Vagal responsiveness to gavage feeding as an index of preterm status.

Abstract:

:Vagal responsivity to orogastric stimulation is necessary for gastrointestinal function and may reflect autonomic regulation. Our study evaluated vagal responsivity during gavage feeding as an index of preterm clinical status. Vagal and behavioral responsivity of 26 preterm infants during gavage feeding was measured. Vagal tone was quantified with a noninvasive measure (vagal tone index) developed by Porges (Porges SW: U.S. patent 4,510.944, 1985), which extracts a valid measure of cardiac vagal tone from the ECG. The study investigated whether vagal tone changed during gavage feeding and whether individual differences in the vagal tone response pattern were related to clinical outcome. Infants who demonstrated an increase in vagal tone during feeding and a decrease after feeding had significantly shorter hospitalizations. This effect was independent of weight gain trajectories. Baseline levels of vagal tone were positively associated with subsequent weight gain. Traditional risk measures did not predict length of hospitalization independently of gestational age. This study represents the first documentation that small changes in cardiac vagal tone during gavage feeding, previously imperceptible to clinicians and researchers, may be quantitatively extracted from the ECG and provide an important index of clinical status.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

DiPietro JA,Porges SW

doi

10.1203/00006450-199103000-00003

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

231-6

issue

3

eissn

0031-3998

issn

1530-0447

journal_volume

29

pub_type

杂志文章
  • Pineal and adrenal effects on calcium homeostasis in the rat.

    abstract::In human infants and newborn rats, white light at the intensity used to treat hyperbilirubinemia lowers serum calcium concentration. Occipital shielding or (in newborn rats) exogenous melatonin prevents this effect. Propranolol, by inhibiting melatonin synthesis, also causes hypocalcemia, which is preventable by melat...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199006000-00006

    authors: Hakanson DO,Bergstrom WH

    更新日期:1990-06-01 00:00:00

  • Salivary cortisol levels as a biomarker for severity of withdrawal in opioid-exposed newborns.

    abstract:BACKGROUND:Scoring tools used to quantify withdrawal in infants with neonatal abstinence syndrome (NAS) are often confounded by subjective measurements. This study assessed salivary cortisol as an objective biomarker of withdrawal severity in opioid-exposed newborns. METHODS:A prospective study was conducted in 25 ful...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0601-7

    authors: Rodriguez N,Vining M,Bloch-Salisbury E

    更新日期:2020-05-01 00:00:00

  • RT-PCR detection of respiratory pathogens in newborn children admitted to a neonatal medium care unit.

    abstract:BACKGROUND:This study aimed to determine the prevalence of respiratory pathogens among newborns admitted to a neonatal medium care unit (NMCU) and to identify clinical predictors. METHODS:A 1-y observational study was performed of neonates admitted to an NMCU in Amsterdam, The Netherlands. Nasopharyngeal samples were ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2012.176

    authors: Smit PM,Pronk SM,Kaandorp JC,Weijer O,Lauw FN,Smits PH,Claas EC,Mulder JW,Beijnen JH,Brandjes DP

    更新日期:2013-03-01 00:00:00

  • Changes in hyaluronan deposition during early respiratory distress syndrome in premature monkeys.

    abstract::Increased deposition of hyaluronan (HA) is part of the early response to fibrogenic stimulus in the lung exposed to bleomycin injury and has been associated with increased lung water in adult animals. Early respiratory distress syndrome (RDS) in premature infants is characterized by increased lung water, and late sequ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199402000-00024

    authors: Juul SE,Kinsella MG,Jackson JC,Truog WE,Standaert TA,Hodson WA

    更新日期:1994-02-01 00:00:00

  • Intestinal glucose transport in suckling rats fed artificial milk with and without added epidermal growth factor.

    abstract::Epidermal growth factor (EGF), a potent mitogen present in milk, is postulated to play an important physiologic role in the ontogeny of the intestine. An artificial rat milk, free of EGF, was developed and fed to newborn rats in an effort to evaluate the physiologic role of EGF on intestinal glucose transport. Compari...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198704000-00017

    authors: Greene HL,Moore MC,Said HM,Ghishan FK,Orth DN

    更新日期:1987-04-01 00:00:00

  • Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and reduce hyperoxic lung injury in newborn mice.

    abstract::We have shown that vitamin A (VA) and retinoic acid (RA) synergistically increase lung retinyl ester content in neonatal rats. To confirm whether this biochemical synergism attenuates early neonatal hyperoxic lung injury in mice, we exposed newborn C57BL/6 mice to 95% O2 or air from birth to 4 d. The agent [vehicle, V...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3181dbac3d

    authors: James ML,Ross AC,Bulger A,Philips JB 3rd,Ambalavanan N

    更新日期:2010-06-01 00:00:00

  • Multiple acyl-CoA-dehydrogenase deficiency (MADD): use of acylcarnitines and fatty acids to monitor the response to dietary treatment.

