Hope on the horizon: promising novel therapies for necrotizing enterocolitis.

Abstract:

:Necrotizing enterocolitis (NEC) remains among the most common and devastating diseases in neonates. Despite advances in neonatal clinical care, specific treatment strategies and diagnostic modalities remain lacking. As a result, morbidity and mortality remain high. Improved understanding of the pathogenesis of NEC has the potential for improved therapeutics. Some of the areas of research leading to promising discoveries include inhibition of Toll-like receptor signaling, modulation of vascular endothelial growth factor signal pathways, defining metabolomic alterations in NEC to discover potential biomarkers, probing for genetic predispositions to NEC susceptibility, determining mechanistic relations between anemia and NEC, and microflora modulation through the use of probiotics. All of these areas may represent novel promising approaches to the prevention and treatment of NEC. This review will focus on these current and possible therapeutic perspectives.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Shelby RD,Raab R,Besner GE,McElroy SJ

doi

10.1038/s41390-020-1077-1

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

30-34

issue

Suppl 1

eissn

0031-3998

issn

1530-0447

pii

10.1038/s41390-020-1077-1

journal_volume

88

pub_type

杂志文章,评审
  • mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure.

    abstract::Irreversible congenital heart block (CHB) and the transient rash of neonatal lupus are strongly associated with maternal antibodies to SSA/Ro and SSB/La proteins; however, the precise mechanism by which these antibodies mediate organ-specific injury is not yet defined. Culturing of keratinocytes has provided critical ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199902000-00018

    authors: Tseng CE,Miranda E,Di Donato F,Boutjdir M,Rashbaum W,Chan EK,Buyon JP

    更新日期:1999-02-01 00:00:00

  • Identification of increased expression of activating Fc receptors and novel findings regarding distinct IgE and IgM receptors in Kawasaki disease.

    abstract:BACKGROUND:Kawasaki disease (KD) is associated with expression and methylation of Fc gamma receptor genes. We characterized immunoglobulin A (IgA), IgE, IgG, and IgM receptor expression levels in KD. METHODS:Fc receptor expression levels were characterized using GeneChip Human Transcriptome Array 2.0 (HTA 2.0) with 18...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0707-y

    authors: Chang LS,Ming-Huey Guo M,Lo MH,Kuo HC

    更新日期:2019-12-09 00:00:00

  • Utilization of intravenously administered glucose-oligosaccharides in growing miniature pigs.

    abstract::The ability of intravenously administered glucose or glucose oligosaccharides to supply 12% of the energy requirement of the growing miniature pig was determined. All pigs were fed a stock diet from days 5-28 of life, and a central venous catheter was inserted at 29 days. For the next 30 days, all pigs were fed both e...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198204000-00013

    authors: Andersen DW,Filer LJ Jr,Wu-Rideout YC,White LB,Stegink LD

    更新日期:1982-04-01 00:00:00

  • Maternally administered dexamethasone at 0.7 of gestation suppresses maternal and fetal pituitary and adrenal responses to hypoxemia in sheep.

    abstract::Women who are at risk of preterm delivery are treated with antenatal steroids to facilitate fetal lung maturation. During this period, there is a potential for fetal or maternal hypoxemia to occur. Fetal responses to hypoxemia in sheep are well documented. However, less is known regarding maternal responses to hypoxem...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000117847.59343.B2

    authors: Kutzler MA,Coksaygan T,Ferguson AD,Vincent SE,Nathanielsz PW

    更新日期:2004-05-01 00:00:00

  • The history of Pediatric Infectious Diseases.

    abstract::The history of Pediatric Infectious Diseases closely parallels the history of Pediatrics at least until the last century, because historically infections comprised the major causes of childhood morbidity and mortality, as they still do in the developing world. This history reviews developments in the field through the...

    journal_title:Pediatric research

    pub_type: 历史文章,杂志文章

    doi:10.1203/01.PDR.0000101756.93542.09

    authors: Shulman ST

    更新日期:2004-01-01 00:00:00

  • Mitochondrial myopathy studies on permeabilized muscle fibers.

    abstract::Respiratory parameters of skeletal muscle were determined in permeabilized muscle fibers by adapting a technique described by Veksler et al. for cardiac fibers (Biochim Biophys Acta, 892:191-196, 1987). This method consists of the permeabilization of muscle fibers by saponin by allowing respiratory substrates and inhi...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199207000-00004

    authors: Letellier T,Malgat M,Coquet M,Moretto B,Parrot-Roulaud F,Mazat JP

    更新日期:1992-07-01 00:00:00

  • An in vitro study of choline uptake by intestine from neonatal and adult rats.

