Abstract：
:BackgroundBeing aware of the impact of low birth weight on late-onset hypertension, our aim was to describe systolic blood pressure (sBP) and renal function in 3-5-year-old preterm-born children and to determine which perinatal factors or childhood factors were associated with an altered renal function at 5 years in these children.MethodsThis was a prospective longitudinal cohort study of children born at 27-31 weeks of gestation and included at birth and examined at 3, 4, and 5 years of age. The primary outcome was renal function at 5 years: BP, estimated glomerular filtration rate, and albuminuria.ResultsOne hundred and sixty five children were examined, of whom 93 (56.4%) were male. Gestational age was 29.2±1.4 weeks and birth weight was 1,217±331 g. Overall, 25% children had sBP ≥90th percentile at age 3 and 4 years and 11% at 5 years. In multivariate analysis, sBP ≥90th percentile at 5 years was associated with the use of antenatal steroids (OR=0.19(0.05;0.65)). There was a significant association between protein intake on day 28 and sBP at 5 years (β=2.1±1.0, P=0.03). Glomerular filtration rate at 5 years was significantly decreased in case of hyaline membrane disease or necrotizing enterocolitis. High urine albumin was not predictable from one year to another.ConclusionIn preterm-born children, sBP was often high and neonatal protein intake was associated with increased blood pressure during childhood.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Vieux R,Gerard M,Roussel A,Sow A,Gatin A,Guillemin F,Hascoet JMdoi
10.1038/pr.2017.148subject
Has Abstractpub_date
2017-12-01 00:00:00pages
979-985issue
6eissn
0031-3998issn
1530-0447pii
pr2017148journal_volume
82pub_type
杂志文章abstract：:The factors that mediate the postnatal fall in pulmonary vascular resistance, which is crucial for normal gas exchange, are not fully understood. The endothelium has been implicated in this phenomenon, through the release of vasorelaxant factors such as nitric oxide (NO). Human pulmonary expression of endothelial NO s...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1203/01.PDR.0000159575.58834.8D
更新日期：2005-05-01 00:00:00
abstract：:Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine distention. Heredity is 25-40% and mostly involves the maternal genome, with contribution of the fetal genome. Si...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/s41390-018-0180-z
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Recent studies suggest that infantile hypertrophic pyloric stenosis (IHPS) and congenital heart defects (CHDs) may share some genetic risk factors, but little is known about the co-occurrence of the two conditions in patients. METHODS:Our study cohort included 2,212,756 persons born in Denmark 1977-2013. We...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-019-0369-9
更新日期：2019-06-01 00:00:00
abstract：:Perinatal brain injury is a leading cause of death and disability in young children. Recent advances in obstetrics, reproductive medicine and neonatal intensive care have resulted in significantly higher survival rates of preterm or sick born neonates, at the price of increased prevalence of neurological, behavioural ...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/s41390-018-0222-6
更新日期：2019-01-01 00:00:00
abstract：:Exercise-induced arterial hypoxemia (EIAH) is a recognized phenomenon in highly trained adults. Like adult athletes, prepubescent trained children may develop high-level metabolic demand but with a limited lung capacity in comparison with adults. The purpose of this investigation was to search for evidence of EIAH in ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000114481.58902.FB
更新日期：2004-04-01 00:00:00
abstract：:The possible role played by albumin in regulating brain metabolism during development has been studied. The effects of fatty acid-free BSA on lactate, glucose, 3-hydroxybutyrate, and glutamine oxidation and lipogenesis by rat neurons and astrocytes from primary culture were studied. The rate of lactate oxidation and l...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199312000-00002
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Aminoglycoside exposure is a common cause of acute kidney injury (AKI). Delay in the diagnosis of AKI using conventional biomarkers has been one of the important obstacles in applying early effective interventions. We tested the hypothesis that urinary metabolomics could identify novel early biomarkers for t...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2013.34
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Bradycardia and oxygen desaturation episodes are common among preterm very low birth weight (VLBW) infants in the Neonatal Intensive Care Unit (NICU), and their association with adverse outcomes such as bronchopulmonary dysplasia (BPD) is unclear. METHODS:For 502 VLBW infants we quantified bradycardias (HR ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-018-0223-5
