Selective impairment of taurine transport by cyclosporin A in a human placental cell line.

Abstract:

:We investigated, using a human placental choriocarcinoma cell line as a model, the effects of the immunosuppressive drug cyclosporin A on several placental transport systems mediating the transfer of glucose and amino acids from mother to fetus. The results of the investigation show that the transport system responsible for the transfer of taurine is selectively impaired by the drug, whereas the other transport systems are either stimulated or not affected. The inhibitory effect of the drug on taurine transport appears to be due to interference with calmodulin-dependent processes because calmodulin antagonists such as W-7, calmidazolium, and CGS 9343B mimic the effects of cyclosporin A. FK506, another immunosuppressive drug that is currently undergoing clinical trials, does not have this inhibitory effect.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Ramamoorthy S,Leibach FH,Mahesh VB,Ganapathy V

doi

10.1203/00006450-199207000-00024

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

125-7

issue

1

eissn

0031-3998

issn

1530-0447

journal_volume

32

pub_type

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