Pulmonary toxicity of monocrotaline differs at critical periods of lung development.

abstract：:Plasma aldosterone (A), corticosterone (B), deoxycorticosterone (DOC), progesterone (P), 17-hydroxyprogesterone (17-OHP), cortisol (F), and cortisone (E) were measured simultaneously by specific radioimmunoassays in small plasma samples obtained from 174 normal infants and children between 2 hr and 15 yr of age. The s...

journal_title：Pediatric research

authors： Sippell WG,Dörr HG,Bidlingmaier F,Knorr D

更新日期：1980-01-01 00:00:00

abstract：:BackgroundAcute kidney injury (AKI) is common in pediatric inpatients and is associated with increased morbidity, mortality, and length of stay. Its early identification can reduce severity.MethodsTo create and validate an electronic health record (EHR)-based AKI screening tool, we generated temporally distinct develo...

journal_title：Pediatric research

authors： Wang L,McGregor TL,Jones DP,Bridges BC,Fleming GM,Shirey-Rice J,McLemore MF,Chen L,Weitkamp A,Byrne DW,Van Driest SL

更新日期：2017-09-01 00:00:00

abstract：:The aim of this study was to evaluate the changes in Doppler transmitral flow patterns during the 1st d of life. Doppler echocardiography of the ascending aorta and mitral valve was performed serially in 20 normal neonates at 2, 12, and 24 h of age. A computer-interfaced digitizer pad was used to measure the following...

journal_title：Pediatric research

authors： Harada K,Shiota T,Takahashi Y,Tamura M,Toyono M,Takada G

更新日期：1994-04-01 00:00:00

abstract：:The hypoxanthine concentration in plasma was found to be a sensitive parameter of hypoxia of the fetus and the newborn infant. The plasma level of hypoxanthine in the umbilical cord in 29 newborn infants with normal delivery varied between 0 and 11.0 mumol/liter with a mean of 5.8 mumol/liter, SD 3.0 mumol/liter. Comp...

journal_title：Pediatric research

authors： Saugstad OD

更新日期：1975-04-01 00:00:00

abstract：:Clinical trials demonstrated decreasing rates of bronchopulmonary dysplasia in preterm infants with hypoxic respiratory failure treated with inhaled nitric oxide (iNO). However, the molecular and biochemical effects of iNO on developing human fetal lungs remain vastly unknown. By using a well-characterized model of hu...

journal_title：Pediatric research

authors： Johnston LC,Gonzales LW,Lightfoot RT,Guttentag SH,Ischiropoulos H

更新日期：2010-05-01 00:00:00

abstract：:Blue and white phototherapy was given to infant (and weanling) homozygous Gunn rats treated with different doses of riboflavin-5-phosphate (ribofl.5'p.) During the first hours after a flavin-injection, the effect of phototherapy with both types of fluorescent lamps was enhanced. With equal radiant power applied, the s...

journal_title：Pediatric research

authors： Ballowitz L,Bunjamin A,Hanefeld F,Lietz L,Stüttgen G,Wirjadi D

更新日期：1979-12-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) remains among the most common and devastating diseases in neonates. Despite advances in neonatal clinical care, specific treatment strategies and diagnostic modalities remain lacking. As a result, morbidity and mortality remain high. Improved understanding of the pathogenesis of NEC has...

journal_title：Pediatric research

authors： Shelby RD,Raab R,Besner GE,McElroy SJ

更新日期：2020-08-01 00:00:00

abstract：:Inhibition of Pseudomonas cepacia (but not Pseudomonas aeruginosa) by beta-lactams was decreased in 5% CO2 in air compared with air alone. The effect of CO2 and pH (range, 6.0 to 8.0) on beta-lactam susceptibility, beta-lactamase expression, and outer membrane proteins was studied in isolates recovered from the sputum...

journal_title：Pediatric research

authors： Corkill JE,Deveney J,Pratt J,Shears P,Smyth A,Heaf D,Hart CA

更新日期：1994-03-01 00:00:00

abstract：:The fetal brain develops rapidly during the last trimester of pregnancy. Therefore, the brain of infants who are born preterm is vulnerable to changes in oxygen and nutrient supply in the neonatal period. The objective was to determine the effect of gestational age (GA) on the cerebral O2 supply threshold level for pr...

journal_title：Pediatric research

authors： van Os S,Liem D,Hopman J,Klaessens J,van de Bor M

更新日期：2005-03-01 00:00:00

abstract：:Although cisapride is widely used to treat gastrointestinal motility disorders, it has been associated with QT prolongation, torsades de pointes, and cardiac arrest. Only in children, however, has atrioventricular (AV) block after cisapride been reported. This study used Langendorff perfusion to determine the direct e...

