Abstract：
:The present study investigates the effects of polycythemia on renal hemodynamics and function in 15 anesthetized newborn dogs, 2-10 days of age. Microspheres were used to study renal blood flow. Experimental animals received an exchange transfusion with adult dog packed red blood cells resulting in an increase in hematocrit from 38% +/- 2.1% to 69% +/- 2.1%. Control animals received an exchange transfusion with adult dog whole blood so that there was no change in hematocrit. Polycythemia resulted in a marked increase in blood viscosity, a 40% fall in cardiac output from 251.8 +/- 14 ml/kg/min to 150.7 +/- 9 ml/kg/min and a 98% increase in total vascular resistance from 0.32 +/- 0.02 mmHg/ml/kg/min to 0.63 +/- 0.07 mmHg/ml/kg/min. Nevertheless, renal blood flow was not significantly altered indicating renal vasodilation (1.4 +/- 0.06 ml/g/min initial versus 1.2 +/- 0.09 ml/g/min final). Although renal blood flow was well preserved, renal plasma flow decreased by 63% as the hematocrit increased from 0.86 +/- 0.03 ml/g/min to 0.38 +/- 0.04 ml/g/min, resulting in a 53% fall in glomerular filtration rate from 0.21 +/- 0.02 ml/min/g kidney weight to 0.09 +/- 0.02 ml/min/g kidney weight. There was also a large drop in urine output and Na and K excretion following polycythemia. This was due primarily to the decreased filtered load, because fractional Na reabsorption remained constant. Thus, in spite of well-preserved renal blood flow, polycythemia markedly affected renal function, resulting in water and salt retention.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Kotagal UR,Kleinman LIdoi
10.1203/00006450-198202000-00014subject
Has Abstractpub_date
1982-02-01 00:00:00pages
148-51issue
2eissn
0031-3998issn
1530-0447journal_volume
16pub_type
杂志文章abstract：:The objective was to investigate any possible relationship between functional and structural vascular changes in women with low gestational age and/or low birth weight by analyzing the retinal vascular pattern in women with thoroughly documented blood pressure. Retinal vessel morphology was evaluated by digital image ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200206000-00003
更新日期：2002-06-01 00:00:00
abstract：:Pulmonary surfactant is inactivated in meconium aspiration syndrome and neonatal pneumonia. Development of an exogenous surfactant less sensitive to inactivation might be useful for treating these diseases. We investigated in vitro whether addition of the cationic cyclic membrane cross-linking peptide polymyxin B (PxB...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000200806.32822.e6
更新日期：2006-03-01 00:00:00
abstract：:Neutrophils contribute to ischemic brain injury in adult animals. The role of neutrophils in perinatal hypoxic-ischemic (HI) brain injury is unknown. Allopurinol reduces neutrophil accumulation after tissue ischemia and is protective against HI brain injury. This study was designed to investigate how neutrophils contr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199705000-00002
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:Food allergy is common in children with prevalence up to 10%. We assessed the clinico-laboratory characteristics and frequency of food sensitization to the commonly consumed food among upper Egyptian preschool children with recurrent wheezy chest. METHODS:This cross-sectional descriptive study was conducted...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0960-0
更新日期：2020-10-01 00:00:00
abstract：:Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) are mitogenic to the intestinal epithelium. To further clarify their role in the developing human fetal gut, their expression was studied in fetuses at 15 to 20 wk of gestation. TGF-alpha mRNA was present throughout the gastrointestinal tra...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199305000-00012
更新日期：1993-05-01 00:00:00
abstract：:Young adult macrosomic offspring of streptozotocin-induced mildly hyperglycemic rats exhibit accelerated growth through the first 10 wk of age. At 10 wk, oral glucose loading resulted in elevated plasma insulin and glucose concentrations compared to controls. To assess the mechanism of the abnormal glucose tolerance i...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199107000-00008
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:Observational studies suggest that asthma control improves after adenotonsillectomy, but longitudinal studies that correlate the effect of the procedure on the levels of biomarkers associated with airway inflammation are limited. METHODS:We conducted a longitudinal, observational study on pediatric patients...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2013.237
更新日期：2014-03-01 00:00:00
