Abstract:
:Immunologic consequences of exposure to HIV-1 in utero are still poorly understood. This study investigates relationships between type-1 [interferon-gamma (IFN-gamma)] and type-2 (IL-10) cytokine production and maternal-infant HIV-1 transmission. Cord blood leukocytes from deliveries of 71 HIV-1-infected and 11 uninfected mothers were tested for in vitro IFN-gamma and IL-10 production after phytohemagglutinin (PHA) stimulation. The infants of these HIV-1-infected mothers were followed prospectively after birth to determine HIV vertical transmission, and IFN-gamma and IL-10 production was measured again at 6 mo. Median PHA-stimulated IFN-gamma production was 210 pg/mL in cord blood cells from infected and 73 pg/mL from uninfected mothers (p = 0.12), and median PHA-stimulated IL-10 production was 491 pg/mL in cord blood cells from infected and 161 pg/mL from uninfected mothers (p = 0.004). PHA-stimulated IFN-gamma and IL-10 production alone were not significantly associated with transmission, but relationships between the two cytokines differed among infected and uninfected infants of HIV-1-infected mothers. PHA-stimulated IFN-gamma and IL-10 production was positively correlated among infected (r = 0.7, p = 0.12 in cord blood and r = 0.66, p = 0.03 at 6 mo) but not uninfected infants, and stronger relative production of IFN-gamma to IL-10 was observed among exposed uninfected than among infected infants (p = 0.04). Exposure in utero to HIV-1 may augment production of IL-10 detectable in fetal cord blood. Stronger relative production of IFN-gamma to IL-10 in cord blood cells from infants of HIV-1-infected mothers may be associated with protection against perinatal HIV infection.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Kuhn L,Coutsoudis A,Moodley D,Mngqundaniso N,Trabattoni D,Shearer GM,Clerici M,Coovadia HMdoi
10.1203/00006450-200109000-00018subject
Has Abstractpub_date
2001-09-01 00:00:00pages
412-6issue
3eissn
0031-3998issn
1530-0447journal_volume
50pub_type
杂志文章abstract::The odds risk of vertical transmission of human immunodeficiency virus (HIV) to preterm infants is almost four times that of term infants and may relate to maternal and neonatal factors. We characterized the competence of early nonspecific cellular immunity, namely natural killer cytotoxicity (NKC) and antibody-depend...
journal_title:Pediatric research
pub_type: 杂志文章
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abstract::The nutritional status, prenatally and early postnatally, plays a critical role in postnatal growth and development. Early malnutrition may change the original programming of organs, especially those in developmental phases, which can result in long-term changes in metabolism. The association between a low birth weigh...
journal_title:Pediatric research
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doi:10.1203/00006450-200012000-00017
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journal_title:Pediatric research
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更新日期:1980-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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更新日期:2003-12-01 00:00:00
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更新日期:1999-08-01 00:00:00
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journal_title:Pediatric research
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更新日期:1996-05-01 00:00:00
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更新日期:2013-09-01 00:00:00
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更新日期:2006-03-01 00:00:00
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更新日期:2021-01-27 00:00:00
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journal_title:Pediatric research
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doi:
更新日期:1994-04-01 00:00:00
abstract::Developmental disability, intrauterine growth retardation, renal anomalies, and dysmorphic features have been described in offspring of women who abuse toluene during pregnancy. A Sprague-Dawley rat model was developed to study this clinical syndrome. During d 6-19 of gestation, 11 treated dams received daily gavage d...
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更新日期:1994-12-01 00:00:00
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更新日期:2002-09-01 00:00:00
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journal_title:Pediatric research
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更新日期:1998-08-01 00:00:00
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更新日期:2013-09-01 00:00:00
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doi:10.1203/00006450-198008000-00006
更新日期:1980-08-01 00:00:00
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更新日期:2010-05-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2020-04-21 00:00:00
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doi:10.1203/00006450-199802000-00013
更新日期:1998-02-01 00:00:00
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更新日期:2020-01-01 00:00:00
abstract::Fetal lung cyclic AMP phosphodiesterase, cyclic AMP, phosphatidyl choline, and incorporation of precursors into phosphatidyl choline were measured in rabbits after maternal administration of hydrocortisone phosphate and aminophylline. Both agents inhibited lung phosphodiesterase activity and augmented cyclic AMP conce...
journal_title:Pediatric research
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doi:10.1203/00006450-197606000-00011
更新日期:1976-06-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/00006450-198910000-00015
更新日期:1989-10-01 00:00:00
abstract::The effect of hypertension in pregnant women on fetal maturation is an issue of considerable importance. Because of a possible role of prolactin in fetal adrenal steroidogenesis and in fetal lung maturation, we have investigated the relationship between hypertension in pregnant women and levels of prolactin and dehydr...
journal_title:Pediatric research
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doi:10.1203/00006450-198609000-00014
更新日期:1986-09-01 00:00:00
abstract::To clarify the prevalence of Japanese children thought to be at a risk for infection with GB virus-C (GBV-C)/hepatitis G virus (HGV), we investigated the detection rates of serum GBV-C/ HGV ribonucleic acid (RNA) by reverse transcription-seminested PCR and serum anti-HGV-E2 antibody by ELISA in 162 children with histo...
journal_title:Pediatric research
pub_type: 临床试验,杂志文章
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更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Neonates with hypoxic-ischemic encephalopathy (HIE) frequently develop acute kidney injury (AKI). Aminophylline has been shown to reduce severe renal dysfunction in neonates after perinatal asphyxia. However, the effect of aminophylline on renal function in neonates undergoing hypothermia has not been studie...
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更新日期:2020-06-05 00:00:00