Abstract：
:Thyrotropin releasing hormone (TRH) and its precursor peptide pGlu-His-Pro-Gly (TRH-Gly) were measured in serum and in a variety of tissues of developing rats using specific RIA. TRH and TRH-Gly immunoreactivities were detected in most tissues. TRH concentrations were highest in pancreas, in which mean (+/- SEM) TRH concentrations were 138 +/- 20 pmol/g wet tissue 2 d before birth and 644 +/- 80 and 586 +/- 86 pmol/g, respectively, 2 and 5 d after birth. Hypothalamic TRH levels gradually increased from 4 d before birth (12 +/- 2.5 pmol/g) to 77 d of postnatal age (348 +/- 33 pmol/g). Hypothalamic concentrations were lower than levels in pancreas until 13 d of age. The mean serum TRH level at 2 d was 80 +/- 20 pmol/L and fell to the adult range by 21 d. TRH-Gly concentrations were highest in small gut (371 +/- 64 pmol/g) during the neonatal period, falling gradually to adult levels (33 +/- 4.8 pmol/g) by 35 d. Mean hypothalamic TRH-Gly concentrations increased to a peak of 62 +/- 4.5 pmol/g at 13 d, falling thereafter. High TRH-Gly concentrations (greater than 100 pmol/g) also were observed in pancreas (at d 2), kidney, and pituitary gland (at d 21). Serum TRH-Gly concentrations were highest (mean 417 +/- 26 pmol/L) on the 2nd postnatal day and gradually decreased to the adult level by 35 d. Changes in the TRH-Gly/TRH ratio were inversely correlated with tissue TRH concentrations in hypothalamus, pancreas, and liver.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Fuse Y,Polk DH,Lam RW,Fisher DAdoi
10.1203/00006450-199107000-00006subject
Has Abstractpub_date
1991-07-01 00:00:00pages
28-33issue
1eissn
0031-3998issn
1530-0447journal_volume
30pub_type
杂志文章abstract：INTRODUCTION:Cerebral white-matter (WM) abnormalities on magnetic resonance imaging (MRI) correlate with neurodevelopmental disability in infants born prematurely. RESULTS:Quantitative histological measures of WM and ventricular volumes correlated with qualitative MRI scores of WM volume loss and ventriculomegaly. Dif...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2011.33
更新日期：2012-02-01 00:00:00
abstract：:The cerebral metabolic effects of hypoglycemia due to intrauterine growth retardation were studied in newborn dogs. Intrauterine growth retardation was induced in newborn dogs after 3 days of maternal nutritional deprivation (birth weight 251 +/- 7 versus 227 +/- 7 g, p less than 0.01). After birth, growth retarded pu...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198811000-00022
更新日期：1988-11-01 00:00:00
abstract：:The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between clinically obese black and white children and if a difference existed to determine whether it was related to hematological profiles and/or physical activity/inactivity levels. Twenty-three black and 21 white...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000176909.66057.a3
更新日期：2005-09-01 00:00:00
abstract：:The role of microbial colonization is indispensable for keeping a balanced immune response in life. However, the events that regulate the establishment of the microbiota, their timing, and the way in which they interact with the host are not yet fully understood. Factors such as gestational age, mode of delivery, envi...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2015.54
更新日期：2015-06-01 00:00:00
abstract：INTRODUCTION:To examine the immune-modulatory effects of probiotics during early infancy, Bifidobacterium breve M-16V (B. breve) was administered to rat pups during the newborn or weaning period, and the expression of inflammatory genes was investigated using a cDNA microarray and real-time PCR. RESULTS:After B. breve...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2011.11
更新日期：2012-01-01 00:00:00
abstract：:Changes in high-density lipoprotein (HDL) subclass distribution were evaluated in a group of premature infants during the early postnatal period to ascertain whether enteral feeding brought about a rapid shift from neonatal to adult-like distributions. All infants were fed a combination of breast milk and formula. Cor...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198806000-00001
更新日期：1988-06-01 00:00:00
abstract：:There is significant uncertainty over the role of assessment of long-term neurodevelopmental outcome (LTO) in neonatal clinical trials. A multidisciplinary working group was established to identify key issues in this area and to make recommendations about optimal approaches to evaluate LTO in therapeutic trials in new...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/s41390-019-0526-1