    abstract::We studied choline uptake by slices of adult and 10-day-old rat intestine which were exposed on their mucosal surface to radiolabeled choline. Both neonatal and adult intestine transported choline. Choline uptake was observed in duodenum, jejunum, ileum, and colon of the adult rat. In the small intestine, choline upta...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198608000-00014

    authors: Sheard NF,Zeisel SH

    更新日期:1986-08-01 00:00:00

  • Congenital hypoaldosteronism: the Visser-Cost syndrome revisited.

    abstract::In 1964, H. K. A. Visser and W. S. Cost were the first to suggest a defect of the terminal aldosterone (Aldo) biosynthesis in patients with hypoaldosteronism. In the last years, the molecular basis of the terminal Aldo biosynthesis has been elucidated. Aldo biosynthesis requires 11beta-hydroxylation of 11-deoxycortico...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199603000-00027

    authors: Peter M,Sippell WG

    更新日期:1996-03-01 00:00:00

  • Validity of child anthropometric measurements in the Special Supplemental Nutrition Program for Women, Infants, and Children.

    abstract:INTRODUCTION:The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) serves 50% of infants and 25% of preschool-aged children in the United States and collects height and weight measurements from eligible children every 6 mo, making WIC data a valuable resource for studying childhood growth an...

    journal_title:Pediatric research

    pub_type: 杂志文章,多中心研究

    doi:10.1038/pr.2011.37

    authors: Crespi CM,Alfonso VH,Whaley SE,Wang MC

    更新日期:2012-03-01 00:00:00

  • The central effects of thyrotropin-releasing hormone on the breathing movements and electrocortical activity of the fetal sheep.

    abstract::The fetal respiratory and electrocortical effects of thyrotropin-releasing hormone (TRH) administered into the lateral cerebral ventricles, have been investigated in chronically catheterized unanesthetized fetal sheep at 125-140 days of gestation. Stimulatory effects on fetal breathing movements were seen at doses as ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198801000-00016

    authors: Bennet L,Gluckman PD,Johnston BM

    更新日期:1988-01-01 00:00:00

  • IUGR alters postnatal rat skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a fiber specific manner.

    abstract::Uteroplacental insufficiency and subsequent intrauterine growth retardation (IUGR) increase the risk of insulin resistance in humans and rats. Aberrant skeletal muscle lipid metabolism contributes to the pathogenesis of insulin resistance. Peroxisome proliferator-activated receptor-gamma co-activator-1 (PGC-1) is a tr...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000064583.40495.51

    authors: Lane RH,Maclennan NK,Daood MJ,Hsu JL,Janke SM,Pham TD,Puri AR,Watchko JF

    更新日期:2003-06-01 00:00:00

  • Hypoxia induces alteration of bone morphogenetic protein receptor signaling in pulmonary artery endothelial cell.

    abstract::Reduced expression of bone morphogenetic protein receptors (BMPR) has been implicated in the pathogenesis of pulmonary hypertension (PH), but changes in the intracellular signaling pathway of BMPR have not been fully understood. We hypothesized that BMPR signaling in pulmonary endothelial cells is altered during the d...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/pdr.0b013e3180332cba

    authors: Takahashi K,Kogaki S,Matsushita T,Nasuno S,Kurotobi S,Ozono K

    更新日期:2007-04-01 00:00:00

  • Correction of gamma-glutamyl transpeptidase deficiency in amniotic fluid of some cystic fibrosis fetuses by mixing with nondeficient fluids.

    abstract::The deficiency of gamma-glutamyl transpeptidase activity, which was evident in some but not all cystic fibrosis amniotic fluids, could be corrected by mixing with either normal fluids or nondeficient cystic fibrosis fluids. Incubation of any amniotic fluid for 20 min at 62 degrees C resulted in total loss of gamma-glu...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198412000-00025

    authors: Ben-Yoseph Y,Rembelski P,Nadler HL

    更新日期:1984-12-01 00:00:00

  • 12- and 15-hydroxyeicosatetraenoic acid are excreted in the urine of peroxisome-deficient patients: evidence for peroxisomal metabolism in vivo.

    abstract::To determine the importance of peroxisomes and mitochondria in hydroxyeicosatetraenoic acid (HETE) oxidation in vivo, urinary excretion of 12- and 15-HETE was measured in eight patients with a peroxisome deficiency disorder (Zellweger syndrome) showing normal mitochondrial beta-oxidation capacity, in three patients wi...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199601000-00022

    authors: Mayatepek E,Lehmann WD

    更新日期:1996-01-01 00:00:00

  • Intrauterine growth retardation alters mitochondrial gene expression and function in fetal and juvenile rat skeletal muscle.

