Cerebral metabolic response to neonatal hypoglycemia in growth-retarded dogs.

abstract：:Prenatal maternal therapy with glucocorticoid reduces the incidence of respiratory distress syndrome (RDS) in premature infants. To investigate the effects of this treatment on the fetal endocrine system, we determined serum concentrations of betamethasone, cortisol, dehydroepiandrosterone sulfate, growth hormone, and...

journal_title：Pediatric research

authors： Ballard PL,Gluckman PD,Liggins GC,Kaplan SL,Grumbach MM

更新日期：1980-02-01 00:00:00

abstract：:Previous studies have shown that proton magnetic resonance spectroscopy (MRS) is useful in predicting neurologic prognosis in children with traumatic brain injury (TBI). Reductions in N-acetyl derived metabolites and presence of lactate have been predictive of poor outcomes. We examined another spectroscopy metabolite...

journal_title：Pediatric research

authors： Ashwal S,Holshouser B,Tong K,Serna T,Osterdock R,Gross M,Kido D

更新日期：2004-10-01 00:00:00

abstract：:The visual evoked potential (VEP) of five healthy, near-term exteriorized fetal lambs was compared with the VEP obtained from the same animals during the first hour after ventilation. Characteristics of the individual wave components and their relationship to blood pressure, heart rate, and arterial blood gas measurem...

journal_title：Pediatric research

authors： Woods JR Jr,Coppes V,Brooks DE,Knowles PJ,Freeman M,Parisi V,Omara P,McCarty GE

更新日期：1981-11-01 00:00:00

abstract：:Mucolipidosis 4 (ML4) is an autosomal recessive disorder with both lipid and mucopolysaccharide storage. The disease is characterized by severe visual impairment and psychomotor retardation. In our effort to find a phenotypic marker for ML4 fibroblasts, living cells were stained with fluorescent compounds. The stainin...

journal_title：Pediatric research

authors： Goldin E,Blanchette-Mackie EJ,Dwyer NK,Pentchev PG,Brady RO

更新日期：1995-06-01 00:00:00

abstract：:Cell-based therapies hold significant promise for infants at risk for cerebral palsy (CP) from perinatal brain injury (PBI). PBI leading to CP results from multifaceted damage to neural cells. Complex developing neural networks are injured by neural cell damage plus unique perturbations in cell signaling. Given that c...

journal_title：Pediatric research

authors： Jantzie LL,Scafidi J,Robinson S

更新日期：2018-01-01 00:00:00

abstract：:The two pathways of de novo lecithin synthesis, choline incorporation (I) and phosphatidylethanolamine methylation (II), were examined in lung slices from rhesus monkey fetuses throughout the last half of gestation. Incorporation rates of pathway-specific radioactive precursors were used as a measure of lecithin produ...

journal_title：Pediatric research

authors： Epstein MF,Farrell PM

更新日期：1975-08-01 00:00:00

abstract：:Carbon monoxide (CO) and the excitatory amino acid glutamate both dilate cerebral arterioles in newborn pigs. The key enzyme in CO synthesis is heme oxygenase, which is highly expressed in neurons with glutamatergic receptor activity as well as cerebral microvessels. During seizures the extracellular level of glutamat...

journal_title：Pediatric research

authors： Pourcyrous M,Bada HS,Parfenova H,Daley ML,Korones SB,Leffler CW

更新日期：2002-05-01 00:00:00

abstract：:Infants dying with bronchopulmonary dysplasia (BPD) demonstrate increased numbers of pulmonary neuroendocrine cells (PNEC). These infants also possess altered airway epithelial and smooth muscle dimensions reminiscent of oxygen-exposed animals. Because the pathogenesis of BPD involves oxygen toxicity, we hypothesized ...

journal_title：Pediatric research

authors： Shenberger JS,Shew RL,Johnson DE

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Clinicians could modify dietary interventions during early infancy by monitoring fat and fat-free mass accretion in very preterm infants. METHODS:Preterm infants were randomly assigned to either having reports on infant body composition available to the clinicians caring for them (intervention group) or not...

journal_title：Pediatric research

authors： Salas AA,Jerome ML,Chandler-Laney P,Ambalavanan N,Carlo WA

更新日期：2020-11-01 00:00:00

abstract：:The presence of high concentrations of sodium in the sweat of patients with cystic fibrosis is widely accepted by all investigators as one of the most important manifestations of the genetic defect. However, the simple means of sweat collection utilized for diagnostic purposes has been extended to the biochemical and ...

journal_title：Pediatric research

authors： Sens DA,Simmons MA,Spicer SS

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:No study has examined the association between prenatal phthalate exposure and intrauterine growth retardation (IUGR). This study aimed to investigate whether prenatal exposure to phthalates was associated with increased risk of IUGR. METHODS:A total of 126 mother-newborn pairs, including 42 IUGR cases and 8...

