Humoral and cell-mediated immunity in growth hormone-deficient children: effect of therapy with human growth hormone.

abstract：:Endothelin-1 can cause pulmonary vasoconstriction via endothelin-A (ET(A)) receptor activation. We hypothesized that ET(A) blockers (EMD 122946 and BQ 610) would reduce hypoxia-induced (HYP) but not group B streptococcal infusion (GBS)-induced pulmonary hypertension in a juvenile whole animal model. Pulmonary hyperten...

journal_title：Pediatric research

authors： Ambalavanan N,Philips JB 3rd,Bulger A,Oparil S,Chen YF

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:The associations between prenatal exposure to endocrine disruptive chemicals (EDCs) and fetal growth are inconsistent, and few studies have considered small-for-gestational-age (SGA) birth as an outcome. Our current study of Scandinavian parous women aimed to address these inconsistencies and gaps in the lit...

journal_title：Pediatric research

authors： Lauritzen HB,Larose TL,Øien T,Sandanger TM,Odland JØ,van de Bor M,Jacobsen GW

更新日期：2017-01-01 00:00:00

abstract：:Intracellular levels of cysteine (CSH) and reduced glutathione (GSH) in the kidney and liver of rats from the newborn to the adult period have been determined using a sensitive high performance liquid chromatography method. In the kidney, the intracellular level of free CSH increased 4-fold from 1 to 4 nmol/mg protein...

journal_title：Pediatric research

authors： States B,Foreman JW,Segal S

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Sepsis is an important cause of neonatal morbidity and mortality worldwide. Diagnosis and treatment of neonatal sepsis relies on clinical judgment and interpretation of nonspecific laboratory tests. In a prospective cohort, we measured inflammatory cytokines as a potential biomarker for neonatal sepsis. MET...

journal_title：Pediatric research

authors： Ye Q,Du LZ,Shao WX,Shang SQ

更新日期：2017-04-01 00:00:00

abstract：:Bubble continuous positive airway pressure (B-CPAP) applies small-amplitude, high-frequency oscillations in airway pressure (DeltaPaw) that may improve gas exchange in infants with respiratory disease. We developed a device, high-amplitude B-CPAP (HAB-CPAP), which provides greater DeltaPaw than B-CPAP provides. We stu...

journal_title：Pediatric research

authors： Diblasi RM,Zignego JC,Tang DM,Hildebrandt J,Smith CV,Hansen TN,Richardson CP

更新日期：2010-06-01 00:00:00

abstract：:Increased concentrations of carcinoembryonic antigen (CEA) have been reported in the sera and sputum of patients with cystic fibrosis. We have found significantly higher concentrations of CEA in both extracted and unextracted saliva of patients with cystic fibrosis compared to age-matched controls and a comparable gro...

journal_title：Pediatric research

authors： MacSween JM,Gillespie CT

更新日期：1980-03-01 00:00:00

abstract：:Plasma antioxidant status and total radical-trapping antioxidant potential (TRAP) of children (n = 24) with cystic fibrosis (CF) were compared with those of children (n = 21) without the disease. Children with CF were found to have elevated plasma concentrations of ascorbic acid (94.6 +/- 58.2 mumol/L), with respect t...

journal_title：Pediatric research

authors： Langley SC,Brown RK,Kelly FJ

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Neonatal encephalopathy (NE) carries high risk for neurodevelopmental impairments. Therapeutic hypothermia (TH) reduces this risk, particularly for moderate encephalopathy (ME). Nevertheless, these infants often have subtle functional deficits, including abnormal memory function. Detection of deficits at the...

journal_title：Pediatric research

authors： Pfister KM,Zhang L,Miller NC,Hultgren S,Boys CJ,Georgieff MK

更新日期：2016-12-01 00:00:00

abstract：:Epidemiologic studies have linked intrauterine growth restriction (IUGR) with an increased incidence of cardiovascular disease later in life; reduced cardiomyocyte number in IUGR hearts may underlie such prenatal programming. Our aim was to examine the effect of IUGR, as a result of maternal protein restriction, on th...

journal_title：Pediatric research

authors： Corstius HB,Zimanyi MA,Maka N,Herath T,Thomas W,van der Laarse A,Wreford NG,Black MJ

更新日期：2005-06-01 00:00:00

abstract：:Tyrosine (Tyr) phosphorylation is implicated in the modification of several erythrocyte functions, such as metabolic pathways and membrane transport, as well as in signal transduction systems. Here we describe the map of Tyr-phosphorylated soluble proteins of newborn red blood cells (RBC) using an in vitro model simul...

journal_title：Pediatric research

authors： Marzocchi B,Ciccoli L,Tani C,Leoncini S,Rossi V,Bini L,Perrone S,Buonocore G

