Abstract：
:Girls with Turner syndrome (TS) are treated with supraphysiological doses of growth hormone (GH) to improve final height; however in some girls, the growth response can be poor. This may reflect aberrations in GH and/or IGF-I actions at the cellular level, and thus this study compared the response of skin fibroblasts from normal children (n = 5) and girls with TS (n = 8) to GH, IGF-I, or a combination, by assessing the IGF binding protein (IGFBP) profile of conditioned medium harvested over 7 d. The two cell types had a comparable IGFBP profile; IGFBP-3 and IGFBP-4 were the most abundant species. TS fibroblasts produced more IGFBP-3 (d 7, 51.4 ± 45 ng/mL versus 20 ± 22 ng/mL; p < 0.05) than control cells; levels of IGFBP-4 were similar (21 ± 12 ng/mL versus 30 ± 21 ng/mL). GH did not influence IGFBP production. IGF-I treatment did not affect IGFBP-4 levels but enhanced the production of IGFBP-3 by both cell types (p < 0.05). However, the response of TS fibroblasts to IGF-I was approximately half that observed in normal cells (p < 0.05). Altered IGF-I activity, because of reduced bioavailability and/or reduced sensitivity, could contribute to the need for high GH doses in TS and for the poor response to GH in some girls with TS.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Westwood M,Tajbakhsh SH,Siddals KW,Whatmore AJ,Clayton PEdoi
10.1203/PDR.0b013e31821b570bsubject
Has Abstractpub_date
2011-07-01 00:00:00pages
25-30issue
1eissn
0031-3998issn
1530-0447journal_volume
70pub_type
杂志文章abstract：:Prolonged unconjugated hyperbilirubinemia in infants associated with breast milk feeding is a common pediatric problem known as breast milk jaundice (BMJ). A polymorphic mutation (G71R) of bilirubin UDP-glucuronosyltransferase (UGT1A1) is a known cause of BMJ on the infantile side, but the responsible components of br...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e31822f242e
更新日期：2011-11-01 00:00:00
abstract：:There has been recent interest in the use of the phosphodiesterase-5 inhibitor sildenafil for treating pulmonary hypertension. We examined the interaction between inhaled nitric oxide (iNO) and i.v. sildenafil in 12 piglets with acute pulmonary hypertension and lung injury secondary to meconium aspiration. Six animals...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000112033.81970.C2
更新日期：2004-03-01 00:00:00
abstract：:Bubble continuous positive airway pressure (B-CPAP) applies small-amplitude, high-frequency oscillations in airway pressure (DeltaPaw) that may improve gas exchange in infants with respiratory disease. We developed a device, high-amplitude B-CPAP (HAB-CPAP), which provides greater DeltaPaw than B-CPAP provides. We stu...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181dcd580
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Exposure to inflammation exacerbates injury in neonatal encephalopathy (NE). We hypothesized that brain biomarker mRNA, cytokine mRNA and microRNA differentiate inflammation (E. coli LPS), hypoxia (Hypoxia), and inflammation-sensitized hypoxia (LPS+Hypoxia) in an NE piglet model. METHODS:Sixteen piglets wer...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0986-3
更新日期：2020-06-10 00:00:00
abstract：:Maternal smoking doubles the risk of delivering a low birth weight infant. The purpose of this study was to analyze differential gene expression in umbilical cord tissue as a function of maternal smoking, with an emphasis on growth-related genes. We recruited 15 pregnant smokers and 15 women who never smoked during pr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e31817c5507
更新日期：2008-08-01 00:00:00
abstract：:A 2-month-old white girl had severe liver disease (but without signs of hepatic necrosis, infection or cirrhosis), urinary cytomegalovirus, transient reduction of alpha 1-antitrypsin concentration and transient abnormal alpha 1-antitrypsin phenotype that were not present in her parents. Five serum specimens that were ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198203000-00006
更新日期：1982-03-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197604000-00008
更新日期：1976-04-01 00:00:00
abstract：BACKGROUND:There is a strong need for continuous cerebral circulation monitoring in neonatal care, since suboptimal cerebral blood flow may lead to brain injuries in preterm infants and other critically ill neonates. NeoDoppler is a novel ultrasound system, which can be gently fixed to the anterior fontanel and measure...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-019-0535-0
更新日期：2020-01-01 00:00:00
abstract：:In persistent hyperinsulinemic hypoglycemia of infancy, ketone body concentrations are abnormally low at times of hypoglycemia, depriving the brain of its most important alternative fuel. The neuroprotective effect of endogenous ketone bodies is evidenced by animal and human studies, but knowledge about exogenous supp...