journal_title：Pediatric research

authors： Zhao Y,Chen L,Li LX,Xie CM,Li D,Shi HJ,Zhang YH

更新日期：2014-10-01 00:00:00

abstract：:Glutaryl-CoA dehydrogenase (GCDH) deficiency is a rare inborn disorder of L-lysine, L-hydroxylysine, and L-tryptophan metabolism complicated by striatal damage during acute encephalopathic crises. Three decades after its description, the natural history and how to treat this disorder are still incompletely understood....

journal_title：Pediatric research

authors： Kölker S,Garbade SF,Greenberg CR,Leonard JV,Saudubray JM,Ribes A,Kalkanoglu HS,Lund AM,Merinero B,Wajner M,Troncoso M,Williams M,Walter JH,Campistol J,Martí-Herrero M,Caswill M,Burlina AB,Lagler F,Maier EM,Schwahn B

更新日期：2006-06-01 00:00:00

abstract：:A prospective study to define the normal patterns of development of mucosal immunity in 263 children provided a unique opportunity to study the mucosal immune response in an infant who unexpectedly died from sudden infant death syndrome. The subject initially had a normal pattern of mucosal immune function, which was ...

journal_title：Pediatric research

authors： Gleeson M,Clancy RL,Cripps AW

更新日期：1993-06-01 00:00:00

abstract：:Preterm infants are more prone to bone mineral deficiency the lower their birth weight. To achieve the intrauterine bone mineral accretion rate postnatally, 74 low-birth-weight infants (median birth weight, 980 g; range 430-1.580 g) were each supplemented enterally and/or parenterally with calcium and/or phosphorus in...

journal_title：Pediatric research

authors： Pohlandt F

更新日期：1994-01-01 00:00:00

abstract：:We studied the effect of maternal concentration and mode of administration on transfer rate of TSH-releasing hormone (TRH) in an in vitro model of dually perfused isolated lobule of human term placenta. Varying concentrations (4-40 microg dL(-1)) of TRH were added either to the open maternal circulation to mimic an in...

journal_title：Pediatric research

authors： Bajoria R,Fisk NM

更新日期：1997-05-01 00:00:00

abstract：:Critically ill infants are treated with dexamethasone (Dx) and other glucocorticoids to reduce inflammation and to promote lung and cardiac function. The neonatal immune system is immature, so neonatal dendritic cells (DCs) might be especially sensitive to glucocorticoid-mediated immunosuppression. To test this, we co...

journal_title：Pediatric research

authors： Mainali ES,Kikuchi T,Tew JG

更新日期：2005-07-01 00:00:00

abstract：:In human infants and newborn rats, white light at the intensity used to treat hyperbilirubinemia lowers serum calcium concentration. Occipital shielding or (in newborn rats) exogenous melatonin prevents this effect. Propranolol, by inhibiting melatonin synthesis, also causes hypocalcemia, which is preventable by melat...

journal_title：Pediatric research

authors： Hakanson DO,Bergstrom WH

更新日期：1990-06-01 00:00:00

abstract：:In seven patients with mucopolysaccharidoses (1 Hurler, 1 Hurler-Scheie, 4 Hunter, 1 Sly), cranial (1)H-magnetic resonance spectroscopy was performed to evaluate the accumulation of mucopolysaccharides and biochemical changes in the CNS in vivo before and after bone marrow transplantation (BMT). In two of seven patien...

journal_title：Pediatric research

authors： Takahashi Y,Sukegawa K,Aoki M,Ito A,Suzuki K,Sakaguchi H,Watanabe M,Isogai K,Mizuno S,Hoshi H,Kuwata K,Tomatsu S,Kato S,Ito T,Kondo N,Orii T

更新日期：2001-03-01 00:00:00

abstract：:The renal effects of endothelin-1 were investigated in 16 anesthetized and mechanically ventilated newborn rabbits. Renal blood flow and glomerular filtration rate were determined by the clearance of para-aminohippuric acid and inulin, respectively. Each animal acted as its own control. In eight newborn rabbits, a bol...

journal_title：Pediatric research

authors： Semama DS,Thonney M,Guignard JP,Gouyon JB

更新日期：1993-08-01 00:00:00

abstract：:Plasma aldosterone (A), corticosterone (B), deoxycorticosterone (DOC), progesterone (P), 17-hydroxyprogesterone (17-OHP), cortisol (F), and cortisone (E) were measured simultaneously by specific radioimmunoassays in small plasma samples obtained from 174 normal infants and children between 2 hr and 15 yr of age. The s...

