Hyperoxia-induced airway remodeling and pulmonary neuroendocrine cell hyperplasia in the weanling rat.

abstract：:Antigenic analysis of neuroblastoma cells was performed by autologous typing and indirect immunofluorescent test combined with absorption tests. Serum of a patient with neuroblastoma before treatment showed weak reactivity with cultured autologous neuroblastoma cells, while serum obtained from the same patient 3 month...

journal_title：Pediatric research

authors： Kawai K,Sakatoku H,Matsuda T,Kazuoka K,Kubo S,Kamiya H,Sakurai M

更新日期：1986-10-01 00:00:00

abstract：:Astrocyte end-feet ensheathe blood vessels in the brain and are believed to provide structural integrity to the cerebral vasculature. We sought to determine in developing infants whether the coverage of blood vessels by astrocyte end-feet is decreased in germinal matrix (GM) compared with cerebral cortex and white mat...

journal_title：Pediatric research

authors： El-Khoury N,Braun A,Hu F,Pandey M,Nedergaard M,Lagamma EF,Ballabh P

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Prematurity may influence the levels of amino acids, enzymes, and endocrine markers obtained through newborn screening. Identifying which analytes are the most affected by degree of prematurity could provide insight into how prematurity impacts metabolism. METHODS:Analytes from blood spots assayed by Newbor...

journal_title：Pediatric research

authors： Wilson K,Hawken S,Ducharme R,Potter BK,Little J,Thébaud B,Chakraborty P

更新日期：2014-02-01 00:00:00

abstract：:The incidence and prevalence of celiac disease vary internationally. We studied the incidence of identified cases of childhood celiac disease in six Dutch provinces that cover 47.9% of the surface area and 67.6% of the total population of The Netherlands. Children with celiac disease aged 0-14 y, diagnosed from Januar...

journal_title：Pediatric research

authors： George EK,Mearin ML,van der Velde EA,Houwen RH,Bouquet J,Gijsbers CF,Vandenbroucke JP

更新日期：1995-02-01 00:00:00

abstract：:Atherosclerosis originates in childhood and adolescence. The goal of this review is to highlight how exercise and physical activity during childhood and adolescence, critical periods of growth and development, can prevent adult cardiovascular disease (CVD), particularly through molecular mechanisms of monocytes, a key...

journal_title：Pediatric research

authors： Cooper DM,Radom-Aizik S

更新日期：2020-01-01 00:00:00

abstract：:The objective of this study was to determine the plasma leptin concentrations in twin pregnancies in relation to chorionicity and discordant fetal growth. We studied 53 twin pregnancies of which 26 had growth discordance of > or =20% and 27 were concordant for growth (discordance of < or =10%). Paired maternal and fet...

journal_title：Pediatric research

authors： Sooranna SR,Ward S,Bajoria R

更新日期：2001-05-01 00:00:00

abstract：:Chloroform:methanol extracts of bovine pulmonary surfactant contain small hydrophobic proteins, designated surfactant-associated apoproteins 6,000 (SAP-6), but do not contain the major surfactant-associated 35,000-dalton glycoprotein, designated SAP-35. Examination of lipid extract surfactant on sodium dodecylsulfate-...

journal_title：Pediatric research

authors： Yu SH,Wallace D,Bhavnani B,Enhorning G,Harding PG,Possmayer F

更新日期：1988-01-01 00:00:00

abstract：:Changes in high-density lipoprotein (HDL) subclass distribution were evaluated in a group of premature infants during the early postnatal period to ascertain whether enteral feeding brought about a rapid shift from neonatal to adult-like distributions. All infants were fed a combination of breast milk and formula. Cor...

journal_title：Pediatric research

authors： Genzel-Boroviczény O,D'Harlingue AE,Kao LC,Scott C,Forte TM

更新日期：1988-06-01 00:00:00

abstract：:DGCR6 is the most centromeric gene in the human DiGeorge critical region and is the only gene in the region with a second functional copy on a repeat localized more distally on chromosome 22. We isolated the chicken ortholog of DGCR6 and showed an embryonic expression pattern that is initially broad but becomes gradua...

journal_title：Pediatric research

authors： Hierck BP,Molin DG,Boot MJ,Poelmann RE,Gittenberger-de Groot AC

更新日期：2004-09-01 00:00:00

abstract：:Cerebral blood flow (CBF) measurement by near infrared spectroscopy (NIRS) using oxyhemoglobin (HbO2) as a tracer (CBF-HbO2) needs rapid changes in arterial oxygen saturation (SaO2) which often cannot be achieved in many sick infants. An alternative method based on the same adaptation of the Fick principle using i.v. ...

