Surface cooling rapidly induces coordinated activity in the upper and lower airway muscles of the fetal lamb in utero.

Abstract:

:Stimulation of cutaneous thermoreceptors may be an important factor in the initiation of continuous breathing at birth. Maintenance of a patent airway is also important in the continuation of effective ventilation after birth, but whereas in the adult the principal pharyngeal dilator is the genioglossus muscle, in the fetus genioglossus phasic activity is not synchronous with that of the fetal diaphragm. To ascertain whether a cold stimulus that initiates continuous breathing would also induce synchronized inspiratory activity in the upper airway muscles of the fetus, we have cooled fetal lambs in utero and examined the response of the genioglossus and alae nasi muscles in relation to diaphragm activity. Deep regular breathing as recorded by diaphragmatic activity and tracheal pressure started within 1-102 s after cooling commenced and coordinated inspiratory activity was seen in the alae nasi within 2-356 s. Genioglossus activity became synchronized with that of the diaphragm within 11-356 s. Cooling was continued for 4 h but although in one fetus continuous breathing with associated inspiratory activity in the genioglossus and alae nasi muscles lasted throughout the 4-h period, in the others continuous breathing was not sustained and adaptation to the cold stimulus occurred after periods ranging from 27-218 min. The relationship between breathing, upper airway muscle activity, and sleep state passed through one or more different phases, including breathing through high voltage electrocortical activity, before the normal fetal pattern of episodic breathing restricted to the low voltage electrocortical state resumed.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Johnston BM,Gunn TR,Gluckman PD

doi

10.1203/00006450-198803000-00005

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

257-61

issue

3

eissn

0031-3998

issn

1530-0447

journal_volume

23

pub_type

杂志文章
  • Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell populations in children and adolescents with Graves' disease.

    abstract::The aim of the present study was to determine the proportion of gamma/delta T-lymphocytes and CD16/CD56 (CD3- and CD3+) cells in the peripheral blood of children and adolescents with Graves' disease (GD; n = 27; mean age, 15.5 +/- 5.1 y) and nontoxic nodular goiter (NTNG; n = 25; mean age, 15.2 +/- 5.7 y), in comparis...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000076663.94850.44

    authors: Bossowski A,Urban M,Stasiak-Barmuta A

    更新日期:2003-09-01 00:00:00

  • The effect of early human diet on caudate volumes and IQ.

    abstract::Early nutrition in animals affects both behavior and brain structure. In humans, randomized trials show that early nutrition affects later cognition, notably in males. We hypothesized that early nutrition also influences brain structure, measurable using magnetic resonance imaging. Prior research suggested that the ca...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e318163a271

    authors: Isaacs EB,Gadian DG,Sabatini S,Chong WK,Quinn BT,Fischl BR,Lucas A

    更新日期:2008-03-01 00:00:00

  • Effect of topical emollient treatment of preterm neonates in Bangladesh on invasion of pathogens into the bloodstream.

    abstract::Topical emollient therapy may reduce the incidence of serious infections and mortality of preterm infants in developing countries. We tested whether emollient therapy reduced the burden of pathogens on skin and/or prevented bacterial translocation. Neonates <33 wk gestational age were randomized to treatment with sunf...

    journal_title:Pediatric research

    pub_type: 杂志文章,随机对照试验

    doi:10.1203/pdr.0b013e3180459f75

    authors: Darmstadt GL,Saha SK,Ahmed AS,Choi Y,Chowdhury MA,Islam M,Law PA,Ahmed S

    更新日期:2007-05-01 00:00:00

  • Effects of hypothermia on hypoxia-induced apoptosis in cultured neurons from developing rat forebrain: comparison with preconditioning.

    abstract::In neuronal cultures from the forebrain of 14-d-old rat embryos, transient hypoxia (95% N2/5% CO2, 37 degrees C) for 6 h has been shown to trigger delayed apoptotic death through sequential changes in protein synthesis, whereas preconditioning by a brief episode of hypoxia can rescue neurons. Because hypothermia has b...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200003000-00017

    authors: Bossenmeyer-Pourié C,Koziel V,Daval JL

    更新日期:2000-03-01 00:00:00

  • Mesenteric blood flow velocity and its relation to transitional circulatory adaptation in appropriate for gestational age preterm infants.

    abstract::We investigated the early postnatal changes of the mesenteric circulation and its relation to the systemic circulation in 15 preterm infants. The infants were studied before the first feeding on d 1 and pre- and postprandially on d 3, 4, 5, and 7. Blood flow velocity was measured by ultrasound Doppler in the superior ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199602000-00015

    authors: Martinussen M,Brubakk AM,Vik T,Yao AC

    更新日期:1996-02-01 00:00:00

  • Body composition at birth and height at 2 years: a prospective cohort study among children in Jimma, Ethiopia.

