Temperature-sensitive mutants of influenza A virus: response of children to the influenza A/Hong Kong/68-ts-1(E) (H3N2) and influenza A/Udorn/72-ts-1(E) (H3N2) candidate vaccine viruses and significance of immunity to neuraminidase antigen.

abstract：:There has been recent interest in the use of the phosphodiesterase-5 inhibitor sildenafil for treating pulmonary hypertension. We examined the interaction between inhaled nitric oxide (iNO) and i.v. sildenafil in 12 piglets with acute pulmonary hypertension and lung injury secondary to meconium aspiration. Six animals...

journal_title：Pediatric research

authors： Shekerdemian LS,Ravn HB,Penny DJ

更新日期：2004-03-01 00:00:00

abstract：:Despite the availability of successful prevention strategies to prevent excessive hyperbilirubinemia, the neurological sequelae of bilirubin neurotoxicity (BNTx) still occur throughout the world. Kernicterus, encephalopathy due to BNTx, is now understood to be a spectrum of severity and phenotypes known as kernicterus...

journal_title：Pediatric research

authors： Riordan SM,Shapiro SM

更新日期：2020-01-01 00:00:00

abstract：:Momentum around the era of genomic medicine is building, and with it, anticipation of the benefits that whole genome analysis (personalized or individualized genomics) will bring for the provision of health care. These technologies have the potential to revolutionize genetic diagnosis; however, the expansive data gene...

journal_title：Pediatric research

authors： Ali-Khan SE,Daar AS,Shuman C,Ray PN,Scherer SW

更新日期：2009-10-01 00:00:00

abstract：:Tolazoline is used in neonatal intensive care to treat hypoxia secondary to persistent pulmonary hypertension of the newborn. Its use is often complicated by systemic hypotension. We compared the effect of tolazoline-induced hypotension on organ blood flow, regional brain blood flow, and cerebral metabolism in hypoxic...

journal_title：Pediatric research

authors： Balsan MJ,Cronin CM,Shaw MD,Milley JR

更新日期：1990-08-01 00:00:00

abstract：:Neonatal PMN (polymorphonuclear neutrophils) exhibit altered inflammatory responsiveness and greater longevity compared with adult PMN; however, the involved mechanisms are incompletely defined. Receptors containing immunoreceptor tyrosine-based inhibitory motif (ITIM) domains promote apoptosis by activating inhibitor...

journal_title：Pediatric research

authors： Rashmi R,Bode BP,Panesar N,King SB,Rudloff JR,Gartner MR,Koenig JM

更新日期：2009-09-01 00:00:00

abstract：:Response characteristics of a transcutaneous PO2 electrode to step changes in PaO2 were determined. In vitro lag time and 95% response time of a transcutaneous PO2 monitor were compared to in vivo response. Release of arterial occlusion was used to produce rapid local PaO2 changes in human infants and adults. In vitro...

journal_title：Pediatric research

authors： Abu-Osba YK,Thach BT,Brouillette RT

更新日期：1981-02-01 00:00:00

abstract：:Lung deposition of inhaled drugs in ventilated neonates has been studied in models of questionable relevance. With conventional nebulizers, pulmonary deposition has been limited to 1% of the total dose. The objective of this study was to assess lung delivery of aerosols in a model of neonatal ventilation using a conve...

journal_title：Pediatric research

authors： Dubus JC,Vecellio L,De Monte M,Fink JB,Grimbert D,Montharu J,Valat C,Behan N,Diot P

更新日期：2005-07-01 00:00:00

abstract：:We measured the cortisol and corticosterone responses to insulin-induced hypoglycemia in 13 growth hormone (GH)-deficient children and 30 short children without GH deficiency. Although there was no difference between the two groups in degree of hypoglycemia attained, baseline cortisol, baseline corticosterone, or cort...

journal_title：Pediatric research

authors： Chasalow FI,Blethen SL

更新日期：1985-08-01 00:00:00

abstract：:The purpose of this investigation was twofold: (1) to identify and characterize the enzymatic ATP hydrolysis system of epithelial cilia, and (2) to develop a quantitative, biochemical test for the ciliotoxic cystic fibrosis (CF) factor based on inhibition of ATP utilization by ciliary preparations. Our rationale for s...

journal_title：Pediatric research

authors： Farrell PM,Fox GN,Spicer SS

更新日期：1976-02-01 00:00:00

abstract：:A series of in vivo experiments is described in which [1-13C]phytanic acid was given as an oral substrate to a healthy subject and two patients showing an impairment in phytanic acid degradation, one with Refsum's disease and one with chondrodysplasia punctata. After intake of the substrate by the control in a dose of...

