Magnesium sulfate after transient hypoxia-ischemia fails to prevent delayed cerebral energy failure in the newborn piglet.

abstract：:Conversion of adenosine to inosine is decreased in adenosine deaminase (ADA)-deficient fibroblasts at all concentrations of adenosine tested. Adenosine is not differentially toxic to ADA-deficient fibroblasts except at very high (5 X 10(-4) -1 X 10(-3) M) adenosine levels. Conversion of [14C] adenosine to GTP is not d...

journal_title：Pediatric research

authors： Benke PJ,Dittmar D

更新日期：1976-07-01 00:00:00

abstract：:Synchronized atrial contraction may be much more important in the newborn, who has a faster heart rate and a less compliant ventricle, than in the adult. We therefore investigated the extent by which synchronized atrioventricular contraction contributes to cardiac output and cardiac work in a neonatal circulation, and...

journal_title：Pediatric research

authors： Klautz RJ,Baan J,Teitel DF

更新日期：1998-03-01 00:00:00

abstract：:Matrix metalloproteinases (MMP) are likely effectors of normal lung development, especially branching morphogenesis, angiogenesis, and extracellular matrix degradation. Because hyperoxia exposure (>95% O(2)) from d 4 to 14 in newborn rat pups leads to arrest of alveolarization and mimics newborn chronic lung disease, ...

journal_title：Pediatric research

authors： Hosford GE,Fang X,Olson DM

更新日期：2004-07-01 00:00:00

abstract：:This study aimed to investigate 1) the plasma resistin concentration at birth, 2) the relationship of resistin with leptin and insulin, and 3) the association of resistin with anthropometric indexes in newborn infants. Blood samples for hormonal assay were obtained from preterm and term newborns within the first 2 h o...

journal_title：Pediatric research

authors： Ng PC,Lee CH,Lam CW,Chan IH,Wong E,Fok TF

更新日期：2005-10-01 00:00:00

abstract：:We report a study on the effect of herpes simplex virus 1 (HSV-1) infection on apoptosis of neutrophils from both adults and neonates and present evidence showing that HSV-1 enhances apoptosis in neonatal, but not adult, neutrophils. HSV-1 enhanced the expression of both Fas and Fas ligand on the surface of neonatal n...

journal_title：Pediatric research

authors： Ennaciri J,Menezes J,Proulx F,Toledano BJ

更新日期：2006-01-01 00:00:00

abstract：:Functional disturbances in microcirculation in juvenile type 1 diabetes (T1D) are believed to underlie, in part, the later occurrence of cardiovascular complications. Some epidemiologic studies suggested greater risk of microvascular complications in those with T1D-risk genotypes of human leukocyte antigen (HLA). We i...

journal_title：Pediatric research

authors： Odermarsky M,Lernmark A,Truedsson L,Liuba P

更新日期：2008-04-01 00:00:00

abstract：:Mother's milk represents a foundational step in the proper development of newborn immunity. This is achieved, in part, through the action of numerous regulatory proteins such as soluble cluster of differentiation 14 (sCD14) found in significant quantities in human milk (~25-50 μg/mL). In adults, CD14 stimulates cytoki...

journal_title：Pediatric research

authors： Spencer WJ,Binette A,Ward TL,Davis LD,Blais DR,Harrold J,Mack DR,Altosaar I

更新日期：2010-12-01 00:00:00

abstract：:BackgroundThe mechanisms underlying aberrant activation of intestinal Toll-like receptor 4 (TLR4) signaling in necrotizing enterocolitis (NEC) remain unclear. In this study, we examined the role of single-immunoglobulin interleukin-1 receptor-related molecule (SIGIRR), an inhibitor of TLR signaling, in modulating expe...

journal_title：Pediatric research

authors： Fawley J,Cuna A,Menden HL,McElroy S,Umar S,Welak SR,Gourlay DM,Li X,Sampath V

更新日期：2018-01-01 00:00:00

abstract：:Bilirubin-IX alpha photooxidation products were detected by high performance liquid chromatography in the urine of neonates undergoing phototherapy for hyperbilirubinemia. The in vivo photoproducts were identified by chromatographic comparison with authentic synthetic standards using two complementary methods. Bilirub...

journal_title：Pediatric research

authors： Lightner DA,Linnane WP 3rd,Ahlfors CE

更新日期：1984-08-01 00:00:00

abstract：:Alveolar macrophages were isolated from three cystic fibrosis patients, and the structure and function of these cells were compared to that of normal alveolar macrophages. The cystic fibrosis (CF) and normal alveolar macrophages were able to phagocytize Pseudomonas in the presence of normal serum, but cells from both ...

