Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders.

abstract：:Acute postasphyxial encephalopathy around the time of birth remains a major cause of death and disability. The possibility that hypothermia may be able to prevent or lessen asphyxial brain injury is a "dream revisited". In this review, a historical perspective is provided from the first reported use of therapeutic hyp...

journal_title：Pediatric research

authors： Gunn AJ,Laptook AR,Robertson NJ,Barks JD,Thoresen M,Wassink G,Bennet L

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Regular physical activity provides children with health and developmental benefits. This study investigated if active play and walking with the family dog was associated with better social-emotional development in young children. METHODS:We surveyed 1646 parents to ascertain if families with pre-schoolers o...

journal_title：Pediatric research

authors： Wenden EJ,Lester L,Zubrick SR,Ng M,Christian HE

更新日期：2020-07-06 00:00:00

abstract：:The mitochondria play a major role in the regulation of intracellular calcium. Despite the fact that the enterocytes receive the majority of absorbed calcium, the role of the intestinal mitochondria in calcium transport during maturation is not known. Therefore, the current studies were designed to characterize calciu...

journal_title：Pediatric research

authors： Kikuchi T,Kikuchi K,Arab N,Ghishan FK

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs). To develop interventions to prevent recurrent infections, household attributes and individual practices influencing S. aureus colonization must be discerned. METHODS:Households of healthy children with methicillin-resista...

journal_title：Pediatric research

authors： Mork RL,Hogan PG,Muenks CE,Boyle MG,Thompson RM,Morelli JJ,Sullivan ML,Gehlert SJ,Ross DG,Yn A,Bubeck Wardenburg J,Rzhetsky A,Burnham CD,Fritz SA

更新日期：2018-11-01 00:00:00

abstract：:The fetal respiratory and electrocortical effects of thyrotropin-releasing hormone (TRH) administered into the lateral cerebral ventricles, have been investigated in chronically catheterized unanesthetized fetal sheep at 125-140 days of gestation. Stimulatory effects on fetal breathing movements were seen at doses as ...

journal_title：Pediatric research

authors： Bennet L,Gluckman PD,Johnston BM

更新日期：1988-01-01 00:00:00

abstract：:To determine the pathophysiologic significance of pertussis toxin (PT) on the human beta-adrenergic system, beta-adrenoceptor (beta-R)-density and cyclic AMP response of peripheral mononuclear blood cells (MN leukocytes) were studied in children during the paroxysmal stage of natural pertussis infection, after vaccina...

journal_title：Pediatric research

authors： Griese M,Sideropoulou O,Reinhardt D

更新日期：1989-02-01 00:00:00

abstract：:We report energy intake and selected nutrient intakes-protein, fat (total, saturated, and polyunsaturated), carbohydrate (total, starch, and sucrose), and cholesterol-for 1251 white children ages 6-19 years. The data were obtained, by means of a 24-h dietary recall, from children who were randomly selected from the No...

journal_title：Pediatric research

authors： Salz KM,Tamir I,Ernst N,Kwiterovich P,Glueck C,Christensen B,Larsen R,Pirhonen D,Prewitt TE,Scott LW

更新日期：1983-02-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) remains among the most common and devastating diseases in neonates. Despite advances in neonatal clinical care, specific treatment strategies and diagnostic modalities remain lacking. As a result, morbidity and mortality remain high. Improved understanding of the pathogenesis of NEC has...

journal_title：Pediatric research

authors： Shelby RD,Raab R,Besner GE,McElroy SJ

更新日期：2020-08-01 00:00:00

abstract：:A 10-year longitudinal study was conducted on 16 prepubescent youngsters who had undergone successful weight reduction. Their ages ranged from 2 to 10 years when the study began. In all subjects, weight reduction proceeded only by a decrease in adipose cell size (from 0.62 +/- 0.02 to 0.46 +/- 0.02 micrograms lipid pe...

journal_title：Pediatric research

authors： Ginsberg-Fellner F,Knittle JL

更新日期：1981-10-01 00:00:00

abstract：:The microchemical study of growth cartilage biopsies may improve the classification and the genetic advice of some types of growth disturbances and contribute to the understanding of biochemical defects. Small tibial growth cartilage biopsies were performed during orthopedic surgery in cases with achondroplasia, pseud...

journal_title：Pediatric research

authors： Stanescu V,Maroteaux P

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:Real-time detection and classification of apneic episodes remain significant challenges. This study explores the applicability of a novel method of monitoring the respiratory effort and dynamics for rapid detection and classification of apneic episodes. METHODS:Obstructive apnea (OA) and hypopnea/central ap...

