Amelioration of adverse effects of valproic acid on ketogenesis and liver coenzyme A metabolism by cotreatment with pantothenate and carnitine in developing mice: possible clinical significance.

abstract：:Previous studies in adults have shown that chronic pulmonary hypertension is associated with decreased endothelial nitric oxide synthase (eNOS) expression in pulmonary arteries. However, the role of decreased eNOS expression in persistent pulmonary hypertension of the newborn (PPHN) is unknown. We investigated the hyp...

journal_title：Pediatric research

authors： Villanueva ME,Zaher FM,Svinarich DM,Konduri GG

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Cardiovascular (CV) complications are the most significant cause of mortality in adults with Cushing disease (CD); little is known about CV risk factors in children with CD. Measurement of lipoprotein particles by nuclear magnetic resonance (NMR) spectroscopy is a novel technology to assess CV risk. The obje...

journal_title：Pediatric research

authors： Makri A,Cheung A,Sinaii N,Remaley AT,Sampson M,Keil M,Belyavskaya E,Lyssikatos C,De La Luz Sierra M,Stratakis CA,Lodish M

更新日期：2019-09-01 00:00:00

abstract：:Thyrotropin releasing hormone (TRH) and its precursor peptide pGlu-His-Pro-Gly (TRH-Gly) were measured in serum and in a variety of tissues of developing rats using specific RIA. TRH and TRH-Gly immunoreactivities were detected in most tissues. TRH concentrations were highest in pancreas, in which mean (+/- SEM) TRH c...

journal_title：Pediatric research

authors： Fuse Y,Polk DH,Lam RW,Fisher DA

更新日期：1991-07-01 00:00:00

abstract：:The ontogeny of glutamine uptake by jejunal brush border membrane vesicles was studied in suckling and weanling rats and compared with the data obtained from previous studies done on adult rats in our laboratory. Glutamine uptake represented transport into the intravesicular space rather than mere binding into the mem...

journal_title：Pediatric research

authors： al-Mahroos FT,Bulus N,Abumrad N,Said H,Ghishan FK

更新日期：1990-05-01 00:00:00

abstract：:A method is developed for the detection of homozygotes and heterozygote carriers of Niemann-Pick disease type A by employing a high performance liquid chromatography (HPLC) technique for the measurement of sphingomyelin (SP) as well as for the assay of the enzyme sphingomyelinase (SPase) in skin fibroblasts and amniot...

journal_title：Pediatric research

authors： Jungalwala FB,Milunsky A

更新日期：1978-05-01 00:00:00

abstract：:Periventricular leukomalacia (PVL), the major substrate of neurologic deficits in premature infants, is associated with reduced white matter volume. Using immunomarkers of axonal pathology [beta-amyloid precursor protein (beta-APP) and apoptotic marker fractin], we tested the hypothesis that widespread (diffuse) axona...

journal_title：Pediatric research

authors： Haynes RL,Billiards SS,Borenstein NS,Volpe JJ,Kinney HC

更新日期：2008-06-01 00:00:00

abstract：:Aspiration is a major cause of lung disease in infants and young children. As the symptoms and signs of aspiration are not specific, the diagnosis is delayed due to a low index of suspicion and low sensitivity and specificity of the available diagnostic tests. In the present study, we evaluated the utility of microsph...

journal_title：Pediatric research

authors： Springer C,Benita S,Sherman Y,Gursoy N,Gilhar D,Avital A

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The effect of birth location on hypothermia-related outcomes has not been rigorously examined in the literature. In this study, we determined whether birth location had an impact on the benefits of whole-body cooling to 33.5 °C for 72 h in term infants (n = 208) with hypoxic-ischemic encephalopathy (HIE) who...

journal_title：Pediatric research

authors： Natarajan G,Pappas A,Shankaran S,Laptook AR,Walsh M,McDonald SA,Ehrenkranz RA,Tyson JE,Goldberg RN,Bara R,Higgins RD,Das A,Munoz B

更新日期：2012-10-01 00:00:00

abstract：:The lipid profile, total cholesterol, triglycerides, and lipoproteins (beta-, pre-beta-, and alpha-) of cord blood, is presented for 419 black and white infants (94% of the eligible population) born during an 18-month period in Bogalusa, Louisiana. At birth, white neonates of both sexes had higher average levels than ...

journal_title：Pediatric research

authors： Frerichs RR,Srinivasan SR,Webber LS,Rieth MC,Berenson GS

更新日期：1978-08-01 00:00:00

abstract：:Extracellular glutathione peroxidase (E-GPx) is a selenoenzyme that reduces hydrogen peroxide and organic peroxides. All plasma glutathione peroxidase (GPx) activity in humans is attributable to E-GPx. The gastrointestinal (GI) tract also synthesizes and secretes E-GPx into the extracellular milieu. Endogenously gener...