journal_title：Pediatric research

authors： Thomassen MJ,Demko CA,Wood RE,Tandler B,Dearborn DG,Boxerbaum B,Kuchenbrod PJ

更新日期：1980-05-01 00:00:00

abstract：:The effect of Cis-platin on the glomerular filtration rate and effective renal plasma flow was determined using a radioisotope clearance technique in young (3 wk old) and adult (more than 12 wk old) rats. Cis-platin was administered intravenously in dosages ranging from 2.5 to 10 mg/kg body weight, either as a single ...

journal_title：Pediatric research

authors： Jongejan HT,Provoost AP,Wolff ED,Molenaar JC

更新日期：1986-01-01 00:00:00

abstract：:The rat undergoes profound maturational changes in the intestinal structure and function during the third week of its life. To investigate the role of peripheral glucocorticoid metabolism in this process, we studied the postnatal maturation of intestinal structure and function. The peripheral metabolism of glucocortic...

journal_title：Pediatric research

authors： Pácha J,Vagnerová R,Bryndová J

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Bilirubin-induced neurologic dysfunction (BIND) is a spectrum of preventable neurological sequelae in jaundiced newborns. Current total plasma bilirubin (BT) concentration thresholds for phototherapy and/or exchange transfusion poorly predict BIND. METHODS:The unbound (free) bilirubin (Bf) measured at these...

journal_title：Pediatric research

authors： Ahlfors CE,Bhutani VK,Wong RJ,Stevenson DK

更新日期：2018-10-01 00:00:00

abstract：:Sex steroids accelerate bone maturation, but it is believed that estrogen action is needed for terminal epiphyseal fusion. In this study, we investigated the effects of a new estrogen-blocking agent, Faslodex (ICI 182,780), on estrogen-accelerated skeletal maturation in immature mice. On day-of-life 2 through 8, mice ...

journal_title：Pediatric research

authors： Gunther DF,Calikoglu AS,Underwood LE

更新日期：1999-09-01 00:00:00

abstract：:Phototherapy results in the conversion of native bilirubin to more water-soluble configurational and structural isomers. The serum half-life for the configurational isomer, the principal photoproduct in vivo, was determined by high pressure liquid chromatography in six premature infants following cessation of photothe...

journal_title：Pediatric research

authors： Ennever JF,Knox I,Denne SC,Speck WT

更新日期：1985-02-01 00:00:00

abstract：:The objective of the present study was to explore whether a free radical spin trap agent, alpha-phenyl-N-tert-butyl nitrone (PBN), influences bioenergetic failure induced in the 20-day-old fetal brain by 30 min of intrauterine ischemia in Wistar rats. Fetal brains were frozen in situ at the end of ischemia and after 1...

journal_title：Pediatric research

authors： Nakai A,Asakura H,Taniuchi Y,Koshino T,Araki T,Siesjö BK

更新日期：2000-04-01 00:00:00

abstract：:The effects of passive respiratory syncytial virus (RSV) immune serum given as preinoculation prophylaxis, postinoculation prophylaxis, and as therapy on d 5 after inoculation were evaluated in an illness model of RSV infection in BALB/c mice. Pre- and postinoculation prophylaxis reduced RSV replication in lung after ...

journal_title：Pediatric research

authors： Graham BS,Davis TH,Tang YW,Gruber WC

更新日期：1993-08-01 00:00:00

abstract：:Keratinocyte growth factor (KGF, or fibroblast growth factor 7) was previously reported to enhance the synthesis of surfactant in alveolar type II cells. We investigated the possible interactions between KGF and a glucocorticoid, dexamethasone (Dex), on surfactant protein (SP) gene expression. In cultured fetal rat ty...

journal_title：Pediatric research

authors： Mouhieddine-Gueddiche OB,Pinteur C,Chailley-Heu B,Barlier-Mur AM,Clement A,Bourbon JR

更新日期：2003-02-01 00:00:00

abstract：:Several lines of evidence suggest that formula with protein content of 3.0 g/100 kcal does not fully meet the protein needs of very-low-birth weight infants. Our purpose was to compare nitrogen balance, metabolic status and growth in infants fed a standard (3.0 g/100 kcal; RegPro) and high (3.6 g/100 kcal; HiPro) prot...

journal_title：Pediatric research

authors： Cooke R,Embleton N,Rigo J,Carrie A,Haschke F,Ziegler E

更新日期：2006-02-01 00:00:00

abstract：:Alterations of the architecture of cerebral white matter in the developing human brain can affect cortical development and result in functional disabilities. A line scan diffusion-weighted magnetic resonance imaging (MRI) sequence with diffusion tensor analysis was applied to measure the apparent diffusion coefficient...