    abstract::Uteroplacental insufficiency alters the anabolic metabolism of the fetus, resulting in intrauterine growth retardation (IUGR). The metabolic and physiologic factors that cause IUGR have long standing consequences after birth. Postnatal growth and glucose metabolism are altered in the IUGR infant. Skeletal muscle is an...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199805000-00001

    authors: Lane RH,Chandorkar AK,Flozak AS,Simmons RA

    更新日期:1998-05-01 00:00:00

  • Cardiovascular responses to feeding in newborn piglets.

    abstract::Cardiovascular responses to feeding have been observed in several species during various periods of development and have been implicated in the development of cardiovascular regulation. In the rat, these responses are characterized by short-lasting, large increases in blood pressure (BP) and moderate increases in hear...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199207000-00007

    authors: Scalzo FM

    更新日期:1992-07-01 00:00:00

  • Lung and systemic inflammation in preterm lambs on continuous positive airway pressure or conventional ventilation.

    abstract::Intratracheal lipopolysaccharide (LPS) causes acute inflammation and injurious mechanical ventilation results in pulmonary and systemic inflammation. We aimed to determine in preterm lungs if continuous positive airway pressure (CPAP) protects against pulmonary and systemic inflammation, compared with conventional mec...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e318189487e

    authors: Polglase GR,Hillman NH,Ball MK,Kramer BW,Kallapur SG,Jobe AH,Pillow JJ

    更新日期:2009-01-01 00:00:00

  • Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency.

    abstract::Glutaryl-CoA dehydrogenase (GCDH) deficiency is a rare inborn disorder of L-lysine, L-hydroxylysine, and L-tryptophan metabolism complicated by striatal damage during acute encephalopathic crises. Three decades after its description, the natural history and how to treat this disorder are still incompletely understood....

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.pdr.0000219387.79887.86

    authors: Kölker S,Garbade SF,Greenberg CR,Leonard JV,Saudubray JM,Ribes A,Kalkanoglu HS,Lund AM,Merinero B,Wajner M,Troncoso M,Williams M,Walter JH,Campistol J,Martí-Herrero M,Caswill M,Burlina AB,Lagler F,Maier EM,Schwahn B

    更新日期:2006-06-01 00:00:00

  • Hypoxanthine, xanthine, and uric acid concentrations in plasma, cerebrospinal fluid, vitreous humor, and urine in piglets subjected to intermittent versus continuous hypoxemia.

    abstract::Infants with sudden infant death syndrome have higher hypoxanthine (Hx) concentrations in their vitreous humor than infants with respiratory distress syndrome and other infant control populations. However, previous research on piglets and pigs applying continuous hypoxemia has not been able to reproduce the concentrat...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199312000-00013

    authors: Stoltenberg L,Rootwelt T,Oyasaeter S,Rognum TO,Saugstad OD

    更新日期:1993-12-01 00:00:00

  • Magnesium sulfate after transient hypoxia-ischemia fails to prevent delayed cerebral energy failure in the newborn piglet.

    abstract::Severely birth-asphyxiated human infants develop delayed ("secondary") cerebral energy failure, which carries a poor prognosis, during the first few days of life. This study tested the hypothesis that i.v. magnesium sulfate (MgSO4) after severe transient cerebral hypoxia-ischemia decreases the severity of delayed ener...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199703000-00024

    authors: Penrice J,Amess PN,Punwani S,Wylezinska M,Tyszczuk L,D'Souza P,Edwards AD,Cady EB,Wyatt JS,Reynolds EO

    更新日期:1997-03-01 00:00:00

  • Haemophilus influenzae type B impairment of pial vessel autoregulation in rats.

    abstract::To examine the mechanisms of autoregulatory impairment in meningitis, we studied the effects of Haemophilus influenzae type b (Hib) on pial vessels during hemorrhagic hypotension in rats, using a cranial window technique. We prepared cranial windows in barbiturate-anesthetized, mechanically ventilated rats. Artificial...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199301000-00010

    authors: Berkowitz ID,Hayden WR,Traystman RJ,Jones MD Jr

    更新日期:1993-01-01 00:00:00

  • Hydrolysis of dipeptides by human and ovine placentas.

    abstract::Human and ovine placental tissue homogenates were assayed for dipeptidase activity in vitro. Glycyl-L-leucine, L-leucyl glycine, glycyl-L-lysine, and L-lysyl glycine were hydrolyzed by placental homogenates. The pH optimum for the reaction was 8.0. The relationship between enzyme activity and concentration was linear ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198104000-00013

    authors: Crandell SS,Adcock EW 3rd,Morriss FH Jr

    更新日期:1981-04-01 00:00:00

  • Neutrophil recruitment by fetal porcine endothelial cells: implications in scarless fetal wound healing.

