Impaired formation of the second messenger cAMP in mononuclear blood cells of children with pertussis.

abstract：:To investigate the detailed pattern of change in circulating gonadotropin and testosterone concentrations around the onset of puberty and to determine the temporal relationship between the gonadotropin and testosterone secretion, plasma gonadotropin and testosterone were measured at 20-min intervals for 24 h in 21 nor...

journal_title：Pediatric research

authors： Goji K,Tanikaze S

更新日期：1993-08-01 00:00:00

abstract：:After an initial postnatal diuresis, neonates are in positive sodium balance. Because atrial natriuretic peptide (ANP) contributes to sodium homeostasis, this study was designed to evaluate the maturational effects of increased dietary sodium intake on cardiac ANP production. Preweaned Sprague-Dawley rat pups were art...

journal_title：Pediatric research

authors： Muchant DG,Belmonte DC,Garmey MJ,Baertschi AJ,Pence RA,Chevalier RL

更新日期：1995-03-01 00:00:00

abstract：:Vascular dopamine (DA1) receptors may modulate circulatory hemodynamics in lambs. We evaluated resting dopaminergic tone in lambs by pharmacologically manipulating peripheral DA1 receptors with i.v. SCH 23390, (a highly selective, competitive DA1 receptor antagonist) and i.v. fenoldopam, (a highly selective DA1 recept...

journal_title：Pediatric research

authors： Polak MJ,Drummond WH

更新日期：1993-02-01 00:00:00

abstract：:Stimulation of cutaneous thermoreceptors may be an important factor in the initiation of continuous breathing at birth. Maintenance of a patent airway is also important in the continuation of effective ventilation after birth, but whereas in the adult the principal pharyngeal dilator is the genioglossus muscle, in the...

journal_title：Pediatric research

authors： Johnston BM,Gunn TR,Gluckman PD

更新日期：1988-03-01 00:00:00

abstract：:This patient presented on the first day of life with pronounced lactic acidosis with an elevated lactate/pyruvate ratio. Urine organic acids showed Krebs cycle metabolites and mildly elevated methylmalonate and methylcitrate. The acylcarnitine profile showed elevated propionylcarnitine and succinylcarnitine. Amino aci...

journal_title：Pediatric research

authors： Van Hove JL,Saenz MS,Thomas JA,Gallagher RC,Lovell MA,Fenton LZ,Shanske S,Myers SM,Wanders RJ,Ruiter J,Turkenburg M,Waterham HR

更新日期：2010-08-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of constant light in a neonatal care unit on the development of the sleep-and-wakefulness rhythm in preterm infants. Two groups of infants (57 preterm infants without other complications and 58 healthy term infants) were prospectively studied over infancy by a da...

journal_title：Pediatric research

authors： Shimada M,Segawa M,Higurashi M,Akamatsu H

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Bradycardia and oxygen desaturation episodes are common among preterm very low birth weight (VLBW) infants in the Neonatal Intensive Care Unit (NICU), and their association with adverse outcomes such as bronchopulmonary dysplasia (BPD) is unclear. METHODS:For 502 VLBW infants we quantified bradycardias (HR ...

journal_title：Pediatric research

authors： Fairchild KD,Nagraj VP,Sullivan BA,Moorman JR,Lake DE

更新日期：2019-06-01 00:00:00

abstract：:The metabolic demands of the newborn heart are met primarily by glucose and lactate. Mitochondria are impermeable to the NADH produced by these cytosolic reactions. The malate/aspartate and alpha-glycerophosphate (alpha-GP) shuttles provide two pathways to transport reducing equivalents into mitochondria. The goals of...

journal_title：Pediatric research

authors： Scholz TD,Koppenhafer SL

更新日期：1995-08-01 00:00:00

abstract：:The objective of this study was to establish longitudinal normative limits for home memory monitors during early infancy. Eighty-eight healthy infants were monitored overnight at 0.25-19 wk of age using the Healthdyne Smart Monitor. Apnea settings were 14 s for recording and 40 s for alarm; the bradycardia setting was...

journal_title：Pediatric research

authors： Hunt CE,Hufford DR,Bourguignon C,Oess MA

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Bronchopulmonary dysplasia (BPD) is an important cause of morbidity. The aim of this study was to evaluate the preventive effect of cytidine 5'-diphosphocholine (CDP-choline) treatment on hyperoxic lung injury in a neonatal rat model. METHODS:A total of 30 newborn pups were divided into control, hyperoxia, ...

journal_title：Pediatric research

authors： Cetinkaya M,Cansev M,Kafa IM,Tayman C,Cekmez F,Canpolat FE,Tunc T,Sarici SU

更新日期：2013-07-01 00:00:00

abstract：:Allergies are increasing, and despite deeper insights into the immunologic basis of these diseases, preventive measures are not yet efficient. As the induction of allergic diseases is often triggered in early childhood, perinatal or prenatal preventive strategies would be beneficial. We investigated the transfer of in...