journal_title：Pediatric research

authors： Patel J,Marks K,Roberts I,Azzopardi D,Edwards AD

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Abnormal PCO2 is common in infants with hypoxic ischemic encephalopathy (HIE). The objective was to determine whether hypocapnia was independently associated with unfavorable outcome (death or severe neurodevelopmental disability at 18 mo) in infants with moderate-to-severe HIE. METHODS:This was a post hoc ...

journal_title：Pediatric research

authors： Lingappan K,Kaiser JR,Srinivasan C,Gunn AJ

更新日期：2016-08-01 00:00:00

abstract：:Children with nephropathic cystinosis store 50 to 100 times normal amounts of free cystine in many cells and display negligible lysosomal cystine transport in their leucocytes and cultured fibroblasts. A patient with intermediate (adolescent) cystinosis exhibited a similar deficiency of egress out of fibroblast lysoso...

journal_title：Pediatric research

authors： Gahl WA,Tietze F

更新日期：1987-02-01 00:00:00

abstract：:We evaluated the hypothesis that increased endogenous opioid activity mediates part or all of the left ventricular contractile and pump dysfunction previously demonstrated in HCl-induced metabolic acidemia. Eighteen Western newborn lambs were catheterized and instrumented; pacing wires were sutured to the right atrial...

journal_title：Pediatric research

authors： Fisher DJ,Dreyer WJ,Tate C,Michael L,Smith EO,Entman M

更新日期：1988-06-01 00:00:00

abstract：:Ethylmalonic aciduria is a common biochemical finding in patients with inborn errors of short chain fatty acid beta-oxidation. The urinary excretion of ethylmalonic acid (EMA) may stem from decreased oxidation by short chain acyl-CoA dehydrogenase (SCAD) of butyryl-CoA, which is alternatively metabolized by propionyl-...

journal_title：Pediatric research

authors： Corydon MJ,Gregersen N,Lehnert W,Ribes A,Rinaldo P,Kmoch S,Christensen E,Kristensen TJ,Andresen BS,Bross P,Winter V,Martinez G,Neve S,Jensen TG,Bolund L,Kølvraa S

更新日期：1996-06-01 00:00:00

abstract：:Alterations in thermoregulatory mechanisms related to sleep state may play an important role in the problems of homeostasis experienced by the premature infant. In the adult, homeothermic regulation of body temperature may be suspended during REM. We measured oxygen consumption (VO2) in six premature infants 33-35 wk ...

journal_title：Pediatric research

authors： Darnall RA Jr,Ariagno RL

更新日期：1982-07-01 00:00:00

abstract：:Although obstructive nephropathy is a frequent cause of renal insufficiency in infancy, factors influencing adaptation to chronic partial ureteral obstruction (CPUO) are poorly understood. Guinea pigs were subjected to unilateral CPUO within the first 2 days of life (Group I) and microsphere studies were performed at ...

journal_title：Pediatric research

authors： Chevalier RL,Kaiser DL

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:The preterm newborn is at high risk of developing cardiovascular compromise during the first day of life and this is associated with increased risk of brain injury. Standard treatments are volume expansion and administration of inotropes, typically dopamine and/or dobutamine, but there is limited evidence th...

journal_title：Pediatric research

authors： Eiby YA,Shrimpton NY,Wright IM,Lumbers ER,Colditz PB,Duncombe GJ,Lingwood BE

更新日期：2016-12-01 00:00:00

abstract：:In vitro experiments were performed to examine the contractile responsiveness of guinea pig gallbladder smooth muscle as a function of developmental age. Gallbladder muscle strips from preterm (day 50-55 gestation), newborn (days 1-3 post partum), and 1-month-old animals were stimulated with agonists that initiate the...

journal_title：Pediatric research

authors： Denehy CM,Ryan JR

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:General movements (GMs) in infants occur as fidgety movements (FMs) between postterm 9 and 20 weeks. We aimed to evaluate FMs and motor repertoire in infants with cystic fibrosis (CF) and their relation with clinical findings. METHODS:Demographic and clinical characteristics were recorded. FMs and motor rep...

journal_title：Pediatric research

authors： Tekerlek H,Mutlu A,Inal-Ince D,Livanelioglu A,Kahraman A,Eryilmaz-Polat S,Karakaya J,Ozcelik U

更新日期：2020-07-27 00:00:00

abstract：BACKGROUND:Fetal hypoxia-ischemia (H-I) results in significant morbidity and mortality. Little is known about the timing of death in human stillbirths. The vulnerability of the fetus varies with age at the time of insult, but it is unknown what happens to the timing of fetal death in relation to a fetal insult. We aske...