journal_title：Pediatric research

authors： ten Brink HJ,Schor DS,Kok RM,Stellaard F,Kneer J,Poll-The BT,Saudubray JM,Jakobs C

更新日期：1992-11-01 00:00:00

abstract：:We hypothesized that nitric oxide (NO) production by the fetal ductus arteriosus is limited because of low fetal PO2, but that at neonatal PO2, NO might be an important regulator of ductus arteriosus tone. We exposed isolated rings of fetal lamb ductus arteriosus to elevated PO2. L-NG-nitro-L-arginine methyl ester (L-...

journal_title：Pediatric research

authors： Clyman RI,Waleh N,Black SM,Riemer RK,Mauray F,Chen YQ

更新日期：1998-05-01 00:00:00

abstract：:BackgroundPost-hemorrhagic ventricular dilatation (PHVD) is predictive of mortality and morbidity among very-low-birth-weight preterm infants. Impaired cerebral blood flow (CBF) due to elevated intracranial pressure (ICP) is believed to be a contributing factor.MethodsA hyperspectral near-infrared spectroscopy (NIRS) ...

journal_title：Pediatric research

authors： McLachlan PJ,Kishimoto J,Diop M,Milej D,Lee DSC,de Ribaupierre S,St Lawrence K

更新日期：2017-10-01 00:00:00

abstract：:Seven plasma protease inhibitors were analyzed in 8-yr-old children-75 PiZ (severely deficient), one PiZ-(with a null gene), 32 PiSZ (moderately deficient), and 35 normals. In PiZ and PiSZ alpha 1-antitrypsin-deficient children, significantly higher concentrations of alph 2-macroglobulin (p less than 0.001) and antith...

journal_title：Pediatric research

authors： Sveger T

更新日期：1985-08-01 00:00:00

abstract：:To determine the effects of age, feeding regimen, and antenatal glucocorticoids on intestinal permeability, preterm infants (n = 132) were stratified by gestational age and by diet (mothers' own milk versus preterm formula), and assigned randomly to one of four feeding regimens: early-continuous, early-bolus, standard...

journal_title：Pediatric research

authors： Shulman RJ,Schanler RJ,Lau C,Heitkemper M,Ou CN,Smith EO

更新日期：1998-10-01 00:00:00

abstract：:The purpose of this study was to begin to examine the influence of inhaled NO on O2 toxicity. The survival of Sprague-Dawley rats exposed to >95% O2, >95% O2 + 10 ppm NO, >95% O2 + 100 ppm NO, and >95% O2 + 3 ppm NO2 was determined. Survival at 120 h was 2/24 in >95% O2, 2/12 in >95% O2 + 10 ppm NO, and 1/12 in >95% O...

journal_title：Pediatric research

authors： Nelin LD,Welty SE,Morrisey JF,Gotuaco C,Dawson CA

更新日期：1998-06-01 00:00:00

abstract：:In studies in the newborn infant, it is often assumed that there are similarities in airflow in successive breaths, and, therefore, it is only necessary to measure parameters in a small number of breaths. However, other studies have shown considerable variability in breathing patterns in successive breaths. It was, th...

journal_title：Pediatric research

authors： Hathorn MK

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Prodromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement regulator, leading to aHUS. METH...

journal_title：Pediatric research

authors： Togarsimalemath SK,Si-Mohammed A,Puraswani M,Gupta A,Vabret A,Liguori S,Mariani-Kurkdjian P,Bagga A,Dragon-Durey MA

更新日期：2018-07-01 00:00:00

abstract：:The effects of an emulsified intravenous fat preparation (Intralipid) on bilirubin transport were analyzed by cholestyramine extraction, spectrophotometric analysis, Sephadex gel filtration, peroxidase assay, bilirubin uptake by red blood cells, and by toxicity in tissue culture (L-929) cells. Intralipid is capable of...

journal_title：Pediatric research

authors： Thaler MM,Wennberg RP

更新日期：1977-03-01 00:00:00

abstract：:The incidence and prevalence of celiac disease vary internationally. We studied the incidence of identified cases of childhood celiac disease in six Dutch provinces that cover 47.9% of the surface area and 67.6% of the total population of The Netherlands. Children with celiac disease aged 0-14 y, diagnosed from Januar...

journal_title：Pediatric research

authors： George EK,Mearin ML,van der Velde EA,Houwen RH,Bouquet J,Gijsbers CF,Vandenbroucke JP