journal_title：Pediatric research

authors： Hüppi PS,Maier SE,Peled S,Zientara GP,Barnes PD,Jolesz FA,Volpe JJ

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Severe traumatic brain injury (TBI) is a leading cause of mortality in children, but the accurate prediction of outcomes at the point of admission remains very challenging. Admission laboratory results are a promising potential source of prognostic data, but have not been widely explored in paediatric cohort...

journal_title：Pediatric research

authors： Kayhanian S,Young AMH,Mangla C,Jalloh I,Fernandes HM,Garnett MR,Hutchinson PJ,Agrawal S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Despite substantial heritability in pubertal development, children differ in maturational tempo. HYPOTHESES:(i) puberty and its duration are influenced by early changes in height and adiposity. (ii) Adiposity rebound (AR) is a marker for pubertal tempo. METHODS:We utilized published prospective data from 6...

journal_title：Pediatric research

authors： German A,Shmoish M,Hochberg Z

更新日期：2015-10-01 00:00:00

abstract：:Establishment of Helicobacter pylori infection as an etiologic agent of peptic ulcer disease and other gastric pathologies marked a revolution in gastroenterology which spurred an enormous interest in gastric physiology and immunology research. The association was soon also demonstrated in children as well. Applicatio...

journal_title：Pediatric research

authors： Blanchard TG,Czinn SJ

更新日期：2017-01-01 00:00:00

abstract：:Contributions from multidisciplinary investigations have focused attention on the potential of tissue engineering to yield novel therapeutics. Congenital malformations, including cleft palate, craniosynostosis, and craniofacial skeletal hypoplasias represent excellent targets for the implementation of tissue engineeri...

journal_title：Pediatric research

authors： Panetta NJ,Gupta DM,Slater BJ,Kwan MD,Liu KJ,Longaker MT

更新日期：2008-05-01 00:00:00

abstract：:Astrocyte end-feet ensheathe blood vessels in the brain and are believed to provide structural integrity to the cerebral vasculature. We sought to determine in developing infants whether the coverage of blood vessels by astrocyte end-feet is decreased in germinal matrix (GM) compared with cerebral cortex and white mat...

journal_title：Pediatric research

authors： El-Khoury N,Braun A,Hu F,Pandey M,Nedergaard M,Lagamma EF,Ballabh P

更新日期：2006-05-01 00:00:00

abstract：:Seven plasma protease inhibitors were analyzed in 8-yr-old children-75 PiZ (severely deficient), one PiZ-(with a null gene), 32 PiSZ (moderately deficient), and 35 normals. In PiZ and PiSZ alpha 1-antitrypsin-deficient children, significantly higher concentrations of alph 2-macroglobulin (p less than 0.001) and antith...

journal_title：Pediatric research

authors： Sveger T

更新日期：1985-08-01 00:00:00

abstract：:In human infants and newborn rats, white light at the intensity used to treat hyperbilirubinemia lowers serum calcium concentration. Occipital shielding or (in newborn rats) exogenous melatonin prevents this effect. Propranolol, by inhibiting melatonin synthesis, also causes hypocalcemia, which is preventable by melat...

journal_title：Pediatric research

authors： Hakanson DO,Bergstrom WH

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Cardiovascular instability immediately after birth is associated with intraventricular hemorrhage (IVH) in very-low-birth-weight (VLBW) infants. For circulatory management, evaluation of organ blood flow is important. In this study, the relationship between peripheral perfusion within 48 h after birth and IV...

journal_title：Pediatric research

authors： Ishiguro A,Suzuki K,Sekine T,Sudo Y,Kawasaki H,Itoh K,Kanai M,Kato I,Sobajima H,Tamura M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Neonatal encephalopathy (NE) carries high risk for neurodevelopmental impairments. Therapeutic hypothermia (TH) reduces this risk, particularly for moderate encephalopathy (ME). Nevertheless, these infants often have subtle functional deficits, including abnormal memory function. Detection of deficits at the...

journal_title：Pediatric research

authors： Pfister KM,Zhang L,Miller NC,Hultgren S,Boys CJ,Georgieff MK

更新日期：2016-12-01 00:00:00

abstract：:The mechanisms of how glutamine benefits critically ill patients have not been established. The purpose of this study was to determine the effects of dietary and endogenously produced glutamine on small intestinal morphology using light and transmission electron microscopy in artificially reared rat pups. It was hypot...

journal_title：Pediatric research

authors： Potsic B,Holliday N,Lewis P,Samuelson D,DeMarco V,Neu J

更新日期：2002-09-01 00:00:00