更新日期：2019-06-01 00:00:00
abstract：:Severely birth-asphyxiated human infants develop delayed ("secondary") cerebral energy failure, which carries a poor prognosis, during the first few days of life. This study tested the hypothesis that i.v. magnesium sulfate (MgSO4) after severe transient cerebral hypoxia-ischemia decreases the severity of delayed ener...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199703000-00024
更新日期：1997-03-01 00:00:00
abstract：:Neonatal PMN (polymorphonuclear neutrophils) exhibit altered inflammatory responsiveness and greater longevity compared with adult PMN; however, the involved mechanisms are incompletely defined. Receptors containing immunoreceptor tyrosine-based inhibitory motif (ITIM) domains promote apoptosis by activating inhibitor...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181b1bc19
更新日期：2009-09-01 00:00:00
abstract：:Pulmonary surfactant proteins SP-B and SP-C were isolated from lavage fluids of bovine lungs and recombined (lipid/proteins, 9/1, wt/wt) with dipalmitoyl phosphatidylcholine for testing in vitro and in surfactant-deficient adult rats. Using a pulsating bubble surfactometer, we found that inflation pressures of bubbles...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198805000-00010
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND:More pediatric drug trials are needed, but although specific pediatric regulations warrant safety, recruitment of children for these trials remains one of the main difficulties. Therefore, we investigated potential determining factors of nonparticipation in clinical research, in order to optimize research pa...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2015.74
更新日期：2015-07-01 00:00:00
abstract：:Magnesium-deficient fetuses exhibited malformations (44%), anemia, and edema. Maternal plasma magnesium levels at day 21 of pregnancy reflected the level of dietary magnesium (2.43 +/- 0.09 mg Mg/100 ml, control; 0.74 +/- 0.02 mg Mg/100 ml, deficient). Plasma magnesium levels of deficient fetuses showed similar decrea...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197706000-00013
更新日期：1977-06-01 00:00:00
abstract：:Alveolar macrophages were isolated from three cystic fibrosis patients, and the structure and function of these cells were compared to that of normal alveolar macrophages. The cystic fibrosis (CF) and normal alveolar macrophages were able to phagocytize Pseudomonas in the presence of normal serum, but cells from both ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198005000-00003
更新日期：1980-05-01 00:00:00
abstract：:To study the course of regional metabolite concentrations during early brain development, we measured in vivo metabolites [N-acetyl-aspartate (NAA), choline-containing compounds, and myoinositol (M-Ino)] in the precentral area of the cerebrum by short echo-time single volume proton magnetic resonance spectroscopy and ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199502000-00003
更新日期：1995-02-01 00:00:00
abstract：:Indomethacin is used to constrict the patent ductus arteriosus in premature infants. To clarify possible prostanoid receptor antagonists that can constrict the ductus, we studied in vivo constriction of the fetal and neonatal ductus arteriosus by AE3-208, a prostanoid EP4-receptor antagonist, in rats. Following quick ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000182182.49476.24
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Necrotising enterocolitis (NEC) and late-onset sepsis (LOS) are the leading causes of death among preterm infants in the developed world. This study aimed to explore the serum proteome and metabolome longitudinally in preterm infants with NEC or LOS, matched to controls. METHODS:Nineteen patients (10 cases,...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2015.235
更新日期：2016-03-01 00:00:00
abstract：:Depression is one of the most debilitating chronic disorders in the United States, affecting 15 million children in homes with depressed mothers, many of whom endure household chaos, inconsistent nurturing, inadequate safety practices, and harsh discipline. Depressed mothers are under diagnosed and undertreated, yet t...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2015.214
更新日期：2016-01-01 00:00:00
abstract：:The absolute and the percentage plasma NEFA pattern of healthy children, Cystic Fibrosis (C.F.) patients and their parents have been determined (table I, III, V) and compared with those of age and sex matched control subjects (table II, Iv, V). There is a striking difference in the percentage plasma NEFA pattern of C....
