Utility of cytokines to predict neonatal sepsis.

abstract：:Very young children with organic brain damage, intractable seizures, and developmental retardation are at particular risk of developing fatal hepatic dysfunction coincident with valproate therapy, especially if the children are also receiving other anticonvulsant drugs. The mechanism of valproate-associated hepatic fa...

journal_title：Pediatric research

authors： Thurston JH,Hauhart RE

更新日期：1992-04-01 00:00:00

abstract：:Supine sleeping, recommended to prevent sudden infant death, should be started in the delivery hospital, but meets concern that neonates may exhibit more intermittent hypoxia in this position. We aimed to demonstrate that intermittent hypoxia is equally rare in supine and side position. We enrolled 609 term neonates i...

journal_title：Pediatric research

authors： Poets A,Urschitz MS,Poets CF

更新日期：2009-06-01 00:00:00

abstract：:BackgroundPatent ductus arteriosus (PDA) is a common complication seen in preterm infants. Indomethacin is routinely used to treat PDA. Evidence suggests that the response of indomethacin is highly heritable. This study investigated the association between single-nucleotide polymorphisms (SNPs) in CYP2C9 and the closu...

journal_title：Pediatric research

authors： Smith CJ,Ryckman KK,Bahr TM,Dagle JM

更新日期：2017-11-01 00:00:00

abstract：:Alterations in thermoregulatory mechanisms related to sleep state may play an important role in the problems of homeostasis experienced by the premature infant. In the adult, homeothermic regulation of body temperature may be suspended during REM. We measured oxygen consumption (VO2) in six premature infants 33-35 wk ...

journal_title：Pediatric research

authors： Darnall RA Jr,Ariagno RL

更新日期：1982-07-01 00:00:00

abstract：:The field of regenerative medicine continues to make substantial advancements in therapeutic strategies addressing urologic diseases. Tissue engineering borrows principles from the fields of cell biology, materials science, transplantation and engineering in an effort to repair or replace damaged tissues. This review ...

journal_title：Pediatric research

authors： Yamzon JL,Kokorowski P,Koh CJ

更新日期：2008-05-01 00:00:00

abstract：:Late Onset Central Hypoventilation Syndrome associated with Hypothalamic Dysfunction (LO-CHS/HD) is a distinct entity among the clinical and genetic heterogeneous group of patients with late onset central hypoventilation. Here we report a series of 13 patients with LO-CHS/HD. Rapid onset obesity is the first symptom o...

journal_title：Pediatric research

authors： De Pontual L,Trochet D,Caillat-Zucman S,Abou Shenab OA,Bougneres P,Crow Y,Cunningham S,Esteva B,Heberle LC,Leger J,Pinto G,Polak M,Shafik MH,Straus C,Trang H,Munnich A,Lyonnet S,Desguerre I,Amiel J

更新日期：2008-12-01 00:00:00

abstract：:Prematurity is associated with delayed postnatal activation of mitochondrial oxidative phosphorylation and impaired switch from glycolytic to oxidative metabolism. Fatty acids (FA), which represent a major energy substrate in mature muscle cells, are engaged in the postnatal activation of genes of energy metabolism an...

journal_title：Pediatric research

authors： Brauner P,Kopecký P,Flachs P,Ruffer J,Sebron V,Plavka R,Vítková I,Vorlícek J,Kopecký J

更新日期：2003-04-01 00:00:00

abstract：:This study examined the relationships between cerebral fractional oxygen extraction (FOE), mean arterial blood pressure (MABP), left ventricular output (LVO), blood gases, and other physiologic variables in 36 very-low-birth-weight preterm infants during the first 3 d after birth. There was a decrease in cerebral FOE ...

journal_title：Pediatric research

authors： Kissack CM,Garr R,Wardle SP,Weindling AM

更新日期：2004-03-01 00:00:00

abstract：:Various assay methods for detection of thyroid hormones in human milk were evaluated in recovery and dilution experiments after which the concentrations of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) were measured and compared with those in serum. The effect of breast feeding on pituitary thyroid function of norma...

journal_title：Pediatric research

authors： Mizuta H,Amino N,Ichihara K,Harada T,Nose O,Tanizawa O,Miyai K

更新日期：1983-06-01 00:00:00

abstract：:Prolonged unconjugated hyperbilirubinemia in infants associated with breast milk feeding is a common pediatric problem known as breast milk jaundice (BMJ). A polymorphic mutation (G71R) of bilirubin UDP-glucuronosyltransferase (UGT1A1) is a known cause of BMJ on the infantile side, but the responsible components of br...