journal_title：Pediatric research

authors： Sippell WG,Dörr HG,Bidlingmaier F,Knorr D

更新日期：1980-01-01 00:00:00

abstract：:Gastrointestinal (GI) blood flow, O2 transport, and O2 uptake were measured during recovery from severe hypoxemia in newborn piglets. Hypoxemia was induced by lowering the inspired O2 concentration to 0.05 for 15 min. This resulted in an 82% decrease in GI O2 uptake. Recovery measurements were obtained 5 and 65 min af...

journal_title：Pediatric research

authors： Nowicki PT,Miller RR,Hansen NB,Hayes JR

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Adolescents born preterm have altered hypothalamic-pituitary-adrenal axis function with a blunted cortisol stress response, however, the influences of intrauterine growth restriction and race are unclear. METHODS:We measured salivary cortisol before and 20 min after a maximal-exercise stress test and calcul...

journal_title：Pediatric research

authors： Brown CL,Myers K,South AM,Shaltout HA,Jensen ET,Nixon PA,Washburn LK

更新日期：2020-05-01 00:00:00

abstract：:Iron is essential for fetal organ development, but the effect of isolated iron deficiency on nephrogenesis is unknown. Human premature infants are at risk for disrupted nephrogenesis because glomerular development is incomplete until 36-wk gestation. We modeled the effects of iron on postnatal glomerulogenesis in four...

journal_title：Pediatric research

authors： Drake KA,Sauerbry MJ,Blohowiak SE,Repyak KS,Kling PJ

更新日期：2009-12-01 00:00:00

abstract：:Blood mononuclear cells from newborns and from adults, immune or nonimmune to herpes simplex virus, were cultured with IL 2 and herpes simplex virus and the amount of gamma-interferon in the supernatant measured after 3 days. The newborn and nonimmune adult cells made equivalent trace amounts of gamma-interferon in cu...

journal_title：Pediatric research

authors： Hayward AR,Herberger M,Saunders D

更新日期：1986-05-01 00:00:00

abstract：:Alpha-mannosidosis is a lysosomal storage disorder resulting from deficient activity of lysosomal alpha-mannosidase. It has been described previously in humans, cattle, and cats, and is characterized in all of these species principally by neuronal storage leading to progressive mental deterioration. Two guinea pigs wi...

journal_title：Pediatric research

authors： Crawley AC,Jones MZ,Bonning LE,Finnie JW,Hopwood JJ

更新日期：1999-11-01 00:00:00

abstract：:The incidence and prevalence of celiac disease vary internationally. We studied the incidence of identified cases of childhood celiac disease in six Dutch provinces that cover 47.9% of the surface area and 67.6% of the total population of The Netherlands. Children with celiac disease aged 0-14 y, diagnosed from Januar...

journal_title：Pediatric research

authors： George EK,Mearin ML,van der Velde EA,Houwen RH,Bouquet J,Gijsbers CF,Vandenbroucke JP

更新日期：1995-02-01 00:00:00

abstract：:The transport of phosphate into jejunal brush border membrane vesicles isolated from 14- to 42-day-old rats was investigated using a rapid filtration technique. The presence of a sodium gradient enhanced phosphate uptake at all ages. Both sodium-dependent phosphate uptake and passive phosphate uptake declined with inc...

journal_title：Pediatric research

authors： Borowitz SM,Ghishan FK

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Previous studies indicate an increased risk for neuropsychological difficulties in young children prenatally exposed to opioids and polysubstances, but longitudinal information is scarce. The present longitudinal study investigated whether these waned, persisted, or increased over time. METHODS:The cognitiv...

journal_title：Pediatric research

authors： Nygaard E,Moe V,Slinning K,Walhovd KB

更新日期：2015-09-01 00:00:00

abstract：:To date, many mutations, including intronic nucleotide changes, in the SLC12A3 gene encoding the thiazide-sensitive sodium-chloride cotransporter (NCCT) have been reported in Gitelman's syndrome (GS) patients. However, it has not been clarified whether intronic nucleotide changes affect mRNA content. Since mRNA analys...

journal_title：Pediatric research

authors： Kaito H,Nozu K,Fu XJ,Kamioka I,Fujita T,Kanda K,Krol RP,Suminaga R,Ishida A,Iijima K,Matsuo M

更新日期：2007-04-01 00:00:00

abstract：:Nitric Oxide (NO) can be cytotoxic or cytoprotective depending on amount and location of its generation. eNOS is important in modulating blood flow and is allosterically regulated. Inducible NOS (iNOS) tends to produce large quantities of NO leading to cell injury. We studied the role and regulation of NOS in carbon t...

journal_title：Pediatric research

authors： Liu H,Subramony C,Nowicki M

更新日期：2008-06-01 00:00:00