当前位置： SCI文献检索 > PEDIATRIC RESEARCH期刊下所有文献 > Endogenous surfactant metabolism in newborn infants with and without respiratory failure.

Endogenous surfactant metabolism in newborn infants with and without respiratory failure.

Abstract：

:Studies using stable isotopically labeled glucose and palmitate as precursors of pulmonary surfactant synthesis have demonstrated slow surfactant turnover in premature infants with respiratory distress syndrome (RDS). However, only limited data about surfactant turnover are available for term infants. Because acetate is a direct precursor of de novo synthesized surfactant fatty acid, we measured [1-13C1]acetate incorporation into surfactant of term infants without respiratory dysfunction (control group), preterm infants with RDS, and term infants with primary respiratory failure to determine whether stable isotopically labeled acetate would yield similar results to previous studies of preterm infants with RDS and, furthermore, would distinguish normal from abnormal surfactant turnover. Despite similar amounts of phospholipids and acetate precursor enrichment, the control group had higher fractional synthetic rate and shorter half-life of clearance than preterm infants with RDS, (fractional synthetic rate, 15.4 +/- 2.4 versus 2.2 +/- 0.4%/d, p < 0.001; half-life of clearance, 27 +/- 3 versus 105 +/- 11 h, p < 0.001). Term infants with severe respiratory failure had a lower fractional synthetic rate than those with mild disease (2.9 +/- 0.6 versus 13.8 +/- 3.5%/d, p = 0.014) and a reduced amount of phospholipids recovered from tracheal aspirates (54 +/- 17 versus 300 +/- 28 nmol, severe versus mild disease, respectively, p < 0.001). The amount of phospholipids in tracheal aspirates correlated inversely with disease severity, (r = -0.75, p = 0.01). We conclude that normal surfactant turnover in term infants is faster than in preterm infants with RDS. Surfactant turnover in term infants with severe respiratory failure is similar to that of preterm infants with RDS, suggesting either delayed maturity of the surfactant system or disruption from the underlying disease process.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Bohlin K,Merchak A,Spence K,Patterson BW,Hamvas A

doi

10.1203/01.PDR.0000075084.56255.E0

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

185-91

issue

eissn

0031-3998

issn

1530-0447

pii

01.PDR.0000075084.56255.E0

journal_volume

pub_type

杂志文章

在线工具

Endogenous surfactant metabolism in newborn infants with and without respiratory failure.