journal_title：Pediatric research

authors： Szépfalusi Z,Loibichler C,Pichler J,Reisenberger K,Ebner C,Urbanek R

更新日期：2000-09-01 00:00:00

abstract：:The purpose of this study was to determine the effect of chest wall distortion on esophageal manometry by measuring simultaneous esophageal pressure changes at two sites in preterm infants. Fourteen infants were studied (mean +/- SD; birth weight, 1340 +/- 260 g; age, 8.5 +/- 4 d). Esophageal pressure was measured thr...

journal_title：Pediatric research

authors： Silva Neto G,Gerhardt TO,Claure N,Duara S,Bancalari E

更新日期：1995-05-01 00:00:00

abstract：:After the infusion of fructose, 0.25 g/kg body wt, the mean peak plasma uric acid level was 5.4 +/- 0.7 (SEM) mg/100 ml in six normal children and was not significantly increased compared with that of the mean basal value of 4.1 +/- 0.5 mg/100 ml. The mean blood inorganic phosphate (Pi) levels were significantly less ...

journal_title：Pediatric research

authors： Kogut MD,Roe TF,Ng W,Nonnel GN

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:Risk factors for diastolic dysfunction in hypertrophic cardiomyopathy (HCM) are poorly understood. We investigated the association of variants in hypoxia-response genes with phenotype severity in pediatric HCM. METHODS:A total of 80 unrelated patients <21 y and 14 related members from eight families with HC...

journal_title：Pediatric research

authors： Alkon J,Friedberg MK,Manlhiot C,Manickaraj AK,Kinnear C,McCrindle BW,Benson LN,Addonizio LJ,Colan SD,Mital S

更新日期：2012-12-01 00:00:00

abstract：:Responses of pial arterioles to topically applied arachidonic acid, conversion of exogenous arachidonic acid to prostanoids, and pial arteriolar dilation to hypercapnia were examined before and at progressive times after treatment with indomethacin (5 mg/kg i.v.) in chloralose-anesthetized newborn pigs with closed cra...

journal_title：Pediatric research

authors： Leffler CW,Mirro R,Shibata M,Parfenova H,Armstead WM,Zuckerman S

更新日期：1993-06-01 00:00:00

abstract：:In vitro experiments were performed to examine the contractile responsiveness of guinea pig gallbladder smooth muscle as a function of developmental age. Gallbladder muscle strips from preterm (day 50-55 gestation), newborn (days 1-3 post partum), and 1-month-old animals were stimulated with agonists that initiate the...

journal_title：Pediatric research

authors： Denehy CM,Ryan JR

更新日期：1986-03-01 00:00:00

abstract：:The mitochondrial DNA (mtDNA) point mutation T8993G has been associated with maternally inherited Leigh syndrome (MILS) when very abundant (> 95%). MILS patients are usually severely affected and die in early infancy. In 1993, a novel T8993C point mutation was described in a juvenile form of Leigh syndrome (LS) charac...

journal_title：Pediatric research

authors： Santorelli FM,Mak SC,Vazquez-Memije ME,Shanske S,Kranz-Eble P,Jain KD,Bluestone DL,De Vivo DC,DiMauro S

更新日期：1996-05-01 00:00:00

abstract：:Circadian rhythms of plasma renin activity (PRA) and plasma aldosterone (PA) were studied in eight healthy children, 7 to 15 years old. Blood samples were obtained at 7:00 AM, 10:00 AM, 1:00 PM, 4:00 PM, 5:00 PM, 8.00 PM, and midnight on day 1 and 4:00 AM and 7:00 AM on day 2. Children had normal activity during this ...

journal_title：Pediatric research

authors： Dechaux M,Broyer M,Lenoir G,Limal JM,Sachs C

更新日期：1982-05-01 00:00:00

abstract：:L-selectin, a surface adhesion glycoprotein expressed on leukocytes, has a well-established role in mediating inflammation and lymphocyte recirculation. Recent evidence suggests that L-selectin may also influence hematopoiesis. We observed that a greater proportion of CD34+ cells express L-selectin in cord blood compa...

journal_title：Pediatric research

authors： Koenig JM,Baron S,Luo D,Benson NA,Deisseroth AB

更新日期：1999-06-01 00:00:00

abstract：:We have shown previously that polynucleotides enhance in vitro antibody and Ig production in response to T-dependent antigens in mice and augment Ig production by adult human peripheral blood mononuclear cells. Herein, we report their effects on umbilical cord blood mononuclear cells (CBMNC) obtained from full-term ba...

