The effect of recombinant human insulin-like growth factor-I on chronic puromycin aminonucleoside nephropathy in rats.

abstract：BACKGROUND:Observational studies suggest that asthma control improves after adenotonsillectomy, but longitudinal studies that correlate the effect of the procedure on the levels of biomarkers associated with airway inflammation are limited. METHODS:We conducted a longitudinal, observational study on pediatric patients...

journal_title：Pediatric research

authors： Levin JC,Gagnon L,He X,Baum ED,Karas DE,Chupp GL

更新日期：2014-03-01 00:00:00

abstract：:Alterations in thermoregulatory mechanisms related to sleep state may play an important role in the problems of homeostasis experienced by the premature infant. In the adult, homeothermic regulation of body temperature may be suspended during REM. We measured oxygen consumption (VO2) in six premature infants 33-35 wk ...

journal_title：Pediatric research

authors： Darnall RA Jr,Ariagno RL

更新日期：1982-07-01 00:00:00

abstract：:In the fetal rat, nitrofen induces congenital diaphragmatic hernia (CDH) and pulmonary vascular remodeling similar to what is observed in the human condition. Airway hyperactivity is common in infants with CDH and attributed to the ventilator-induced airway damage. The purpose of this study was to test the hypothesis ...

journal_title：Pediatric research

authors： Belik J,Davidge ST,Zhang W,Pan J,Greer JJ

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Appearance of sleep cycling has been associated with good outcome in term and preterm infants, but the normal time of its appearance has not been determined. The objectives of this study were, to correlate the time of sleep cycling appearance and the length of quiet sleep in neonates with different degrees o...

journal_title：Pediatric research

authors： Abramsky R,Stavsky M,Novack V,Shany E

更新日期：2020-03-01 00:00:00

abstract：:Although fetal asphyxia, i.e. hypoxemia, acidosis, and hypercapnia, increases plasma arginine vasopressin (AVP) greater than 40-fold, hypoxemia and metabolic acidosis occurring independently cause only 5-fold and 2-fold increases, respectively. To determine the effects of hypercapnia on AVP release, we examined the ef...

journal_title：Pediatric research

authors： Faucher DJ,Laptook AR,Porter JC,Rosenfeld CR

更新日期：1991-10-01 00:00:00

abstract：:Nitric oxide (NO) serves many vasoprotective roles, but the massive release of NO causes arterial wall degeneration. We investigated whether enhanced nitric oxide synthase (iNOS) expression in peripheral blood leukocytes and circulating endothelial cells mirrors the progression of coronary arterial lesions in 55 child...

journal_title：Pediatric research

authors： Yu X,Hirono KI,Ichida F,Uese K,Rui C,Watanabe S,Watanabe K,Hashimoto I,Kumada T,Okada E,Terai M,Suzuki A,Miyawaki T

更新日期：2004-04-01 00:00:00

abstract：:Infants with polycythemia and hyperviscosity are known to have a reduced cerebral blood flow. Eight newborn lambs were studied to determine what effect the reduction in cerebral blood flow might have on the cerebral delivery and uptake of oxygen, glucose, lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate. Meas...

journal_title：Pediatric research

authors： Rosenkrantz TS,Philipps AF,Skrzypczak PS,Raye JR

更新日期：1988-03-01 00:00:00

abstract：:To determine whether epidermal growth factor (EGF) or EGF-like transforming growth factors (TGFs) are present in ovine fetal tissues, we have tested acid-ethanol extracts of ovine fetal kidney for the ability to induce anchorage-independent growth of normal rat kidney fibroblasts in soft agar and to compete with 125I-...

journal_title：Pediatric research

authors： Freemark M,Comer M

更新日期：1987-11-01 00:00:00

abstract：:The objective of this study was to investigate changes of cerebral oxygenation and hemodynamics related to opening of the bypass bridge during veno-arterial extracorporeal membrane oxygenation (ECMO). Ten newborn infants and 12 piglets were studied during opening of the bridge for 10 and 1 s, respectively. Changes in ...

journal_title：Pediatric research

authors： Liem KD,Kollée LA,Klaessens JH,Geven WB,Festen C,De Haan AF,Oeseburg B

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Neonatal seizures can result in chronic epilepsy and long-term behavioral and cognitive deficits. Levetiracetam (LEV), an antiepileptic drug that binds to the synaptic vesicle protein 2A (SV2A), has been increasingly used off-label for the therapy of neonatal seizures. Preclinical data regarding the acute or...

journal_title：Pediatric research

authors： Talos DM,Chang M,Kosaras B,Fitzgerald E,Murphy A,Folkerth RD,Jensen FE

更新日期：2013-01-01 00:00:00

abstract：:An assessment of pulsatile secretion of luteinizing hormone (LH), measured by both immunoassay (I-LH) and rat interstitial cell testosterone production bioassay (B-LH), as well as of follicle-stimulating hormone and glycoprotein hormone alpha-subunit was carried out in seven normal prepubertal and six normal premenarc...