journal_title：Pediatric research

authors： Wu MH,Su MJ,Sun SS

更新日期：2003-03-01 00:00:00

abstract：:Supine sleeping, recommended to prevent sudden infant death, should be started in the delivery hospital, but meets concern that neonates may exhibit more intermittent hypoxia in this position. We aimed to demonstrate that intermittent hypoxia is equally rare in supine and side position. We enrolled 609 term neonates i...

journal_title：Pediatric research

authors： Poets A,Urschitz MS,Poets CF

更新日期：2009-06-01 00:00:00

abstract：:Amplitude-integrated EEG (aEEG) is used to select patients for neuroprotective therapy after perinatal asphyxia because of its prognostic accuracy within several hours after birth. We aimed to determine the natural course of aEEG patterns during the first 72 h of life, in relation to neurologic outcome, in a group of ...

journal_title：Pediatric research

authors： ter Horst HJ,Sommer C,Bergman KA,Fock JM,van Weerden TW,Bos AF

更新日期：2004-06-01 00:00:00

abstract：:The perinatal ontogeny of preprotachykinin-A gene expression was assessed in central respiration-related structures. On the day of birth, there was an enhanced expression of preprotachykinin-A mRNA in the region of the nucleus tractus solitarii, the primary relay station for respiratory and cardiovascular reflexes. Th...

journal_title：Pediatric research

authors： Srinivasan M,Yamamoto Y,Persson H,Lagercrantz H

更新日期：1991-04-01 00:00:00

abstract：:Neonatal susceptibility to overwhelming bacterial infection is commonly attributed to a relative deficiency in serum opsonic activity. However, few studies have compared the functional capacity of the classical complement pathway with that of the alternative complement pathway in the neonate. The opsonic activity of n...

journal_title：Pediatric research

authors： Mills EL,Björksteń B,Quie PG

更新日期：1979-12-01 00:00:00

abstract：:There is significant uncertainty over the role of assessment of long-term neurodevelopmental outcome (LTO) in neonatal clinical trials. A multidisciplinary working group was established to identify key issues in this area and to make recommendations about optimal approaches to evaluate LTO in therapeutic trials in new...

journal_title：Pediatric research

authors： Marlow N,Doyle LW,Anderson P,Johnson S,Bhatt-Mehta V,Natalucci G,Darlow BA,Davis JM,Turner MA,International Neonatal Consortium (INC).

更新日期：2019-11-01 00:00:00

abstract：:The mucopolysaccharidoses (MPS) are inherited metabolic disorders resulting from the defective catabolism of glycosaminoglycans. In this report, we find that the stimulation of MPS connective tissue cells by the inflammatory cytokines causes enhanced secretion of several matrix-degrading metalloproteinases (MMPs). In ...

journal_title：Pediatric research

authors： Simonaro CM,D'Angelo M,Haskins ME,Schuchman EH

更新日期：2005-05-01 00:00:00

abstract：:Early-life stress has been shown to destabilize the homeostatic synaptic plasticity and compromise the developing brain to the later encountered insults. This study would determine the long-term epileptogenic effect of neonatal isolation (NI) on early-life seizure. There were five groups: normal rearing (NR) rats; NI ...

journal_title：Pediatric research

authors： Lai MC,Lui CC,Yang SN,Wang JY,Huang LT

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Staphylococcus epidermidis (SE) is an important cause of late-onset sepsis in neonates. SE frequently produces a polysaccharide intercellular adhesin (PIA) biofilm, important in the pathogenesis of these infections. Little is known about how the neonatal innate immune system reacts to SE biofilm-associated i...

journal_title：Pediatric research

authors： Granslo HN,Klingenberg C,Fredheim EA,Acharya G,Mollnes TE,Flægstad T

更新日期：2013-03-01 00:00:00

abstract：:BackgroundCaffeine promotes spontaneous breathing by antagonizing adenosine. We assessed the direct effect of caffeine on respiratory effort in preterm infants at birth.MethodsThirty infants of 24-30 weeks of gestation were randomized for receiving caffeine directly after birth in the delivery room (caffeine DR group)...

journal_title：Pediatric research

authors： Dekker J,Hooper SB,van Vonderen JJ,Witlox RSGM,Lopriore E,Te Pas AB

更新日期：2017-08-01 00:00:00

abstract：:Responses of pial arterioles to topically applied arachidonic acid, conversion of exogenous arachidonic acid to prostanoids, and pial arteriolar dilation to hypercapnia were examined before and at progressive times after treatment with indomethacin (5 mg/kg i.v.) in chloralose-anesthetized newborn pigs with closed cra...