更新日期：1995-02-01 00:00:00

abstract：:Cancer stem cells (CSC) are recently proposed to be the cancer initiating cells responsible for tumorigenesis and contribute to cancer resistance. Advances have been made in identifying and enriching CSC in leukemia and several solid tumors, including breast, brain and lung cancers. These studies suggest that, like no...

journal_title：Pediatric research

authors： Guo W,Lasky JL 3rd,Wu H

更新日期：2006-04-01 00:00:00

abstract：:We studied the effect of maternal concentration and mode of administration on transfer rate of TSH-releasing hormone (TRH) in an in vitro model of dually perfused isolated lobule of human term placenta. Varying concentrations (4-40 microg dL(-1)) of TRH were added either to the open maternal circulation to mimic an in...

journal_title：Pediatric research

authors： Bajoria R,Fisk NM

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to examine in detail levels and patterns of physical activity in preschool children and the effects of gender and BMI on this activity. METHODS:Two hundred and fifty-three children aged 5 y participating in the Copenhagen Prospective Studies on Asthma in Childhood wore an accelerom...

journal_title：Pediatric research

authors： Brasholt M,Chawes B,Kreiner-Møller E,Vahlkvist S,Sinding M,Bisgaard H

更新日期：2013-09-01 00:00:00

abstract：:The functional activity of naturally acquired IgG and IgM with specificity for the capsular polysaccharide of type III, group B Streptococcus (III-GBS) was compared. Sera collected during convalescence from 14 infants who had developed specific antibodies following III-GBS infection were employed for separation of IgG...

journal_title：Pediatric research

authors： Campbell JR,Baker CJ,Metzger TG,Edwards MS

更新日期：1988-01-01 00:00:00

abstract：:The zeta subunit of the CD3 T-cell receptor complex and the major histocompatibility complex class 1 (MHC-I) are important not only for the immune response to antigens, they also function as signal molecules in the brain, where they play a role in the postnatal maturation process. The expression of these molecules can...

journal_title：Pediatric research

authors： Sourial-Bassillious N,Eklöf AC,Scott L,Aperia A,Zelenin S

更新日期：2006-10-01 00:00:00

abstract：:Sequential magnitude and the rate of change in tracheal mechanics after application of intermittent positive pressure (IPP), and the time constant, tau, of this deformation were determined in fetal (21 and 27 days gestation), neonatal (term, 31 days gestation) and adult rabbits. In vitro tracheal mechanics were determ...

journal_title：Pediatric research

authors： Bhutani VK,Shaffer TH

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is associated with expression and methylation of Fc gamma receptor genes. We characterized immunoglobulin A (IgA), IgE, IgG, and IgM receptor expression levels in KD. METHODS:Fc receptor expression levels were characterized using GeneChip Human Transcriptome Array 2.0 (HTA 2.0) with 18...

journal_title：Pediatric research

authors： Chang LS,Ming-Huey Guo M,Lo MH,Kuo HC

更新日期：2019-12-09 00:00:00

abstract：:A double-label, double-substrate incubation technique has been developed and used to study the conversion of progesterone to testosterone in testes extracts from incompletely virilized males. The procedure involves separation of the microsomes from a testicular homogenate, incubating the microsomes with 1 microM [7-3H...

journal_title：Pediatric research

authors： Chasalow FI,Blethen SL,Marr HB,French FS

更新日期：1984-08-01 00:00:00

abstract：:Ethanol consumption during pregnancy can cause fetal alcohol syndrome (FAS). Although the exact mechanism is unknown, nutritional alterations caused by ethanol exposure may be an etiologic factor in FAS. The congenital heart defects seen in FAS are similar to those found in vitamin A teratogenesis. Because ethanol ing...

journal_title：Pediatric research

authors： DeJonge MH,Zachman RD

更新日期：1995-04-01 00:00:00

abstract：:The age-related changes in fasting arterial levels of energy substrates and insulin were studied at birth and/or 6 wk in eleven baboon infants. In addition, the renal contribution to glucose release in the primate infant was estimated. Arterial blood glucose levels were similar in six fasted newborns and in nine faste...

journal_title：Pediatric research

authors： Levitsky LL,Paton JB,Fisher DE,Delannoy CW

更新日期：1980-08-01 00:00:00

abstract：:Neonatal hypoxic-ischemic encephalopathy (HIE) is a clinically defined neurological condition after lack of oxygen and often associated with cardiac dysfunction in term infants. Therapeutic hypothermia (HT) after birth is neuroprotective in infants with HIE. However, it is not known whether HT is also cardioprotective...

journal_title：Pediatric research

authors： Liu X,Tooley J,Løberg EM,Suleiman MS,Thoresen M

更新日期：2011-10-01 00:00:00