更新日期：2005-10-01 00:00:00

abstract：:Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism and a potent chemoattractant for adult polymorphonuclear leukocytes (PMN). LTB4 may be an important inflammatory mediator in neonatal lung disorders such as bronchopulmonary dysplasia, but neonatal PMN chemotaxis to LTB4 has not been studied. We compare...

journal_title：Pediatric research

authors： Dos Santos C,Davidson D

更新日期：1993-03-01 00:00:00

abstract：:This study aimed to characterize early neonatal microvascular function after preeclamptic pregnancy with respect to infant sex and in utero growth. Peripheral microvascular blood flow was examined prospectively from 6 to 72 h of age using laser Doppler flowmetry in a cohort of term infants of normotensive women and wo...

journal_title：Pediatric research

authors： Stark MJ,Clifton VL,Wright IM

更新日期：2009-03-01 00:00:00

abstract：:Acute kidney injury (AKI) is common in premature infants and is associated with poor outcomes. Novel biomarkers can detect AKI promptly. Because premature infants are born with underdeveloped kidneys, baseline biomarker values may differ. We describe baseline values of urinary neutrophil gelatinase-associated lipocali...

journal_title：Pediatric research

authors： Askenazi DJ,Koralkar R,Levitan EB,Goldstein SL,Devarajan P,Khandrika S,Mehta RL,Ambalavanan N

更新日期：2011-09-01 00:00:00

abstract：:BackgroundPatent ductus arteriosus (PDA) is a common complication seen in preterm infants. Indomethacin is routinely used to treat PDA. Evidence suggests that the response of indomethacin is highly heritable. This study investigated the association between single-nucleotide polymorphisms (SNPs) in CYP2C9 and the closu...

journal_title：Pediatric research

authors： Smith CJ,Ryckman KK,Bahr TM,Dagle JM

更新日期：2017-11-01 00:00:00

abstract：:The dipeptides carnosine and anserine, found exclusively in meats, are hydrolyzed in serum by the enzyme carnosinase. Several reports of serum carnosinase deficiency describe a variable phenotype, which ranges from normal to severe psychomotor retardation, hypotonia, and myoclonic seizures in the first year of life. W...

journal_title：Pediatric research

authors： Willi SM,Zhang Y,Hill JB,Phelan MC,Michaelis RC,Holden KR

更新日期：1997-02-01 00:00:00

abstract：:BACKGROUNDThe aims of this study were to (i) compare the concentrations of two neural injury markers, S100B protein and neuron-specific enolase (NSE), in intrauterine growth-restricted (IUGR) fetuses and in fetuses with appropriate growth-for-gestational-age (AGA), and (ii) investigate potential relationships between ...

journal_title：Pediatric research

authors： Mazarico E,Llurba E,Cumplido R,Valls A,Melchor JC,Iglesias M,Cabero L,Gratacós E,Gómez-Roig MD

更新日期：2017-09-01 00:00:00

abstract：:Diabetes mellitus is characterized by microangiopathy and increased angiogenic response in various organs. Basic fibroblast growth factor (bFGF) as well as vascular endothelial growth factor (VEGF) are both angiogenic and are involved in vascular endothelial cell growth. The purpose of this study was to determine seru...

journal_title：Pediatric research

authors： Malamitsi-Puchner A,Sarandakou A,Tziotis J,Dafogianni C,Bartsocas CS

更新日期：1998-12-01 00:00:00

abstract：:Although fetal asphyxia, i.e. hypoxemia, acidosis, and hypercapnia, increases plasma arginine vasopressin (AVP) greater than 40-fold, hypoxemia and metabolic acidosis occurring independently cause only 5-fold and 2-fold increases, respectively. To determine the effects of hypercapnia on AVP release, we examined the ef...

journal_title：Pediatric research

authors： Faucher DJ,Laptook AR,Porter JC,Rosenfeld CR

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:The prevalence of autism spectrum disorders (ASD) is 5-fold higher in preterm (PT) infants born ≤28 weeks gestational age (GA) as compared to the general population. The relationship between placental pathologic lesions and ASD in PT infants has not been studied. OBJECTIVES:The objective of this study was t...

journal_title：Pediatric research

authors： Mir IN,White SP,Steven Brown L,Heyne R,Rosenfeld CR,Chalak LF

更新日期：2020-09-19 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether small-for-gestational-age (SGA) infants born very prematurely had increased respiratory morbidity in the neonatal period and at follow-up. METHODS:Data were examined from infants recruited into the United Kingdom Oscillation Study (UKOS). Of the 797 infants who...

