The expression of VEGF and its receptors in the human ductus arteriosus.

Abstract:

:Programmed proliferative degeneration of the human fetal ductus arteriosus (DA) preceding definite postnatal closure has a large developmental variability and is controlled by several signaling pathways. Among these vascular endothelial growth factor (VEGF) and its receptors (VEGF-Rs) play an important role. Until now, gestational age dependent expression of VEGF and its receptors has not been investigated in a large number of human DA tissue specimens. We examined protein expression of VEGF and the three VEGF-Rs immunohistochemically in 63 human fetal autopsy DA specimens of 11-38 wk gestation. Specimens were classified into different maturity stages according to their histologic appearance. VEGF and VEGF-Rs-staining was detected in all maturity stages. VEGF-staining was localized perinuclearly in all vascular layers and did not change during development. VEGF-R1 and VEGF-R3 expression was marked in the endothelium in early maturity stages and decreased during development. In contrast, -R2 predominated in the media in later developmental stages. Our results emphasize the importance of VEGF as a mediator during programmed proliferative degeneration of fetal DA and support the hypothesis that VEGF-R1 and VEGF-R3 are required for normal blood vessel development during embryogenesis. In contrast, VEGF-R2 is the predominant receptor in later angiogenic signaling.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Weber SC,Rheinlaender C,Sarioglu N,Peiser C,Rüdiger M,Obladen M,Koehne PS

doi

10.1203/PDR.0b013e318180a375

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

340-5

issue

4

eissn

0031-3998

issn

1530-0447

journal_volume

64

pub_type

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