase defici...

journal_title：Pediatric research

authors： Yeager AM,Shinohara M,Shinn C

更新日期：1991-03-01 00:00:00

abstract：:A number of neuromuscular diseases are associated with molecular defects in the mitochondrial DNA (mtDNA). These include: 1) a missense mutation at nucleotide 11778 in the mtDNA of Leber's hereditary optic neuropathy patients; 2) a heterogeneous array of deletions in the mtDNA of ocular myopathy patients; and 3) small...

journal_title：Pediatric research

authors： Wallace DC,Lott MT,Lezza AM,Seibel P,Voljavec AS,Shoffner JM

更新日期：1990-11-01 00:00:00

abstract：:The perinatal ontogeny of preprotachykinin-A gene expression was assessed in central respiration-related structures. On the day of birth, there was an enhanced expression of preprotachykinin-A mRNA in the region of the nucleus tractus solitarii, the primary relay station for respiratory and cardiovascular reflexes. Th...

journal_title：Pediatric research

authors： Srinivasan M,Yamamoto Y,Persson H,Lagercrantz H

更新日期：1991-04-01 00:00:00

abstract：:The field of regenerative medicine continues to make substantial advancements in therapeutic strategies addressing urologic diseases. Tissue engineering borrows principles from the fields of cell biology, materials science, transplantation and engineering in an effort to repair or replace damaged tissues. This review ...

journal_title：Pediatric research

authors： Yamzon JL,Kokorowski P,Koh CJ

更新日期：2008-05-01 00:00:00