Abstract:
:Microangiopathy, one of the most important complications of diabetes mellitus in humans, is associated with increased angiogenic response and proliferative lesions in various organs. Angiogenin, a polypeptide with a molecular size of 14 kD, is a potent inducer of vascular growth. This study aimed at investigating whether serum angiogenin levels are elevated in children and adolescents (youngsters) with insulin-dependent diabetes mellitus and whether angiogenin levels are affected by duration and metabolic control of the disease. It is assumed that angiogenin levels reflect the increased angiogenesis associated with microangiopathy, whether clinically evident or not. Forty diabetic youngsters were compared with 30 healthy control subjects (mean age +/- SD, 14.3 +/- 3.6 y and 13.8 +/- 3.6 y, respectively). The patients' disease duration and glycosylated Hb were (mean +/- SD) 6.2 +/- 3.8 y and 9.6 +/- 1.8%, respectively. Angiogenin (ng/mL) was measured in serum samples by an enzyme immunoassay and was found to be significantly higher (mean +/- SE) in patients (353.3 +/- 20.0) than in control subjects (244.7 +/- 9.6) (p = 0.0002). Levels did not vary with age, but were significantly higher in females compared with male subjects (p = 0.01). In the diabetic youngsters no significant differences were noticed with respect to duration or metabolic control of the disease. In conclusion, serum angiogenin levels were found to be increased among diabetic youngsters, irrespective of the duration and metabolic control of the disease, as well as in female subjects, with or without diabetes.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Malamitsi-Puchner A,Sarandakou A,Dafogianni C,Tziotis J,Bartsocas CSdoi
10.1203/00006450-199806000-00013subject
Has Abstractpub_date
1998-06-01 00:00:00pages
798-800issue
6eissn
0031-3998issn
1530-0447journal_volume
43pub_type
杂志文章abstract::The effect of intrauterine growth retardation (IUGR) on cerebral and adrenal monoamine metabolism was studied in the fetuses of eight nulliparous rat dams after unilateral uterine artery ligation on d 18 of gestation. On d 22 (term = 23 d), four dams were subjected to normoxia and four to hypoxia (10% O2) for 58 min w...
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更新日期:1996-05-01 00:00:00
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更新日期:1999-05-01 00:00:00
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更新日期:1982-05-01 00:00:00
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更新日期:2008-03-01 00:00:00
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更新日期:1981-09-01 00:00:00
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更新日期:2013-08-01 00:00:00
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更新日期:1983-06-01 00:00:00
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更新日期:1997-09-01 00:00:00
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更新日期:1994-02-01 00:00:00
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更新日期:2004-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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更新日期:1997-04-01 00:00:00
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