journal_title：Pediatric research

authors： Peacock JL,Lo JW,D'Costa W,Calvert S,Marlow N,Greenough A

更新日期：2013-04-01 00:00:00

abstract：:A recently introduced test measures the concentration of transferrin receptor (TfR) in serum, which increases shortly after the onset of iron deficiency. In adults this increase reflects the degree to which tissue iron availability is impaired. We developed a fluoroimmunoassay to quantify TfR. The purpose of this stud...

journal_title：Pediatric research

authors： Kivivuori SM,Anttila R,Viinikka L,Pesonen K,Siimes MA

更新日期：1993-09-01 00:00:00

abstract：:Heart rate turbulence (HRT) is a chronotropic response of the sinus heart rhythm to ventricular premature beat (VPB). Children show decreasing heart rate together with the maturation of the autonomic nervous system. The aim of the research was to assess the relationship between HRT parameters, age, and heart rate and ...

journal_title：Pediatric research

authors： Kowalewski M,Alifier M,Bochen D,Urban M

更新日期：2007-12-01 00:00:00

abstract：:Argininosuccinate synthetase and argininosuccinate lyase catalyze the conversion of citrulline to arginine in kidney. Immunohistochemical staining of mouse kidney sections with antibodies to these two enzymes, compared with the staining patterns of known markers for proximal tubules, demonstrated that these enzymes ar...

journal_title：Pediatric research

authors： Morris SM Jr,Sweeney WE Jr,Kepka DM,O'Brien WE,Avner ED

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVES:(1) Examine associations of a branched-chain amino acid (BCAA) metabolite pattern with metabolic risk across adolescence; (2) use Least Absolute Shrinkage and Selection Operator (LASSO) to identify novel metabolites of metabolic risk. METHODS:We used linear regression to examine associations of a BCAA score...

journal_title：Pediatric research

authors： Perng W,Tang L,Song PXK,Tellez-Rojo MM,Cantoral A,Peterson KE

更新日期：2019-02-01 00:00:00

abstract：:Mutations of genes involved in the innate immune system have been reported to be associated with an increased sepsis rate in adults. We determined the -159T mutation of the CD14 gene, the 896G mutation of the toll-like receptor 4 gene, the 3020insC mutation of the NOD2 gene (NOD2-3020insC), the IL-6 174G/C promoter po...

journal_title：Pediatric research

authors： Ahrens P,Kattner E,Köhler B,Härtel C,Seidenberg J,Segerer H,Möller J,Göpel W,Genetic Factors in Neonatology Study Group.

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Maternal smoking impairs fetal growth; however, if postnatal growth differs between children born small for gestational age (SGA) with smoking and non-smoking mother is unknown. METHODS:Cohort-study of term born children born appropriate for gestational age with non-smoking mother (AGA-NS, n = 30,561), SGA ...

journal_title：Pediatric research

authors： Lindström L,Wikström AK,Bergman E,Mulic-Lutvica A,Högberg U,Ahlsson F,Lundgren M

更新日期：2019-06-01 00:00:00

abstract：:To assess the National Institutes of Health extramural activity in the area of pediatric nephrology research, the rate of submission of grant applications to the National Institutes of Health and available indicators of the quality of these applications were analyzed. This was accomplished by utilizing the grant appli...

journal_title：Pediatric research

authors： Novello AC

更新日期：1985-11-01 00:00:00

abstract：:Birth is characterized by swift and complex transitions in hemodynamic and respiratory variables. Unrecognized pathologies or incidents may quickly become fatal or cause permanent damage. This article introduces an essential component of an acute perinatal care simulator, namely a model for educational simulation of n...

journal_title：Pediatric research

authors： Sá-Couto CD,Andriessen P,Van Meurs WL,Ayres-de-Campos D,Sá-Couto PM

更新日期：2010-02-01 00:00:00

abstract：:Hydrocephalus may result in loss of tissue associated with neuronal degeneration, axonal damage, and reactive gliosis. The soluble form of the anti-apoptotic regulator Fas (sFas) and the pro-apoptotic factors soluble FasL (sFasL) and activated caspase 3 were studied in the cerebrospinal fluid of infants with hydroceph...

journal_title：Pediatric research

authors： Felderhoff-Mueser U,Buhrer C,Groneck P,Obladen M,Bartmann P,Heep A

更新日期：2003-11-01 00:00:00

abstract：:Seven essentially healthy term infants who received gentamicin starting on the 1st day of life for prolonged rupture of membranes and maternal fever were compared with nine healthy term infants to determine whether this drug induces alterations in the auditory pathway. The auditory pathway was studied on the 3rd day o...

journal_title：Pediatric research

authors： Kohelet D,Usher M,Arbel E,Arlazoroff A,Goldberg M

更新日期：1990-09-01 00:00:00