    abstract::BACKGROUNDLow birth weight is associated with childhood stunting, but equivalent associations for birth body composition (BC) remain unknown. The aim of this study was to assess associations between birth BC and height-for-age z-score (HAZ) at 2 years of age.METHODSIn a prospective cohort study, fat mass (FM) and fat-...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2017.59

    authors: Admassu B,Wells JCK,Girma T,Andersen GS,Owino V,Belachew T,Michaelsen KF,Abera M,Wibaek R,Friis H,Kæstel P

    更新日期:2017-08-01 00:00:00

  • Spectral analysis of electroencephalography in premature newborn infants: normal ranges.

    abstract::Continuous EEG monitoring has not been used widely in neonatal intensive care, especially in the care of extremely premature infants, probably in part because of a lack of a reliable quantitative method. The purpose of this study was to quantify the EEG of the very premature infants just after birth by using spectral ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000153868.77623.43

    authors: Victor S,Appleton RE,Beirne M,Marson AG,Weindling AM

    更新日期:2005-03-01 00:00:00

  • Placental transfer and fetal metabolism of zidovudine in the baboon.

    abstract::Zidovudine (azidothymidine, AZT) is used in pregnancy to reduce mother to infant transmission of HIV. Understanding the disposition of AZT in the fetus is necessary to optimize therapeutic regimens directed toward the fetus. Recent studies in primates found similar steady-state levels of the glucuronide metabolite of ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199807000-00008

    authors: Garland M,Szeto HH,Daniel SS,Tropper PJ,Myers MM,Stark RI

    更新日期:1998-07-01 00:00:00

  • Major circadian variations of glucose homeostasis in a patient with Rabson-Mendenhall syndrome and primary insulin resistance due to a mutation (Cys284-->Tyr) in the insulin receptor alpha-subunit.

    abstract::We have performed clinical, in vitro biochemical, and genetic studies of a patient with severe insulin resistance, considerable growth restriction, and Rabson-Mendenhall syndrome (patient RM-3). The blood IGF-I level was undetectable in this patient, although the GH level was moderately decreased. During the postprand...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199707000-00012

    authors: Desbois-Mouthon C,Magré J,Duprey J,Caron M,Blivet-Van Eggelpoel MJ,Daubas C,Gourmelen M,Chevallier B,Rizkalla S,Robert JJ,Capeau J

    更新日期:1997-07-01 00:00:00

  • Maternal preeclampsia predicts elevated blood pressure in 12-year-old children: evaluation by ambulatory blood pressure monitoring.

    abstract::Ambulatory blood pressure (ABP) monitoring offers a reliable method for determining blood pressure (BP) in children. The aim of this cohort study was to examine whether maternal preeclampsia is associated with elevated BP in an offspring. The study population consisted of 57 children born to preeclamptic mothers (PRE)...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.pdr.0000196734.54473.e3

    authors: Tenhola S,Rahiala E,Halonen P,Vanninen E,Voutilainen R

    更新日期:2006-02-01 00:00:00

  • Effect of oxypurinol, a xanthine oxidase inhibitor, on hepatic injury in the bile duct-ligated rat.

    abstract::Oxidant stress has been implicated as playing a role in the pathogenesis of cholestatic liver injury. The objective of this study was to determine whether the xanthine oxidase/xanthine dehydrogenase enzyme system was involved in this oxidant stress. Adult Sprague-Dawley rats were treated with the xanthine oxidase inhi...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199809000-00022

    authors: Sokol RJ,Devereaux MW,Khandwala R

    更新日期:1998-09-01 00:00:00

  • Human lactation. II: Endogenous fatty acid synthesis by the mammary gland.

    abstract::We studied the effects of a diet that was low in fat, high in carbohydrate (CHO) on milk lipid composition and de novo endogenous fatty acid synthesis by the mammary gland in five lactating women. The women consumed either a low fat (LF) (5% fat, 80% CHO) diet or a high fat (HF) (40% fat, 45% CHO) diet. Fat synthesis ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198901000-00015

    authors: Hachey DL,Silber GH,Wong WW,Garza C

    更新日期:1989-01-01 00:00:00

  • Changes in hyaluronan deposition during early respiratory distress syndrome in premature monkeys.