journal_title：Pediatric research

authors： Reiter EO,Biggs DE,Veldhuis JD,Beitins IZ

更新日期：1987-04-01 00:00:00

abstract：:Neonatal susceptibility to overwhelming bacterial infection is commonly attributed to a relative deficiency in serum opsonic activity. However, few studies have compared the functional capacity of the classical complement pathway with that of the alternative complement pathway in the neonate. The opsonic activity of n...

journal_title：Pediatric research

authors： Mills EL,Björksteń B,Quie PG

更新日期：1979-12-01 00:00:00

abstract：:The odds risk of vertical transmission of human immunodeficiency virus (HIV) to preterm infants is almost four times that of term infants and may relate to maternal and neonatal factors. We characterized the competence of early nonspecific cellular immunity, namely natural killer cytotoxicity (NKC) and antibody-depend...

journal_title：Pediatric research

authors： Merrill JD,Sigaroudinia M,Kohl S

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Angiotensin (ANG) II is involved in experimental hyperoxia-induced lung fibrosis. Angiotensin-converting enzyme-2 (ACE-2) degrades ANG II and is thus protective, but is downregulated in adult human and experimental lung fibrosis. Hyperoxia is a known cause of chronic fibrotic lung disease in neonates, but th...

journal_title：Pediatric research

authors： Oarhe CI,Dang V,Dang M,Nguyen H,Gopallawa I,Gewolb IH,Uhal BD

更新日期：2015-05-01 00:00:00

abstract：:Human milk was fractionated to obtain a partially purified growth factor preparation. The growth factor in this fraction, designated as human milk growth factor III, exhibits chromatographic and biological characteristics similar to epidermal growth factor-urogastrone. Pretreatment of mice with human milk growth facto...

journal_title：Pediatric research

authors： Dai S,Klagsbrun M,Shing YW

更新日期：1985-09-01 00:00:00

abstract：:Early nutrition in animals affects both behavior and brain structure. In humans, randomized trials show that early nutrition affects later cognition, notably in males. We hypothesized that early nutrition also influences brain structure, measurable using magnetic resonance imaging. Prior research suggested that the ca...

journal_title：Pediatric research

authors： Isaacs EB,Gadian DG,Sabatini S,Chong WK,Quinn BT,Fischl BR,Lucas A

更新日期：2008-03-01 00:00:00

abstract：:11-Beta hydroxysteroid dehydrogenase type 2 (HSD2) oxidizes the biologically active glucocorticoid (GC), cortisol, to inactive cortisone. We characterized HSD2 gene expression and activity in human adult and fetal lung tissues and in cultured fetal lung explants, and examined the potential regulation of HSD2 in the fe...

journal_title：Pediatric research

authors： Garbrecht MR,Klein JM,McCarthy TA,Schmidt TJ,Krozowski ZS,Snyder JM

更新日期：2007-07-01 00:00:00

abstract：:To further assess bile acid transport by the developing rat liver, we compared the rate of efflux of taurocholate from hepatocytes isolated from suckling and mature rat livers. Cell content of taurocholate (nmol/mg cell protein), after preloading with [14C]-radiolabeled plus cold bile acid (5-100 microM) was similar i...

journal_title：Pediatric research

authors： Belknap WM,Zimmer-Nechemias L,Suchy FJ,Balistreri WF

更新日期：1988-04-01 00:00:00

abstract：:The purpose of this project was to study the role of lipid peroxidation in oxygen-induced lung injury in the newborn lamb. It was our hypothesis that injury to the microvascular bed of the lung by oxygen would coincide with a burst of peroxidative activity and would be accompanied by an increased rate of excretion of ...

journal_title：Pediatric research

authors： Hansen TN,Smith CV,Gest AL,Smith HW,Giesler M

更新日期：1990-12-01 00:00:00

abstract：:We measured the changes in tidal volume, duration of the various phases of the respiratory cycle, and peak nasal pressure during elastic and resistive loading in preterm infants. Values were calculated during the first loaded breath, when chemical drive was unchanged. Tidal volume decreased by equivalent percentages w...

journal_title：Pediatric research

authors： Boychuk RB,Seshia MM,Rigatto H

更新日期：1977-04-01 00:00:00

abstract：:Adverse perinatal events affecting cerebral functions are a major cause of neonatal mortality, morbidity, and long-term neurologic deficit. Intrapartum fetal EEG, which records fetal brain electrical activity, provides a monitoring modality for evaluating the fetal CNS during labor. In this study, we describe a new ap...

