Salivary carcinoembryonic antigen (CEA) in cystic fibrosis.

abstract：:Indomethacin is used to constrict the patent ductus arteriosus in premature infants. To clarify possible prostanoid receptor antagonists that can constrict the ductus, we studied in vivo constriction of the fetal and neonatal ductus arteriosus by AE3-208, a prostanoid EP4-receptor antagonist, in rats. Following quick ...

journal_title：Pediatric research

authors： Momma K,Toyoshima K,Takeuchi D,Imamura S,Nakanishi T

更新日期：2005-11-01 00:00:00

abstract：:Many attempts have been made to obtain safe and effective analgesia in newborns. Oral glucose-water has been found to have analgesic properties in neonates. We investigated whether other sensory stimulation added to oral glucose provided more effective analgesia than oral glucose alone. In a randomized prospective dou...

journal_title：Pediatric research

authors： Bellieni CV,Bagnoli F,Perrone S,Nenci A,Cordelli DM,Fusi M,Ceccarelli S,Buonocore G

更新日期：2002-04-01 00:00:00

abstract：:Perinatal brain injury is a leading cause of death and disability in young children. Recent advances in obstetrics, reproductive medicine and neonatal intensive care have resulted in significantly higher survival rates of preterm or sick born neonates, at the price of increased prevalence of neurological, behavioural ...

journal_title：Pediatric research

authors： Bendix I,Hadamitzky M,Herz J,Felderhoff-Müser U

更新日期：2019-01-01 00:00:00

abstract：:A model of patent ductus arteriosus in premature lambs was created to examine the lamb's ability to handle the volume load imposed by a patent ductus arteriosus and to determine the lamb's ability to handle any additional volume load. Fifteen preterm lambs [133 +/- 2 (+/- SD) days gestation, term 145 days], whose duct...

journal_title：Pediatric research

authors： Clyman RI,Roman C,Heymann MA,Mauray F

更新日期：1987-11-01 00:00:00

abstract：:Epidemiologic studies have linked intrauterine growth restriction (IUGR) with an increased incidence of cardiovascular disease later in life; reduced cardiomyocyte number in IUGR hearts may underlie such prenatal programming. Our aim was to examine the effect of IUGR, as a result of maternal protein restriction, on th...

journal_title：Pediatric research

authors： Corstius HB,Zimanyi MA,Maka N,Herath T,Thomas W,van der Laarse A,Wreford NG,Black MJ

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Newborn pigs offer theoretical advantages for studying newborn hypoxic-ischemic (HI) brain damage because of a development and structure similar to the human brain. However, the correlation between functional features and actual HI brain damage has not been reported. METHODS:Newborn pigs were examined daily...

journal_title：Pediatric research

authors： Barata L,Cabañas A,Lafuente H,Vargas C,Ceprián M,Campa L,Jiménez-Sánchez L,Pazos MR,Alvarez FJ,Martínez-Orgado J

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Previous studies indicate an increased risk for neuropsychological difficulties in young children prenatally exposed to opioids and polysubstances, but longitudinal information is scarce. The present longitudinal study investigated whether these waned, persisted, or increased over time. METHODS:The cognitiv...

journal_title：Pediatric research

authors： Nygaard E,Moe V,Slinning K,Walhovd KB

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Secreted frizzled-related protein 5 (SFRP5) is an adipokine protecting against obesity-related insulin resistance and diabetes. SFRP5 binds to wingless type mouse mammary tumor virus (MMTV) integration site family member 5A (WNT5A) to improve insulin sensitivity. We performed the first study of SFRP5 and WNT...

journal_title：Pediatric research

authors： Prats-Puig A,Soriano-Rodríguez P,Carreras-Badosa G,Riera-Pérez E,Ros-Miquel M,Gomila-Borja A,de Zegher F,Ibáñez L,Bassols J,López-Bermejo A

更新日期：2014-06-01 00:00:00

abstract：:To examine the levels and relationship of blood pressure and insulin during puberty, blood pressure and serum insulin were measured in 3596 subjects, aged 3-18 y, whose pubertal status was graded according to the Tanner classification. The same study protocol was repeated in two follow-up surveys 3 and 6 y later for 2...

journal_title：Pediatric research

authors： Taittonen L,Uhari M,Turtinen J,Nuutinen M

更新日期：1997-02-01 00:00:00

abstract：:Fetal growth and development is dependent on the transfer of amino acids from maternal to fetal blood across the microvillous plasma membrane (MVM) and basal plasma membrane of placental syncytiotrophoblast. The aim of this study was to determine the relationship of system A amino acid transporter (SysA) activity in M...

