Abstract：
:After an initial postnatal diuresis, neonates are in positive sodium balance. Because atrial natriuretic peptide (ANP) contributes to sodium homeostasis, this study was designed to evaluate the maturational effects of increased dietary sodium intake on cardiac ANP production. Preweaned Sprague-Dawley rat pups were artificially reared by feeding them either a normal-sodium or high-sodium diet for 7 d and were compared with maternally reared rat pups. Adult rats were divided into three groups: the first group was given ad libitum rat food and 1% sodium chloride to drink, the second group was pair-fed with this group but given tap water to drink, and the third group was fed ad libitum rat food and water for 10 d. Atrial and ventricular pro-ANP and ANP contents and plasma ANP concentrations were measured by RIA. Steady state atrial and ventricular ANP mRNA expression was determined by Northern and dot-blot analysis. There was a 2-fold increase in atrial pro-ANP and ANP content and a 50% decrease in plasma ANP concentration in preweaned rat pups fed a high-salt diet. In contrast, atrial pro-ANP and ANP content and plasma ANP concentration were not affected by increased sodium intake in adult rats. Atrial and ventricular ANP mRNA levels and ventricular pro-ANP and ANP contents were not altered by dietary sodium at either age. We conclude that chronic increase in sodium intake in the preweaning period results in increased storage of atrial pro-ANP. The decrease in plasma ANP concentration in these preweaned rats may be due to reduced basal secretion or enhanced degradation of the peptide.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Muchant DG,Belmonte DC,Garmey MJ,Baertschi AJ,Pence RA,Chevalier RLdoi
10.1203/00006450-199503000-00010subject
Has Abstractpub_date
1995-03-01 00:00:00pages
310-5issue
3eissn
0031-3998issn
1530-0447journal_volume
37pub_type
杂志文章abstract：:Exposure of neonatal rats to > or = 95% O2 for 2 wk, a widely used model of oxidant/antioxidant interactions in neonatal lung injury, results in arrested lung growth without the dysplastic lesions observed in chronic human neonatal lung injury. To determine whether dysplastic lung cell growth would be seen at lesser O...
journal_title：Pediatric research
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doi：10.1203/00006450-199606000-00001
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:Severe traumatic brain injury (TBI) is a leading cause of mortality in children, but the accurate prediction of outcomes at the point of admission remains very challenging. Admission laboratory results are a promising potential source of prognostic data, but have not been widely explored in paediatric cohort...
journal_title：Pediatric research
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journal_title：Pediatric research
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journal_title：Pediatric research
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更新日期：1994-04-01 00:00:00
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journal_title：Pediatric research
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更新日期：2016-08-01 00:00:00
abstract：:This paper has been retracted at the request of the authors. ...
journal_title：Pediatric research
pub_type： 杂志文章,撤回出版物
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更新日期：2019-11-01 00:00:00
abstract：:BackgroundPatent ductus arteriosus (PDA) is a common complication seen in preterm infants. Indomethacin is routinely used to treat PDA. Evidence suggests that the response of indomethacin is highly heritable. This study investigated the association between single-nucleotide polymorphisms (SNPs) in CYP2C9 and the closu...
journal_title：Pediatric research
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doi：10.1038/pr.2017.145
更新日期：2017-11-01 00:00:00
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journal_title：Pediatric research
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doi：10.1203/00006450-199701000-00009
更新日期：1997-01-01 00:00:00
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journal_title：Pediatric research
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doi：10.1038/s41390-019-0578-2
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journal_title：Pediatric research
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doi：10.1203/00006450-198211000-00004
更新日期：1982-11-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199010000-00007
更新日期：1990-10-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2014.90
更新日期：2014-09-01 00:00:00
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journal_title：Pediatric research
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doi：10.1203/00006450-200211000-00009
更新日期：2002-11-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199904010-00017
更新日期：1999-04-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199808000-00006
更新日期：1998-08-01 00:00:00
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journal_title：Pediatric research
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doi：10.1203/PDR.0b013e318179957d
更新日期：2008-08-01 00:00:00
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journal_title：Pediatric research
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doi：10.1203/00006450-197803000-00007
更新日期：1978-03-01 00:00:00
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journal_title：Pediatric research
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doi：10.1203/00006450-199902000-00018
更新日期：1999-02-01 00:00:00
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journal_title：Pediatric research
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更新日期：2017-10-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197812000-00011
更新日期：1978-12-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197710000-00008
更新日期：1977-10-01 00:00:00
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更新日期：2020-12-01 00:00:00
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doi：10.1038/s41390-020-0951-1
更新日期：2020-05-14 00:00:00
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journal_title：Pediatric research
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doi：10.1203/01.pdr.0000190577.62426.45
更新日期：2006-01-01 00:00:00
abstract：:Epidemiologic studies have linked intrauterine growth restriction (IUGR) with an increased incidence of cardiovascular disease later in life; reduced cardiomyocyte number in IUGR hearts may underlie such prenatal programming. Our aim was to examine the effect of IUGR, as a result of maternal protein restriction, on th...
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doi：10.1203/01.PDR.0000157726.65492.CD
更新日期：2005-06-01 00:00:00
abstract：:Antibodies of restricted specificity have been identified in the human in response to certain antigens. The present study analyzed tetanus and diphtheria antitoxins isolated from selected human sera and suggested a restricted response in antibody production to each of these antigens. Purified antibodies from eight ser...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197712000-00009
更新日期：1977-12-01 00:00:00
