Abstract:
BACKGROUND:General movements (GMs) in infants occur as fidgety movements (FMs) between postterm 9 and 20 weeks. We aimed to evaluate FMs and motor repertoire in infants with cystic fibrosis (CF) and their relation with clinical findings. METHODS:Demographic and clinical characteristics were recorded. FMs and motor repertoire were analyzed from a 5-min video recording of each infant. Videos were rated based on the Prechtl General Movement Assessment and motor optimality score (MOS) was calculated. RESULTS:The analysis included 18 infants with CF and 20 healthy infants at postterm age of 3-5 months. MOS was significantly lower in the infants with CF compared to controls (p < 0.05). Fifty percent of the infants with CF had abnormal or absent/sporadic FMs. MOS was negatively associated with hospitalization duration (r = -0.378, p = 0.036); and positively associated with vitamin A level in CF infants (r = 0.665, p = 0.026). CONCLUSIONS:Infants with genetically anticipated severe CF phenotype tended to have lower MOS. MOS may be used in addition to genetic testing to predict disease severity in infants with CF. Infants with CF, absent/sporadic FMs, and lower MOS could be considered for planning specific age-adequate early intervention programs. IMPACT:Motor repertoire was age-inadequate in infants with cystic fibrosis (CF).50% of infants with CF had abnormal or absent/sporadic fidgety movements (FMs).Motor optimality score (MOS) was positively associated with vitamin A level and negatively correlated with hospitalization duration in infants with CF.MOS tended to decrease as genetically anticipated disease severity increased; thus, MOS might enable us to predict disease severity in CF. The relationship between motor repertoire and phenotype and genotype is unclear and warrants further study.CF infants with absent/sporadic FMs, and lower MOS could be considered for planning early intervention.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Tekerlek H,Mutlu A,Inal-Ince D,Livanelioglu A,Kahraman A,Eryilmaz-Polat S,Karakaya J,Ozcelik Udoi
10.1038/s41390-020-1082-4subject
Has Abstractpub_date
2020-07-27 00:00:00eissn
0031-3998issn
1530-0447pii
10.1038/s41390-020-1082-4pub_type
杂志文章abstract::A 10-year longitudinal study was conducted on 16 prepubescent youngsters who had undergone successful weight reduction. Their ages ranged from 2 to 10 years when the study began. In all subjects, weight reduction proceeded only by a decrease in adipose cell size (from 0.62 +/- 0.02 to 0.46 +/- 0.02 micrograms lipid pe...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198110000-00016
更新日期:1981-10-01 00:00:00
abstract::Depression is one of the most debilitating chronic disorders in the United States, affecting 15 million children in homes with depressed mothers, many of whom endure household chaos, inconsistent nurturing, inadequate safety practices, and harsh discipline. Depressed mothers are under diagnosed and undertreated, yet t...
journal_title:Pediatric research
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journal_title:Pediatric research
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abstract:BACKGROUND:Real-time detection and classification of apneic episodes remain significant challenges. This study explores the applicability of a novel method of monitoring the respiratory effort and dynamics for rapid detection and classification of apneic episodes. METHODS:Obstructive apnea (OA) and hypopnea/central ap...
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abstract::We have investigated the impaired secretion response of neonatal platelets. We compared the response of washed neonatal and adult platelets to thrombin and collagen, and to specific activators of calcium flux (inositol trisphosphate) and protein kinase C activation (oleoyl-acetyl glycerol). Neonatal platelets show no ...
journal_title:Pediatric research
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abstract::We investigated the role of circulating bone marrow cells (BMC) in cardiomyocyte regeneration. BMC, isolated from transgenic mice expressing enhanced green fluorescent protein (GFP), were transplanted into lethally irradiated C57BL6 mice. Five weeks after bone marrow transplantation (BMT), flow cytometric analysis for...
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abstract:BACKGROUND:Although it is commonly accepted that upper airway obstruction (UAO) increases gastroesophageal reflux (GER), the link is poorly understood and insufficiently documented. In addition, while hypoxia is often encountered in infants with UAO, its consequences on GER are virtually unknown. The two aims of the pr...
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journal_title:Pediatric research
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abstract::The objective of this study was to investigate changes of cerebral oxygenation and hemodynamics related to opening of the bypass bridge during veno-arterial extracorporeal membrane oxygenation (ECMO). Ten newborn infants and 12 piglets were studied during opening of the bridge for 10 and 1 s, respectively. Changes in ...
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journal_title:Pediatric research
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pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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更新日期:2008-02-01 00:00:00
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更新日期:2003-08-01 00:00:00
abstract::A male child presented on the first day of life with metabolic acidosis with elevated blood lactate (15 mM), pyruvate (0.4 mM), and free fatty acid (1.3 mM) levels and a blood pH of 7.16. The severity of the acidosis was diminished by intravenous administration of glucose in large doses and by bicarbonate. On two occa...
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更新日期:2007-08-01 00:00:00
abstract::The intranasal live attenuated influenza vaccine (LAIV), FluMist, has been widely appreciated by pediatricians, parents, and children alike for its ease of administration. However, concerns regarding lack of effectiveness in recent influenza seasons led to the CDC Advisory Committee on Immunization Practices (ACIP) re...
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更新日期:1988-01-01 00:00:00
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更新日期:2002-02-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/00006450-199210000-00021
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doi:10.1203/00006450-198011000-00022
更新日期:1980-11-01 00:00:00
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journal_title:Pediatric research
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更新日期:2000-07-01 00:00:00
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更新日期:1991-03-01 00:00:00