journal_title：Pediatric research

authors： Jyonouchi H,Zhang-Shanbhag L,Georgieff M,Tomita Y

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Early brain development is closely dictated by distinct neurobiological principles. Here, we aimed to map early trajectories of structural brain wiring in the neonatal brain. METHODS:We investigated structural connectome development in 44 newborns, including 23 preterm infants and 21 full-term neonates scan...

journal_title：Pediatric research

authors： Keunen K,van der Burgh HK,de Reus MA,Moeskops P,Schmidt R,Stolwijk LJ,de Lange SC,Išgum I,de Vries LS,Benders MJ,van den Heuvel MP

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Though prenatal antidepressant exposure has been associated with adverse developmental outcomes, the extent to which the effects are due to prenatal drug exposure or underlying maternal mood disturbances is unclear. METHODS:This was a population-based retrospective cohort study using administrative data fro...

journal_title：Pediatric research

authors： Park M,Hanley GE,Guhn M,Oberlander TF

更新日期：2020-12-09 00:00:00

abstract：:This study was conducted to investigate myocardial excitation-contraction coupling in the fetus of the diabetic rabbit (FDM). On day 14 of gestation, diabetes was induced in pregnant rabbits by alloxan injection. On day 28 of gestation, mechanical function of the fetal myocardium was determined in the isolated arteria...

journal_title：Pediatric research

authors： Nakanishi T,Matsuoka S,Uemura S,Shimizu T,Nishioka K,Neufeld ND,Jarmakani JM

更新日期：1984-12-01 00:00:00

abstract：:Animal models with complex cortical development are useful for improving our understanding of the wide spectrum of neurodevelopmental challenges facing human preterm infants. MRI techniques can define both cerebral injury and alterations in cerebral development with translation between animal models and the human infa...

journal_title：Pediatric research

authors： Barnette AR,Neil JJ,Kroenke CD,Griffith JL,Epstein AA,Bayly PV,Knutsen AK,Inder TE

更新日期：2009-07-01 00:00:00

abstract：:We examined the long-term effects of dietary protein restriction during rat pregnancy on serum IGF-I, serum IGF binding proteins, and liver IGF-I gene expression during postnatal development. Pregnant Wistar rats were fed ad libitum throughout gestation a normal (20% casein diet; P20 controls) or a low (5% casein; P5)...

journal_title：Pediatric research

authors： Muaku SM,Beauloye V,Thissen JP,Underwood LE,Fossion C,Gérard G,Ketelslegers JM,Maiter D

更新日期：1996-04-01 00:00:00

abstract：:The odds risk of vertical transmission of human immunodeficiency virus (HIV) to preterm infants is almost four times that of term infants and may relate to maternal and neonatal factors. We characterized the competence of early nonspecific cellular immunity, namely natural killer cytotoxicity (NKC) and antibody-depend...

journal_title：Pediatric research

authors： Merrill JD,Sigaroudinia M,Kohl S

更新日期：1996-09-01 00:00:00

abstract：:The ciliated, mucus-secreting urn cell complex (UCC) is found swimming in the coelomic cavity of the marine invertebrate Sipunculus nudus. This cell complex, which can be maintained in suspension cultures, responds to various stimuli by hypersecreting mucus in the form of a cohesive mucus "tail." This tail can be meas...

journal_title：Pediatric research

authors： Kurlandsky LE,Berninger RW,Talamo RC

更新日期：1980-11-01 00:00:00

abstract：:Tracheal aspirate IL-8 concentration and airway epithelial cell IL-8 expression are each increased in premature infants undergoing mechanical ventilation. We sought to determine the cytokines responsible for IL-8 expression in this context. Tracheal aspirates were collected from 18 mechanically ventilated premature in...

journal_title：Pediatric research

authors： Shimotake TK,Izhar FM,Rumilla K,Li J,Tan A,Page K,Brasier AR,Schreiber MD,Hershenson MB

更新日期：2004-12-01 00:00:00

abstract：:Microangiopathy, one of the most important complications of diabetes mellitus in humans, is associated with increased angiogenic response and proliferative lesions in various organs. Angiogenin, a polypeptide with a molecular size of 14 kD, is a potent inducer of vascular growth. This study aimed at investigating whet...

journal_title：Pediatric research

authors： Malamitsi-Puchner A,Sarandakou A,Dafogianni C,Tziotis J,Bartsocas CS

更新日期：1998-06-01 00:00:00

abstract：:Mutations in multidrug resistance 3 gene (MDR3 or ABCB4) underlie progressive familial intrahepatic cholestasis type 3 (PFIC3), a severe pediatric liver disease progressing to cirrhosis. Abcb4-/- mice exhibit slowly developing hepatic lesions that can be accelerated by feeding a cholic acid (CA)-supplemented diet. We ...

journal_title：Pediatric research

authors： Lamireau T,Bouchard G,Yousef IM,Clouzeau-Girard H,Rosenbaum J,Desmoulière A,Tuchweber B

更新日期：2007-02-01 00:00:00