    abstract::The treatment of multiple acyl-CoA-dehydrogenase deficiency (MADD) includes a low-fat, low-protein, high-carbohydrate diet, avoiding long fasting periods. However, there is no useful biochemical marker to determine the response to different diets or fasting periods. The aims of this study are to report a patient with ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200107000-00013

    authors: Abdenur JE,Chamoles NA,Schenone AB,Jorge L,Guinle A,Bernard C,Levandovskiy V,Fusta M,Lavorgna S

    更新日期:2001-07-01 00:00:00

  • Change in blood pressure during pubertal insulin resistance.

    abstract::To examine the levels and relationship of blood pressure and insulin during puberty, blood pressure and serum insulin were measured in 3596 subjects, aged 3-18 y, whose pubertal status was graded according to the Tanner classification. The same study protocol was repeated in two follow-up surveys 3 and 6 y later for 2...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1203/00006450-199702000-00019

    authors: Taittonen L,Uhari M,Turtinen J,Nuutinen M

    更新日期:1997-02-01 00:00:00

  • Effects of a protein-rich diet during convalescence from shigellosis on catch-up growth, serum proteins, and insulin-like growth factor-I.

    abstract::Shigellosis in children can cause growth retardation, worsening of malnutrition, and hypoproteinemia. To assess the effects of ingestion of a protein-rich diet during convalescence, 22 children aged 2 to 4 y with culture-proven shigellosis were randomly assigned after 5 d of antibiotic treatment to 21-d feeding regime...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1203/00006450-199212000-00014

    authors: Kabir I,Butler T,Underwood LE,Rahman MM

    更新日期:1992-12-01 00:00:00

  • Serum lipids and lipoproteins at birth in a biracial population: the Bogalusa heart study.

    abstract::The lipid profile, total cholesterol, triglycerides, and lipoproteins (beta-, pre-beta-, and alpha-) of cord blood, is presented for 419 black and white infants (94% of the eligible population) born during an 18-month period in Bogalusa, Louisiana. At birth, white neonates of both sexes had higher average levels than ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197808000-00011

    authors: Frerichs RR,Srinivasan SR,Webber LS,Rieth MC,Berenson GS

    更新日期:1978-08-01 00:00:00

  • Food and nutrient intakes in young adults born preterm.

    abstract::BackgroundAdults born preterm have higher levels of cardiometabolic risk factors than their term-born peers. Studies have suggested that at least those born smallest eat less healthily. We examined the association between early (<34 weeks) and late (34-36 weeks) preterm birth and diet and food preferences in adult age...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2017.301

    authors: Matinolli HM,Männistö S,Sipola-Leppänen M,Tikanmäki M,Heinonen K,Eriksson JG,Wolke D,Lano A,Järvelin MR,Vääräsmäki M,Räikkönen K,Kajantie E

    更新日期:2018-03-01 00:00:00

  • Cardiovascular risk factors in parents of short children born small for gestational age.

    abstract::Small for gestational age (SGA) children have a higher prevalence of cardiovascular risk factors at a young age. It is not known whether this increased risk is caused by their size at birth, a familial predisposition for cardiovascular disease or smallness at birth or a combination of these factors. The cardiovascular...

    journal_title:Pediatric research

    pub_type: 杂志文章,多中心研究

    doi:10.1203/PDR.0b013e3181732922

    authors: De Kort SW,Van Dijk M,Willemsen RH,Ester WA,Viet L,De Rijke YB,Hokken-Koelega AC

    更新日期:2008-07-01 00:00:00

  • Glycogenosis due to liver and muscle phosphorylase kinase deficiency.

    abstract::A four-year-old Israeli Arab boy was found to have glycogen accumulation in both liver and muscle without clinical symptoms. Liver phosphorylase kinase (PK) activity was 20% of normal, resulting in undetectable activity of phosphorylase a. Muscle PK activity was about 25% of normal, resulting in a marked decrease of p...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198104000-00002

    authors: Bashan N,Iancu TC,Lerner A,Fraser D,Potashnik R,Moses SW

    更新日期:1981-04-01 00:00:00

  • Cardiomyocyte regeneration from circulating bone marrow cells in mice.

    abstract::We investigated the role of circulating bone marrow cells (BMC) in cardiomyocyte regeneration. BMC, isolated from transgenic mice expressing enhanced green fluorescent protein (GFP), were transplanted into lethally irradiated C57BL6 mice. Five weeks after bone marrow transplantation (BMT), flow cytometric analysis for...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000078275.14079.77

    authors: Kuramochi Y,Fukazawa R,Migita M,Hayakawa J,Hayashida M,Uchikoba Y,Fukumi D,Shimada T,Ogawa S