journal_title：Pediatric research
pub_type： 临床试验,杂志文章
doi：10.1203/00006450-200208000-00025
更新日期：2002-08-01 00:00:00
abstract：:Data are scant regarding the development of cerebrovascular autoregulation in intrauterine growth-restricted (IUGR) newborns. We tested the hypothesis that IUGR improves the ability of neonates to withstand critical periods of gradual hemorrhagic hypotension by optimizing cerebrovascular autoregulation. Studies were c...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000139425.94975.77
更新日期：2004-10-01 00:00:00
abstract：:Vagal responsivity to orogastric stimulation is necessary for gastrointestinal function and may reflect autonomic regulation. Our study evaluated vagal responsivity during gavage feeding as an index of preterm clinical status. Vagal and behavioral responsivity of 26 preterm infants during gavage feeding was measured. ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199103000-00003
更新日期：1991-03-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3180686cc5
更新日期：2007-07-01 00:00:00
abstract：:All-trans retinoic acid (ATRA) stimulates platelet-derived growth factor (PDGF)-A expression and enhances alveolarization in rat lungs. On d 16 of gestation, pregnant Sprague-Dawley rats were randomly assigned to either a retinoic acid group (intragastric ATRA at 10 mg/kg body weight) or a vehicle group. We punctured ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e31815685b9
更新日期：2007-11-01 00:00:00
abstract：:The role of microbial colonization is indispensable for keeping a balanced immune response in life. However, the events that regulate the establishment of the microbiota, their timing, and the way in which they interact with the host are not yet fully understood. Factors such as gestational age, mode of delivery, envi...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2015.54
更新日期：2015-06-01 00:00:00
abstract：:We studied the effects of anemia and ouabain administration on cardiac function, oxygen physiology, and blood catecholamine levels in nine newborn lambs. We measured oxygen consumption continuously, along with traditional hemodynamic variables. Oxygen transport was calculated. Following baseline measurements, lambs we...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198705000-00005
更新日期：1987-05-01 00:00:00
abstract：:Newborn Sprague-Dawley rat pups were found to have reduced net tubular reclamation of the beta-amino acid taurine in vivo. The reabsorption of this compound increased between the 2nd and 4th week of life and the excreted taurine fell despite a rise in glomerular filtration rate indicative of increased transport with m...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197907000-00012
更新日期：1979-07-01 00:00:00
abstract：:The metabolic demands of the newborn heart are met primarily by glucose and lactate. Mitochondria are impermeable to the NADH produced by these cytosolic reactions. The malate/aspartate and alpha-glycerophosphate (alpha-GP) shuttles provide two pathways to transport reducing equivalents into mitochondria. The goals of...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199508000-00015
更新日期：1995-08-01 00:00:00
abstract：:The two pathways of de novo lecithin synthesis, choline incorporation (I) and phosphatidylethanolamine methylation (II), were examined in lung slices from rhesus monkey fetuses throughout the last half of gestation. Incorporation rates of pathway-specific radioactive precursors were used as a measure of lecithin produ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197508000-00009
更新日期：1975-08-01 00:00:00
abstract：:Chloroform:methanol extracts of bovine pulmonary surfactant contain small hydrophobic proteins, designated surfactant-associated apoproteins 6,000 (SAP-6), but do not contain the major surfactant-associated 35,000-dalton glycoprotein, designated SAP-35. Examination of lipid extract surfactant on sodium dodecylsulfate-...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198801000-00006
更新日期：1988-01-01 00:00:00
abstract：:Phototherapy results in the conversion of native bilirubin to more water-soluble configurational and structural isomers. The serum half-life for the configurational isomer, the principal photoproduct in vivo, was determined by high pressure liquid chromatography in six premature infants following cessation of photothe...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198502000-00012