journal_title：Pediatric research

authors： Leffler CW,Mirro R,Shibata M,Parfenova H,Armstead WM,Zuckerman S

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Hurricane Maria struck Puerto Rico on 20 September 2017 causing catastrophic devastation. Prolonged shortage of food had been a substantial challenge to the residents after Maria. Experiencing food insecurity in utero has been associated with negative health outcomes later in life. We aim to examine whether ...

journal_title：Pediatric research

authors： Wang L,de Ángel Solá D,Acevedo Flores M,Schriefer A,Wang L,Gerónimo López K,Chang A,Warner B,Shan L,Holtz LR,Rosario Matos N

更新日期：2020-12-01 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) causes a progressive immunodeficiency, often manifested in adults by the development of infections with relatively rare, opportunistic organisms. However, in HIV-infected children, recurrent serious infections with common encapsulated bacteria, as well as recurrent min...

journal_title：Pediatric research

authors： Mofenson LM,Moye J Jr

更新日期：1993-01-01 00:00:00

abstract：:Pulmonary surfactant proteins SP-B and SP-C were isolated from lavage fluids of bovine lungs and recombined (lipid/proteins, 9/1, wt/wt) with dipalmitoyl phosphatidylcholine for testing in vitro and in surfactant-deficient adult rats. Using a pulsating bubble surfactometer, we found that inflation pressures of bubbles...

journal_title：Pediatric research

authors： Smith GB,Taeusch HW,Phelps DS,Keough KM

更新日期：1988-05-01 00:00:00

abstract：:To define respiratory effects of peripheral acidemia during early development, we injected lactic acid (LA) into the jugular vein of 32 1- to 7-d-old rabbit pups and four adult rabbits. The body weight of newborns varied between 67 +/- 17 g in 1-d-old and 119.8 +/- 33.7 g in 7-d-old animals versus 4 +/- 0.1 kg in adul...

journal_title：Pediatric research

authors： Ducros G,Trippenbach T

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Adult human airway smooth muscle (ASM) produce cytokines involved in recruitment and survival of leukocytes within airway walls. Cytokine generation by adult ASM is glucocorticoid-sensitive. Whether developing lung ASM produces cytokines in a glucocorticoid-sensitive fashion is unknown. METHODS:Cultured fet...

journal_title：Pediatric research

authors： Pearson H,Britt RD Jr,Pabelick CM,Prakash YS,Amrani Y,Pandya HC

更新日期：2015-12-01 00:00:00

abstract：:Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine distention. Heredity is 25-40% and mostly involves the maternal genome, with contribution of the fetal genome. Si...

journal_title：Pediatric research

authors： Hallman M,Haapalainen A,Huusko JM,Karjalainen MK,Zhang G,Muglia LJ,Rämet M

更新日期：2019-03-01 00:00:00

abstract：:Our goal for this study was to determine whether the maturation of fat absorption in neonatal life is functionally related to an increased ability to hydrolyze dietary fat, to absorb long-chain fatty acids, or to do both. In 16 preterm and in eight term neonates, the intestinal ability to hydrolyze triacylglycerols an...

journal_title：Pediatric research

authors： Rings EH,Minich DM,Vonk RJ,Stellaard F,Fetter WP,Verkade HJ

更新日期：2002-01-01 00:00:00

abstract：:A number of neuromuscular diseases are associated with molecular defects in the mitochondrial DNA (mtDNA). These include: 1) a missense mutation at nucleotide 11778 in the mtDNA of Leber's hereditary optic neuropathy patients; 2) a heterogeneous array of deletions in the mtDNA of ocular myopathy patients; and 3) small...

journal_title：Pediatric research

authors： Wallace DC,Lott MT,Lezza AM,Seibel P,Voljavec AS,Shoffner JM

更新日期：1990-11-01 00:00:00

abstract：:Pediatric research may be entering a period of failure to thrive. This is despite impressive scientific achievements, significant financial benefits, intriguing unanswered questions and a rewarding life for the pediatric researcher. Many of the difficulties are financial and situational, including small departments an...

journal_title：Pediatric research

authors： Stiehm ER

更新日期：1985-06-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency encountered in the neonatal intensive care unit. Despite advances in neonatal care, NEC remains a leading cause of morbidity and mortality among premature infants. Epidemiologic studies have identified multiple factors that ...

journal_title：Pediatric research

authors： Hunter CJ,Upperman JS,Ford HR,Camerini V

更新日期：2008-02-01 00:00:00