journal_title：Pediatric research

authors： Waisman D,Lev-Tov L,Levy C,Faingersh A,Colman Klotzman I,Bibi H,Rotschild A,Landesberg A

更新日期：2015-07-01 00:00:00

abstract：:Exposure of neonatal rats to > or = 95% O2 for 2 wk, a widely used model of oxidant/antioxidant interactions in neonatal lung injury, results in arrested lung growth without the dysplastic lesions observed in chronic human neonatal lung injury. To determine whether dysplastic lung cell growth would be seen at lesser O...

journal_title：Pediatric research

authors： Han RN,Buch S,Tseu I,Young J,Christie NA,Frndova H,Lye SJ,Post M,Tanswell AK

更新日期：1996-06-01 00:00:00

abstract：:Serum insulin, growth hormone (GH), insulin-like growth factors (IGFs) I and II, cortisol, and albumin concentrations were measured in 15 children with kwashiorkor, 15 with marasmic-kwashiorkor, and 21 with marasmus, before and in the survivors, after nutritional rehabilitation, as well as in 10 underweight and eight ...

journal_title：Pediatric research

authors： Soliman AT,Hassan AE,Aref MK,Hintz RL,Rosenfeld RG,Rogol AD

更新日期：1986-11-01 00:00:00

abstract：:Newborn human infants, particularly those born prematurely, are susceptible to infection with a variety of microorganisms. We questioned whether limitations in the T cell repertoire contribute to the neonatal immunocompromised state. To describe developmental changes of the T cell repertoire, cDNA segments correspondi...

journal_title：Pediatric research

authors： Schelonka RL,Raaphorst FM,Infante D,Kraig E,Teale JM,Infante AJ

更新日期：1998-03-01 00:00:00

abstract：:We determined the concentrations of copper, the activities of ceruloplasmin and peptidylglycine alpha-amidating monooxygenase (PAM), and the stimulation index of PAM by the in vitro addition of copper in plasma samples obtained from three male patients with occipital horns and a milder Menkes disease phenotype, having...

journal_title：Pediatric research

authors： Prohaska JR,Tamura T,Percy AK,Turnlund JR

更新日期：1997-12-01 00:00:00

abstract：:Irreversible congenital heart block (CHB) and the transient rash of neonatal lupus are strongly associated with maternal antibodies to SSA/Ro and SSB/La proteins; however, the precise mechanism by which these antibodies mediate organ-specific injury is not yet defined. Culturing of keratinocytes has provided critical ...

journal_title：Pediatric research

authors： Tseng CE,Miranda E,Di Donato F,Boutjdir M,Rashbaum W,Chan EK,Buyon JP

更新日期：1999-02-01 00:00:00

abstract：INTRODUCTION:Cerebral white-matter (WM) abnormalities on magnetic resonance imaging (MRI) correlate with neurodevelopmental disability in infants born prematurely. RESULTS:Quantitative histological measures of WM and ventricular volumes correlated with qualitative MRI scores of WM volume loss and ventriculomegaly. Dif...

journal_title：Pediatric research

authors： Griffith JL,Shimony JS,Cousins SA,Rees SE,McCurnin DC,Inder TE,Neil JJ

更新日期：2012-02-01 00:00:00

abstract：:The purpose of this study was to investigate atrial myocardial blood flow in the fetus under conditions of acute right ventricular pressure load and adenosine infusion. Late gestation fetal sheep were instrumented for acute right ventricular pressure loading or adenosine infusion, and regional myocardial blood flow wa...

journal_title：Pediatric research

authors： Lohr JL,Reller MD,Morton MJ,Wu DE,Thornburg KL

更新日期：1994-03-01 00:00:00

abstract：:We have performed clinical, in vitro biochemical, and genetic studies of a patient with severe insulin resistance, considerable growth restriction, and Rabson-Mendenhall syndrome (patient RM-3). The blood IGF-I level was undetectable in this patient, although the GH level was moderately decreased. During the postprand...

journal_title：Pediatric research

authors： Desbois-Mouthon C,Magré J,Duprey J,Caron M,Blivet-Van Eggelpoel MJ,Daubas C,Gourmelen M,Chevallier B,Rizkalla S,Robert JJ,Capeau J

更新日期：1997-07-01 00:00:00

abstract：:This study was made to determine the life span of adult red cells transfused to early preterm infants. Nineteen very preterm infants (birth weight, 878.7 +/- 221 g; gestational age, 26.8 +/- 1.5 wk at birth) were sampled weekly after their last blood transfusion to determine the level (%) of fetal Hb in their circulat...