abstract：:Vitamin K deficiency is a relatively common condition in neonates. However, the role of vitamin K in neonatal bone metabolism remains to be determined. Osteocalcin (OC) is the most abundant noncollagenous protein in bone, and is regulated to be gamma-carboxylated by vitamin K. In this study, we measured gamma-carboxyl...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200211000-00009
更新日期：2002-11-01 00:00:00
abstract：:We studied healthy and saline lavaged rabbits during high frequency oscillatory ventilation to determine what combination of frequency (f), tidal volume (Vt), and mean airway pressure (Paw) produced the lowest peak-to-peak alveolar pressure amplitude (Palv) and physiologic blood gas tensions. Sinusoidal volume changes...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199001000-00018
更新日期：1990-01-01 00:00:00
abstract：:Docosahexaenoic acid (DHA), a 22-carbon, highly unsaturated, n-3 fatty acid, is important for optimal nervous system function. In this study, designed to quantify how preformed dietary DHA regulates metabolic pathways in vivo, 8-d-old rat pups were divided into four groups and fed artificial rat milk diets. One group ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000147572.57627.AE
更新日期：2005-01-01 00:00:00
abstract：:The gastrointestinal (GI) barrier function is immature in the preterm neonate and might thus facilitate translocation of enteric bacteria and gut-derived septicemia. Circumstantial evidence suggests that bacterial uptake from the intestine may be further enhanced by an alteration of the host nutritional status. To tes...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199603000-00007
更新日期：1996-03-01 00:00:00
abstract：:Isolated TSH deficiency leading to hypothyroidism seems to be a rare condition, escaping the diagnosis by neonatal screening programs, which are based on the primary determination of TSH. This is the first report of a case with an autosomal recessive TSH defect caused by a homozygous mutation of the betaTSH gene that ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199908000-00007
更新日期：1999-08-01 00:00:00
abstract：:Active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) with the inspiratory threshold valve (ITV) has been recently recommended by the American Heart Association for treatment of adults in cardiac arrest (class IIb: alternative, useful intervention), but this new technique has never been used in a ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200204000-00020
更新日期：2002-04-01 00:00:00
abstract：:A new animal experimental model of human neuroblastoma is described. The model involves xenotransplantation of a poorly differentiated human neuroblastoma cell line (SH-SY5Y) to the subcutaneous tissue in the hind leg of nude rats (WAG mu/rnu). Injection of 20 million cells suspended in 0.2 mL of medium in each hind l...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199703000-00004
更新日期：1997-03-01 00:00:00
abstract：:In the small bowel of patients with cystic fibrosis, primary defects involving both chloride transport and mucus secretion have been demonstrated, but there is no general consensus about the morphologic counterpart of functional and biochemical abnormalities. We have studied the intestinal mucosa in a group of patient...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199802000-00013
更新日期：1998-02-01 00:00:00
abstract：:Chloroform:methanol extracts of bovine pulmonary surfactant contain small hydrophobic proteins, designated surfactant-associated apoproteins 6,000 (SAP-6), but do not contain the major surfactant-associated 35,000-dalton glycoprotein, designated SAP-35. Examination of lipid extract surfactant on sodium dodecylsulfate-...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198801000-00006
更新日期：1988-01-01 00:00:00
abstract：:This paper has been retracted at the request of the authors. ...
journal_title：Pediatric research
pub_type： 杂志文章,撤回出版物
doi：10.1038/s41390-019-0529-y
更新日期：2019-11-01 00:00:00
abstract：:BackgroundAcute kidney injury (AKI) is common in pediatric inpatients and is associated with increased morbidity, mortality, and length of stay. Its early identification can reduce severity.MethodsTo create and validate an electronic health record (EHR)-based AKI screening tool, we generated temporally distinct develo...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.116
更新日期：2017-09-01 00:00:00
abstract：:Preterm infants are prone to abnormal bacterial colonization of the intestine with ensuing adverse health effects. To examine whether the oral application of Bifidobacterium lactis Bb12 (probiotic) may improve selected indicators of health status in preterm infants, a double blind, placebo controlled randomized clinic...