    更新日期:2003-09-01 00:00:00

  • Hexapeptides from human milk prevent the induction of oxidative stress from parenteral nutrition in the newborn guinea pig.

    abstract:INTRODUCTION:In preterm neonates, peroxides contaminating total parenteral nutrition (TPN) contribute to oxidative stress, which is suspected to be a strong inducer of hepatic complications related to prematurity. Recently, others reported that hexapeptides derived from human milk (HM) exerted free radical-scavenging a...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2012.29

    authors: Miloudi K,Tsopmo A,Friel JK,Rouleau T,Comte B,Lavoie JC

    更新日期:2012-06-01 00:00:00

  • Ethylmalonic aciduria is associated with an amino acid variant of short chain acyl-coenzyme A dehydrogenase.

    abstract::Ethylmalonic aciduria is a common biochemical finding in patients with inborn errors of short chain fatty acid beta-oxidation. The urinary excretion of ethylmalonic acid (EMA) may stem from decreased oxidation by short chain acyl-CoA dehydrogenase (SCAD) of butyryl-CoA, which is alternatively metabolized by propionyl-...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199606000-00021

    authors: Corydon MJ,Gregersen N,Lehnert W,Ribes A,Rinaldo P,Kmoch S,Christensen E,Kristensen TJ,Andresen BS,Bross P,Winter V,Martinez G,Neve S,Jensen TG,Bolund L,Kølvraa S

    更新日期:1996-06-01 00:00:00

  • Development of gallbladder contractility in the guinea pig.

    abstract::In vitro experiments were performed to examine the contractile responsiveness of guinea pig gallbladder smooth muscle as a function of developmental age. Gallbladder muscle strips from preterm (day 50-55 gestation), newborn (days 1-3 post partum), and 1-month-old animals were stimulated with agonists that initiate the...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198603000-00003

    authors: Denehy CM,Ryan JR

    更新日期:1986-03-01 00:00:00

  • Inotropic effect of increasing concentration of Ca2+ in the fetal rat heart with retinoic acid-induced malformations.

    abstract::Cardiac malformations (pulmonary trunk stenosis, ventricular septal defect, and double outlet right ventricle) were induced by the administration of two doses of retinoic acid (RA) to Wistar rats on d 13 of pregnancy. Contractile performance of the isolated perfused rat heart and its inotropic response to Ca2+ (0.6-10...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199512000-00011

    authors: Ostádalová I,Pexieder T,Ostádal B,Kolár F

    更新日期:1995-12-01 00:00:00

  • Mitogen-activated protein kinase phosphatase-1 prevents lipopolysaccharide-induced apoptosis in immature rat intestinal epithelial cells.

    abstract:BACKGROUND:Necrotizing enterocolitis is characterized by intestinal inflammation and epithelial barrier dysfunction. Mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 plays a pivotal role in the feedback control of MAPK signaling, which regulates inflammation and apoptosis. We hypothesized that MKP-1 prevents...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2015.88

    authors: Talavera MM,Kralik N,Jin Y,Chen B,Liu Y,Nelin LD

    更新日期:2015-08-01 00:00:00

  • Thyroid hormones in human milk and their influence on thyroid function of breast-fed babies.

    abstract::Various assay methods for detection of thyroid hormones in human milk were evaluated in recovery and dilution experiments after which the concentrations of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) were measured and compared with those in serum. The effect of breast feeding on pituitary thyroid function of norma...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198306000-00008

    authors: Mizuta H,Amino N,Ichihara K,Harada T,Nose O,Tanizawa O,Miyai K

    更新日期:1983-06-01 00:00:00

  • Feasibility of long-term continuous EEG monitoring during the first days of life in preterm infants: an automated quantification of the EEG activity.

    abstract::Long-term EEG monitoring (LTM) with several electrodes could be a useful tool for surveillance of the brain during the first critical days of life. This study aimed to assess the feasibility of multichannel LTM for automated analysis of EEG activity from d 1 to 3 using eight electrodes. Premature infants (GA <31 wk; n...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e31821267d2

    authors: Schumacher EM,Westvik AS,Larsson PG,Lindemann R,Westvik J,Stiris TA

    更新日期:2011-05-01 00:00:00

  • Regional metabolic assessment of human brain during development by proton magnetic resonance spectroscopy in vivo and by high-performance liquid chromatography/gas chromatography in autopsy tissue.

    abstract::To study the course of regional metabolite concentrations during early brain development, we measured in vivo metabolites [N-acetyl-aspartate (NAA), choline-containing compounds, and myoinositol (M-Ino)] in the precentral area of the cerebrum by short echo-time single volume proton magnetic resonance spectroscopy and ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199502000-00003

    authors: Hüppi PS,Fusch C,Boesch C,Burri R,Bossi E,Amato M,Herschkowitz N

    更新日期:1995-02-01 00:00:00

  • Growth trajectories of extremely low birth weight infants from birth to young adulthood: a longitudinal, population-based study.