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198009000-00015
更新日期：1980-09-01 00:00:00
abstract：:Human autoimmune lymphoproliferative syndrome (ALPS) is caused by defective CD95-mediated apoptosis of lymphocytes. In most patients, heterozygous mutations within the CD95 gene are found. Mutated proteins interfere with CD95-signaling in a dominant-negative way. However, the penetrance of clinical disease is variable...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e318191f7e4
更新日期：2009-02-01 00:00:00
abstract：:Cell-based therapies hold significant promise for infants at risk for cerebral palsy (CP) from perinatal brain injury (PBI). PBI leading to CP results from multifaceted damage to neural cells. Complex developing neural networks are injured by neural cell damage plus unique perturbations in cell signaling. Given that c...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2017.233
更新日期：2018-01-01 00:00:00
abstract：:Clinical studies have suggested that the early stages of bilirubin encephalopathy are reversible. These phenomena are investigated at the cellular level using the neuroblastoma cell line N-115 as a model system. To determine whether the cell line N-115 can recover from bilirubin toxicity, and whether the cellular func...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198904000-00012
更新日期：1989-04-01 00:00:00
abstract：:We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic puromycin aminonucleoside (PAN) nephropathy, an experimental model of glomerular disease. Therefore, we examined whether recombinant human (rh) IGF-I is a safer alternative for the treatment of growth failure in...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199601000-00002
更新日期：1996-01-01 00:00:00
abstract：:The mitochondria play a major role in the regulation of intracellular calcium. Despite the fact that the enterocytes receive the majority of absorbed calcium, the role of the intestinal mitochondria in calcium transport during maturation is not known. Therefore, the current studies were designed to characterize calciu...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198901000-00023
更新日期：1989-01-01 00:00:00
abstract：:The effect of various lipids, proteins, and other substances on the adsorption rate of dipalmitoyl phosphatidylcholine (DPC) was investigated. Each substance was added to a sonicated suspension of DPC in saline, and the surface pressure of the adsorbed surface film was measured using a platinum plate suspended from an...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198107000-00010
更新日期：1981-07-01 00:00:00
abstract：:L-selectin, a surface adhesion glycoprotein expressed on leukocytes, has a well-established role in mediating inflammation and lymphocyte recirculation. Recent evidence suggests that L-selectin may also influence hematopoiesis. We observed that a greater proportion of CD34+ cells express L-selectin in cord blood compa...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199906000-00015
更新日期：1999-06-01 00:00:00
abstract：:Alveolar hypoxia increases pulmonary artery pressure in lambs and sheep but increases lung lymph flow only in lambs; the reasons for this are unknown. To test the hypothesis that hypoxia-induced pulmonary venous constriction could in part explain the fluid filtration response in young lambs, eight young lambs (13 +/- ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198712000-00013
更新日期：1987-12-01 00:00:00
abstract：BACKGROUND:Though prenatal antidepressant exposure has been associated with adverse developmental outcomes, the extent to which the effects are due to prenatal drug exposure or underlying maternal mood disturbances is unclear. METHODS:This was a population-based retrospective cohort study using administrative data fro...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-01269-6
更新日期：2020-12-09 00:00:00
abstract：:Immunosuppressive effects of carrageenan, a high-molecular-weight polysaccharide, on antibody and T cell responses have been previously demonstrated. However, its effect on anaphylaxis is unknown. Our objectives were to test carrageenan-mediated oral tolerance induction in young mice subsequently sensitized to a commo...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200103000-00018
更新日期：2001-03-01 00:00:00
abstract：:A strongly positive tuberculin skin reaction (> 1.5 cm2) was observed during the acute phase of the illness in 11 children with Kawasaki disease (KD), but not in control pediatric patients with other febrile infections (41 patients) or diseases similar to KD (9 patients). The cutaneous sensitivity to intermediate stre...
journal_title：Pediatric research
pub_type： 临床试验,杂志文章
doi：10.1203/00006450-199704000-00017
更新日期：1997-04-01 00:00:00