journal_title：Pediatric research
pub_type： 杂志文章,随机对照试验
doi：10.1203/PDR.0b013e318181b7fa
更新日期：2008-10-01 00:00:00
abstract：:In vitro experiments were performed to examine the contractile responsiveness of guinea pig gallbladder smooth muscle as a function of developmental age. Gallbladder muscle strips from preterm (day 50-55 gestation), newborn (days 1-3 post partum), and 1-month-old animals were stimulated with agonists that initiate the...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198603000-00003
更新日期：1986-03-01 00:00:00
abstract：:Fetal growth and development is dependent on the transfer of amino acids from maternal to fetal blood across the microvillous plasma membrane (MVM) and basal plasma membrane of placental syncytiotrophoblast. The aim of this study was to determine the relationship of system A amino acid transporter (SysA) activity in M...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199906000-00005
更新日期：1999-06-01 00:00:00
abstract：:We studied the effect of maternal concentration and mode of administration on transfer rate of TSH-releasing hormone (TRH) in an in vitro model of dually perfused isolated lobule of human term placenta. Varying concentrations (4-40 microg dL(-1)) of TRH were added either to the open maternal circulation to mimic an in...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199705000-00012
更新日期：1997-05-01 00:00:00
abstract：:Several hours after an hypoxic-ischemic injury to the developing brain, hyperemia, then seizures, edema, and infarction can develop. The roles of nitric oxide (NO) synthesis and excitotoxin accumulation during these later phases of injury are not known. The time course of extracellular levels of amino acids within the...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199605000-00008
更新日期：1996-05-01 00:00:00
abstract：:Blood mononuclear cells from newborns and from adults, immune or nonimmune to herpes simplex virus, were cultured with IL 2 and herpes simplex virus and the amount of gamma-interferon in the supernatant measured after 3 days. The newborn and nonimmune adult cells made equivalent trace amounts of gamma-interferon in cu...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198605000-00004
更新日期：1986-05-01 00:00:00
abstract：BACKGROUND:Hirschsprung disease (HSCR) is the third most common congenital disorder of the gastrointestinal tract. This study aims to elucidate changes in protein expression between the normal and aganglionic hindgut in human HSCR. METHODS:The biopsies were obtained from the normal and aganglionic hindgut in human HSC...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2014.33
更新日期：2014-06-01 00:00:00
abstract：:We investigated the role of circulating bone marrow cells (BMC) in cardiomyocyte regeneration. BMC, isolated from transgenic mice expressing enhanced green fluorescent protein (GFP), were transplanted into lethally irradiated C57BL6 mice. Five weeks after bone marrow transplantation (BMT), flow cytometric analysis for...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000078275.14079.77
更新日期：2003-09-01 00:00:00
abstract：:Plasma selenium concentration and glutathione peroxidase activity in red blood cells were determined in subjects from different age groups. The selenium level (mean +/- SD) found in infancy (0 to 6 months) was 2 +/- 0.6 micrograms/dl, with the lowest value of 1 microgram/dl observed in a 4-month-old infant. These leve...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198606000-00021
更新日期：1986-06-01 00:00:00
abstract：:Premature birth causes significant health risks of the neonate and increases the cost for neonatal care. Urogenital infection, often caused by Gram-negative bacteria, is a known risk factor. Toll-like receptor-4 (TLR4) is the major endotoxin-signaling receptor and as such is crucial for the initiation of the innate im...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200209000-00011
更新日期：2002-09-01 00:00:00
abstract：:Growth hormone (GH) regulates growth and development in the postnatal period but lacks somatotropic activity in the fetus. In contrast, the placental hormone placental lactogen (PL) stimulates amino acid transport, DNA synthesis, and somatomedin production in isolated fetal tissues, suggesting that PL may function as ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199208000-00015
更新日期：1992-08-01 00:00:00
abstract：:In artificial tubes as well as in blood vessels with diameters less than 500 microns, blood viscosity decreases with decreasing diameter (Fahraeus-Lindqvist effect). Our study measured viscosity of red blood cells (RBC) from 10 preterm infants, 10 term neonates, and 10 adults by means of a capillary viscometer. RBC we...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198906000-00009
更新日期：1989-06-01 00:00:00