journal_title：Pediatric research

authors： Ota Y,Maruo Y,Matsui K,Mimura Y,Sato H,Takeuchi Y

更新日期：2011-11-01 00:00:00

abstract：:The zeta subunit of the CD3 T-cell receptor complex and the major histocompatibility complex class 1 (MHC-I) are important not only for the immune response to antigens, they also function as signal molecules in the brain, where they play a role in the postnatal maturation process. The expression of these molecules can...

journal_title：Pediatric research

authors： Sourial-Bassillious N,Eklöf AC,Scott L,Aperia A,Zelenin S

更新日期：2006-10-01 00:00:00

abstract：:Wolfram syndrome 1 (WS1) is a rare autosomal recessive neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and other abnormalities. WS1 usually results in death before the age of 50 years. The pathogenesis of WS1 is ascribed to mutations of human WFS1 gene on chro...

journal_title：Pediatric research

authors： Rigoli L,Bramanti P,Di Bella C,De Luca F

更新日期：2018-05-01 00:00:00

abstract：:Mother's milk represents a foundational step in the proper development of newborn immunity. This is achieved, in part, through the action of numerous regulatory proteins such as soluble cluster of differentiation 14 (sCD14) found in significant quantities in human milk (~25-50 μg/mL). In adults, CD14 stimulates cytoki...

journal_title：Pediatric research

authors： Spencer WJ,Binette A,Ward TL,Davis LD,Blais DR,Harrold J,Mack DR,Altosaar I

更新日期：2010-12-01 00:00:00

abstract：:The growth hormone-releasing hexapeptide (GHRP-6) specifically stimulates growth hormone (GH) secretion in several animal species and humans. The mechanism of action of GHRP-6 is largely unknown, although experimental evidence indicates that it may modulate growth hormone-releasing hormone (GHRH) and somatostatin acti...

journal_title：Pediatric research

authors： Locatelli V,Grilli R,Torsello A,Cella SG,Wehrenberg WB,Müller EE

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The pathogenesis of neonatal group B Streptococcus (GBS) lung infection may be associated with surfactant dysfunction or deficiency. This study aimed to investigate the efficacy of surfactants on early postnatal GBS infection in ventilated newborn rabbit lungs. METHODS:A near-term newborn rabbit model was e...

journal_title：Pediatric research

authors： Xu Y,Dong Y,Guo X,Sun B

更新日期：2019-08-01 00:00:00

abstract：:The lymphocytes of human breast milk have been previously shown to be immunologically competent while the monocytes have been described as actively motile in some reports but not in another. Cells were separated from milk samples collected by lactating women 2 to 9 days postpartum. Milk cell migration and production o...

journal_title：Pediatric research

authors： Hawes CS,Jones WR

更新日期：1985-10-01 00:00:00

abstract：:The purpose of this investigation was twofold: (1) to identify and characterize the enzymatic ATP hydrolysis system of epithelial cilia, and (2) to develop a quantitative, biochemical test for the ciliotoxic cystic fibrosis (CF) factor based on inhibition of ATP utilization by ciliary preparations. Our rationale for s...

journal_title：Pediatric research

authors： Farrell PM,Fox GN,Spicer SS

更新日期：1976-02-01 00:00:00

abstract：:Inhibition of Pseudomonas cepacia (but not Pseudomonas aeruginosa) by beta-lactams was decreased in 5% CO2 in air compared with air alone. The effect of CO2 and pH (range, 6.0 to 8.0) on beta-lactam susceptibility, beta-lactamase expression, and outer membrane proteins was studied in isolates recovered from the sputum...

journal_title：Pediatric research

authors： Corkill JE,Deveney J,Pratt J,Shears P,Smyth A,Heaf D,Hart CA

更新日期：1994-03-01 00:00:00

abstract：:In vitro experiments were performed to examine the contractile responsiveness of guinea pig gallbladder smooth muscle as a function of developmental age. Gallbladder muscle strips from preterm (day 50-55 gestation), newborn (days 1-3 post partum), and 1-month-old animals were stimulated with agonists that initiate the...

journal_title：Pediatric research

authors： Denehy CM,Ryan JR

更新日期：1986-03-01 00:00:00

abstract：:Indomethacin is used to constrict the patent ductus arteriosus in premature infants. To clarify possible prostanoid receptor antagonists that can constrict the ductus, we studied in vivo constriction of the fetal and neonatal ductus arteriosus by AE3-208, a prostanoid EP4-receptor antagonist, in rats. Following quick ...

