Abstract:
BACKGROUND:Bradycardia and oxygen desaturation episodes are common among preterm very low birth weight (VLBW) infants in the Neonatal Intensive Care Unit (NICU), and their association with adverse outcomes such as bronchopulmonary dysplasia (BPD) is unclear. METHODS:For 502 VLBW infants we quantified bradycardias (HR < 100 for ≥ 4 s) and desaturations (SpO2 < 80% for ≥ 10 s), combined bradycardia and desaturation (BD) events, and percent time in events in the first 4 weeks after birth (32 infant-years of data). We tested logistic regression models of clinical risks (including a respiratory acuity score incorporating FiO2 and level of respiratory support) to estimate the risks of BPD or death and secondary outcomes. We then tested the additive value of the bradycardia and desaturation metrics for outcomes prediction. RESULTS:BPD occurred in 187 infants (37%). The clinical risk model had ROC area for BPD of 0.874. Measures of desaturation, but not bradycardia, significantly added to the predictive model. Desaturation metrics also added to clinical risks for prediction of severe intraventricular hemorrhage, retinopathy of prematurity and prolonged length of stay in the NICU. CONCLUSIONS:Oxygen desaturations in the first month of the NICU course are associated with risk of BPD and other morbidities in VLBW infants.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Fairchild KD,Nagraj VP,Sullivan BA,Moorman JR,Lake DEdoi
10.1038/s41390-018-0223-5subject
Has Abstractpub_date
2019-06-01 00:00:00pages
987-993issue
7eissn
0031-3998issn
1530-0447pii
10.1038/s41390-018-0223-5journal_volume
85pub_type
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