journal_title：Pediatric research

authors： Derrick M,Englof I,Drobyshevsky A,Luo K,Yu L,Tan S

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Neonatal mortality and morbidity are increasingly recognized as important globally, but detailed estimates of neonatal morbidity from conditions and long-term consequences are yet to be published. METHODS:We describe the general methods for systematic reviews, meta-analyses, and modeling used in this supple...

journal_title：Pediatric research

authors： Blencowe H,Vos T,Lee AC,Philips R,Lozano R,Alvarado MR,Cousens S,Lawn JE

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Bronchopulmonary dysplasia (BPD) is the most common and serious chronic lung disease of premature infants. Connective tissue growth factor (CTGF) plays an important role in tissue development and remodeling. We have previously shown that targeted overexpression of CTGF in alveolar type II epithelial cells re...

journal_title：Pediatric research

authors： Rong M,Chen S,Zambrano R,Duncan MR,Grotendorst G,Wu S

更新日期：2016-07-01 00:00:00

abstract：:Catecholamines (CA) are released from and resynthesized in the adrenal medulla in response to stress. In the mature animal, stimulus-secretion-synthesis coupling occurs through transsynaptic (neuronal) activity. In contrast, in the immature animal, before functional adrenal innervation, certain stressors (hypoglycemia...

journal_title：Pediatric research

authors： DeCristofaro JD,LaGamma EF

更新日期：1994-12-01 00:00:00

abstract：:Gaucher disease, the most common of the sphingolipidoses, results from the inherited deficiency of the enzyme glucocerebrosidase (EC 3.2.1.45). Although type 2 (acute neuronopathic) Gaucher disease is associated with rapidly progressive and fatal neurologic deterioration, the pathophysiologic mechanisms leading to the...

journal_title：Pediatric research

authors： Orvisky E,Sidransky E,McKinney CE,Lamarca ME,Samimi R,Krasnewich D,Martin BM,Ginns EI

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Near-infrared spectroscopy is used in the assessment of regional splanchnic oxygen saturation (rsSO2), but solid reference values are scarce. We aimed to establish reference values of rsSO2 for preterm infants during the first week after birth, both crude and modeled based on predictors. METHODS:We included...

journal_title：Pediatric research

authors： van der Heide M,Dotinga BM,Stewart RE,Kalteren WS,Hulscher JBF,Reijneveld SA,Bos AF,Kooi EMW

更新日期：2021-01-27 00:00:00

abstract：:The intranasal live attenuated influenza vaccine (LAIV), FluMist, has been widely appreciated by pediatricians, parents, and children alike for its ease of administration. However, concerns regarding lack of effectiveness in recent influenza seasons led to the CDC Advisory Committee on Immunization Practices (ACIP) re...

journal_title：Pediatric research

authors： Gill MA,Schlaudecker EP

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Angiotensin (ANG) II is involved in experimental hyperoxia-induced lung fibrosis. Angiotensin-converting enzyme-2 (ACE-2) degrades ANG II and is thus protective, but is downregulated in adult human and experimental lung fibrosis. Hyperoxia is a known cause of chronic fibrotic lung disease in neonates, but th...

journal_title：Pediatric research

authors： Oarhe CI,Dang V,Dang M,Nguyen H,Gopallawa I,Gewolb IH,Uhal BD

更新日期：2015-05-01 00:00:00

abstract：:The ability of synthetic metalloporphyrins to suppress heme oxygenase activity and bilirubin formation has recently become of considerable clinical and experimental interest for suppression of jaundice in humans, including neonatal hyperbilirubinemia. The present investigation compares the biochemical effects of Sn- a...

journal_title：Pediatric research

authors： Mark JA,Maines MD

更新日期：1992-09-01 00:00:00

abstract：:In studies in the newborn infant, it is often assumed that there are similarities in airflow in successive breaths, and, therefore, it is only necessary to measure parameters in a small number of breaths. However, other studies have shown considerable variability in breathing patterns in successive breaths. It was, th...

journal_title：Pediatric research

authors： Hathorn MK

更新日期：2000-07-01 00:00:00

abstract：:Gluconeogenesis decreases during septic shock, but its mechanism is not well known. Tumor necrosis factor alpha (TNF-alpha), which is a key cytokine in septic shock, can increase GLUT1 gene expression and glucose uptake in muscles and fatty tissues. TNF-alpha does not alter the metabolism of hepatocytes in which GLUT2...

journal_title：Pediatric research

authors： Goto M,Yoshioka T,Battelino T,Ravindranath T,Zeller WP

更新日期：2001-04-01 00:00:00