    abstract::Increased deposition of hyaluronan (HA) is part of the early response to fibrogenic stimulus in the lung exposed to bleomycin injury and has been associated with increased lung water in adult animals. Early respiratory distress syndrome (RDS) in premature infants is characterized by increased lung water, and late sequ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199402000-00024

    authors: Juul SE,Kinsella MG,Jackson JC,Truog WE,Standaert TA,Hodson WA

    更新日期:1994-02-01 00:00:00

  • The concentration of the 35-kDa surfactant apoprotein in amniotic fluid from normal and diabetic pregnancies.

    abstract::A specific, enzyme-linked immunoabsorbent assay was used to determine the concentration of the 35,000 mol wt surfactant apoprotein (SP-A) in samples of amniotic fluid obtained from nondiabetic (n = 358) and diabetic (n = 29) women. The enzyme-linked immunoabsorbent assay was performed with rabbit antibodies directed a...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198812000-00016

    authors: Snyder JM,Kwun JE,O'Brien JA,Rosenfeld CR,Odom MJ

    更新日期:1988-12-01 00:00:00

  • Purification of fibroblast-derived celiac disease autoantigen molecules.

    abstract::We have recently purified autoantigen polypeptides reacting with celiac disease patient sera IgA from the extracellular noncollagenous matrix compartment of fetal lung tissue. These molecules trigger the production of different tissue antibodies, the so-called antireticulin and antiendomysium antibodies in celiac dise...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199310000-00007

    authors: Marttinen A,Mäki M

    更新日期:1993-10-01 00:00:00

  • Thyroid hormones in human milk and their influence on thyroid function of breast-fed babies.

    abstract::Various assay methods for detection of thyroid hormones in human milk were evaluated in recovery and dilution experiments after which the concentrations of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) were measured and compared with those in serum. The effect of breast feeding on pituitary thyroid function of norma...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198306000-00008

    authors: Mizuta H,Amino N,Ichihara K,Harada T,Nose O,Tanizawa O,Miyai K

    更新日期:1983-06-01 00:00:00

  • Leukotriene antagonists attenuate thromboxane-inducible pulmonary hypertension.

    abstract::Leukotrienes C4 and D4 and thromboxane A2 are potent vasoconstrictors that may mediate pulmonary vasoconstriction in many clinical situations. There is a complex interaction among leukotrienes and thromboxane A2, because inhibition of thromboxane synthesis prevents some of the hemodynamic effects of exogenous leukotri...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198908000-00001

    authors: Soifer SJ,Schreiber MD,Heymann MA

    更新日期:1989-08-01 00:00:00

  • Preserved fetal plasma amino acid concentrations in the presence of maternal hypoaminoacidemia.

    abstract::The effects on the conceptus of persistently decreased maternal plasma amino acid concentrations were studied in pregnant rats by the infusion of glucagon (0.21 mg/day) to the mother from day 14 to 20 of gestation with a subcutaneous, osmotically driven minipump. Controls received diluent. The experimental animals eit...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198611000-00002

    authors: Domenech M,Gruppuso PA,Nishino VT,Susa JB,Schwartz R

    更新日期:1986-11-01 00:00:00

  • The analysis of human sweat proteins by isoelectric focusing. I. Sweat collection utilizing the macroduct system demonstrates the presence of previously unrecognized sex-related proteins.

    abstract::The presence of high concentrations of sodium in the sweat of patients with cystic fibrosis is widely accepted by all investigators as one of the most important manifestations of the genetic defect. However, the simple means of sweat collection utilized for diagnostic purposes has been extended to the biochemical and ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198508000-00020

    authors: Sens DA,Simmons MA,Spicer SS

    更新日期:1985-08-01 00:00:00

  • Glucose kinetics in glucose-infused small for gestational age infants.

    abstract::To evaluate the maturation of glucose homeostasis in the small for gestational age (SGA) neonate, glucose kinetics were measured with 78% enriched D-[U-13C]glucose by the prime plus constant infusion technique in nine SGA infants and compared with the rate obtained in seven term appropriate for gestational age infants...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:

    authors: Cowett RM,Susa JB,Oh W,Schwartz R

    更新日期:1984-01-01 00:00:00

  • Ischemia-reperfusion injury in the intestines of newborn pigs.

    abstract::Although the pathogenesis of necrotizing enterocolitis remains uncertain, ischemia appears to be an important contributing factor to the development of this disorder. Reperfusion plays a major role in ischemia-related injury, and oxygen free radicals produced during reperfusion most likely contribute to the injury. Th...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199708000-00009

    authors: Papparella A,DeLuca FG,Oyer CE,Pinar H,Stonestreet BS

    更新日期:1997-08-01 00:00:00

  • A micromethod for the analysis of cryoglobulins via laser nephelometry: evaluation and comparison to C1q binding activity in autoimmune diseases in pediatrics.