    abstract::We compared sex-specific growth attainment of a population-based cohort of 147/166 (89%) extremely low birthweight (ELBW < 1000 g) and 131/145 (90%) sociodemographically comparable normal birthweight (NBW) cohort at young adulthood, and examined the pattern of growth trajectories and correlates of growth at ages 1, 2,...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.pdr.0000246201.93662.8e

    authors: Saigal S,Stoskopf B,Streiner D,Paneth N,Pinelli J,Boyle M

    更新日期:2006-12-01 00:00:00

  • Regulation of ductus arteriosus patency by nitric oxide in fetal lambs: the role of gestation, oxygen tension, and vasa vasorum.

    abstract::We hypothesized that nitric oxide (NO) production by the fetal ductus arteriosus is limited because of low fetal PO2, but that at neonatal PO2, NO might be an important regulator of ductus arteriosus tone. We exposed isolated rings of fetal lamb ductus arteriosus to elevated PO2. L-NG-nitro-L-arginine methyl ester (L-...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199805000-00012

    authors: Clyman RI,Waleh N,Black SM,Riemer RK,Mauray F,Chen YQ

    更新日期:1998-05-01 00:00:00

  • Hyperprolactinemia, a tool in treatment control of tetrahydrobiopterin deficiency: endocrine studies in an affected girl.

    abstract::Severe tetrahydrobiopterin (BH4) deficiency is a naturally occurring model of cerebral catecholamine and serotonin shortage. Examination of the stimulated release and physiologic secretion pattern of several hormones in affected individuals permits certain conclusions concerning the involvement of these neurotransmitt...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199804000-00006

    authors: Birnbacher R,Scheibenreiter S,Blau N,Bieglmayer C,Frisch H,Waldhauser F

    更新日期:1998-04-01 00:00:00

  • Ontogeny of the immune system: fetal lamb as a model.

    abstract::We examined adult sheep lymphocytes for the following surface markers: Surface membrane immunoglobulin, antigen identified by anti-sheep thymocyte globulin and complement receptors. We quantitated sheep peripheral blood mononuclear leukocyte proliferative responses to mitogens and alloantigens, and demonstrated a neut...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198405000-00012

    authors: Raghunathan R,Miller ME,Wuest C,Faust J

    更新日期:1984-05-01 00:00:00

  • Neonatal group B streptococcal sepsis: effects of late treatment with dazmegrel.

    abstract::Neonatal group B streptococcal (GBS) sepsis produces pulmonary arterial hypertension and hypoxemia that are preventable by pretreatment with the selective thromboxane A2 synthase inhibitor, dazmegrel. In the present experiment we administered dazmegrel (8 mg/kg) 2 h after the initiation of a 2 1/2 h infusion of 5 X 10...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198804000-00003

    authors: Truog WE,Gibson RL,Juul SE,Henderson WR,Redding GJ

    更新日期:1988-04-01 00:00:00

  • Co-occurrence of infantile hypertrophic pyloric stenosis and congenital heart defects: a nationwide cohort study.

    abstract:BACKGROUND:Recent studies suggest that infantile hypertrophic pyloric stenosis (IHPS) and congenital heart defects (CHDs) may share some genetic risk factors, but little is known about the co-occurrence of the two conditions in patients. METHODS:Our study cohort included 2,212,756 persons born in Denmark 1977-2013. We...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0369-9

    authors: Feenstra B,Gørtz S,Lund M,Ranthe MF,Geller F,Melbye M

    更新日期:2019-06-01 00:00:00

  • Fetal leptin influences birth weight in twins with discordant growth.

    abstract::The objective of this study was to determine the plasma leptin concentrations in twin pregnancies in relation to chorionicity and discordant fetal growth. We studied 53 twin pregnancies of which 26 had growth discordance of > or =20% and 27 were concordant for growth (discordance of < or =10%). Paired maternal and fet...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200105000-00010

    authors: Sooranna SR,Ward S,Bajoria R

    更新日期:2001-05-01 00:00:00

  • Synergistic effect of influenza a virus on endotoxin-induced mortality in rat pups: a potential model for sudden infant death syndrome.

    abstract::Sudden infant death syndrome is the most common cause of postneonatal infant mortality in the developed world. It is a diagnosis of exclusion with peak age of incidence between 2 and 6 mo. Fifty to 63% of these infants have a preexisting upper respiratory tract infection before death. We hypothesized that the immature...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200210000-00005

    authors: Blood-Siegfried J,Nyska A,Lieder H,Joe M,Vega L,Patterson R,Germolec D

    更新日期:2002-10-01 00:00:00