Abstract:
BACKGROUND:Cardiovascular instability immediately after birth is associated with intraventricular hemorrhage (IVH) in very-low-birth-weight (VLBW) infants. For circulatory management, evaluation of organ blood flow is important. In this study, the relationship between peripheral perfusion within 48 h after birth and IVH was evaluated in VLBW infants. METHODS:In this prospective observational study involving 83 VLBW infants, forehead blood flow (FBF) and lower-limb blood flow (LBF) were measured for 48 h after birth using a laser Doppler flowmeter. Blood flow was compared between infants with and without IVH. Multivariate logistic regression analysis was performed to identify the risk factors for IVH. RESULTS:IVH developed in nine infants. In eight of these patients, IVH occurred after 24 h. LBF was lower in infants with IVH at 18 and 24 h and increased to the same level as that of infants without IVH at 48 h. Multivariate logistic regression analysis identified a correlation only between LBF and IVH at 18 h. CONCLUSION:These findings were consistent with the hypoperfusion-reperfusion theory, which states that IVH develops after reperfusion subsequent to hypoperfusion. We speculate that measurement of skin blood flow in addition to systemic and cerebral circulation may be helpful in predicting IVH.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Ishiguro A,Suzuki K,Sekine T,Sudo Y,Kawasaki H,Itoh K,Kanai M,Kato I,Sobajima H,Tamura Mdoi
10.1038/pr.2013.215subject
Has Abstractpub_date
2014-02-01 00:00:00pages
322-7issue
2eissn
0031-3998issn
1530-0447pii
pr2013215journal_volume
75pub_type
杂志文章abstract::Vagal responsivity to orogastric stimulation is necessary for gastrointestinal function and may reflect autonomic regulation. Our study evaluated vagal responsivity during gavage feeding as an index of preterm clinical status. Vagal and behavioral responsivity of 26 preterm infants during gavage feeding was measured. ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199103000-00003
更新日期:1991-03-01 00:00:00
abstract::We evaluated the effectiveness of administration of high-dose busulfan (BU), an alkylating agent with substantial myeloablative but negligible immunosuppressive properties, on the engraftment of congenic normal bone marrow and spleen cells (hematopoietic cell transplantation; HCT) in murine galactosylceramidase defici...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199103000-00016
更新日期:1991-03-01 00:00:00
abstract::Changes in high-density lipoprotein (HDL) subclass distribution were evaluated in a group of premature infants during the early postnatal period to ascertain whether enteral feeding brought about a rapid shift from neonatal to adult-like distributions. All infants were fed a combination of breast milk and formula. Cor...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198806000-00001
更新日期:1988-06-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3181e17c90
更新日期:2010-07-01 00:00:00
abstract::Bubble continuous positive airway pressure (B-CPAP) applies small-amplitude, high-frequency oscillations in airway pressure (DeltaPaw) that may improve gas exchange in infants with respiratory disease. We developed a device, high-amplitude B-CPAP (HAB-CPAP), which provides greater DeltaPaw than B-CPAP provides. We stu...
journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:Pediatric research
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更新日期:2008-11-01 00:00:00
abstract::We have shown that vitamin A (VA) and retinoic acid (RA) synergistically increase lung retinyl ester content in neonatal rats. To confirm whether this biochemical synergism attenuates early neonatal hyperoxic lung injury in mice, we exposed newborn C57BL/6 mice to 95% O2 or air from birth to 4 d. The agent [vehicle, V...
journal_title:Pediatric research
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更新日期:2010-06-01 00:00:00
abstract::Neurological injury is the primary lethal mechanism of injury in children, and the primary etiology of long-term disability after trauma. Laboratories and clinical/translational teams have sought to develop stem/progenitor cell therapies to improve recovery in a clinical setting in which there is no significant repara...
journal_title:Pediatric research
pub_type: 杂志文章,评审
doi:10.1038/pr.2017.253
更新日期:2018-01-01 00:00:00
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journal_title:Pediatric research
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更新日期:2005-07-01 00:00:00
abstract::Nutrition in early life, growth, and subsequent health over a lifetime are significantly interrelated. The aim of this study was to assess body composition changes in exclusively breast-fed infants from birth up to 6 mo of age. An observational, prospective, cohort study was conducted. Fifty-nine full-term, healthy, e...