journal_title：Pediatric research

authors： Harrington B,Glazier J,D'Souza S,Sibley C

更新日期：1999-06-01 00:00:00

abstract：:Surfactant-associated proteins (SP-A, SP-B, and SP-C) are critical for the endogenous function of surfactant. Keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF) are key regulators of lung development. The objective of this study was to evaluate the effects of early mechanical ventilation on...

journal_title：Pediatric research

authors： Digeronimo RJ,Mustafa SB,Ryan RM,Sternberg ZZ,Ashton DJ,Seidner SR

更新日期：2007-09-01 00:00:00

abstract：:We investigated, using a human placental choriocarcinoma cell line as a model, the effects of the immunosuppressive drug cyclosporin A on several placental transport systems mediating the transfer of glucose and amino acids from mother to fetus. The results of the investigation show that the transport system responsib...

journal_title：Pediatric research

authors： Ramamoorthy S,Leibach FH,Mahesh VB,Ganapathy V

更新日期：1992-07-01 00:00:00

abstract：:This study investigated the effects of intraventricular/periventricular blood on cerebral cAMP production and cortical cerebrovascular reactivity. Under halothane and N2O anesthesia, 3 mL of either autologous blood or artificial cerebrospinal fluid (CSF) were injected into the left caudate nucleus; volume was adequate...

journal_title：Pediatric research

authors： Pourcyrous M,Parfenova H,Shibata M,Bada HS,Korones SB,Leffler CW

更新日期：1997-09-01 00:00:00

abstract：:Early nutrition in animals affects both behavior and brain structure. In humans, randomized trials show that early nutrition affects later cognition, notably in males. We hypothesized that early nutrition also influences brain structure, measurable using magnetic resonance imaging. Prior research suggested that the ca...

journal_title：Pediatric research

authors： Isaacs EB,Gadian DG,Sabatini S,Chong WK,Quinn BT,Fischl BR,Lucas A

更新日期：2008-03-01 00:00:00

abstract：:Infants with polycythemia and hyperviscosity are known to have a reduced cerebral blood flow. Eight newborn lambs were studied to determine what effect the reduction in cerebral blood flow might have on the cerebral delivery and uptake of oxygen, glucose, lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate. Meas...

journal_title：Pediatric research

authors： Rosenkrantz TS,Philipps AF,Skrzypczak PS,Raye JR

更新日期：1988-03-01 00:00:00

abstract：:Previous studies have shown that early life stress in the form of intermittent maternal separation (MS) predisposes adult rats to develop stress-induced intestinal mucosal dysfunction and visceral hypersensitivity. However, the mechanism involved in the functional abnormalities is unclear. Our aim was to study immatur...

journal_title：Pediatric research

authors： Gareau MG,Jury J,Yang PC,MacQueen G,Perdue MH

更新日期：2006-01-01 00:00:00

abstract：:Tracheal epithelial cells obtained from adult and infant ferrets were grown in primary culture in vitro. Cells from adult animals grew readily, and many ciliated cells were observed in the cultures. Successful cultures were derived from infant animals, but cell number in infant and adult cultures began to decrease aft...

journal_title：Pediatric research

authors： Kercsmar CM,Chung Y,Davis PB

更新日期：1991-07-01 00:00:00

abstract：:Vitamin K deficiency is a relatively common condition in neonates. However, the role of vitamin K in neonatal bone metabolism remains to be determined. Osteocalcin (OC) is the most abundant noncollagenous protein in bone, and is regulated to be gamma-carboxylated by vitamin K. In this study, we measured gamma-carboxyl...

journal_title：Pediatric research

authors： Shimizu N,Shima M,Hirai H,Nakajima S,Nishimura K,Yamaoka K,Okada S

更新日期：2002-11-01 00:00:00

abstract：:The response of cerebral blood volume (CBVR) to a small induced change in arterial carbon dioxide tension was studied by near-infrared spectroscopy in 17 newborn infants born from 26 wk of gestation to term. All 17 infants were undergoing mechanical ventilation but had apparently normal brains. The CBVR per kPa change...

journal_title：Pediatric research

authors： Wyatt JS,Edwards AD,Cope M,Delpy DT,McCormick DC,Potter A,Reynolds EO

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Therapeutic hypothermia (TH) has become standard treatment for severe and moderate hypoxic-ischemic neonatal encephalopathy (HIE). Our group has developed an optically based, noninvasive concept of assessing the capacity for oxygen delivery from the microcirculation to the cells of a tissue under investigati...