更新日期：2019-11-01 00:00:00
abstract：:The ontogenetic renal responsiveness to exogenous cortisol was examined in the chronically cannulated ovine fetus. The contribution of effects at proximal and distal tubule of the kidney were studied also. Cortisol (81.5 micrograms/h) was infused into immature ovine fetuses (mean gestational age -113.9 days) on five o...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198907000-00002
更新日期：1989-07-01 00:00:00
abstract：:Previous studies in mature fetal sheep have shown that alcohol depresses cerebral blood flow (CBF), cerebral O2 consumption (CMRO2), and cerebral glucose consumption (CMRglu). This effect earlier in gestation might contribute to the pathogenesis of fetal alcohol syndrome. Physiologic studies of immature fetal sheep ha...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199206000-00021
更新日期：1992-06-01 00:00:00
abstract：BACKGROUND:Irisin is a myokine secreted by skeletal muscle during physical activity. Irisin treatment increased cortical bone mineral density (BMD) in young healthy mice and restored bone and muscle mass loss in a mouse model of disuse-induced osteoporosis and muscular atrophy. In humans, Irisin was positively correlat...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-019-0278-y
更新日期：2019-03-01 00:00:00
abstract：:We studied the effect of maternal concentration and mode of administration on transfer rate of TSH-releasing hormone (TRH) in an in vitro model of dually perfused isolated lobule of human term placenta. Varying concentrations (4-40 microg dL(-1)) of TRH were added either to the open maternal circulation to mimic an in...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199705000-00012
更新日期：1997-05-01 00:00:00
abstract：:BackgroundTo investigate the association between electronic cigarette (e-cig) use and smoking cessation among smokers who called the Youth Quitline in Hong Kong.MethodsThis longitudinal study collected data on youth smokers' (N=189) use and perception of e-cigs, conventional cigarette smoking behavior, and sociodemogr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.80
更新日期：2017-07-01 00:00:00
abstract：:Developmental disability, intrauterine growth retardation, renal anomalies, and dysmorphic features have been described in offspring of women who abuse toluene during pregnancy. A Sprague-Dawley rat model was developed to study this clinical syndrome. During d 6-19 of gestation, 11 treated dams received daily gavage d...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199412000-00023
更新日期：1994-12-01 00:00:00
abstract：:Circadian rhythms of plasma renin activity (PRA) and plasma aldosterone (PA) were studied in eight healthy children, 7 to 15 years old. Blood samples were obtained at 7:00 AM, 10:00 AM, 1:00 PM, 4:00 PM, 5:00 PM, 8.00 PM, and midnight on day 1 and 4:00 AM and 7:00 AM on day 2. Children had normal activity during this ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198205000-00007
更新日期：1982-05-01 00:00:00
abstract：:Several hours after an hypoxic-ischemic injury to the developing brain, hyperemia, then seizures, edema, and infarction can develop. The roles of nitric oxide (NO) synthesis and excitotoxin accumulation during these later phases of injury are not known. The time course of extracellular levels of amino acids within the...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199605000-00008
更新日期：1996-05-01 00:00:00
abstract：:Sequential magnitude and the rate of change in tracheal mechanics after application of intermittent positive pressure (IPP), and the time constant, tau, of this deformation were determined in fetal (21 and 27 days gestation), neonatal (term, 31 days gestation) and adult rabbits. In vitro tracheal mechanics were determ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198210000-00006
更新日期：1982-10-01 00:00:00
abstract：:Monocyte chemoattractant protein-1 (MCP-1), acting through its C-C chemokine receptor 2 (CCR-2), has important roles in inflammation, angiogenesis, and wound repair. The individual and combined effects of inhaled nitric oxide (NO) and hyperoxia on lung MCP-1 and CCR-2 in relation to lung leukocyte dynamics are unknown...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200111000-00017
更新日期：2001-11-01 00:00:00
abstract：:BackgroundHyperoxic lung injury is characterized by cellular damage from high oxygen concentrations that lead to an inflammatory response and it disrupts normal alveolarization in the developing newborn lung. Adenosine is a signaling molecule that is generated extracellularly by ecto-5'-nucleotidase (CD73) in response...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.176