journal_title:Pediatric research
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更新日期:2010-12-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2012.176
更新日期:2013-03-01 00:00:00
abstract::Alterations in the pancreatic secretion of fluid and of enzymes in response to either pilocarpine (15 mg/kg) or an octapeptide of cholecystokinin (0.1 microgram/kg) have been found in rats that received daily injections of reserpine (0.5 mg/kg) for 7 days. During a 3-hr secretory period, significant reductions in the ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198109000-00015
更新日期:1981-09-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198202000-00010
更新日期:1982-02-01 00:00:00
abstract::Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cereb...
journal_title:Pediatric research
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199311000-00013
更新日期:1993-11-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3180686cc5
更新日期:2007-07-01 00:00:00
abstract::Synchronized atrial contraction may be much more important in the newborn, who has a faster heart rate and a less compliant ventricle, than in the adult. We therefore investigated the extent by which synchronized atrioventricular contraction contributes to cardiac output and cardiac work in a neonatal circulation, and...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199803000-00004
更新日期:1998-03-01 00:00:00
abstract::The effect of ingestion of uncooked cornstarch (2 g/kg body weight) in water, uncooked starch (1 g/kg) added to a meal, and glucose (2 g/kg) in water, was studied in eight patients with type IA glycogen storage disease (GSD) and one patient with type IB GSD. Blood glucose concentrations were determined at 30-min inter...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198409000-00015
更新日期:1984-09-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/00006450-199207000-00004
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journal_title:Pediatric research
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doi:10.1203/00006450-198411000-00020
更新日期:1984-11-01 00:00:00
abstract::Pulmonary surfactant is inactivated in meconium aspiration syndrome and neonatal pneumonia. Development of an exogenous surfactant less sensitive to inactivation might be useful for treating these diseases. We investigated in vitro whether addition of the cationic cyclic membrane cross-linking peptide polymyxin B (PxB...
journal_title:Pediatric research
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doi:10.1203/01.pdr.0000200806.32822.e6
更新日期:2006-03-01 00:00:00
abstract::Preterm infants are more prone to bone mineral deficiency the lower their birth weight. To achieve the intrauterine bone mineral accretion rate postnatally, 74 low-birth-weight infants (median birth weight, 980 g; range 430-1.580 g) were each supplemented enterally and/or parenterally with calcium and/or phosphorus in...
journal_title:Pediatric research
pub_type: 临床试验,杂志文章
doi:10.1203/00006450-199401000-00027
更新日期:1994-01-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199512000-00011
更新日期:1995-12-01 00:00:00
abstract::The field of regenerative medicine continues to make substantial advancements in therapeutic strategies addressing urologic diseases. Tissue engineering borrows principles from the fields of cell biology, materials science, transplantation and engineering in an effort to repair or replace damaged tissues. This review ...
journal_title:Pediatric research
pub_type: 杂志文章,评审
doi:10.1203/PDR.0b013e31816a704a
更新日期:2008-05-01 00:00:00
abstract::Left ventricular (LV) output nearly triples at birth, in association with increases in serum catecholamines. Similar increases in catecholamines in utero, however, do not increase output. We hypothesized that catecholamines increase contractility in utero, but that output cannot increase until LV loading conditions ar...
journal_title:Pediatric research
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doi:10.1203/00006450-199701000-00009
更新日期:1997-01-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-200003000-00017
更新日期:2000-03-01 00:00:00
abstract::We used an in vitro assay to study and compare the growth-promotional activity of protein and nonprotein components in human milk (HM) and cow milk (CM) samples for infant strains of Bifidobacterium species. HM samples varied considerably in growth-promotion activity for Bifidobacterium bifidum var pennsylvanicus, Bif...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199102000-00021
更新日期:1991-02-01 00:00:00
abstract::The aim of this study was to produce a neonatal piglet model which, avoiding vessel ligation, exposed the whole animal to hypoxia and produced dose-dependent clinical encephalopathy and neuropathologic damage similar to that seen after birth asphyxia. Twenty-three piglets were halothane-anesthetized. Hypoxia was induc...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199611000-00014
更新日期:1996-11-01 00:00:00