    abstract::Fetal dermal wounds heal scarlessly and with a minimal inflammatory response. When a robust inflammatory response is induced at the site of fetal dermal wounds by the application of cytokines, healing results in fibrosis. To test the hypothesis that the reduced inflammatory response in fetal wounds is due to impaired ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.pdr.0000184326.01884.bc

    authors: Olutoye OO,Zhu X,Cass DL,Smith CW

    更新日期:2005-12-01 00:00:00

  • Comparison of maximal oxygen consumption between obese black and white adolescents.

    abstract::The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between clinically obese black and white children and if a difference existed to determine whether it was related to hematological profiles and/or physical activity/inactivity levels. Twenty-three black and 21 white...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.pdr.0000176909.66057.a3

    authors: Andreacci JL,Robertson RJ,Dubé JJ,Aaron DJ,Dixon CB,Arslanian SA

    更新日期:2005-09-01 00:00:00

  • Motor repertoire is age-inadequate in infants with cystic fibrosis.

    abstract:BACKGROUND:General movements (GMs) in infants occur as fidgety movements (FMs) between postterm 9 and 20 weeks. We aimed to evaluate FMs and motor repertoire in infants with cystic fibrosis (CF) and their relation with clinical findings. METHODS:Demographic and clinical characteristics were recorded. FMs and motor rep...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-1082-4

    authors: Tekerlek H,Mutlu A,Inal-Ince D,Livanelioglu A,Kahraman A,Eryilmaz-Polat S,Karakaya J,Ozcelik U

    更新日期:2020-07-27 00:00:00

  • Effect of human milk or formula on gastric function and fat digestion in the premature infant.

    abstract::The effect of diet, human milk or formula, on gastric function (lipase and pepsin activity, pH, and volume) and intragastric digestion of fat was assessed in 28 appropriate for gestational age preterm infants (gestational age, 28.9 +/- 1.4, 29.1 +/- 0.9, 29.5 +/- 0.6 wk; birth weight, 1.00 +/- 0.14 to 1.18 +/- 0.07 kg...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1203/00006450-199609000-00011

    authors: Armand M,Hamosh M,Mehta NR,Angelus PA,Philpott JR,Henderson TR,Dwyer NK,Lairon D,Hamosh P

    更新日期:1996-09-01 00:00:00

  • Antioxidant status and nitric oxide in the malnutrition syndrome kwashiorkor.

    abstract::The pathophysiology of kwashiorkor, a severe edematous manifestation of malnutrition, is still poorly understood. The syndrome is, however, known to be associated with alterations in redox metabolism. To further elucidate the role of oxidative stress in kwashiorkor, we carried out a longitudinal study on the major blo...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200102000-00018

    authors: Fechner A,Böhme C,Gromer S,Funk M,Schirmer R,Becker K

    更新日期:2001-02-01 00:00:00

  • Statins prevent adverse effects of postnatal glucocorticoid therapy on the developing brain in rats.

    abstract:BACKGROUND:Postnatal glucocorticoid therapy in the treatment of chronic lung disease benefits lung function, however it adversely affects brain development. We hypothesized that combined postnatal glucocorticoid and statin therapy diminishes adverse effects of glucocorticoids on the developing brain. METHODS:On postna...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2013.152

    authors: Tijsseling D,Camm EJ,Richter HG,Herrera EA,Kane AD,Niu Y,Cross CM,de Vries WB,Derks JB,Giussani DA

    更新日期:2013-12-01 00:00:00

  • Cerebral metabolic response to neonatal hypoglycemia in growth-retarded dogs.

    abstract::The cerebral metabolic effects of hypoglycemia due to intrauterine growth retardation were studied in newborn dogs. Intrauterine growth retardation was induced in newborn dogs after 3 days of maternal nutritional deprivation (birth weight 251 +/- 7 versus 227 +/- 7 g, p less than 0.01). After birth, growth retarded pu...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198811000-00022

    authors: Kliegman RM

    更新日期:1988-11-01 00:00:00

  • Neonatal group B streptococcal sepsis: effects of late treatment with dazmegrel.

    abstract::Neonatal group B streptococcal (GBS) sepsis produces pulmonary arterial hypertension and hypoxemia that are preventable by pretreatment with the selective thromboxane A2 synthase inhibitor, dazmegrel. In the present experiment we administered dazmegrel (8 mg/kg) 2 h after the initiation of a 2 1/2 h infusion of 5 X 10...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198804000-00003

    authors: Truog WE,Gibson RL,Juul SE,Henderson WR,Redding GJ

    更新日期:1988-04-01 00:00:00