Abstract：
:The purpose of this study was to begin to examine the influence of inhaled NO on O2 toxicity. The survival of Sprague-Dawley rats exposed to >95% O2, >95% O2 + 10 ppm NO, >95% O2 + 100 ppm NO, and >95% O2 + 3 ppm NO2 was determined. Survival at 120 h was 2/24 in >95% O2, 2/12 in >95% O2 + 10 ppm NO, and 1/12 in >95% O2 + 3 ppm NO2. Survival at 120 h was 21/30 in >95% O2 + 100 ppm NO (p < 0.01 compared with >95% O2). Three additional groups of rats were exposed for 60 h to: 21% O2, >95% O2, or >95% O2 + 100 ppm NO. The lungs were then assayed for total protein, reduced (GSH) and oxidized glutathione (GSSG), and 4-hydroxy-2(E)-nonenal. Both of the high O2 groups had significantly (p < 0.05) lower GSH/mg protein and GSH/GSSG ratios compared with the 21% O2 group. The >95% O2 group had a higher 4-hydroxy-2(E)-nonenal/mg of protein than either the 21% O2 group (p < 0.05), or the >95% O2 + 100 ppm NO group (p < 0.05 compared with >95% O2, not different from the 21% O2 group). Additional groups of rats were exposed to either 21% O2, >95% O2, or >95% O2 + 100 ppm NO for 0, 24, 48, and 60 h. The lungs were examined for neutrophil accumulation, which was increased at 60 h in the two groups exposed to >95% O2, but adding NO had no effect. Thus, the overall result was that 100 ppm inhaled NO improved the survival of rats in high O2.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Nelin LD,Welty SE,Morrisey JF,Gotuaco C,Dawson CAdoi
10.1203/00006450-199806000-00003subject
Has Abstractpub_date
1998-06-01 00:00:00pages
727-32issue
6eissn
0031-3998issn
1530-0447journal_volume
43pub_type
杂志文章abstract：:Topical emollient therapy may reduce the incidence of serious infections and mortality of preterm infants in developing countries. We tested whether emollient therapy reduced the burden of pathogens on skin and/or prevented bacterial translocation. Neonates <33 wk gestational age were randomized to treatment with sunf...
journal_title：Pediatric research
pub_type： 杂志文章,随机对照试验
doi：10.1203/pdr.0b013e3180459f75
更新日期：2007-05-01 00:00:00
abstract：:Both severe impairments of brain development in untreated infants and acute reversible neurotoxic effects on brain function are clinical features of phenylketonuria (PKU). For determining whether impairments of cerebral energy metabolism play a role in the pathophysiology of PKU, quantitative in vivo 31P magnetic reso...
journal_title：Pediatric research
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abstract：:Adverse perinatal events affecting cerebral functions are a major cause of neonatal mortality, morbidity, and long-term neurologic deficit. Intrapartum fetal EEG, which records fetal brain electrical activity, provides a monitoring modality for evaluating the fetal CNS during labor. In this study, we describe a new ap...
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doi：10.1203/00006450-200009000-00013
更新日期：2000-09-01 00:00:00
abstract：:Heme oxygenase (HO), the rate-limiting enzyme in the formation of bilirubin, is expressed in the lung and may serve as an antioxidant. This enzyme results in the formation of antioxidant bile pigments and the degradation of pro-oxidant heme. We wanted to evaluate the differences in expression of HO-1, the inducible fo...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200301000-00010
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abstract：:The in vitro incorporation and transport of plasma nonesterified fatty acids into phospholipids of red cell membranes have been studied in cystic fibrosis and healthy children. Red blood cells were labeled in vitro by an active "acyltransferase"-dependent incorporation of radioactively labeled nonesterified fatty acid...
journal_title：Pediatric research
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doi：10.1203/00006450-198209000-00011
更新日期：1982-09-01 00:00:00
abstract：:To determine the influence of an altered carotid body function on the laryngeal chemoreflex (LCR) response, reflex apnea was induced by laryngeal water stimulation during normoxia or acute hypoxia in unanesthetized awake lambs in which the ventilatory response to acute hypoxia was attenuated by prolonged postnatal hyp...
journal_title：Pediatric research
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doi：10.1203/00006450-199312000-00024
更新日期：1993-12-01 00:00:00
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pub_type： 杂志文章,评审
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abstract：:Hypothalamic growth hormone releasing hormone (GHRH) stimulates pituitary growth hormone secretion, which is essential for normal postnatal growth. Reports of an immunoreactive and biologically active GHRH-like peptide in placenta led us to investigate placental expression of GHRH mRNA. Placentas from d 19 gestation f...
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更新日期：1991-05-01 00:00:00
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更新日期：2017-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1993-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
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更新日期：1996-04-01 00:00:00
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doi：10.1203/00006450-200211000-00019
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更新日期：1981-03-01 00:00:00
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更新日期：2017-08-23 00:00:00
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更新日期：2009-02-01 00:00:00
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更新日期：1995-01-01 00:00:00
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更新日期：1994-04-01 00:00:00
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abstract：:Alveolar macrophages were isolated from three cystic fibrosis patients, and the structure and function of these cells were compared to that of normal alveolar macrophages. The cystic fibrosis (CF) and normal alveolar macrophages were able to phagocytize Pseudomonas in the presence of normal serum, but cells from both ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198005000-00003
更新日期：1980-05-01 00:00:00