journal_title：Pediatric research

authors： Momma K,Toyoshima K,Takeuchi D,Imamura S,Nakanishi T

更新日期：2005-11-01 00:00:00

abstract：:Kawasaki disease, which is characterized by systemic vasculitis causing coronary arterial involvement in childhood, shows a variety of immunoregulatory abnormalities. Especially the direct or indirect deleterious effects on endothelial cells of cytokines and anti-endothelial cell antibodies (AECA) are considered to be...

journal_title：Pediatric research

authors： Sakata K,Kita M,Imanishi J,Onouchi Z,Liu Y,Mitsui Y

更新日期：1995-10-01 00:00:00

abstract：:Lung development progresses through a process reliant on mechanical cell stretch. However, this process is not well defined at the molecular level. Our goal was to globally analyze the transcriptome of fetal mouse lungs following short periods of tracheal occlusion (TO) to identify cellular processes that are rapidly ...

journal_title：Pediatric research

authors： Seaborn T,St-Amand J,Cloutier M,Tremblay MG,Maltais F,Dinel S,Moulin V,Khan PA,Piedboeuf B

更新日期：2008-02-01 00:00:00

abstract：:BackgroundPregnant women at a high risk of preterm delivery receive glucocorticoids to accelerate fetal lung maturation and surfactant synthesis. However, the effect of antenatal steroids on the developing diaphragm remains unclear. We hypothesized that maternal betamethasone impairs the fetal diaphragm, and the magni...

journal_title：Pediatric research

authors： Mahzabin T,Pillow JJ,Pinniger GJ,Bakker AJ,Noble PB,White RB,Karisnan K,Song Y

更新日期：2017-09-01 00:00:00

abstract：:The use of erythrocyte entrapment as a strategy to deliver and protect exogenously administered enzymes for replacement therapy in selected genetic diseases has been evaluated in a mammalian model system. The uptake, tissue distribution, intracellular localization, and in vivo lifetime of erythrocyte-entrapped bovine ...

journal_title：Pediatric research

authors： Thorpe SR,Fiddler MB,Desnick RJ

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Clinicians could modify dietary interventions during early infancy by monitoring fat and fat-free mass accretion in very preterm infants. METHODS:Preterm infants were randomly assigned to either having reports on infant body composition available to the clinicians caring for them (intervention group) or not...

journal_title：Pediatric research

authors： Salas AA,Jerome ML,Chandler-Laney P,Ambalavanan N,Carlo WA

更新日期：2020-11-01 00:00:00

abstract：:A child diagnosed at birth as deficient in red blood cell adenosine deaminase (ADA) but with substantial residual lymphocyte ADA has been evaluated for two and one-half years. The only immunologic abnormality observed was hypogammaglobulinemia during the fifth month of life. This was unexpected because children with t...

journal_title：Pediatric research

authors： Borkowsky W,Gershon AA,Shenkman L,Hirschhorn R

更新日期：1980-07-01 00:00:00

abstract：:Platelet volume was measured in 20 healthy children, 18 patients with acute idiopathic thrombocytopenic purpura (ITP), 24 patients with chronic ITP, 22 patients with aplastic anemia, and 17 patients with acute leukemia in childhood. The authors compared the platelet volume of these patients by use of peak platelet vol...

journal_title：Pediatric research

authors： Tomita E,Akatsuka JI,Kokubun Y

更新日期：1980-02-01 00:00:00

abstract：:This study aimed to characterize early neonatal microvascular function after preeclamptic pregnancy with respect to infant sex and in utero growth. Peripheral microvascular blood flow was examined prospectively from 6 to 72 h of age using laser Doppler flowmetry in a cohort of term infants of normotensive women and wo...

journal_title：Pediatric research

authors： Stark MJ,Clifton VL,Wright IM

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs). To develop interventions to prevent recurrent infections, household attributes and individual practices influencing S. aureus colonization must be discerned. METHODS:Households of healthy children with methicillin-resista...

journal_title：Pediatric research

authors： Mork RL,Hogan PG,Muenks CE,Boyle MG,Thompson RM,Morelli JJ,Sullivan ML,Gehlert SJ,Ross DG,Yn A,Bubeck Wardenburg J,Rzhetsky A,Burnham CD,Fritz SA

更新日期：2018-11-01 00:00:00

abstract：:We have shown that cerebellar injury in the premature infant is followed by significant growth impairment of the contralateral cerebral hemisphere evident as early as term adjusted age. In this study, we hypothesize that this remote growth restriction is region specific in the cerebrum. In a prospectively enrolled coh...

journal_title：Pediatric research

authors： Limperopoulos C,Chilingaryan G,Guizard N,Robertson RL,Du Plessis AJ

更新日期：2010-08-01 00:00:00