Phototherapy for neonatal jaundice: in vivo clearance of bilirubin photoproducts.

Abstract:

:Phototherapy results in the conversion of native bilirubin to more water-soluble configurational and structural isomers. The serum half-life for the configurational isomer, the principal photoproduct in vivo, was determined by high pressure liquid chromatography in six premature infants following cessation of phototherapy. The mean half-life for this isomer was 15 h. The excretion of this isomer, calculated from the measured half-life, is less than half of daily bilirubin production, and therefore cannot account for the total bilirubin elimination observed during phototherapy. The serum concentration of the structural isomer, lumirubin, is lower than that of the configurational isomer; however, excretion is more rapid (serum half-life less than 2 h). Because of its rapid excretion, lumirubin may be an important pathway for bilirubin elimination during phototherapy.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Ennever JF,Knox I,Denne SC,Speck WT

doi

10.1203/00006450-198502000-00012

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

205-8

issue

2

eissn

0031-3998

issn

1530-0447

journal_volume

19

pub_type

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