journal_title：Pediatric research

authors： Tham DM,Whitin JC,Cohen HJ

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:To understand the increased susceptibility of preterm neonates to infection. METHODS:A murine listeriosis model using immunohistochemistry, microarray technology, and real-time polymerase chain reaction (PCR). RESULTS:We report that recombinant serum amyloid A (SAA) administered prophylactically 18 h befor...

journal_title：Pediatric research

authors： Hawkins JS,Wu Q,Wang Y,Lu CY

更新日期：2013-12-01 00:00:00

abstract：:In seven patients with mucopolysaccharidoses (1 Hurler, 1 Hurler-Scheie, 4 Hunter, 1 Sly), cranial (1)H-magnetic resonance spectroscopy was performed to evaluate the accumulation of mucopolysaccharides and biochemical changes in the CNS in vivo before and after bone marrow transplantation (BMT). In two of seven patien...

journal_title：Pediatric research

authors： Takahashi Y,Sukegawa K,Aoki M,Ito A,Suzuki K,Sakaguchi H,Watanabe M,Isogai K,Mizuno S,Hoshi H,Kuwata K,Tomatsu S,Kato S,Ito T,Kondo N,Orii T

更新日期：2001-03-01 00:00:00

abstract：:Tonsillectomy and adenoidectomy (T&A) is a frequent surgical procedure in children with obstructive sleep apnea (OSA). Many symptomatic children who do not fulfill the currently recommended criteria for T&A may benefit from topical intranasal steroid therapy. However, the expression of glucocorticoid receptor (GCR) ex...

journal_title：Pediatric research

authors： Goldbart AD,Veling MC,Goldman JL,Li RC,Brittian KR,Gozal D

更新日期：2005-02-01 00:00:00

abstract：:Infants with sudden infant death syndrome have higher hypoxanthine (Hx) concentrations in their vitreous humor than infants with respiratory distress syndrome and other infant control populations. However, previous research on piglets and pigs applying continuous hypoxemia has not been able to reproduce the concentrat...

journal_title：Pediatric research

authors： Stoltenberg L,Rootwelt T,Oyasaeter S,Rognum TO,Saugstad OD

更新日期：1993-12-01 00:00:00

abstract：:Cell-mediated immunity is not well characterized in very low birth weight infants, and abnormalities may represent a significant vulnerability to infection. This report describes 165 serial studies in 58 infants between 700 and 1300 g birth weight during the first 8 wk of life. Two ml of blood were drawn at 2-wk inter...

journal_title：Pediatric research

authors： Bussel JB,Cunningham-Rundles S,LaGamma EF,Shellabarger M

更新日期：1988-05-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a common pulmonary complication in preterm infants that leads to fibrosis of the bronchoalveolar walls and often to severe clinical consequences. Type III collagen is deposited early in progressive fibrosis. Because the N-terminal propeptide of type III collagen (PIIINP), a by-produ...

journal_title：Pediatric research

authors： Heikinheimo M,Halila R,Marttinen E,Raivio K

更新日期：1992-04-01 00:00:00

abstract：:A new animal experimental model of human neuroblastoma is described. The model involves xenotransplantation of a poorly differentiated human neuroblastoma cell line (SH-SY5Y) to the subcutaneous tissue in the hind leg of nude rats (WAG mu/rnu). Injection of 20 million cells suspended in 0.2 mL of medium in each hind l...

journal_title：Pediatric research

authors： Wassberg E,Påhlman S,Westlin JE,Christofferson R

更新日期：1997-03-01 00:00:00

abstract：:We investigated, using a human placental choriocarcinoma cell line as a model, the effects of the immunosuppressive drug cyclosporin A on several placental transport systems mediating the transfer of glucose and amino acids from mother to fetus. The results of the investigation show that the transport system responsib...

journal_title：Pediatric research

authors： Ramamoorthy S,Leibach FH,Mahesh VB,Ganapathy V

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Despite substantial heritability in pubertal development, children differ in maturational tempo. HYPOTHESES:(i) puberty and its duration are influenced by early changes in height and adiposity. (ii) Adiposity rebound (AR) is a marker for pubertal tempo. METHODS:We utilized published prospective data from 6...

journal_title：Pediatric research

authors： German A,Shmoish M,Hochberg Z

更新日期：2015-10-01 00:00:00

abstract：:To investigate the detailed pattern of change in circulating gonadotropin and testosterone concentrations around the onset of puberty and to determine the temporal relationship between the gonadotropin and testosterone secretion, plasma gonadotropin and testosterone were measured at 20-min intervals for 24 h in 21 nor...