更新日期：1985-02-01 00:00:00
abstract：:Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism and a potent chemoattractant for adult polymorphonuclear leukocytes (PMN). LTB4 may be an important inflammatory mediator in neonatal lung disorders such as bronchopulmonary dysplasia, but neonatal PMN chemotaxis to LTB4 has not been studied. We compare...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199303000-00006
更新日期：1993-03-01 00:00:00
abstract：:The possible role played by albumin in regulating brain metabolism during development has been studied. The effects of fatty acid-free BSA on lactate, glucose, 3-hydroxybutyrate, and glutamine oxidation and lipogenesis by rat neurons and astrocytes from primary culture were studied. The rate of lactate oxidation and l...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199312000-00002
更新日期：1993-12-01 00:00:00
abstract：:To evaluate the maturation of glucose homeostasis in the small for gestational age (SGA) neonate, glucose kinetics were measured with 78% enriched D-[U-13C]glucose by the prime plus constant infusion technique in nine SGA infants and compared with the rate obtained in seven term appropriate for gestational age infants...
journal_title：Pediatric research
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:This paper has been retracted at the request of the authors. ...
journal_title：Pediatric research
pub_type： 杂志文章,撤回出版物
doi：10.1038/s41390-019-0529-y
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Insulin-like growth factor (IGF)-I and -II play an important role in prenatal growth. During the first 2 months from birth, body fat doubles, and rapid weight gain during this time increases future risk of cardiometabolic disease. The aim of this study was to determine whether IGF measurements at birth assoc...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-019-0331-x
更新日期：2019-04-01 00:00:00
abstract：:Thoracoabdominal asynchrony (TAA) and chest wall distortion (CWD) are commonly seen in preterm infants secondary to a highly compliant rib cage and poor compensation of distorting forces by inspiratory rib cage muscles. Continuous positive airway pressure (CPAP) reduces TAA and CWD by stenting the chest wall. We hypot...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200102000-00008
更新日期：2001-02-01 00:00:00
abstract：:Alveolar hypoxia increases pulmonary artery pressure in lambs and sheep but increases lung lymph flow only in lambs; the reasons for this are unknown. To test the hypothesis that hypoxia-induced pulmonary venous constriction could in part explain the fluid filtration response in young lambs, eight young lambs (13 +/- ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198712000-00013
更新日期：1987-12-01 00:00:00
abstract：:Alterations in thermoregulatory mechanisms related to sleep state may play an important role in the problems of homeostasis experienced by the premature infant. In the adult, homeothermic regulation of body temperature may be suspended during REM. We measured oxygen consumption (VO2) in six premature infants 33-35 wk ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198207000-00002
更新日期：1982-07-01 00:00:00
abstract：:Exercise-induced arterial hypoxemia (EIAH) is a recognized phenomenon in highly trained adults. Like adult athletes, prepubescent trained children may develop high-level metabolic demand but with a limited lung capacity in comparison with adults. The purpose of this investigation was to search for evidence of EIAH in ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000114481.58902.FB
更新日期：2004-04-01 00:00:00
abstract：:The effect of various lipids, proteins, and other substances on the adsorption rate of dipalmitoyl phosphatidylcholine (DPC) was investigated. Each substance was added to a sonicated suspension of DPC in saline, and the surface pressure of the adsorbed surface film was measured using a platinum plate suspended from an...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198107000-00010
更新日期：1981-07-01 00:00:00