更新日期：2017-08-23 00:00:00
abstract：:Immune and lectin histochemical and microchemical methods were employed to study growth cartilage from seven cases of achondrogenesis type II (Langer-Saldino). The normal architecture of the epiphyseal and growth plate cartilage was replaced by a morphologically heterogeneous tissue. Some areas were comprised of vascu...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198709000-00017
更新日期：1987-09-01 00:00:00
abstract：:Vagal responsivity to orogastric stimulation is necessary for gastrointestinal function and may reflect autonomic regulation. Our study evaluated vagal responsivity during gavage feeding as an index of preterm clinical status. Vagal and behavioral responsivity of 26 preterm infants during gavage feeding was measured. ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199103000-00003
更新日期：1991-03-01 00:00:00
abstract：:Extracellular glutathione peroxidase (E-GPx) is a selenoenzyme that reduces hydrogen peroxide and organic peroxides. All plasma glutathione peroxidase (GPx) activity in humans is attributable to E-GPx. The gastrointestinal (GI) tract also synthesizes and secretes E-GPx into the extracellular milieu. Endogenously gener...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200205000-00016
更新日期：2002-05-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2015.88
更新日期：2015-08-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-018-0093-x
更新日期：2018-10-01 00:00:00
abstract：:The purpose of the present study was to determine if autoregulation of cerebral blood flow (CBF) is present in the preterm fetal lamb and, if present, to measure the range of mean arterial blood pressure over which autoregulation exists. Thirty-seven measurements of CBF were made in seven preterm fetal lambs (118-122 ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198502000-00001
更新日期：1985-02-01 00:00:00
abstract：:Carbohydrate and lipid intakes have both been found to modulate the metabolism of long-chain fatty acids. To define the respective influence of these two energy substrates on plasma fatty acid concentrations, 32 studies were performed in 16 parenterally fed newborn infants (mean +/- SEM, birth wt: 2.15 +/- 0.1 kg, age...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198910000-00002
更新日期：1989-10-01 00:00:00
abstract：:The effect of various lipids, proteins, and other substances on the adsorption rate of dipalmitoyl phosphatidylcholine (DPC) was investigated. Each substance was added to a sonicated suspension of DPC in saline, and the surface pressure of the adsorbed surface film was measured using a platinum plate suspended from an...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198107000-00010
更新日期：1981-07-01 00:00:00
abstract：:We probed possible developmentally related changes in thin filament activity in rat hearts with the aid of calmidazolium (CDZ). CDZ is a calmodulin antagonist that also binds to troponin C and stimulates Ca2+ troponin C-dependent activation of cardiac myofibrillar contractile activity. In paired experiments, we compar...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199007000-00011
更新日期：1990-07-01 00:00:00
abstract：:Infants with polycythemia and hyperviscosity are known to have a reduced cerebral blood flow. Eight newborn lambs were studied to determine what effect the reduction in cerebral blood flow might have on the cerebral delivery and uptake of oxygen, glucose, lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate. Meas...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198803000-00019
更新日期：1988-03-01 00:00:00
abstract：:The effects of early protein-deficiency on lung development were studied in the rat. Newborn male rats were nursed in groups of eight. Control dams and pups received a 15% protein diet during the whole experiment. Test mothers only received 12 and 8% proteins from the 7th and the 14th day of lactation. Test rats fed a...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198707000-00012
更新日期：1987-07-01 00:00:00
abstract：:Gastrointestinal (GI) blood flow, O2 transport, and O2 uptake were measured during recovery from severe hypoxemia in newborn piglets. Hypoxemia was induced by lowering the inspired O2 concentration to 0.05 for 15 min. This resulted in an 82% decrease in GI O2 uptake. Recovery measurements were obtained 5 and 65 min af...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198511000-00017
更新日期：1985-11-01 00:00:00