journal_title：Pediatric research

authors： Bard H,Widness JA

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:To understand the increased susceptibility of preterm neonates to infection. METHODS:A murine listeriosis model using immunohistochemistry, microarray technology, and real-time polymerase chain reaction (PCR). RESULTS:We report that recombinant serum amyloid A (SAA) administered prophylactically 18 h befor...

journal_title：Pediatric research

authors： Hawkins JS,Wu Q,Wang Y,Lu CY

更新日期：2013-12-01 00:00:00

abstract：:We report reference values for osteocalcin and bone and liver alkaline phosphatase (ALP) isoforms in serum from 114 healthy children and adolescents, age 7-16 y. The bone and liver ALP isoforms were measured by high performance liquid chromatography (HPLC). Six ALP isoforms were separated and quantified in all samples...

journal_title：Pediatric research

authors： Magnusson P,Häger A,Larsson L

更新日期：1995-12-01 00:00:00

abstract：:To date, many mutations, including intronic nucleotide changes, in the SLC12A3 gene encoding the thiazide-sensitive sodium-chloride cotransporter (NCCT) have been reported in Gitelman's syndrome (GS) patients. However, it has not been clarified whether intronic nucleotide changes affect mRNA content. Since mRNA analys...

journal_title：Pediatric research

authors： Kaito H,Nozu K,Fu XJ,Kamioka I,Fujita T,Kanda K,Krol RP,Suminaga R,Ishida A,Iijima K,Matsuo M

更新日期：2007-04-01 00:00:00

abstract：:In spontaneously breathing newborn lambs, alveolar hypoxia increases lung microvascular pressure, which causes lung lymph flow to increase and the concentration of protein in lymph to decrease. To see if this response derives from hypoxia itself rather than from the change in breathing pattern that occurs during hypox...

journal_title：Pediatric research

authors： Hansen TN,Haberkern CM,Hazinski TA,Bland RD

更新日期：1984-05-01 00:00:00

abstract：:The ontogeny of glutamine uptake by jejunal brush border membrane vesicles was studied in suckling and weanling rats and compared with the data obtained from previous studies done on adult rats in our laboratory. Glutamine uptake represented transport into the intravesicular space rather than mere binding into the mem...

journal_title：Pediatric research

authors： al-Mahroos FT,Bulus N,Abumrad N,Said H,Ghishan FK

更新日期：1990-05-01 00:00:00

abstract：:We established an experimental animal model of the gastrointestinal colonization and systemic disease following oral challenge of type III group B streptococcal strain in 3-day-old newborn rats. Two type III group B streptococcal strains isolated from the cerebrospinal fluid of septic newborn infants produced coloniza...

journal_title：Pediatric research

authors： Kim KS,Dunn K,McGeary SA,Stiehm ER

更新日期：1984-12-01 00:00:00

abstract：:Sex steroids accelerate bone maturation, but it is believed that estrogen action is needed for terminal epiphyseal fusion. In this study, we investigated the effects of a new estrogen-blocking agent, Faslodex (ICI 182,780), on estrogen-accelerated skeletal maturation in immature mice. On day-of-life 2 through 8, mice ...

journal_title：Pediatric research

authors： Gunther DF,Calikoglu AS,Underwood LE

更新日期：1999-09-01 00:00:00

abstract：:Cerebral blood flow (CBF) was measured by means of Celabeled microspheres in infant (20-day-old) and adult (3-month-old) rats, anesthetised with Na-5-ethyl-5-(1-methylpropyl)2-thiobarbituric acid. Cerebral arteriovenous differences of acetoacetate, D-beta-hydroxybutyrate, glucose, lactate, and oxygen and brain DNA con...

journal_title：Pediatric research

authors： Dahlquist G,Persson B

更新日期：1976-11-01 00:00:00

abstract：:D-myo-Inositol 1,4,5-triphosphate (IP3) is a key second messenger in many cells, including macrophages, T and B cells, and neutrophils, in which it regulates free intracellular calcium ion levels. In human polymorphonuclear leukocytes the rise of intracellular [Ca2+] is the signal that activates a number of functions ...

journal_title：Pediatric research

authors： Santoro P,Agosti V,Viggiano D,Palumbo A,Sarno T,Ciccimarra F

更新日期：1995-10-01 00:00:00

abstract：:We have previously shown that milk sensitization aggravates intestinal dysfunction in the malnourished guinea pigs, suggesting that it may also impair the recovery from malnutrition. To test this hypothesis, the growing guinea pigs were malnourished by feeding only maize for 7 d and then were refed for 21 d with a bal...

journal_title：Pediatric research

authors： Darmon N,Abdoul E,Roucayrol AM,Blaton MA,Briend A,Desjeux JF,Heyman M

更新日期：1998-12-01 00:00:00