Total parenteral nutrition in the newborn: energy substrates and plasma total fatty acids.

Abstract:

:Carbohydrate and lipid intakes have both been found to modulate the metabolism of long-chain fatty acids. To define the respective influence of these two energy substrates on plasma fatty acid concentrations, 32 studies were performed in 16 parenterally fed newborn infants (mean +/- SEM, birth wt: 2.15 +/- 0.1 kg, age: 10 +/- 1 d). In a paired cross-over design, the infants received for a given level of energy (60 versus 80 kcal/kg/d) two 6-d isonitrogenous and isocaloric regimens constructed so that the level of fat intake, 1 or 3 g/kg/d varied inversely with that of glucose. Total plasma fatty acid levels did not reflect the composition of the emulsion and varied with energy substrates. Plasma levels of three fatty acids rose inversely to the lipid intake, during the high glucose regimen: 16:1w7, 20:3w9 biologic markers of essential fatty acid deficiency, and 20:3w6 a derivative of 18:2w6. Glucose intake could exert its influence on 20:3w9 and 20:3w6 via insulin, an activator of delta 6 desaturase. Both glucose and fat should be taken into account when evaluating plasma fatty acid profile.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Pineault M,Lepage G,Bisaillon S,Roy CC,Chessex P

doi

10.1203/00006450-198910000-00002

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

290-3

issue

4

eissn

0031-3998

issn

1530-0447

journal_volume

26

pub_type

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