journal_title：Pediatric research

authors： Thaler I,Boldes R,Timor-Tritsch I

更新日期：2000-09-01 00:00:00

abstract：:Children with inflammatory bowel disease are known to be at risk of osteopenia. The cause of this osteopenia is likely to be multifactorial, but the inflammatory process with its characteristic overproduction of cytokines has been implicated. To investigate this possible contribution of the disease activity to the dev...

journal_title：Pediatric research

authors： Harbour ME,Gregory JW,Jenkins HR,Evans BA

更新日期：2000-08-01 00:00:00

abstract：:Five enzymes were measured in 50 liver specimens (18 normal liver, 20 Reye liver, 12 diverse liver disorders other than Reye syndrome). The enzymes were: glutamic dehydrogenase (E.C. 1.4.1.3), monoamine oxidase (E.C. 1.4.3.4), lactate dehydrogenase (E.C. 1.1.1.27), D-glucose-6-phosphate dehydrogenase (E.C. 1.1.1.49), ...

journal_title：Pediatric research

authors： Mitchell RA,Arcinue EL,Partin JC,Partin JS,Ram ML,Chang CH,Smialek J,Sarnaik A

更新日期：1985-01-01 00:00:00

abstract：:We have recently purified autoantigen polypeptides reacting with celiac disease patient sera IgA from the extracellular noncollagenous matrix compartment of fetal lung tissue. These molecules trigger the production of different tissue antibodies, the so-called antireticulin and antiendomysium antibodies in celiac dise...

journal_title：Pediatric research

authors： Marttinen A,Mäki M

更新日期：1993-10-01 00:00:00

abstract：:To examine the mechanisms of autoregulatory impairment in meningitis, we studied the effects of Haemophilus influenzae type b (Hib) on pial vessels during hemorrhagic hypotension in rats, using a cranial window technique. We prepared cranial windows in barbiturate-anesthetized, mechanically ventilated rats. Artificial...

journal_title：Pediatric research

authors： Berkowitz ID,Hayden WR,Traystman RJ,Jones MD Jr

更新日期：1993-01-01 00:00:00

abstract：:Premature newborn rabbits, delivered by hysterotomy on day 27 of gestation, were tracheotomized at birth, kept in body plethysmographs, and subjected to pressure-generated ventilation at a working pressure of 25 cm H2O, 100% O2, and frequency 40/min. Thirty-seven animals received 50 microliters of heterologous surfact...

journal_title：Pediatric research

authors： Lachmann B,Berggren P,Curstedt T,Grossmann G,Robertson B

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Exposure to inflammation exacerbates injury in neonatal encephalopathy (NE). We hypothesized that brain biomarker mRNA, cytokine mRNA and microRNA differentiate inflammation (E. coli LPS), hypoxia (Hypoxia), and inflammation-sensitized hypoxia (LPS+Hypoxia) in an NE piglet model. METHODS:Sixteen piglets wer...

journal_title：Pediatric research

authors： Lingam I,Avdic-Belltheus A,Meehan C,Martinello K,Ragab S,Peebles D,Barkhuizen M,Tann CJ,Tachtsidis I,Wolfs TGAM,Hagberg H,Klein N,Fleiss B,Gressens P,Golay X,Kramer BW,Robertson NJ

更新日期：2020-06-10 00:00:00

abstract：:We studied the pre- and postnatal developmental regulation of the hepatic type I IGF receptor in the rat. Fetal rat liver membranes bound IGF-I throughout the latter part of gestation (d 17 to 21). After birth, binding diminished rapidly, reaching barely detectable levels by the 13th postnatal d. However, the presence...

journal_title：Pediatric research

authors： Gruppuso PA,Walker TD,Carter PA

更新日期：1991-03-01 00:00:00

abstract：:BackroundMicrocephaly can either be isolated or it may coexist with other neurological entities and/or multiple congenital anomalies, known as syndromic microcephaly. Although many syndromic cases can be classified based on the characteristic phenotype, some others remain uncertain and require further investigation. T...

journal_title：Pediatric research

authors： Tsoutsou E,Tzetis M,Giannikou K,Braoudaki M,Mitrakos A,Amenta S,Selenti N,Kanavakis E,Zafeiriou D,Kitsiou-Tzeli S,Fryssira H

更新日期：2017-08-01 00:00:00

abstract：:Studies using stable isotopically labeled glucose and palmitate as precursors of pulmonary surfactant synthesis have demonstrated slow surfactant turnover in premature infants with respiratory distress syndrome (RDS). However, only limited data about surfactant turnover are available for term infants. Because acetate ...

journal_title：Pediatric research

authors： Bohlin K,Merchak A,Spence K,Patterson BW,Hamvas A

更新日期：2003-08-01 00:00:00