journal_title：Pediatric research

authors： Fredly S,Fugelseth D,Nygaard CS,Salerud EG,Stiris T,Kvernebo K

更新日期：2016-06-01 00:00:00

abstract：:The purpose of this study was to assess differences in sound spectra of crying of term newborns in relation to different pain levels. Fifty-seven consecutively born neonates were evaluated during heel-prick performed with different analgesic techniques. Crying was recorded and frequency spectrograms analyzed. A pain s...

journal_title：Pediatric research

authors： Bellieni CV,Sisto R,Cordelli DM,Buonocore G

更新日期：2004-01-01 00:00:00

abstract：:The relationship between the development of cytotoxic cellular immune response to herpes simplex virus type I (HSV-1)-infected autologous cells and the production of interferon (IFN) was studied using in vitro secondary sensitization of peripheral blood leukocytes in subjects with recurrent herpes labialis (RHL) and i...

journal_title：Pediatric research

authors： Tsutsumi H,Bernstein JM,Riepenhoff-Talty M,Ogra PL

更新日期：1986-09-01 00:00:00

abstract：:Although obstructive nephropathy is a frequent cause of renal insufficiency in infancy, factors influencing adaptation to chronic partial ureteral obstruction (CPUO) are poorly understood. Guinea pigs were subjected to unilateral CPUO within the first 2 days of life (Group I) and microsphere studies were performed at ...

journal_title：Pediatric research

authors： Chevalier RL,Kaiser DL

更新日期：1984-12-01 00:00:00

abstract：:We measured the cortisol and corticosterone responses to insulin-induced hypoglycemia in 13 growth hormone (GH)-deficient children and 30 short children without GH deficiency. Although there was no difference between the two groups in degree of hypoglycemia attained, baseline cortisol, baseline corticosterone, or cort...

journal_title：Pediatric research

authors： Chasalow FI,Blethen SL

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:Near-infrared spectroscopy is used in the assessment of regional splanchnic oxygen saturation (rsSO2), but solid reference values are scarce. We aimed to establish reference values of rsSO2 for preterm infants during the first week after birth, both crude and modeled based on predictors. METHODS:We included...

journal_title：Pediatric research

authors： van der Heide M,Dotinga BM,Stewart RE,Kalteren WS,Hulscher JBF,Reijneveld SA,Bos AF,Kooi EMW

更新日期：2021-01-27 00:00:00

abstract：:The fetal and maternal concentration of various plasma proteins alters during pregnancy. Cells in the livers of fetal hamsters accumulate serum amyloid A (SAA) and C-reactive protein (CRP) mRNA, major acute phase reactants, when lipopolysaccharide is administered to the fetal circulation. No fetal SAA or CRP mRNA resp...

journal_title：Pediatric research

authors： Dowton SB,Waggoner DJ,Mandl KD

更新日期：1991-11-01 00:00:00

abstract：:Meconium aspiration syndrome (MAS) is a serious condition in newborns, associated with a poorly characterized inflammatory reaction. The aim of this study was to investigate a possible role for complement in pulmonary pathophysiology and systemic inflammation in experimental MAS. MAS was induced by instillation of mec...

journal_title：Pediatric research

authors： Lindenskov PH,Castellheim A,Aamodt G,Saugstad OD,Mollnes TE

更新日期：2004-11-01 00:00:00

abstract：:Depression is one of the most debilitating chronic disorders in the United States, affecting 15 million children in homes with depressed mothers, many of whom endure household chaos, inconsistent nurturing, inadequate safety practices, and harsh discipline. Depressed mothers are under diagnosed and undertreated, yet t...

journal_title：Pediatric research

authors： Weiss-Laxer NS,Platt R,Osborne LM,Kimmel M,Solomon BS,Mendelson T,Webb L,Riley AW

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of neonatal group B Streptococcus (GBS) lung infection may be associated with surfactant dysfunction or deficiency. This study aimed to investigate the efficacy of surfactants on early postnatal GBS infection in ventilated newborn rabbit lungs. METHODS:A near-term newborn rabbit model was e...

journal_title：Pediatric research

authors： Xu Y,Dong Y,Guo X,Sun B

更新日期：2019-08-01 00:00:00

abstract：:Immunologic consequences of exposure to HIV-1 in utero are still poorly understood. This study investigates relationships between type-1 [interferon-gamma (IFN-gamma)] and type-2 (IL-10) cytokine production and maternal-infant HIV-1 transmission. Cord blood leukocytes from deliveries of 71 HIV-1-infected and 11 uninfe...

journal_title：Pediatric research

authors： Kuhn L,Coutsoudis A,Moodley D,Mngqundaniso N,Trabattoni D,Shearer GM,Clerici M,Coovadia HM

更新日期：2001-09-01 00:00:00