journal_title：Pediatric research

authors： Goji K,Tanikaze S

更新日期：1993-08-01 00:00:00

abstract：:Bone disease is an important complication among very low birth weight (VLBW, <1500 g) infants. In adults, osteoporosis is associated with polymorphisms of vitamin D receptor (VDR), estrogen receptor (ER), and collagen Ialpha1 (COLIA1) genes. However, limited information is available regarding the role of these polymor...

journal_title：Pediatric research

authors： Funke S,Morava E,Czakó M,Vida G,Ertl T,Kosztolányi G

更新日期：2006-11-01 00:00:00

abstract：:Pregnane steroids have sedative and neuroprotective effects on the brain, due to interactions with the steroid-binding site of the GABAA receptor. In the adult brain, synthesis of the pregnane steroids is increased in response to stress. Therefore, we have used umbilicoplacental embolization to mimic chronic placental...

journal_title：Pediatric research

authors： Nguyen PN,Billiards SS,Walker DW,Hirst JJ

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Congenital portosystemic shunt (CPSS) has the potential to cause hepatic encephalopathy and thus needs long-term follow-up, but an effective follow-up method has not yet been established. We aimed to evaluate the importance of per-rectal portal scintigraphy (PRPS) for long-term follow-up of CPSS. METHODS:We...

journal_title：Pediatric research

authors： Cho Y,Tokuhara D,Shimono T,Yamamoto A,Higashiyama S,Kotani K,Kawabe J,Okano Y,Shiomi S,Shintaku H

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:There is an emerging evidence that pulmonary hypertension is associated with amino acid, carnitine, and thyroid hormone aberrations. We aimed to characterize metabolic profiles measured by the newborn screen (NBS) in infants with persistent pulmonary hypertension of the newborn (PPHN) METHODS: Nested case-co...

journal_title：Pediatric research

authors： Steurer MA,Oltman S,Baer RJ,Feuer S,Liang L,Paynter RA,Rand L,Ryckman KK,Keller RL,Jelliffe-Pawlowski LL

更新日期：2018-08-01 00:00:00

abstract：:Ventilation of immature airways has been shown to result in pressure-induced deformation and alteration of mechanical properties. These changes in mechanical properties may alter the effect of compressive pressures on pressure-flow relationships. To test this hypothesis, unventilated (Group I, n = 8) and ventilated (g...

journal_title：Pediatric research

authors： Penn RB,Wolfson MR,Shaffer TH

更新日期：1988-05-01 00:00:00

abstract：:The change in the pattern of biotransformation of [14C]corticosterone in fetal mouse brain between gestational day 14 and 17 increased the proportion of unchanged hormone from 9-75%. A sharp decrease in the in vitro incorporation of [14C]leucine, [3H]uridine, and [3H]thymidine into incubated brain coincided with this ...

journal_title：Pediatric research

authors： Tye LM,Michaud NJ,Burton AF

更新日期：1978-12-01 00:00:00

abstract：:Hypothermia is a frequent occurrence in newborns, and thermoregulatory management is a fundamental part of medical stabilization. Although modest reduction in brain temperature (2-3 degrees C) before ischemia provides neuroprotection in adults, the effect of modest hypothermia on immature brain has not been examined. ...

journal_title：Pediatric research

authors： Laptook AR,Corbett RJ,Sterett R,Burns DK,Tollefsbol G,Garcia D

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The genetic basis of dysfunctional immune responses in necrotizing enterocolitis (NEC) remains unknown. We hypothesized that variants in nucleotide binding and oligomerization domain (NOD)-like receptors (NLRs) and autophagy (ATG) genes modulate vulnerability to NEC. METHODS:We genotyped a multi-center coho...

journal_title：Pediatric research

authors： Sampath V,Bhandari V,Berger J,Merchant D,Zhang L,Ladd M,Menden H,Garland J,Ambalavanan N,Mulrooney N,Quasney M,Dagle J,Lavoie PM,Simpson P,Dahmer M

更新日期：2017-04-01 00:00:00

abstract：:We have shown that cerebellar injury in the premature infant is followed by significant growth impairment of the contralateral cerebral hemisphere evident as early as term adjusted age. In this study, we hypothesize that this remote growth restriction is region specific in the cerebrum. In a prospectively enrolled coh...

journal_title：Pediatric research

authors： Limperopoulos C,Chilingaryan G,Guizard N,Robertson RL,Du Plessis AJ

更新日期：2010-08-01 00:00:00

abstract：:Hyperprostaglandin E syndrome (HPS), the prenatal variant of Bartter's syndrome, is characterized by a marked and selective stimulation of prostaglandin E (PGE2) synthesis. In the study group HPS patients showed increased urinary levels of PGE2, an index of renal, and of 11 alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor...

journal_title：Pediatric research

authors： Nüsing RM,Schaub TP,Klein T,Schweer H,Seyberth HW

更新日期：1997-08-01 00:00:00