    abstract::Quantitative determinations of cryoglobulins (IgG, IgA, IgM, and C3) were performed by a laser nephelometry microtechnique on 250 serum samples from a group of pediatric patients suspected of having immune complex-mediated disorders. Approximately 50% of these samples were cryoglobulin positive. Patients with cryoglob...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198007000-00003

    authors: Yang LC,Norman ME,Doughty RA

    更新日期:1980-07-01 00:00:00

  • Dairy product intake decreases bone resorption following a 12-week diet and exercise intervention in overweight and obese adolescent girls.

    abstract:BACKGROUND:We examined whether increased dairy intake was associated with changes in the levels of bone-related biochemical markers in overweight/obese adolescent girls undergoing a 12-week diet and exercise intervention. METHODS:Thirty-five girls were assigned to a low dairy group (LDa; 0-2 servings/day; n = 16) or a...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-0834-5

    authors: Josse AR,Ludwa IA,Kouvelioti R,Calleja M,Falk B,Ward WE,Klentrou P

    更新日期:2020-12-01 00:00:00

  • The expression of VEGF and its receptors in the human ductus arteriosus.

    abstract::Programmed proliferative degeneration of the human fetal ductus arteriosus (DA) preceding definite postnatal closure has a large developmental variability and is controlled by several signaling pathways. Among these vascular endothelial growth factor (VEGF) and its receptors (VEGF-Rs) play an important role. Until now...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e318180a375

    authors: Weber SC,Rheinlaender C,Sarioglu N,Peiser C,Rüdiger M,Obladen M,Koehne PS

    更新日期:2008-10-01 00:00:00

  • Comparing near-infrared spectroscopy devices and their sensors for monitoring regional cerebral oxygen saturation in the neonate.

    abstract:BACKGROUND:Near-infrared spectroscopy (NIRS) is an upcoming clinical method for monitoring regional cerebral oxygen saturation (rScO2) in neonates. There is a growing market offering different devices and sensors. Even though this technique is increasingly clinically applied, little is known about the similarities and/...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2013.133

    authors: Dix LM,van Bel F,Baerts W,Lemmers PM

    更新日期:2013-11-01 00:00:00

  • Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders.

    abstract::Mesenchymal stem cell (MSC) transplantation represents the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia, hypoxic ischemic encephalopathy, and intraventricular hemorrhage. Absent engraftment an...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1038/pr.2017.249

    authors: Park WS,Ahn SY,Sung SI,Ahn JY,Chang YS

    更新日期:2018-01-01 00:00:00

  • Pulmonary Ureaplasma urealyticum is associated with the development of acute lung inflammation and chronic lung disease in preterm infants.

    abstract::Previously, we have reported marked pulmonary inflammation in infants who develop chronic lung disease of prematurity. We revisited these infants who did not have clinical or laboratory evidence of infection and searched for Ureaplasma urealyticum, group B streptococci, and other microbes by reverse transcription-PCR ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000100757.38675.50

    authors: Kotecha S,Hodge R,Schaber JA,Miralles R,Silverman M,Grant WD

    更新日期:2004-01-01 00:00:00

  • Postnatal growth in children born small for gestational age with and without smoking mother.

    abstract:BACKGROUND:Maternal smoking impairs fetal growth; however, if postnatal growth differs between children born small for gestational age (SGA) with smoking and non-smoking mother is unknown. METHODS:Cohort-study of term born children born appropriate for gestational age with non-smoking mother (AGA-NS, n = 30,561), SGA ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0352-5

    authors: Lindström L,Wikström AK,Bergman E,Mulic-Lutvica A,Högberg U,Ahlsson F,Lundgren M

    更新日期:2019-06-01 00:00:00

  • The immediate ventilatory response to added inspiratory elastic and resistive loads in preterm infants.

    abstract::We measured the changes in tidal volume, duration of the various phases of the respiratory cycle, and peak nasal pressure during elastic and resistive loading in preterm infants. Values were calculated during the first loaded breath, when chemical drive was unchanged. Tidal volume decreased by equivalent percentages w...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197704000-00002

    authors: Boychuk RB,Seshia MM,Rigatto H

    更新日期:1977-04-01 00:00:00

  • The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat.

    abstract::Neutrophils contribute to ischemic brain injury in adult animals. The role of neutrophils in perinatal hypoxic-ischemic (HI) brain injury is unknown. Allopurinol reduces neutrophil accumulation after tissue ischemia and is protective against HI brain injury. This study was designed to investigate how neutrophils contr...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199705000-00002

    authors: Hudome S,Palmer C,Roberts RL,Mauger D,Housman C,Towfighi J

    更新日期:1997-05-01 00:00:00